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| 1 | Effect of methyl tert-butyl ether on adipogenesis and glucose metabolism in vitro and in vivo显示文摘Methyl tert-butyl ether (MTBE),as a widely used gasoline additive,is suspected of being environmentally toxic.MTBE accumulates mainly in adipose tissue,but its effect on obesity or obesity-related metabolic disorders has not been well understood yet.Therefore,we examined the effect of MTBE on the adipose function and the related metabolic processes with both 3T3-L1 cell line and C57BL/6J mice model.We found that exposure to MTBE at the environmental relevant concentration (100 μmol/L) could significantly induce differentiation of preadipocyte and disturb insulin-stimulated glucose uptake of mature adipocyte.The in vivo observation in male mice showed a positive correlation of visceral white adipose tissue (vWAT) expansion and cell size increase with MTBE treatment in 14 weeks.Glucose tolerance and insulin sensitivity tests demonstrated that MTBE at 1000 μg/(kg·day) disturbed the systemic glucose metabolism in a gender-specific manner,which might be partly attributed to the alterations of gut microbiota community at genus level with respect to Akkermansia,Clostridium XIVb,and Megamonas.In summary,our study characterized the effect of MTBE on adipose tissue function and glucose homeostasis in vitro and in vivo,and revealed that systemic disorders of the glucose metabolism might be modulated by the related gut microbiota. | Yue Tang Qidong Ren Qing Wen Caixia Yu Xinni Xie Qing Hu Yuguo Du | 2019 | Journal of Environmental Sciences2019，31，11： | 4 |
| 2 | A neglected GABAergic astrocyte:Calcium dynamics and involvement in seizure activity显示文摘Gamma-aminobutyric acid(GABA) contributes substantially to neurocognitive function as an important inhibitory neurotransmitter in the human cerebral cortex. However, the pathophysiology of disorders such as epilepsy are not well understood, since GABA agonists are not quite effective in treating epilepsy. Knowledge of the mechanism of action of GABA would contribute to review previously proposed anti-epileptic processes by GABA agonists. In this study based on recent experiments on GABAergic astrocytes, we developed a modified GABAergic astrocyte model, and successfully simulated a long-lasting Ca^(2+) oscillation in astrocytes after 0.5-s stimulation of GABAergic transmission. We then incorporated this GABAergic astrocyte model into a classical Ullah-Schiff seizure model and surprisingly found that this GABAergic astrocyte model functions to hinder the anti-epileptic action of GABA agonists, thereby explaining their low efficiency in previous experiments. These results also update our knowledge of the mechanism of action of GABA and the effects of astrocytes on physiological and pathological functions of the brain. | LI JiaJia XIE Yong YU YuGuo DU MengMeng WANG Rong WU Ying | 2017 | Science China(Technological Sciences)2017，60，7： | 2 |
| 3 | Effect of drought on pigments, osmotic adjustment and antioxidant enzymes in six woody plant species in karst habitats of southwestern China显示文摘 | Changcheng Liu Yuguo Liu Ke Guo Dayong Fan Guoqing Li Yuanrun Zheng Lifei Yu Rui Yang | 2010 | Environmental and Experimental Botany2010，，2： | 2 |
| 4 | Acute toxicity variation of hydroxyl benzophenone UV filters during photoinduction–chlorination disinfection processes显示文摘Benzophenones(BPs), a group of widely used UV filters, exert multiple, significant toxicity effects. The 11 BPs were selected as target compounds, and the photobacterium acute toxicity test and an index for acute toxicity formation potential(ATFP) were used to evaluate the toxicity variation of BPs before and after a photoinduction–chlorination disinfection process.Orthogonal experiments were performed at different pH values and chlorine dosages. The characteristics of ATFP values for 11 BPs after a photoinduction–chlorination process can be summarized as follows:(1) The ATFPs decreased as the hydroxyl group number increased in BPs molecules.(2) For those BPs with the same hydroxyl group number, the ATFPs were higher when the hydroxyl groups were located at the 3-or 4-position than those at the 2-position; the BPs with hydroxyl groups distributed on two benzene rings had higher ATFPs than those on one ring.(3) Introducing a methoxyl group and sulfonic acid group into BP molecules increased the ATFP values.(4) The ATFPs were p H-dependent, the values of which were lowest at the neutral condition and highest at the acid condition.(5) The ATFPs increased and then decreased as the chlorine dosage increased. The results can be used as a reference to scientifically evaluate the environmental fate and potential risk of BPs in photoinduction–chlorination disinfection processes. | Qi Yu | 2017 | Journal of Environmental Sciences2017，29，4： | 2 |
| 5 | Dynamic study on water diffusivity of soil with super-absorbent polymer application显示文摘 | Yuguo Han Xinxiao Yu Peiling Yang Bo Li Lei Xu Chengzhi Wang | 2013 | Environmental Earth Sciences2013，，1： | 1 |
| 6 | Evidence of Airborne Transmission of the Severe Acute Respiratory Syndromc Virus 显示文摘 | Ignatius T S Yu Li Yuguo Tze Wai Wong etc | 2004 | New England Medicals2004，350，： | 1 |
| 7 | Frequency sensitivity in Hodgkin–Huxley systems显示文摘 | Yuguo Yu Feng Liu Wei Wang | 2001 | Biological Cybernetics2001，，3： | 1 |
| 8 | Eliminating the original cargos of glioblastoma cell-derived small extracellular vesicles for efficient drug delivery to glioblastoma with improved biosafety显示文摘Tumor derived small extracellular vesicles(TsEVs)display a great potential as efficient nanocarriers for chemotherapy because of their intrinsic targeting ability.However,the inherited risks of their original cargos(like loaded proteins or RNAs)from parent cancer cells in tumor progression severely hinder the practical application.In this study,a saponin-mediated cargo elimination strategy was established and practiced in glioblastoma(GBM)cell-derived small extracellular vesicles(GBM-sEVs).A high eliminating efficacy of the cargo molecules was confirmed by systematic analysis of the original proteins and RNAs in GBM-sEVs.In addition,the inherited functions of GBM-sEVs to promote GBM progression vanished after saponin treatment.Moreover,the results of cellular uptake analysis and in vivo imaging analysis demonstrated that saponin treatment preserved the homotypic targeting ability of GBM-sEVs.Thus,we developed an efficient nanocarrier with improved biosafety for GBM suppression.Furthermore,doxorubicin(DOX)transported by the saponin-treated GBM-sEVs(sa-GBM-sEVs)displayed an effective tumor suppression in both subcutaneous and orthotopic GBM models of mouse.Collectively,this study provides a feasible way to avoid the potential protumoral risks of TsEVs and can advance the clinical application of TsEVs in chemotherapy. | Yuhang Guo Guowen Hu Yuguo Xia HaiYan Li Ji Yuan Juntao Zhang Yu Chen Hua Guo Yunlong Yang Yang Wang Zhifeng Deng | 2022 | Bioactive Materials2022，7，10： | 1 |
| 9 | Beyond city expansion:multi-scale environmental impacts of urban megaregion formation in China显示文摘Environmental degradation caused by rapid urbanization is a pressing global issue.However,little is known about how urban changes operate and affect environments across multiple scales.Focusing on China,we found urbanization was indeed massive from 2000 to 2015,but it was also very uneven,exhibiting high internal city dynamics.Urban areas in China as a whole became less green,warmer,and had exacerbated PM2.5 pollution.However,environmental impacts differed in newly developed versus older areas of cities.Adverse impacts were prominent in newly urbanized areas,while old urban areas generally showed improved environmental quality.In addition,regional environmental issues are emerging as cities expand,connect and interact to form urban megaregions.To turn urbanization into an opportunity for,rather than an obstacle to,sustainable development,we must move beyond documenting urban expansion to understand the environmental consequences of both internal city dynamics and the formation of urban megaregions. | Weiqi Zhou Wenjuan Yu Yuguo Qian Lijian Han Steward T.A.Pickett Jing Wang Weifeng Li Zhiyun Ouyang | 2022 | National Science Review2022，9，1： | 1 |
| 10 | Integrating structure and function:mapping the hierarchical spatial heterogeneity of urban landscapes显示文摘Background:Cities are social-ecological systems characterized by remarkably high spatial and temporal heterogeneity,which are closely related to myriad urban problems.However,the tools to map and quantify this heterogeneity are lacking.We here developed a new three-level classification scheme,by considering ecosystem types(level 1),urban function zones(level 2),and land cover elements(level 3),to map and quantify the hierarchical spatial heterogeneity of urban landscapes.Methods:We applied the scheme using an object-based approach for classification using very high spatial resolution imagery and a vector layer of building location and characteristics.We used a top-down classification procedure by conducting the classification in the order of ecosystem types,function zones,and land cover elements.The classification of the lower level was based on the results of the higher level.We used an objectbased methodology to carry out the three-level classification.Results:We found that the urban ecosystem type accounted for 45.3%of the land within the Shenzhen city administrative boundary.Within the urban ecosystem type,residential and industrial zones were the main zones,accounting for 38.4%and 33.8%,respectively.Tree canopy was the dominant element in Shenzhen city,accounting for 55.6%over all ecosystem types,which includes agricultural and forest.However,in the urban ecosystem type,the proportion of tree canopy was only 22.6%because most trees were distributed in the forest ecosystem type.The proportion of trees was 23.2% in industrial zones,2.2%higher than that in residential zones.That information“hidden”in the usual statistical summaries scaled to the entire administrative unit of Shenzhen has great potential for improving urban management.Conclusions:This paper has taken the theoretical understanding of urban spatial heterogeneity and used it to generate a classification scheme that exploits remotely sensed imagery,infrastructural data available at a municipal level,and object-based spatial analysis.For effective planning and management,the hierarchical levels of landscape classification(level 1),the analysis of use and cover by urban zones(level 2),and the fundamental elements of land cover(level 3),each exposes different respects relevant to city plans and management. | Yuguo Qian Weiqi Zhou Steward T.A.Pickett Wenjuan Yu Dingpeng Xiong Weimin Wang Chuanbao Jing | 2020 | Ecological Processes2020，9，1： | 1 |
| 11 | Resonance-enhanced signal detection and transduction in the Hodgkin-Huxley neuronal systems显示文摘 | Yu Yuguo Wang Wei Wang Jiafu | 2001 | Phys Rev E2001，63，02： | 1 |
| 12 | Resonance Enhanced Signal Detection and Transduction in the Hodgkin-Huxley Neuronal Systems 显示文摘 | Yu Yuguo Wang Wei Liu Feng | 2001 | Physics Review Letters2001，63，2： | 1 |
| 13 | Alcohol Fermentation From the Mash of Dried Sweetpotato with its Dregs Using Immobilised Yeast显示文摘 | Bingjun Yu Fuming Zhang Yuguo Zheng | 1996 | Process Biochemistry1996，31，1： | 1 |
| 14 | Research on the Dissemination and Influencing Factors of Big Data and Artificial Intelligence Related Courses in Colleges and Universities-Taking MOOC as an Example显示文摘The rapid development of information technologies such as artificial intelligence,Internet and big data has promoted the deep integration of technology and education,especially the rise of large-scale online courses,which provides a great opportunity for curriculum teaching reform in colleges and universities.At the same time,artificial intelligence,as a cutting-edge technology,has good development prospects and has become a popular professional course in colleges and universities,artificial intelligence technology has become the focus of subject education in many universities.The combination of online education and AI courses will also greatly enhance the enthusiasm of users and expand the dissemination scope of big data and AI related courses.Based on the grounded theory and technology acceptance model,this paper obtains the users’perception evaluation of learning MOOC big data and artificial intelligence courses through field interviews,summarizes the core categories,constructs MOOC user acceptance model,collects sample data by questionnaire and makes an empirical study.It is found that perceived usefulness,expectation confirmation and primary communication effect have a significant positive impact on the secondary communication effect,and the content quality and socialization interaction indirectly affect the secondary communication effect of MOOC curriculum by affecting the primary communication effect. | Zhu Junyan Min Yuguo Li Yudi Chen Xiaoyu Zhou Yu | 2022 | Journal on Artificial Intelligence2022，4，2： | 0 |
| 15 | Mental Calculation Drives Reliable and Weak Distant Connectivity While Music Listening Induces Dense Local Connectivity显示文摘Mathematical calculation usually requires sustained attention to manipulate numbers in the mind,while listening to light music has a relaxing effect on the brain.The differences in the corresponding brain functional network topologies underlying these behaviors remain rarely known.Here,we systematically examined the brain dynamics of four behaviors(resting with eyes closed and eyes open,tasks of music listening and mental calculation)using 64-channel electroencephalogram(EEG)recordings and graph theory analysis.We developed static and dynamic minimum spanning tree(MST)analysis method and demonstrated that the brain network topology under mental calculation is a more line-like structure with less tree hierarchy and leaf fraction;however,the hub regions,which are mainly located in the frontal,temporal and parietal regions,grow more stable over time.In contrast,music-listening drives the brain to exhibit a highly rich network of star structure,and the hub regions are mainly located in the posterior regions.We then adopted the dynamic dissimilarity of different MSTs over time based on the graph Laplacian and revealed low dissimilarity during mental calculation.These results suggest that the human brain functional connectivity of individuals has unique dynamic diversity and flexibility under various behaviors. | Gaoxing Zheng Yuzhu Li Xiaoying Qi Wei Zhang Yuguo Yu | 2021 | Phenomics2021，1，6： | 0 |
| 16 | Unveiling Dynamic System Strategies for Multisensory Processing: From Neuronal Fixed-Criterion Integration to Population Bayesian Inference显示文摘Multisensory processing is of vital importance for survival in the external world.Brain circuits can both integrate and separate visual and vestibular senses to infer self-motion and the motion of other objects.However,it is largely debated how multisensory brain regions process such multisensory information and whether they follow the Bayesian strategy in this process. | Jiawei Zhang Yong Gu Aihua Chen Yuguo Yu | 2023 | Research2023，，2： | 0 |
| 17 | SUPER Score Contributes to Warning and Management in Early-Stage COVID-19显示文摘Background:Some COVID-19 patients deteriorate to severe cases with relatively higher case-fatality rates,which increases the medical burden.This necessitates identification of patients at risk of severe disease.Early assessment plays a crucial role in identifying patients at risk of severe disease.This study is to assess the effectiveness of SUPER score as a predictor of severe COVID-19 cases.Methods:We consecutively enrolled COVID-19 patients admitted to a comprehensive medical center in Wuhan,China,and recorded clinical characteristics and laboratory indexes.The SUPER score was calculated using pa-rameters including oxygen saturation,urine volume,pulse,emotional state,and respiratory rate.In addition,the area under the receiver operating characteristic curve(AUC),specificity,and sensitivity of the SUPER score for the diagnosis of severe COVID-19 were calculated and compared with the National Early Warning Score 2(NEWS2).Results:The SUPER score at admission,with a threshold of 4,exhibited good predictive performance for early identification of severe COVID-19 cases,yielding an AUC of 0.985(95%confidence interval[CI]0.897-1.000),sensitivity of 1.00(95%CI 0.715-1.000),and specificity of 0.92(95%CI 0.775-0.982),similar to NEWS2(AUC 0.984;95%CI 0.895-1.000,sensitivity 0.91;95%CI 0.587-0.998,specificity 0.97;95%CI 0.858-0.999).Com-pared with patients with a SUPER score<4,patients in the high-risk group exhibited lower lymphocyte counts,interleukin-2,interleukin-4 and higher fibrinogen,C-reactive protein,aspartate aminotransferase,and lactate dehydrogenase levels.Conclusions:In conclusion,the SUPER score demonstrated equivalent accuracy to the NEWS2 score in predicting severe COVID-19.Its application in prognostic assessment therefore offers an effective early warning system for critical management and facilitating efficient allocation of health resources. | Yuan Bian Qi Han Yue Zheng Yu Yao Xinhui Fan Ruijuan Lv Jiaojiao Pang Feng Xu Yuguo Chen | 2023 | Infectious Medicine2023，2，4： | 0 |
| 18 | Establishment of highly efficient transgenic system for black soldier fly(Hermetia illucens)显示文摘The black soldier fly(BSF),Hermetia illucens,is a promising insect for miti-gating solid waste problems as its larvae are able to bioconvert organic waste into valuable biomass.We recently reported a high-quality genome assembly of the BSF;analysis of this genome sequence will further the understanding of insect biology and identify genes that can be manipulated to improve efficiency of bioconversion.To enable genetic manip-ulation of the BSF,we have established the first transgenic methods for this economically important insect.We cloned and identified the ubiquitous actin5C promoter(Hiactin5C-p3k)and 3 endogenous U6 promoters(HiU6:1,HiU6:2,and HiU6:3).The Hiactin5C pro-moter was used to drive expression of a hyperactive variant of the piggyBac transposase,which exhibited up to 6-fold improvement in transformation rate when compared to the wild-type transposase.Furthermore,we evaluated the 3 HiU6 promoters using this trans-genic system.HiU6:1 and HiU6:2 promoters provided the highest knockdown efficiency with RNAi and are thus promising candidates for future Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)development.Overall,our findings provide valuable genetic engineering toolkits for basic research and genetic manipulation of the BSF. | Zongqing Kou Xingyu Luo Yuguo Jiang Bihui Chen Yu Song Yaohui Wang Jun Xui Jeffery K.Tomberlin Yongping Huang | 2023 | Insect Science2023，30，4： | 0 |
| 19 | A novel predictor of unsustained return of spontaneous circulation in cardiac arrest patients through a combination of capnography and pulse oximetry: a multicenter observational study显示文摘BACKGROUND:Unsustained return of spontaneous circulation(ROSC)is a critical barrier to survival in cardiac arrest patients.This study examined whether end-tidal carbon dioxide(ETCO_(2))and pulse oximetry photoplethysmogram(POP)parameters can be used to identify unsustained ROSC.METHODS:We conducted a multicenter observational prospective cohort study of consecutive patients with cardiac arrest from 2013 to 2014.Patients’general information,ETCO_(2),and POP parameters were collected and statistically analyzed.RESULTS:The included 105 ROSC episodes(from 80 cardiac arrest patients)comprised 51 sustained ROSC episodes and 54 unsustained ROSC episodes.The 24-hour survival rate was significantly higher in the sustained ROSC group than in the unsustained ROSC group(29.2%vs.9.4%,P<0.05).The logistic regression analysis showed that the difference between after and before ROSC in ETCO_(2)(ΔETCO_(2))and the difference between after and before ROCS in area under the curve of POP(ΔAUCp)were independently associated with sustained ROSC(odds ratio[OR]=0.931,95%confi dence interval[95%CI]0.881-0.984,P=0.011 and OR=0.998,95%CI 0.997-0.999,P<0.001).The area under the receiver operating characteristic curve ofΔETCO_(2),ΔAUCp,and the combination of both to predict unsustained ROSC were 0.752(95%CI 0.660-0.844),0.883(95%CI 0.818-0.948),and 0.902(95%CI 0.842-0.962),respectively.CONCLUSION:Patients with unsustained ROSC have a poor prognosis.The combination ofΔETCO_(2) andΔAUCp showed signifi cant predictive value for unsustained ROSC. | Jing Yang Hanqi Tang Shihuan Shao Feng Xu Yangyang Fu Shengyong Xu Chen Li Yan Li Yang Liu Joseph Harold Walline Huadong Zhu Yuguo Chen Xuezhong Yu Jun Xu | 2024 | World Journal of Emergency Medicine2024，15，1： | 0 |
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