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| 1 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 2 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 3 | Flexible fiber-shaped supercapacitors based on hierarchically nanostructured composite electrodes显示文摘新奇所有固态的、同轴的、塑造纤维的不对称的 supercapacitor 被在 MnO 上包一张进行的复写纸制作了 < 潜水艇 class= “ a-plus-plus ” > 2 -modified nanoporous 金牌电线。这根精力电线展出 12 mF | Henghui Xu Xianluo Hu Yongming Sun Huiling Yang Xiaoxiao Liu Yunhui Huang | 2015 | Nano Research2015，8，4： | 14 |
| 4 | Using the nematode Caenorhabditis elegans as a model animal for assessing the toxicity induced by microcystin-LR显示文摘Among more than 75 variants of microcystin(MC),microcystin-LR(MC-LR) is one of the most common toxins.In this study,the feasibility of using Caenorhabditis elegans to evaluate MC-LR toxicity was studied.C.elegans was treated with MC-LR at different concentrations ranging from 0.1 to 80 μg/L.The results showed that MC-LR could reduce lifespan,delay development,lengthen generation time,decrease brood size,suppress locomotion behavior,and decreases hsp-16-2-gfp expression.The endpoints of generation time,brood size,and percentage of the population expressing hsp-16-2-gfp were very sensitive to 1.0 μg/L of MC-LR,and would be more useful for the evaluation of MC-LR toxicity.Furthermore,the tissue-specific hsp-16-2-gfp expressions were investigated in MC-LR-exposed animals,and the nervous system and intestine were primarily affected by MC-LR.Therefore,the generation time,brood size,and hsp-16-2-gfp expression in C.elegans can be explored to serve as valuable endpoints for evaluating the potential toxicity from MC-LR exposure. | LI Yunhui WANG Yang YIN Lihong PU Yuepu WANG Dayong | 2009 | Journal of Environmental Sciences2009，21，3： | 9 |
| 5 | Highly Enhanced Visible-Light-Driven Photoelectrochemical Performance of ZnO-Modified In_2S_3 Nanosheet Arrays by Atomic Layer Deposition显示文摘Photoanodes based on In_2S_3/ZnO heterojunction nanosheet arrays(NSAs) have been fabricated by atomic layer deposition of ZnO over In_2S_3 NSAs, which were in situ grown on fluorine-doped tin oxide glasses via a facile solvothermal process. The as-prepared photoanodes show dramatically enhanced performance for photoelectrochemical(PEC) water splitting, compared to single semiconductor counterparts. The optical and PEC properties of In_2S_3/ZnO NSAs have been optimized by modulating the thickness of the Zn O overlayer. After pairing with ZnO, the NSAs exhibit a broadened absorption range and an increased light absorptance over a wide wavelength region of 250–850 nm. The optimized sample of In_2S_3/ZnO-50 NSAs shows a photocurrent density of 1.642 m A cm^(-2)(1.5 V vs. RHE) and an incident photonto-current efficiency of 27.64% at 380 nm(1.23 V vs.RHE), which are 70 and 116 times higher than those of the pristine In_2S_3 NSAs, respectively. A detailed energy band edge analysis reveals the type-II band alignment of the In_2S_3/ZnO heterojunction, which enables efficient separation and collection of photogenerated carriers,especially with the assistance of positive bias potential, and then results in the significantly increased PEC activity. | Ming Li Xinglong Tu Yunhui Wang Yanjie Su Jing Hu Baofang Cai Jing Lu Zhi Yang Yafei Zhang | 2018 | Nano-Micro Letters2018，10，3： | 5 |
| 6 | MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation显示文摘 | Ruirui Ji Yunhui Cheng Junming Yue Jian Yang Xiaojun Liu He Chen David B. Dean Chunxiang Zhang | 2007 | Circulation Research2007，，11： | 4 |
| 7 | Analysis of the mass of behind-armor debris generated by RHA subjected to normal penetration of variable cross-section EFP显示文摘Analyzing the mass of behind-armor debris (BAD) generated by Rolled Homogeneous Armor (RHA) subjected to normal penetration of variable cross-section Explosively Formed Projectile (EFP) is the purpose of this paper. So theoretical analysis, numerical simulation and experimental data are combined to analyze the influence of variable cross-section characteristic on the time history of crater radius. Moreover the relationships between time history of crater radius (as well as mass of BAD) and the thickness of RHA (from 30mm to 70 mm) and the impact velocity of EFP (1650 m/s to 1860 m/s) are also investigated. The results indicate that: 1) being compared to the variable cross-section characteristic is ignored, the theoretical time history of crater radius is in better agreement with the simulation results when the variable cross-section characteristic is considered;2) being compared to the other three conditions of plug, the theoretical mass of BAD is in the best agreement with the simulation results when the shape of plug is frustum of a cone and the angle between generatrix and bottom is 45- and the axial length of mushroom is considered. | Boyang Xing Dongjiang Zhang Zhenyan Guo Yunhui Hou Rui Guo Rongzhong Liu Liang Chen Hao Zhou Yongliang Yang Jianhua Luo | 2019 | Defence Technology(防务技术)2019，15，3： | 4 |
| 8 | Direct silylation reactions of inert C-H bonds via transition metal catalysis显示文摘In the past thirty years,transition metal catalyzed silylation of inert C–H bonds has attracted intensive attention due to the importance and wide use of organosilicon compounds.In this review,the silylation reactions of inert C–H bonds catalyzed by transition metal complexes of Ir,Rh,Ru,Pt,Pd,Ni,and Sc,and the strategies utilized to access the site-selective C–H silylation products have been summarized.Furthermore,the mechanisms of C–H silylation reactions have been discussed briefly. | Yunhui Yang Congyang Wang | 2015 | Science China Chemistry2015，58，8： | 4 |
| 9 | Multi-camera calibration method based on minimizing the difference of reprojection error vectors显示文摘In order to achieve a high precision in three-dimensional(3 D) multi-camera measurement system, an efficient multi-camera calibration method is proposed. A stitching method of large scale calibration targets is deduced, and a fundamental of multi-camera calibration based on the large scale calibration target is provided.To avoid the shortcomings of the method, the vector differences of reprojection error with the presence of the constraint condition of the constant rigid body transformation is modelled, and minimized by the Levenberg-Marquardt(LM) method. Results of the simulation and observation data calibration experiment show that the accuracy of the system calibrated by the proposed method reaches 2 mm when measuring distance section of 20 000 mm and scale section of 7 000 mm × 7 000 mm. Consequently, the proposed method of multi-camera calibration performs better than the fundamental in stability. This technique offers a more uniform error distribution for measuring large scale space. | HUO Ju LI Yunhui YANG Ming | 2018 | Journal of Systems Engineering and Electronics2018，29，4： | 3 |
| 10 | Simultaneously optimizing pore morphology and enhancing mechanical properties of Al-Si alloy composite foams by graphene nanosheets显示文摘The integrity and regularity of pore morphology play an important role in determining the mechanical properties of the metallic foam materials.The conventional methods on refining pore morphology are mainly focused on the optimization of fabrication techniques,however,they are usually inconvenient and complicated.Recently,incorporating nano reinforcement is considered to be a suitable way to fabricate metallic composite foams accompanied by optimized pore morphology and enhanced mechanical properties.In this work,through a facile and rapid powder metallurgy foaming method,the aluminum-silicon(Al-Si)alloy composite foams reinforced by graphene nanosheets(GNSs)are successfully fabricated.The microstructure analyses reveal that,for the Al-Si alloy foams incorporating the GNSs(GNSs/Al-Si composite foams),the pore size is transformed to be smaller,the pore size distributions become more homogeneous and the pore shape is also refined to a regular and roundish state.Meanwhile,the shape of Si precipitates is found transforming from an irregular long strip(length of~20μm,width of~5μm)to a fine particle state(diameter of~5μm).Moreover,the compressive testing results show that,the 0.4wt%GNSs/Al-Si composite foams own the optimal compression stress of 11.7±0.5 MPa,plateau stress of 10.0±1.0 MPa and energy absorption capacity of 6.8±0.7 MJ/m^(3),which have improvement of 58.1%,53.8%and 51.1%in comparison with the Al-Si alloy foams counterpart,respectively.The present findings may pave a new way for developing new generation of metallic composite foams that with stable microstructure and excellent mechanical performance. | Weiting Li Xudong Yang Kunming Yang Chunnian He Junwei Sha Chunsheng Shi Yunhui Mei Jiajun Li Naiqin Zhao | 2022 | Journal of Materials Science & Technology2022，，6： | 3 |
| 11 | Determination of ginsenoside compound K in human plasma by liquid chromatography–tandem mass spectrometry of lithium adducts显示文摘Ginsenoside compound K(GCK), the main metabolite of protopanaxadiol constituents of Panax ginseng, easily produces alkali metal adduct ions during mass spectrometry particularly with lithium. Accordingly, we have developed a rapid and sensitive liquid chromatography–tandem mass spectrometric method for analysis of GCK in human plasma based on formation of a lithium adduct. The analyte and paclitaxel(internal standard) were extracted from 50 m L human plasma using methyl tertbutyl ether. Chromatographic separation was performed on a Phenomenex Gemini C18 column(50 mm 2.0 mm; 5 μm) using stepwise gradient elution with acetonitrile–water and 0.2 mmol/L lithium carbonate at a flow rate of 0.5 m L/min. Detection was performed in the positive ion mode using multiple reaction monitoring of the transitions at m/z 629-449 for the GCK-lithium adduct and m/z 860-292 for the adduct of paclitaxel. The assay was linear in the concentration range 1.00–1000 ng/m L(r^2>40.9988)with intra- and inter-day precision of ±8.4% and accuracy in the range of 4.8% to 6.5%. Recovery,stability and matrix effects were all satisfactory. The method was successfully applied to a pharmacokinetic study involving administration of a single GCK 50 mg tablet to healthy Chinese volunteers. | Yunhui Chen Youming Lu Yong Yang Xiaoyan Chen Liang Zhu Dafang Zhong | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 3 |
| 12 | MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation显示文摘 | Yunhui Cheng Xiaojun Liu Jian Yang Ying Lin Da-Zhong Xu Qi Lu Edwin A. Deitch Yuqing Huo Ellise S. Delphin Chunxiang Zhang | 2009 | Circulation Research2009，，2： | 2 |
| 13 | A competitive microcystin-LR immunosensor based on Au NPs@metal-organic framework(MIL-101)显示文摘An electrochemical immunosensor was developed for ultrasensitive detection of microcystin-LR in water. MIL-101, a porous metal-organic frameworks(MOFs) material based on trivalent chromium skeleton were synthesized by hydrothermal synthesis method, and loaded with Au nanoparticles(Au NPs) to prepare Au NPs@MIL-101 composite materials which were used as a marker to label anti microcystin-LR(Anti-MC-LR). The composite materials have strong catalytic properties to the oxidation of ascorbic acid. Anti-MC-LR was immobilized on glassy carbon electrode surface using electrodeposition graphene oxide(GO) as an immobilization matrix to construct a competitive microcystin-LR immunosensor. The electrochemical immunosensor display linear relationship in the range of 0.05 ng/mL-75 μg/mL with linear correlation coefficient of 0.9951 and detection limit of 0.02 ng/mL(S/N = 3). This sensor was used to detect microcystin-LR in the water sample. The recovery was 102.43%,which is satisfied. The good testing results indicate the sensor has a great prospect in practical application. | Kunlei Zhang Kun Dai Ruyan Bai Yuchan Ma Yan Deng Delei Li Xi Zhang Rong Hu Yunhui Yang | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 14 | Ultrathin tellurium nanosheets for simultaneous cancer thermo-chemotherapy显示文摘The emerging two-dimensional monoelemental materials(2D Xenes)have been commonly supposed as promising drug delivery carriers,photothermal and photodynamic therapeutic agents,biosensors,theranostics,and some other candidates for biomedical applications.Here,high-performance and bioactive ultrathin 2D Tellurium nanosheets(Te NSs)are prepared by a simple but efficient liquid-phase exfoliation approach.The as-obtained Te NSs possess a mean size of~90 nm and a mean thickness of~5.43 nm.The pegylation Te NSs(Te-PEG NSs)possess excellent biocompatibility and stability.The Te-PEG NSs could generate local hyperthermia with a remarkable photothermal conversion efficiency of about 55%under 808 nm laser irradiation.Additionally,Te-PEG NSs exhibit an extremely high loading capacity of chemo drug(~162%)owing to their ultra-high surface area and tumor microenvironment-triggered drug release superiority.The results of in vivo experiments show that the Te-PEG NSs have higher tumor elimination efficiency via the combination of photothermal and chemotherapy,comparing to any other single therapeutic modalities.Therefore,our work not only highlights the promising potentials of tellurene as an ideal anti-cancer platform but also expands the application of 2D Te for cancer nanomedicine. | Wen Pan Chuang Liu Yunhui Li Yang Yang Wenliang Li Chan Feng Leijiao Li | 2022 | Bioactive Materials2022，7，7： | 2 |
| 15 | Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms显示文摘Heart failure is the leading cause of death worldwide.Compound Danshen Dripping Pill(CDDP)or CDDP combined with simvastatin has been widely used to treat patients with myocardial infarction and other cardiovascular diseases in China.However,the effect of CDDP on hypercholesterolemia/atherosclerosis-induced heart failure is unknown.We constructed a new model of heart failure induced by hypercholesterolemia/atherosclerosis in apolipoprotein E(ApoE)and LDL receptor(LDLR)dual deficient(ApoE^(–/–)LDLR^(–/–))mice and investigated the effect of CDDP or CDDP plus a low dose of simvastatin on the heart failure.CDDP or CDDP plus a low dose of simvastatin inhibited heart injury by multiple actions including anti-myocardial dysfunction and anti-fibrosis.Mechanistically,both Wnt and lysine-specific demethylase 4A(KDM4A)pathways were significantly activated in mice with heart injury.Conversely,CDDP or CDDP plus a low dose of simvastatin inhibited Wnt pathway by markedly up-regulating expression of Wnt inhibitors.While the anti-inflammation and anti-oxidative stress by CDDP were achieved by inhibiting KDM4A expression and activity.In addition,CDDP attenuated simvastatin-induced myolysis in skeletal muscle.Taken together,our study suggests that CDDP or CDDP plus a low dose of simvastatin can be an effective therapy to reduce hypercholesterolemia/atherosclerosis-induced heart failure. | Yanfang Yang Ke Feng Liying Yuan Yuxin Liu Mengying Zhang Kaimin Guo Zequn Yin Wenjia Wang Shuiping Zhou He Sun Kaijing Yan Xijun Yan Xuerui Wang Yajun Duan Yunhui Hu Jihong Han | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 16 | Effect of degradation of PLGA and PLGA/β-TCP scaffolds on the growth of osteoblasts显示文摘Osteoblasts were cultured on porous scaffolds of poly(L-lactide-co-glycolide) (PLGA) and PLGA/β-tricalcium phosphate (β-TCP) to evaluate their cytocompatibility.The proliferation of the cells on both scaffolds was examined before and after in vitro degradation for 4,8 and 12 weeks under static (shaking water bath) and dynamic (cyclic loading) conditions.Results indicate that porous PLGA and PLGA/β-TCP scaffolds have good biocompatibility and can be used as effective templates for guiding the growth of osteoblasts.The degradation of the scaffolds affects the proliferation of osteoblasts and the cell viability decreased with the degradation time. | YANG YanFang TANG GongWen ZHAO YunHui ZHANG Yang LI XiuLan YUAN XiaoYan | 2011 | Chinese Science Bulletin2011，56，10： | 2 |
| 17 | Claroideoglomus etunicatum improved the growth and saline-alkaline tolerance of Potentilla anserina by altering physiological and biochemical properties显示文摘To investigate the effects of arbuscular mycorrhizal(AM)fungi on the growth and saline–alkaline tolerance of Potentilla anserina L.,the seedlings were inoculated with Claroideoglomus etunicatum(W.N.Becker&Gerd.)C.Walker&A.Schüßler in pot cultivation.After 90 days of culture,saline–alkaline stress was induced with NaCl and NaHCO_(3)solution according to the main salt components in saline–alkaline soils.Based on the physiological response of P.anserina to the stress in the preliminary experiment,the solution concentrations of 0 mmol/L,75 mmol/L,150 mmol/L,225 mmol/L and 300 mmol/L were treated with stress for 10 days,respectively.The mycorrhizal colonization rate,mycorrhizal dependence,chlorophyll content,malondialdehyde content,antioxidant enzyme activities,osmoregulation substances content and water status were measured.The results showed that with the increase of NaCl and NaHCO_(3)stress concentration,mycorrhizal colonization rate,colonization intensity,arbuscular abundance and vesicle abundance decreased,and reached the lowest value at 300 mmol/L.Strong mycorrhizal dependence was observed after the symbiosis with AM fungus,and the dependence was higher under NaHCO_(3)treatment.Under NaCl and NaHCO_(3)stress,inoculation with AM fungus could increase chlorophyll content,decrease malondialdehyde content,increase activities of superoxide dismutase,peroxidase and catalase,increase contents of proline,soluble sugar and soluble protein,increase tissue relative water content and decrease water saturation deficit.It was concluded that salt–alkali stress inhibited the colonization of AM fungus,but the mycorrhiza still played a positive role in maintaining the normal growth of plants under salt–alkali stress. | YUNHUI ZHOU YAJIE LIU YUDAN WANG CHUNXUE YANG | 2022 | BIOCELL2022，46，8： | 2 |
| 18 | Inhibitive determination of mercury ion using a renewable urea biosensor based on self-assembled gold nanoparticlea显示文摘 | YANG Yunhui WANG Zhijie YANG Minhui | 2006 | Sensors and Actuators B: Chemical2006，114，1： | 1 |
| 19 | A protein a-based orientation-controlled immobilization strategy for antibodies using nanometer-sized gold particles and plasma-polymerized film显示文摘 | Wang Hua Liu Yanli Yang Yunhui | 2004 | Anal Biochem2004，324，： | 1 |
| 20 | Forging Three Single Bonds on One Carbon via Metal Carbynes or Carbyne Equivalents显示文摘Metal carbyne(M≡C)complexes have been discovered for nearly half a century,however,they gained far less study in comparison with metal-carbon single bond(M—C)and metal carbene(M=C)species in synthetic chemistry.Up to three sigma bonds are possibly forged on a single carbon through metal carbynes or carbyne equivalents,which holds great potentials in organic synthesis but also requires high efficiency of bond formation and precise control of reactivity and selectivity.Along this line,two systems based on stoi-chiometric transformations of manganese carbynes and ruthenium/rhodium-catalyzed reactions of diazo hypervalent iodine reagents,carbyne equivalents,have emerged recently,which will be highlighted herein.Future potentials and challenges in this intriguing area are also briefly discussed. | Yunhui Yang Congyang Wang | 2021 | Chinese Journal of Chemistry2021，39，12： | 1 |
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