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| 1 | Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM显示文摘Trichosanthin(TCS),extracted from the Chinese medicinal herb Trichosanthes kirilowi,has shown promise for the inhibition of tumor growth.However,its immunomodulatory effect on tumor–host interaction remains unknown.In this study,we focused on the effect of TCS on murine anti-tumor immune response in the 3LL Lewis lung carcinoma tumor model and explored the possible molecular pathways involved.In addition to inhibiting cell proliferation and inducing apoptosis in the 3LL tumor,TCS retarded tumor growth and prolonged mouse survival more significantly in C57BL/6 immunocompetent mice than in nude mice.This reflected the fact that the host immune system was involved in tumor eradication.Using FACS analysis,we found that TCS increased the percentage of effector T cells,particularly Interferon-gamma(IFN-c)producing CD41 and CD81 T cells from tumor-bearing mice.TCS also promoted the vigorous proliferation of antigen-specific effector T cells,markedly increased Th1 cytokine secretion and elicited more memory T cells in tumor-bearing mice,consequently enhancing the anti-tumor response and inducing immune protection.Furthermore,we found that TCS upregulated the expression of tumor suppressor in lung cancer 1(TSLC1)in 3LL tumor cells and the expression of its ligand,class I-restricted T cell-associated molecule(CRTAM),in effector T cells.Blocking TSLC1 expression with small interfering RNA(siRNA)significantly eliminated the effects of TCS on the proliferation and cytokine secretion of effector T cells,suggesting that TCS enhances anti-tumor immune response at least partially by boosting the interaction between TSLC1 and CRTAM.Collectively,our data demonstrate that TCS not only affects tumor cells directly,but also enhances anti-tumor immunity via the interaction between TSLC1 and CRTAM.These findings may lead to the development of a novel approach for tumor regression. | Yuchan Cai Shudao Xiong Yijie Zheng Feifei Luo Pei Jiang Yiwei Chu | 2011 | Cellular & Molecular Immunology2011，8，4： | 12 |
| 2 | Flexible and stable 3D lithium metal anodes based on self-standing MXene/COF frameworks for high-performance lithium-sulfur batteries显示文摘Lithium metal(Li)is believed to be the ultimate anode for lithium-ion batteries(LIBs)owing to the advantages of high theoretical capacity,the lowest electrochemical potential,and light weight.Nevertheless,issues such as uncontrollable growth of Li dendrites,large volume changes,high chemical reactivity,and unstable solid electrolyte interphase(SEI)hinder its rapid development and practical application.Herein a stable and dendrite-free Li-metal anode is obtained by designing a flexible and freestanding MXene/COF framework for metallic Li.COF-LZU1 microspheres are distributed among the MXene film framework.Lithiophilic COF-LZU1 microspheres as nucleation seeds can promote uniform Li nucleation by homogenizing the Li^(+)flux and lowering the nucleation barrier,finally resulting in dense and dendrite-free Li deposition.Under the regulation of the COF-LZU1 seeds,the Coulombic efficiency of the MXene/COF-LZU1 framework and electrochemical stability of corresponding symmetric cells are obviously enhanced.Li-S full cells with the modified Li-metal anode and sulfurized polyacrylonitrile(S@PAN)cathode also exhibited a superior electrochemical performance. | Chuanliang Wei Yusheng Wang Yuchan Zhang Liwen Tan Yi Qian Yuan Tao Shenglin Xiong Jinkui Feng | 2021 | Nano Research2021，14，10： | 5 |
| 3 | Self-assembled, highly-lithiophilic and well-aligned biomass engineered MXene paper enables dendrite-free lithium metal anode in carbonate-based electrolyte显示文摘Lithium metal anode is the ideal candidate for high-energy–density rechargeable batteries.However,uncontrolled dendrite growth hampers its commercialization.Herein,a dendrite-free composite Li metal anode is realized by a flexible,freestanding,well-aligned and highly-lithiophilic MXene paper designed by a facile electrostatic self-assembly of the exfoliated MXene nanosheets and natural polysaccharidechitosan (MX@CS).The MX@CS paper gets a well-aligned layered-3D structure with a micro-crumpled surface that can effectively decrease the local current density,guide even Li plating and suppress dendritic Li growth.More importantly,surface-adsorbed chitosan endows enhanced lithiophilicity for MXene substrate and thus reduces the Li nucleation overpotential,which is confirmed by the density functional theory calculations.Abundant lithiophilic groups on MX@CS surface provide highconcentration Li^(+)anchoring site promoting Li nucleation and laterally inducing uniform Li deposition,which effectively avoids the formation of dendritic Li.As a result,the MX@CS-Li anode with a dendrite-free Li morphology shows a significantly improved cycling life in commercial carbonatebased electrolyte.When coupled with LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)cathode,the full cell exhibits a low capacity decay and steady ultrahigh Coulombic efficiency of 99.6%at a current density of 5C.These findings develop a new approach for designing high-performance metal-based rechargeable batteries. | Liwen Tan Chuanliang Wei Yuchan Zhang Shenglin Xiong Hui Li Jinkui Feng | 2022 | Journal of Energy Chemistry2022，31，6： | 4 |
| 4 | Extremely regular periodic surface structures in a large area efficiently induced on silicon by temporally shaped femtosecond laser显示文摘Femtosecond laser-induced periodic surface structures(LIPSS) have several applications in surface structuring and functionalization. Three major challenges exist in the fabrication of regular and uniform LIPSS: enhancing the periodic energy deposition, reducing the residual heat, and avoiding the deposited debris. Herein, we fabricate an extremely regular low-spatial-frequency LIPSS(LSFL) on a silicon surface by a temporally shaped femtosecond laser. Based on a 4 f configuration zero-dispersion pulse shaping system, a Fourier transform limit(FTL) pulse is shaped into a pulse train with varying intervals in the range of 0.25–16.2 ps using periodic π-phase step modulation. Under the irradiation of the shaped pulse with an interval of 16.2 ps, extremely regular LSFLs are efficiently fabricated on silicon. The scan velocity for fabricating regular LSFL is 2.3 times faster, while the LSFL depth is 2 times deeper, and the diffraction efficiency is 3 times higher than those of LSFL using the FTL pulse.The formation mechanisms of regular LSFL have been studied experimentally and theoretically. The results show that the temporally shaped pulse enhances the excitation of surface plasmon polaritons and the periodic energy deposition while reducing the residual thermal effects and avoiding the deposition of the ejected debris, eventually resulting in regular and deeper LSFL on the silicon surface. | YUCHAN ZHANG QILIN JIANG KAIQIANG CAO TIANQI CHEN KE CHENG SHIAN ZHANG DONGHAI FENG TIANQING JIA ZHENRONG SUN JIANRONG QIU | 2021 | Photonics Research2021，9，5： | 4 |
| 5 | Femtosecond laser-induced periodic structures:mechanisms, techniques, and applications显示文摘Over the past two decades,femtosecond laser-induced periodic structures(femtosecond-LIPSs)have become ubiquitous in a variety of materials,including metals,semiconductors,dielectrics,and polymers.Femtosecond-LIPSs have become a useful laser processing method,with broad prospects in adjusting material properties such as structural color,data storage,light absorption,and luminescence.This review discusses the formation mechanism of LIPSs,specifically the LIPS formation processes based on the pump-probe imaging method.The pulse shaping of a femtosecond laser in terms of the time/frequency,polarization,and spatial distribution is an efficient method for fabricating high-quality LIPSs.Various LIPS applications are also briefly introduced.The last part of this paper discusses the LIPS formation mechanism,as well as the high-efficiency and high-quality processing of LIPSs using shaped ultrafast lasers and their applications. | Yuchan Zhang Qilin Jiang Mingquan Long Ruozhong Han Kaiqiang Cao Shian Zhang Donghai Feng Tianqing Jia Zhenrong Sun Jianrong Qiu Hongxing Xu | 2022 | Opto-Electronic Science2022，1，6： | 3 |
| 6 | A competitive microcystin-LR immunosensor based on Au NPs@metal-organic framework(MIL-101)显示文摘An electrochemical immunosensor was developed for ultrasensitive detection of microcystin-LR in water. MIL-101, a porous metal-organic frameworks(MOFs) material based on trivalent chromium skeleton were synthesized by hydrothermal synthesis method, and loaded with Au nanoparticles(Au NPs) to prepare Au NPs@MIL-101 composite materials which were used as a marker to label anti microcystin-LR(Anti-MC-LR). The composite materials have strong catalytic properties to the oxidation of ascorbic acid. Anti-MC-LR was immobilized on glassy carbon electrode surface using electrodeposition graphene oxide(GO) as an immobilization matrix to construct a competitive microcystin-LR immunosensor. The electrochemical immunosensor display linear relationship in the range of 0.05 ng/mL-75 μg/mL with linear correlation coefficient of 0.9951 and detection limit of 0.02 ng/mL(S/N = 3). This sensor was used to detect microcystin-LR in the water sample. The recovery was 102.43%,which is satisfied. The good testing results indicate the sensor has a great prospect in practical application. | Kunlei Zhang Kun Dai Ruyan Bai Yuchan Ma Yan Deng Delei Li Xi Zhang Rong Hu Yunhui Yang | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 7 | Grass phasiRNAs and male fertility显示文摘Recent studies have indicated that a special type of small noncoding RNAs, phased small-interfering RNAs(phasiRNAs) play crucial roles in many cellular processes of plant development. PhasiRNAs are generated from long RNA precursors at intervals of 21 or 24 nt in plants, and they are produced from both protein-coding gene and long noncoding RNA genes. Different from those in eudicots, grass phasiRNAs include a special class of small RNAs that are specifically expressed in reproductive organs.These grass phasiRNAs are associated with gametogenesis, especially with anther development and male fertility. In this review,we summarized current knowledge on these small noncoding RNAs in male germ cells and their possible biological functions and mechanisms in grass species. | Yang Yu Yanfei Zhou Yuchan Zhang Yueqin Chen | 2018 | Science China(Life Sciences)2018，61，2： | 2 |
| 8 | Bacteroides ovatus-mediated CD27^(−)MAIT cell activation is associated with obesity-related T2D progression显示文摘Type 2 diabetes(T2D)is highly associated with obesity.However,the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve around systemic immune disorder.Mucosal-associated invariant T(MAIT)cells,which are innate-like T cells that recognize bacterial metabolites,have been reported to be altered in obese people and to lead to metabolic dysfunction during obesity.By studying the immunophenotypes of blood MAIT cells from a cross-sectional cohort of obese participants with/without T2D,we found an elevation in CD27^(-)negative(CD27−)MAIT cells producing a high level of IL-17 under T2D obese conditions,which could be positively correlated with impaired glucose metabolism in obese people.We further explored microbial translocation caused by gut barrier dysfunction in obese people as a triggering factor of MAIT cell abnormalities.Specifically,accumulation of the bacterial strain Bacteroides ovatus in the peripheral blood drove IL-17^(-)producing CD27−MAIT cell expansion and could be associated with T2D risk in obese individuals.Overall,these results suggest that an aberrant gut microbiota–immune axis in obese people may drive or exacerbate T2D.Importantly,CD27−MAIT cell subsets and Bacteroides ovatus could represent targets for novel interventional strategies.Our findings extend current knowledge regarding the clinical relevance of body mass index(BMI)-associated variation in circulating MAIT cells to reveal the role of these cells in obesity-related T2D progression and the underlying cellular mechanisms. | Yue Li Yi Yang Jin Wang Peihong Cai Mei Li Xixiang Tang Ying Tan Yuchan Wang Fan Zhang Xiaofeng Wen Qiaoxing Liang Yuanpeng Nie Tufeng Chen Xiang Peng Xuemin He Yanhua Zhu Guojun Shi Wai WCheung Lai Wei Yanming Chen Yan Lu | 2022 | Cellular & Molecular Immunology2022，19，7： | 2 |
| 9 | Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds显示文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment. | Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 10 | Influ- ences of partially hydrolyzed polyacrylamide (HPAM) resi- due on the flocculation behavior of oily wastewater produced from polymer flooding显示文摘 | ZHAO Xiaofei LIN Lixin WANG Yuchan | 2008 | Separation and Purification Tech- nology2008，62，1： | 1 |
| 11 | Influences of par-tially hydrolyzed polyacrylamide (HPAM) residue on the flocculationbehavior of oily wastewater produced from polymer flooding显示文摘 | Zhao Xiaofei Liu Lixin Wang Yuchan | 2008 | Se-paration and Purification Technology2008，62，1： | 1 |
| 12 | Purification of yellow phosphorus tail gas for the removal of PH 3 on the spot with flower-shaped CuO/AC显示文摘 | Ren Zhandong Quan Shanshan Zhu Yuchan | 2015 | RSC Adv2015，，29： | 1 |
| 13 | Microstructural development of Cu-Sn-Ti alloys on graphite显示文摘 | Yuchan H Shuntian L | 2008 | Journal of Alloys and compouuds2008，466，： | 1 |
| 14 | Room-temperature liquid metal engineered iron current collector enables stable and dendrite-free sodium metal batteries in carbonate electrolytes显示文摘Metallic sodium(Na)is believed to be a promising anode material for sodium-ion batteries(SIBs)due to its low electrochemical potential,high theoretical specific capacity,superior electrical conductivity,and so on.However,issues such as high chemical activity,the growth of Na dendrites,large volume change,and unstable interface impede its practical application.We design a cheap iron(Fe)-based substrate decorated by a thin liquid metal Ga layer for stable and dendrite-free Na metal anodes in low-cost carbonate electrolytes.The inherent mechanism of Ga-based liquid metal in inhibiting the growth of Na dendrites was revealed for the first time.Liquid metal Ga with sodiophilic property can act as nucleation seeds to decrease the nucleation barrier and induce homogeneous Na+flux,resulting in uniform and dendrite-free Na deposition.Full cells with Na_(3)V_(2)(PO_(4))_(3) cathode were also assembled to verify the practical application ability of the modified Na metal anode.Under the regulation of the liquid metal layer,the Coulombic efficiency,cycling life,and capacity of batteries are obviously enhanced.The strategy proposed here cannot only reduce the cost of batteries but also improve their electrochemical and safety performance. | Chuanliang Wei Liwen Tan Yuchan Zhang Huiyu Jiang Baojuan Xi Shenglin Xiong Jinkui Feng | 2022 | Journal of Materials Science & Technology2022，，20： | 1 |
| 15 | PHysicochemical properties and bactericidal efficiency of neutral and acidic electrolyzed water under different storage conditions显示文摘 | Cui Xiaodong Shang Yuchan Shi Zhengxiang | 2009 | Journal of Food Engineering2009，91，4： | 1 |
| 16 | Influ- ences of partially hydrolyzed polyacryl-amide (HPAM) residue on the flocculation behavior of oily wastewater produced from polymer flooding 显示文摘 | Zhao Xiaofei Liu Lixin Wang Yuchan | 2008 | Sep Purif Tech- nol2008，62，1： | 1 |
| 17 | Lithocarpinols A and B,a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508显示文摘Lithocarpinols A(1) and B(2), a pair of tenellone diastereoisomers with novel fused skeleton were isolated from the deep-sea derived fungus Phomopsis lithocarpus FS508. Their structures were elucidated by comprehensive spectroscopic analyses, X-ray diffraction and quantum molecular calculation. Their plausible biogenetic pathway featured an intriguing carbonyl-ene cyclization. Lithocarpinol A exhibited moderate inhibitory effect against HepG-2 and A549 tumor cell lines with IC_(50) values of 9.4 μmol/L and10.9 μmol/L,respectively. | Jianlin Xu Haibo Tan Yuchan Chen Saini Li Heng Guo Zilei Huang Haohua Li Xiaoxia Gao Hongxin Liu Weimin Zhang | 2019 | Chinese Chemical Letters2019，30，2： | 1 |
| 18 | Metal-organic frameworks and their derivatives in stable Zn metal anodes for aqueous Zn-ion batteries显示文摘Zn metal anode is believed to be a promising anode material for aqueous Zn-ion batteries(ZIBs)due to the mer-its such as low electrochemical potential,low cost,high theoretical specific capacity,high hydrogen evolution overpotential,less-reactive property,environmental friendliness and easy processing.However,issues including uncontrollable growth of Zn dendrites,corrosion by aqueous electrolyte,large volume change and unstable in-terface hinder its further development.Recently,multifunctional metal-organic frameworks(MOFs)and their derivatives have shown huge advantages in solving the issues facing Zn metal anode,and large advances have been achieved.MOFs and their derivatives can stabilize Zn metal anode by interface engineering,designing host,decorating separator,constructing solid-state electrolyte and so on.Here we carefully summarize and analyse these advances.Meanwhile,some perspectives and outlooks are put forward.This review can promote the de-velopment of MOFs,Zn metal anode as well as aqueous ZIBs. | Chuanliang Wei Liwen Tan Yuchan Zhang Shenglin Xiong Jinkui Feng | 2022 | ChemPhysMater2022，1，4： | 1 |
| 19 | Determination of Multiple Pesticide Residues in Okra by QuEChERS Combined with PTV-GC-MS/MS and UPLC-MS/MS显示文摘[Objectives] To establish Qu ECh ERS based extraction method for determining multiple pesticide residues in okra combined with programmed temperature vaporizer-gas chromatography-triple quadrupole mass spectrometry( PTV-GC-MS/MS) and ultra high performance liquid chromatography-mass spectrometry( UPLC-MS/MS). [Methods] In this experiment,124 pesticide residues in okra were determined by an optimized Qu ECh ERS method combined with PTV-GC-MS/MS and UPLC-MS/MS. The pesticides in okra were extracted and purified by the optimized Qu ECh ERS pretreatment method and determined by PTV-GC-MS/MS and UPLC-MS/MS. [Results] In this experiment,124 kinds of pesticides had a good linearity with a limit of detection( LOD) of 0. 000 5-0. 008 0 mg/kg; the average recovery rate at three levels was 65. 5%-128. 1% with relative standard deviation of 2. 2%-9. 7%. [Conclusions] This method is simple,rapid,accurate and sensitive,and can provide reliable and valid data support for the determination of multiple pesticide residues in okra by GC-MS/MS and UPLC-MS/MS. | Jingwen FU Yuchan LIN Zijing HUANG Mengjun CHEN | 2018 | Medicinal Plant2018，9，3： | 1 |
| 20 | CuO nanowires based sensitive and selective non-enzymatic glucose detection显示文摘 | Yuchan Zhang Yixin Liu Liang Su Zhonghua Zhang Danqun Huo Changjun Hou Yu Lei | 2014 | Sensors & Actuators: B. Chemical2014，，： | 1 |
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