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| 1 | STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury显示文摘AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration. | Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 2 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 3 | Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer显示文摘 | Li Chaoyang Yu Shuiliang Nakamura Fumihiko Yin Shaoman Xu Jinghua Petrolla Amber A Singh Neena Tartakoff Alan Abbott Derek W Xin Wei Sy Man-Sun | 2009 | Journal of Clinical Investigation2009，，9： | 1 |
| 4 | Influences if the horizontal and vertical seismic force on earthquake induced landslides 显示文摘 | Lang Yu -Hua NAKAMURA Hiroyuki | 1997 | Journal of Gansu Science China1997，9，36： | 1 |
| 5 | Coherent control of macroscopic quantum states in a single-Cooper-pair box显示文摘 | Nakamura Y Pashkin Yu A Tsai J S | 1999 | Nature1999，398，： | 1 |
| 6 | Surface modification of Li-excess Mn-based cathode materials 显示文摘 | YU D Y W YANAGIDA K NAKAMURA H | 2010 | J Electrochem Soc2010，157，11： | 1 |
| 7 | Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits显示文摘 | Zhang J Yu Y Nakamura K | 2012 | J Atheroscler Thromb2012，19，3： | 1 |
| 8 | Thermal degradation of poly显示文摘 | Ikeda Masao Nakamura Takashi Nagase Yu | 1981 | Journal of Polymer Science: Polymer Chemistry Edition1981，19，： | 1 |
| 9 | Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues显示文摘 | Takeshi Hirota Yuko Date Yu Nishibatake Hiroshi Takane Yasushi Fukuoka Yuuji Taniguchi Naoto Burioka Eiji Shimizu Hiroshige Nakamura Kenji Otsubo Ichiro Ieiri | 2012 | Lung Cancer2012，，1： | 1 |
| 10 | Surface modi- fication of Li-excess Mn-based cathode materials 显示文摘 | Yu D Y W Yanagida K Nakamura H | 2010 | Journal of the Electrochemical Society2010，157，11： | 1 |
| 11 | Static characteristics of a pilot relief valve.Proceedings of the Institution of Mechanical Engineers Part C显示文摘 | WashioS Nakamura Y Yu Y | | 0，，： | 1 |
| 12 | Phospholipase C deltal is required for skin stem cell lineage commitment显示文摘 | Nakamura Y Fukami K Yu H | 2003 | EMBO2003，22，12： | 1 |
| 13 | Coherent control of macroscopic quantum states in a single-Cooper-pair box显示文摘 | Nakamura Y Pashkin Yu A Tsai J S | 1999 | Nature1999，398，6730： | 1 |
| 14 | Energy calibration of tagged photons by the d(γ,π^-pp) reaction显示文摘The energy of tagged photons, which were provided from the internal photon tagging system of the Laboratory of Nuclear Science, Tohoku University, has been calibrated using the d(γ,π-pp) reaction. Charged pions and protons in the final state were detected with the Neutral Kaon Spectrometer (NKS2). Photon energies were obtained from the reaction of d(γ,π-pp). The derived photon energy was consistent with the design of the tagger system and the previous measurement using electron-positron pair production. The consistency demonstrates the performance of NKS2 and the capability of the photon energy calibration using d(γ,π-pp). | 韩运成 Nobuyuki Chiga Yu Fujii Kenta Futatsukawa Osamu Hashimoto Kentaro Hirose Takatsugu Ishikawa Hiroki Kanda Masashi Kaneta Daisuke Kawama Kazushige Maeda Tomofumi Maruta Nayuta Maruyama Akihiko Matsumura Youhei Miyagi Koji Miwa Satoshi N. Nakamura Hajime Shimizu Koutarou Shirotori Koutaku Suzuki Tadaaki Tamae Hirokazu Tamura Kyo Tsukada 王铁山 Hirohito Yamazaki | 2010 | Chinese Physics C2010，34，1： | 1 |
| 15 | Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression显示文摘 | Zhu Yuyan Li Yuanyuan Haraguchi Seiki Yu Meng Ohira Miki Ozaki Toshinori Nakagawa Atsuko Ushijima Toshikazu Isogai Eriko Koseki Haruhiko Nakamura Yohko Kong Cuize Mehlen Patrick Arakawa Hirofumi Nakagawara Akira | 2013 | Journal of Clinical Investigation2013，，7： | 1 |
| 16 | Static characteristics of a pilot relief valve显示文摘 | Washio S Yu Y Nakamura Y | 1997 | Transactions of The Japan Hydraulics&Pneumatics Society1997，28，6： | 1 |
| 17 | High expression of ncRAN, a novel non-coding RNA mapped to chromosome17q25.1, is associated with poor prognosis in neuroblastoma显示文摘 | Meng Yu Miki Ohira Yuanyuan Li Hidetaka Niizuma Myat Oo Yuyan Zhu Toshinori Ozaki Eriko Isogai Yohko Nakamura Tadayuki Koda Shigeyuki Oba Bingzhi Yu Akira Nakagawara | 2009 | International Journal of Oncology2009，，4： | 1 |
| 18 | Coherent control of macroscopic quantum states in a single - cooper - pair box 显示文摘 | Nakamura Y Pashkin Yu A Tsai J S | 1999 | Nature1999，398，： | 1 |
| 19 | Effects of triterpenoids and flavonoids isolated from alnus firma on HIV-1viral enzymes显示文摘 | Young-Beob Yu Hirotsugu Miyashiro Norio Nakamura | 2007 | Archives of Pharmacal Research2007，30，7： | 1 |
| 20 | Effects of triterpenoids and flavonoids isolated from Alnus firma on HIV-1 viral enzymes 显示文摘 | Yu Y B Miyashiro H Nakamura N | 2007 | Arch Pharm Res2007，30，7： | 1 |
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