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| 1 | A Single-cell Transcriptome Atlas of Cashmere Goat Hair Follicle Morphogenesis显示文摘Cashmere,also known as soft gold,is produced from the secondary hair follicles(SHFs)of cashmere goats.The number of SHFs determines the yield and quality of cashmere;therefore,it is of interest to investigate the transcriptional profiles present during cashmere goat hair follicle development.However,mechanisms underlying this development process remain largely unexplored,and studies regarding hair follicle development mostly use a murine research model.In this study,to provide a comprehensive understanding of cellular heterogeneity and cell fate decisions,single-cell RNA sequencing was performed on 19,705 single cells of the dorsal skin from cashmere goat fetuses at induction(embryonic day 60;E60),organogenesis(E90),and cytodifferentiation(E120)stages.For the first time,unsupervised clustering analysis identified 16 cell clusters,and their corresponding cell types were also characterized.Based on lineage inference,a detailed molecular landscape was revealed along the dermal and epidermal cell lineage developmental pathways.Notably,our current data also confirmed the heterogeneity of dermal papillae from different hair follicle types,which was further validated by immunofluorescence analysis.The current study identifies different biomarkers during cashmere goat hair follicle development and has implications for cashmere goat breeding in the future. | Wei Ge Weidong Zhang Yuelang Zhang Yujie Zheng Fang Li Shanhe Wang Jinwang Liu Shaojing Tan Zihui Yan Lu Wang Wei Shen Lei Qu Xin Wang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 3 |
| 2 | Sclerosing cholangitis in critically ill patients: an important and easily ignored problem based on a German experience显示文摘(ICU ) 特别护理联合起来在极其有病的病人的康复是重要的。在过去的十年,在 ICU 接受了好攻击的治疗的许多病人在多重中心开发了 sclerosing 胆管炎。在极其有病的病人(SC-CIP ) 的 Sclerosing 胆管炎是一个相对新的问题。调查 SC-CIP 的原因,临床的表明,治疗,和预后,我们从 2001 ~ 2012 在 PubMed,高空绳索,和 Elsevier 的数据库寻找了出版案例。数据用一种标准形式被提取并且回顾地分析了。与 64 个男人和 24 个女人一起,盖住 88 个病人的 12 合格研究在这分析被注册。吝啬的年龄是 49.8 年。所有从重病病人恢复了,例如损伤,感染,灼伤,和主要手术。高迫使积极结束吐气的压力(偷看,在 12.8 厘米 H2O 的山峰水平) 为所有病人被利用,与 36.3 d 的平均持续时间。另外, vasopressor 代理人在近似 60%of SC-CIP 被管理。cholestasis 的快速的增加和在 intrahepatic 胆汁管的不规则的苛评在下列月内被观察。与 17.9 个月的平均后续经期,差的结果在 54 个病人被观察,包括 34 死亡。在结论,胆汁的树的 ischemic 损害,可以被偷看或 vasopressor 管理影响,影响 cholangiopathic 过程。作为第二等的 sclerosing 胆管炎的一种最新发现的类型, SC-CIP 是在 ICU 的病人的严重进步复杂并发症并且应该被临床医生小心地监视。 | Ting Lin Kai Qu Xinsen Xu Min Tian Jie Gao Chun Zhang Ying Di Yuelang Zhang Chang Liu | 2014 | Frontiers of Medicine2014，8，1： | 2 |
| 3 | GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependentmanner显示文摘 | Juan Ren Hui Guo Huili Wu Tao Tian Danfeng Dong Yuelang Zhang Yanxia Sui Yong Zhang Dongli Zhao Shufeng Wang Zongfang Li Xiaozhi Zhang Rui Liu Jianshneg Qian Hongxia Wei Wenjun Jiang Ya Liu Yi Li | 2015 | Oncology Reports2015，，： | 1 |
| 4 | A Case Study on Optimization of Urban Design Base on Wind Environment Simulation显示文摘 | Yuelang Gan Ying Wang | 2016 | Journal of Civil Engineering and Architecture2016，10，8： | 0 |
| 5 | Value of Apparent Diffusion Coefficient(ADC) of Diffusion eighted Magnetic Resonance Imaging in Common Renal Disease Diagnosis显示文摘Objective:To find the value of the apparent diffusion coefficient (ADC) of diffusion weighted magnetic resonance imaging of common renal diseases. Methods: There were 30 healthy subjects and 81 patients with renal lesions (56 cases of renal carcinoma, 18 lesions of 12 cases of renal angiomyolipoma, and 21 lesions of 13 cases of renal cysts). Conventional magnetic resonance imaging and diffusion weighted magnetic resonance imaging were carried out. We measured the average ADC value of the renal lesions and normal kidneys. ADC maps from different b values were generated by a statistical package. Results: The ADC values of normal kidneys with three different motion-probing gradients(b=500, 800, 1000 sec/mm2) were 2.78±0.14×10-3mm2s-1, 2.45±0.13×10-3mm2s-1, 2.13±0.14×10-3mm2s- 1, respectively. The ADC values of renal cell carcinoma with three different motion-probing gradients(b=500, 800, 1000 sec/mm2) were 1.63±0.14×10-3mm2s-1, 1.31±0.18×10-3mm2s-1, 1.07±0.15×10-3mm2s-1, respectively. Among the renal cell carcinoma, the ADC value of clear cell type were 1.67±0.09×10-3mm2s-1, 1.36±0.13×10-3mm2s-1, 1.15±0.14×10-3mm2s-1,respectively; the ADC values of granular cell type were 1.59±0.19×10-3mm2s-1, 1.25±0.22×10-3mm2s-1, 0.97±0.12×10-3mm2s-1, respectively. The ADC values of renal angiomyolipoma with three different motion-probing gradients(b=500, 800, 1000 sec/mm2) were 0.88±0.08×10-3mm2s-1, 0.63±0.07× 10-3mm2s-1, 0.43±0.04×10-3mm2s-1, respectively. The ADC values of renal cystic lesions with three different motion-probing gradients (b=500, 800, 1000 sec/mm2) were 3.73±0.18×10-3mm2s-1, 3.44±0.13×10-3mm2s-1, 3.09±0.21×10-3mm2s-1, respectively. Statisti- cally significant differences exists between the ADC values of normal kidney, renal carcinomas, renal angiomyolipomas and renal cysts when the b value is the same. Among the different cell types of renal carcinomas, the ADC value of granular cell carcinoma is lower than that of clear cell carcinomas. Conclusion: It is of benefit in diagnosing and distinguishing between benign and malignant renal tumors to know the ADC values in diffusion weighted magnetic resonance imaging. Furthermore, these values help to know the internal structure of the tumor and the tumor typel, which is helpful to the treatment and in predicting the patients' prognosis. | Yuelang Zhang Xingwang Sun Guangnan Quan Yongqian Qiang Chenxia Li | 2008 | Journal of Nanjing Medical University2008，22，6： | 0 |
| 6 | Experimental investigation on waterproofing performance of segmental joint with double gaskets for shield tunnel显示文摘The waterproofing capacity of segmental joints is an essential indicator for the long-term service performance of shield tunnels.The segmental joints with double gaskets have been adopted to improve the waterproof performance for certain tunnels with high water pressure,especially water-conveyance tunnels.This paper presents a series of waterproofing tests on joints with different settings of double gaskets via an improved test apparatus.Four cases are investigated,including(i)double gaskets with equal high/low waterproof capacity,(ii)the outer gasket with higher waterproof capacity,and(iii)the outer gasket with lower waterproof capacity.Different joint openings are also considered.Moreover,the water pressures at two cavities are continuously monitored to highlight the waterproofing mechanism and failure pattern of double gaskets.The results demonstrate that the gasket with the higher waterproofing capacity dominates the overall waterproofing capacity of joint with double gaskets;only a little enhancement of the waterproofing capacity is found for the joint with the same double gaskets.The waterproofing capacity of joints with double gaskets decreases with the increase of the joint opening.The failure pattern depends on the arrangement of double gaskets,and four stages can be identified during the whole failure process.The advantages of double gaskets in case of joint rotation are also discussed. | Wenqi Ding Qiushi Wang Yafei Qiao Yuelang Jin | 2022 | Underground Space2022，7，5： | 0 |
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