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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | A Genetic Pathway for Tapetum Development and Function in Arabidopsis显示文摘In anther development, tapetal cells take part in complex processes, including endomitosis and apoptosis (programmed cell death). The tapetum provides many of the proteins, lipids, polysaccharides and other molecules necessary for pollen development. Several transcription factors, including DYT1, TDF1, AMS, MS188 and MS1, have been reported to be essential for tapetum development and function in Arabidopsis thaliana. Here, we present a detailed cytological analysis of knockout mutants for these genes, along with an in situ RNA hybridization experiment and double mutant analysis showing that these transcription factors form a genetic pathway in tapetum development. DYT1, TDF1 and AMS function in early tapetum development, while MS188 and MS1 are important for late tapetum development. The genetic pathway revealed in this work facilitates further investigation of the function and molecular mechanisms of tapetum development in Arabidopsis. | Jun Zhu Yue Lou Xiaofeng Xu Zhong-Nan Yang | 2011 | Journal of Integrative Plant Biology2011，53，11： | 32 |
| 3 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China显示文摘Enterovirus 71(EV71),one of the major causative agents for hand-foot-and-mouth disease(HFMD),has caused more than 100 deaths among Chinese children since March 2008.The EV71 genome encodes an RNAdependent RNA polymerase(RdRp),denoted 3D^(pol),which is central for viral genome replication and is a key target for the discovery of specific antiviral therapeutics.Here we report the crystal structures of EV71 RdRp(3D^(pol))and in complex with substrate guanosine-5'-triphosphate and analog 5-bromouridine-5'-triphosphate best to 2.4Åresolution.The structure of EV71 RdRp(3D^(pol))has a wider open thumb domain compared with the most closely related crystal structure of poliovirus RdRp.And the EV71 RdRp(3D^(pol))complex with GTP or Br-UTP bounded shows two distinct movements of the polymerase by substrate or analogue binding.The model of the complex with the template:primer derived by superimposition with foot-and-mouth disease virus(FMDV)3D/RNA complex reveals the likely recognition and binding of template:primer RNA by the polymerase.These results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery. | Yang Wu Zhiyong Lou Yi Miao Yue Yu Hui Dong Wei Peng Mark Bartlam Xuemei Li Zihe Rao | 2010 | Protein & Cell2010，1，5： | 30 |
| 4 | Association of Chronic Kidney Disease with Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus: An Observational Cross-sectional Study in Hangzhou, China显示文摘 | Xue Sun Jie He Xiao-Li Ji Yi-Ming Zhao Han-Yu Lou Xiao-Xiao Song Li-Zhen Shan Ying-Xiu Kang Wen-Heng Zeng Xiao-Hong Pang Song-Zhao Zhang Yue Ding Yue-Zhong Ren Peng-Fei Shan | 2017 | Chinese Medical Journal2017，，1： | 14 |
| 5 | The functional analysis of OsTDF1 reveals a conserved genetic pathway for tapetal development between rice and Arabidopsis显示文摘在花药开发期间, tapetum 为花粉开发提供材料和营养素。在 Arabidopsis,几个抄写因素被识别了为 tapetal 开发和功能形成一条基因小径(DYT1TDF1AMSMS188MS1 ) 。在 TAPETAL 开发和 FUNCTION1 (TDF1 ) 的有缺陷者是 R2R3 MYB 家庭的一个成员并且为在 Arabidopsis 的早 tapetum 开发是必要的。这里,我们在米饭描绘了 Arabidopsis TDF1 的 ortholog, OsTDF1 (LOC_Os03g18480 ) 。OsTDF1 分享 69 ? 有在 N 终端区域附近的通常认为的 MYB 领域的 AtTDF1 的 % 氨基酸顺序身份。RT-PCR 并且在 situ 杂交表演,那 OsTDF1 明确地在米饭花药的 tapetal 房间被表示。在 Arabidopsis tdf1 异种的 OsTDF1 的表达式恢复它的富饶,建议这个相当或相同的事物能完成在 Arabidopsis 的 TDF1 的正常函数。ostdf1 大美人异种展出男性无菌的显型。它的 tapetal 房间展出类似于 Arabidopsis tdf1 异种的 vacuolated 和 hypertrophic 显型。终端 deoxynucleotidyl 当为 tapetum 的一个必要管理者规划了房间死亡,把试金标记的调停 transferase 的 dUTP 刻痕结束揭示了 OsTDF1 行为。qRT-PCR 分析表明 OsTDF1 UDT1 下游地行动,建议为 tapetum 开发的基因小径通常在米饭和 Arabidopsis 之间被保存并且在米饭的 TDR, EAT1, OsMYB103 和 PTC1 在上游。 | Ci-Feng Cai Jun Zhu Yue Lou Zong-Li Guo Shuang-Xi Xiong Ke Wang Zhong-Nan Yang | 2015 | Science Bulletin2015，60，12： | 13 |
| 6 | Liquid-liquid phase separation in biology: mechanisms,physiological functions and human diseases显示文摘Cells are compartmentalized by numerous membrane-enclosed organelles and membraneless compartments to ensure that a wide variety of cellular activities occur in a spatially and temporally controlled manner. The molecular mechanisms underlying the dynamics of membrane-bound organelles, such as their fusion and fission, vesicle-mediated trafficking and membrane contactmediated inter-organelle interactions, have been extensively characterized. However, the molecular details of the assembly and functions of membraneless compartments remain elusive. Mounting evidence has emerged recently that a large number of membraneless compartments, collectively called biomacromolecular condensates, are assembled via liquid-liquid phase separation(LLPS). Phase-separated condensates participate in various biological activities, including higher-order chromatin organization,gene expression, triage of misfolded or unwanted proteins for autophagic degradation, assembly of signaling clusters and actin-and microtubule-based cytoskeletal networks, asymmetric segregations of cell fate determinants and formation of pre-and post-synaptic density signaling assemblies. Biomacromolecular condensates can transition into different material states such as gel-like structures and solid aggregates. The material properties of condensates are crucial for fulfilment of their distinct functions, such as biochemical reaction centers, signaling hubs and supporting architectures. Cells have evolved multiple mechanisms to ensure that biomacromolecular condensates are assembled and disassembled in a tightly controlled manner. Aberrant phase separation and transition are causatively associated with a variety of human diseases such as neurodegenerative diseases and cancers. This review summarizes recent major progress in elucidating the roles of LLPS in various biological pathways and diseases. | Hong Zhang Xiong Ji Pilong Li Cong Liu Jizhong Lou Zheng Wang Wenyu Wen Yue Xiao Mingjie Zhang Xueliang Zhu | 2020 | Science China(Life Sciences)2020，63，7： | 11 |
| 7 | Spinal Cord Stimulation Frequency Influences the Hemodynamic Response in Patients with Disorders of Consciousness显示文摘Spinal cord stimulation(SCS) is a promising technique for treating disorders of consciousness(DOCs).However, differences in the spatio-temporal responsiveness of the brain under varied SCS parameters remain unclear. In this pilot study, functional near-infrared spectroscopy was used to measure the hemodynamic responses of 10 DOC patients to different SCS frequencies(5 Hz, 10 Hz, 50 Hz, 70 Hz, and 100 Hz). In the prefrontal cortex, a key area in consciousness circuits, we found significantly increased hemodynamic responses at 70 Hz and 100 Hz, and significantly different hemodynamic responses between 50 Hz and 70 Hz/100 Hz. In addition, the functional connectivity between prefrontal and occipital areas was significantly improved with SCS at 70 Hz. These results demonstrated that SCS modulates the hemodynamic responses and long-range connectivity in a frequency-specific manner(with 70 Hz apparently better), perhaps by improving the cerebral blood volume and information transmission through the reticular formation-thalamus-cortex pathway. | Juanning Si Yuanyuan Dang Yujin Zhang Yaxin Li Wenyue Zhang Yi Yang Yue Cui Xiaoping Lou Jianghong He Tianzi Jiang | 2018 | Neuroscience Bulletin2018，34，4： | 10 |
| 8 | Arabidopsis AT-hook Protein TEK Positively Regulates the Expression of Arabinogalactan Proteins for Nexine Formation显示文摘Nexine 是花粉墙的保存的层。我们以前报导 nexine 层在经由在钩(TEK ) 基因的 Arabidopsis TRANSPOSABLE 元素 SILENCING 的猛烈异种是不在的。在这研究,我们在花粉开发调查了 TEK 的分子的规章的功能并且识别了作为 TEK 的直接目标编码 Arabinogalactan 蛋白质(AGP ) 的基因,它为 nexine 形成是必要的。tek 和 TEK-SRDX 的 Phenotypic 类似转基因的线建议 TEK 在花药开发在 transcriptional 激活起一个作用。Microarray 分析在 tek 识别了 661 基因 downregulated 的一个总数,包括编码 AGP, AGP6, AGP11, AGP23,和 AGP40 的四基因。Electrophoretic 活动性移动试金证明 TEK 能直接绑原子矩阵附件区域(3 月) 和 AGP6 的倡导者。PCR 分析跟随的染色质 immunoprecipitation 证明 TEK 在四 AGP 基因的倡导者被充实。TEK 倡导者在 tek 驾驶的 AGP6 的表示部分救了 nexine 形成和植物富饶。这些结果显示 TEK 直接在花药调整 AGP 表示控制 nexine 层形成。我们也建议 glycoproteins 可能是在花粉墙中的 nexine 层的必要部件。 | Qi-Shi dia Jun Zhu Xiao-Feng Xu Yue Lou Zhan-Lin Zhang Zhi-Ping Zhang Zhong-Nan Yang | 2015 | Molecular Plant2015，8，2： | 10 |
| 9 | Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury显示文摘Tissue factor (TF)-dependent coagulation contributes to lung inflammation and the pathogenesis of acute lung injury (ALI). In this study, we explored the roles of targeted endothelial anticoagulation in ALI using two strains of transgenic mice expressing either a membrane-tethered human tissue factor pathway inhibitor (hTFPI) or hirudin fusion protein on CD31^+ cells, including vascular endothelial cells (ECs). ALI was induced by intratracheal injection of LPS, and after 24 h the expression of TF and protease-activated receptors (PARs) on EC in lungs were assessed, alongside the extent of inflammation and injury. The expression of TF and PARs on the EC in lungs was upregulated after ALI. In the two strains of transgenic mice, expression of either of hTFPI or hirudin by EC was associated with significant reduction of inflammation, as assessed by the extent of leukocyte infiltration or the levels of proinflammatory cytokines, and promoted survival after LPS-induced ALI. The beneficial outcomes were associated with inhibition of the expression of chemokine CCL2 in lung tissues. The protection observed in the CD31-TFPI-transgenic strain was abolished by injection of an anti-hTFPI antibody, but not by prior engraftment of the transgenic strains with WT bone marrow, confirming that the changes observed were a specific transgenic expression of anticoagulants by EC. These results demonstrate that the inflammation in ALI is TF and thrombin dependent, and that expression of anticoagulants by EC significantly inhibits the development of ALI via repression of leukocyte infiltration, most likely via inhibition of chemokine gradients. These data enhance our understanding of the pathology of ALI and suggest a novel therapeutic strategy for treatment. | Jian Lou Yue Hu Min-dan Wu Luan-qing Che Yin-fang Wu Yun Zhao Bao-ping Tian Zheng-qiang Bao Chen Zhu Yan-ping Wu Lu-lu He Chun-xue Bai Jian Zhou Song-min Ying Wen Li Zhi-hua Chen Da-xin Chen Anthony Dorling Hua-hao Shen | 2019 | Acta Pharmacologica Sinica2019，40，6： | 7 |
| 10 | Combination of olfactory test and substantia nigra transcranial sonopraphy in the differential diagnosis of Parkinson’s disease:a pilot study from China显示文摘Objectives:Both hyposmia and substania nigra(SN)hyperechogenicity on trascranial sonography(TCS)were risk markers for idiopathic Parkinson’s disease(PD),which was beneficial to the differential diagnosis of the disease.However,each of their single diagnostic value is often limited.The purpose of present study was to explore whether the combination of olfactory test and TCS of SN could enhance the differential diagnostic power in Chinese patients with PD.Methods:Thirty-seven patients with PD and twenty-six patients with essential tremor(ET)were evaluated on 16-item odor identification test from extended version of sniffin’sticks and TCS of SN.The frequency of hyposmia and SN hyperechogenicity in each group was compared.The sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)of the two clinical biomarkers were analyzed.Results:The frequency of hyposmia in patients with PD was significantly higher than in patients with ET(62.2%VS.3.8%,P=0.000).The frequency of SN hyperechogenicity in patients with PD was significantly higher than in ET subjects(48.6%VS.15.4%,P=0.006).The combination of hyposmia and SN hyperechogenicity(if either one or both present)discriminated patients with PD from ET with a sensitivity of 78.4%and 29.7%,specificity of 80.8%and 100%,PPV of 85.3%and 100%,and NPV of 72.4%and 50.0%,respectively.Conclusions:Our preliminary data suggested that the combination of hyposmia and SN hyperechogenicity could improve the diagnostic potential for discriminating Chinese patients with PD from ET. | Wei Chen Yu-Yan Tan Yun-Yun Hu Wei-Wei Zhan Li Wu Yue Lou Xi Wang Yi Zhou Pei Huang Yuan Gao Qin Xiao Sheng-Di Chen | 2012 | Translational Neurodegeneration2012，1，1： | 6 |
| 11 | LncRNA NEAT1 promotes colorectal cancer cell proliferation and migration via regulating glial cell-derived neurotrophic factor by sponging miR-196a-5p显示文摘Colorectal cancer (CRC)is the one of the most common malignant tumors worldwide.Recent years,widespread long non-coding RNAs (IncRNAs)have been discovered and are known to regulate gene expression in cancers.However,the roles and underlying mechanisms of IncRNA in CRC remain largely unclear.Here,we firstly revealed that repression of IncRNA nuclear paraspeckle assembly transcript 1 (NEAT1)inhibited cell proliferation and migration in HCT116.cells and overexpression of NEAT1 promoted cell proliferation and migration in SW480 cells using CCK8 assay and transwell assay.Then,we found that suppression of NEAT1 increased the miR- 196a-5p expression in HCT116 cells,while elevation of NEAT1 decreased the miR-196a-5p expression in SW480 cells using qPCR assay.Furthermore,miR-196a-5p could bind to the predicted binding site of NEAT1.We then found that miR-196a-5p was involved in the role of NEAT1 in CRCs.In addition,we demonstrated that miR-196a-Sp mimics inhibited the glial cell-derived neurotrophic factor (GDNF)expression in HCT116 cells and meanwhile,miR-196a-5p inhibitor promoted GDNF expression in SW480 cells using qPCR and western blot analysis.Then,we proved that miR-196a- 5p exerted its function via regulating GDNF expression in CRCs.Ultimately,our study demon- strated that NEAT1 exerted its role via miR-196a-5p/GDNF axis in CRCs.In summary,this work provided the first evidence of a NEAT1/miR-196a-5p/GDNF regulatory pathway in CRC. | Feng Zhong Wei Zhang Yang Cao Qian Wen Yue Cao Bidan Lou Jinxiang Li Wenying Shi Yinghan Liu Rong Luo and Cheng Chen | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 5 |
| 12 | Classification and Functional Separable Solutions to Extended Nonlinear Wave Equations显示文摘The generalized conditional symmetry approach is applied to study the variable separation of the extended wave equations. Complete classification of those equations admitting functional separable solutions is obtained and exact separable solutions to some of the resulting equations are constructed. | ZHANG Shun-Li LOU Sen-Yue QU Chang-Zheng YUE Rui-Hong | 2005 | Communications in Theoretical Physics2005，44，4X： | 2 |
| 13 | Distributed incremental bias-compensated RLS estimation over multi-agent networks显示文摘In this paper, we study the problem of distributed bias-compensated recursive least-squares(BCRLS) estimation over multi-agent networks, where the agents collaborate to estimate a common parameter of interest. We consider the situation where both input and output of each agent are corrupted by unknown additive noise. Under this condition, traditional recursive least-squares(RLS) estimator is biased, and the bias is induced by the input noise variance. When the input noise variance is available, the effect of the noise-induced bias can be removed at the expense of an increase in estimation variance. Fortunately, it has been illustrated that distributed collaboration between agents can effectively reduce the variance and can improve the stability of the estimator. Therefore, a distributed incremental BC-RLS algorithm and its simplified version are proposed in this paper. The proposed algorithms can collaboratively obtain the estimates of the unknown input noise variance and remove the effect of the noise-induced bias. Then consistent estimation of the unknown parameter can be achieved in an incremental fashion. Simulation results show that the incremental BC-RLS solutions outperform existing solutions in some enlightening ways. | Jian LOU Lijuan JIA Ran TAO Yue WANG | 2017 | Science China(Information Sciences)2017，60，3： | 2 |
| 14 | High thermoelectric properties with low thermal conductivity due to the porous structure induced by the dendritic branching in n-type PbS显示文摘PbS-based thermoelectric materials have attracted extensive attention in recent years for the advantages of earth abundancy and low cost,which is considered to be a substitute for traditional PbTe material.However,their high thermal conductivity restricts its development.Hence,in order to improve their thermoelectric performance from reducing the thermal conductivity,a kind of dendritic PbS with controlled crystal grain and morphology are obtained by solution synthesis.By adjusting the amount of surfactant(CTAB),the specific formation process of dendrites is regulated.After sintering,the dendritic PbS nanoparticles are easy to form porous structure due to the overlapping and staggered arrangement of dendritic branches.For comparison,we also prepare a kind of regular octahedral PbS and a dense packing arrangement is formed because of the integrity of the octahedral structure.DFT-based Boltzmann transport equation is used to prove the crucial role of porous structure in scattering phonon.Finally,a maximum zT=1.0 at 773 K in n-type PbS is obtained,which still keep a high-speed growth and is expected to get higher zT value in a higher temperature region.Our work may shed light to other thermoelectric materials from the formation of porous structure to reduce the thermal conductivity. | Zhenyu Zhu Janak Tiwari Tianli Feng Zhan Shi Yue Lou Biao Xu | 2022 | Nano Research2022，15，5： | 1 |
| 15 | Inhibitory effect of riccardin D on growth of human non-small cell lung cancer: In vitro and in vivo studies显示文摘 | Xia Xue De-Fu Sun Cui-Cui Sun Hui-Ping Liu Bin Yue Cui-Rong Zhao Hong-Xiang Lou Xian-Jun Qu | 2011 | Lung Cancer2011，，3： | 1 |
| 16 | Photocatalytic Degradation of Organic Pollutants at Solution Bulk with Pigment/TiO<sub>2</sub> Nanocomposite显示文摘 | Xin Shu Wen Zhong Lou Yue Zhao Min Gru Guo Yue Fu Ying Wang | 2013 | Key Engineering Materials2013，，562： | 1 |
| 17 | A Preliminary Review on the Metallogeny of Pb-Zn Deposits in China显示文摘Lead and zinc resources are abundant in China, with the reserves of 100 million tons ranking only second in the world. There are more than 3000 lead-zinc mine areas nationwide. The classification of lead-zinc(Pb-Zn) deposits has been a highly controversial issue. From the standpoint of evaluating the potential of mineral resources, we construct a Pb-Zn deposit predictive type of classification scheme, and propose a Pb-Zn deposit comprehensive classification scheme(including 5 classes and 13 sub-types) that regards mineralization as the primary factor and the ore rock as secondary. According to the temporal and spatial distribution of Pb-Zn deposits, we conclude that a multi-period, multi-cycle orogenic environment is the most favorable for lead-zinc deposit growth, that the Proterozoic is the major eon for the growth of igneous-type deposits, the Paleozoic is an important development era for sedimentary Pb-Zn deposits, and the Mesozoic and Cenozoic are the heyday eras of magmatic type lead-zinc deposits. On this basis, we analyse the relationship between tectonic evolution and Pb-Zn metallogenic, and propose that the key factors determining geological mineralization are the metallogenic epoch of mineralization and tectonic environment, which determine the temporal and spatial distribution. | ZHANG Changqing LIU Huan WANG Denghong CHEN Yuchuan RUI Zongyao LOU Debo WU Yue JIA Fudong CHEN Zhenghui MENG Xuyang | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 1 |
| 18 | Synthesis of iron- nickel nanoparticles via a nonaqueous organometallic route 显示文摘 | Z Lou X H Yue G H | 2009 | Mater Chem Phys2009，113，： | 1 |
| 19 | Transforming growth factor-β1 enhanced vascular endothelial growth factor synthesis in mesenchymal stem cells显示文摘 | Xiao-Jun Wang Zhan Dong Xiao-Hua Zhong Rui-Zhen Shi Song-Hua Huang Yue Lou Qing-Ping Li | 2007 | Biochemical and Biophysical Research Communications2007，，3： | 1 |
| 20 | Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma:A case report and review of the literature显示文摘Paraneoplastic cerebellar degeneration(PCD),which is rare in clinical practice,is closely related to autoimmunity.Cases positive for anti-Yo antibodies(anti-Purkinje cytoplasmic antibody 1)are the main subtype of PCD.PCD is subacute cerebellar degeneration,and while it progresses over weeks to months,its resultant deficits last much longer.Cancer patients with anti-Yo antibody-positive PCD are very rare.Most of them are breast cancer or ovarian cancer patients but also occasionally lung cancer patients.CASE SUMMARY A 61-year-old woman presented with sudden vertigo,nausea,and vomiting for approximately 10 d.The patient's neurological examination showed torsion with downbeat nystagmus and ataxia of the right limb and trunk.Laboratory examination found that the patient's cerebrospinal fluid and serum were anti-Yo antibody-positive,positron emission tomography computed tomography showed an increased metabolic rate in the retroperitoneal lymph nodes,and the pathology of lymph node punctures in the retroperitoneum and neck suggested adenocarcinoma of the pancreaticobiliary duct,which strengthens the hypothesis of paraneoplastic origin.Intravenous immunoglobulin(IVIg)0.4 g/kg/d for 5 d and methylprednisolone 160 mg for 3 d were initiated,which was reduced to 80 mg for 3 d and then to 40 mg for 7 d.After treatment with IVIg and a steroid,the patient's vertigo and ataxia alleviated.CONCLUSION The patient's vertigo and ataxia alleviated after treatment,suggesting that early immunotherapeutic intervention may have certain value in stopping neurological loss. | Yue Lou Shan-Hu Xu Si-Ran Zhang Qin-Fen Shu Xiao-Li Liu | 2021 | World Journal of Clinical Cases2021，9，17： | 1 |
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