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| 1 | Blocking TNF-[alpha] in mice reduces colorectal carcinogenesis associated with chronic colitis显示文摘 | Popivanova Boryana K Kitamura Kazuya Wu Yu Kondo Toshikazu Kagaya Takashi Kaneko Shiuchi Oshima Masanobu Fujii Chifumi Mukaida Naofumi | 2008 | Journal of Clinical Investigation2008，，2： | 2 |
| 2 | CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc ? and Thereby Promotes Tumor Growth显示文摘 | Takatsugu Ishimoto Osamu Nagano Toshifumi Yae Mayumi Tamada Takeshi Motohara Hiroko Oshima Masanobu Oshima Tatsuya Ikeda Rika Asaba Hideki Yagi Takashi Masuko Takatsune Shimizu Tomoki Ishikawa Kazuharu Kai Eri Takahashi Yu Imamura Yoshifumi Baba Mitsuyo O | 2011 | Cancer Cell2011，，3： | 2 |
| 3 | Positional cloning of the Werner' s syndrome gene 显示文摘 | Yu CE Oshima J Fu YH | 1996 | Science1996，272，5259： | 1 |
| 4 | Single Center Experience With a Low Volume Priming Cardiopulmonary Bypass Circuit for Preventing Blood Transfusion in Infants and Small Children显示文摘 | Yasuhiro Kotani Osami Honjo Mahito Nakakura Yasuhiro Fujii Shinya Ugaki Yu Oshima Ko Yoshizumi Shingo Kasahara Shunji Sano | 2009 | ASAIO Journal2009，，3： | 1 |
| 5 | Positional cloning of the Werner′s syndrome gene显示文摘 | Yu CE Oshima J Fu YH | 1996 | Science1996，272，5259： | 1 |
| 6 | Blocking TNF-[alpha] in mice reduces colorectal carcinogenesis associated with chronic colitis显示文摘 | Popivanova Boryana K Kitamura Kazuya Wu Yu Kondo Toshikazu Kagaya Takashi Kaneko Shiuchi Oshima Masanobu Fujii Chifumi Mukaida Naofumi | 2008 | Journal of Clinical Investigation2008，，2： | 1 |
| 7 | Positional cloning of the Werner's syndrome gene显示文摘 | Yu CE Oshima J Fu YH | 1996 | Science1996，272，： | 1 |
| 8 | Positional cloning of the Werner's syndrome gene显示文摘 | Yu CE Oshima J Fu YH | 1996 | Science1996，272，： | 1 |
| 9 | Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate显示文摘Longitudinal bone growth relies on endochondral ossification in the cartilaginous growth plate,where chondrocytes accumulate and synthesize the matrix scaffold that is replaced by bone.The chondroprogenitors in the resting zone maintain the continuous turnover of chondrocytes in the growth plate.Malnutrition is a leading cause of growth retardation in children;however,after recovery from nutrient deprivation,bone growth is accelerated beyond the normal rate,a phenomenon termed catch-up growth.Although nutritional status is a known regulator of long bone growth,it is largely unknown whether and how chondroprogenitor cells respond to deviations in nutrient availability.Here,using fate-mapping analysis in Axin2CreERT2 mice,we showed that dietary restriction increased the number of Axin2+chondroprogenitors in the resting zone and simultaneously inhibited their differentiation.Once nutrient deficiency was resolved,the accumulated chondroprogenitor cells immediately restarted differentiation and formed chondrocyte columns,contributing to accelerated growth.Furthermore,we showed that nutrient deprivation reduced the level of phosphorylated Akt in the resting zone and that exogenous IGF-1 restored the phosphorylated Akt level and stimulated differentiation of the pooled chondroprogenitors,decreasing their numbers.Our study of Axin2CreERT2 revealed that nutrient availability regulates the balance between accumulation and differentiation of chondroprogenitors in the growth plate and further demonstrated that IGF-1 partially mediates this regulation by promoting the committed differentiation of chondroprogenitor cells. | Takeshi Oichi Joe Kodama Kimberly Wilson Hongying Tian Yuka Imamura Kawasawa Yu Usami Yasushi Oshima Taku Saito Sakae Tanaka Masahiro Iwamoto Satoru Otsuru Motomi Enomoto-Iwamoto | 2023 | Bone Research2023，11，2： | 0 |
| 10 | Shedding new light on the dislocation-mediated plasticity in wurtzite ZnO single crystals by photoindentation显示文摘Dislocation-mediated plasticity in inorganic semiconductors and oxides has attracted increasing research interest because of the promising mechanical and functional properties tuned by dislocations.In this study,we investigated the effects of light illumination on the dislocation-mediated plasticity in hexagonal wurtzite ZnO,a representative third-generation semiconductor material.A(0001)45o off sample was specially designed to preferentially activate the basal slip on(0001)plane.Three types of nanoindentation tests were performed under four different light conditions(550 nm,334 nm,405 nm,and darkness),including low-load(60μN)pop-in tests,high-load(500μN)nanoindentation tests,and nanoindentation creep tests.The maximum shear stresses at pop-in were found to approximate the theoretical shear strength regardless of the light conditions.The activation volume at pop-ins was calculated to be larger in light than in darkness.Cross-sectional transmission electron microscope images taken from beneath the indentation imprints showed that all indentation-induced dislocations were located beneath the indentation imprint in a thin-plate shape along one basal slip plane.These indentation-induced dislocations could spread much deeper in darkness than in light,revealing the suppressive effect of light on dislocation behavior.An analytical model was adopted to estimate the elastoplastic stress field beneath the indenter.It was found that dislocation glide ceased at a higher stress level in light,indicating the increase in the Peierls barrier under light illumination.Furthermore,nanoindentation creep tests showed the suppression of both indentation depth and creep rate by light.Nanoindentation creep also yielded a larger activation volume in light than in darkness. | Yan Li Xufei Fang Eita Tochigi Yu Oshima Sena Hoshino Takazumi Tanaka Hiroto Oguri Shigenobu Ogata Yuichi Ikuhara Katsuyuki Matsunaga Atsutomo Nakamura | 2023 | Journal of Materials Science & Technology2023，，25： | 0 |
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