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| 1 | Glucosylated caffeoylquinic acid derivatives from the flower buds of Lonicera japonica显示文摘Three new glucosylated caffeoylquinic acid isomers(1–3),along with six known compounds,have been isolated from an aqueous extract of the flower buds of Lonicera japonica.Structures of the new compounds were determined by spectroscopic and chemical methods as()-4-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(1),()-3-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(2),and()-5-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(3),respectively.In the preliminary in vitro assays,two known compounds methyl caffeate and 2?-O-methyladenosine showed inhibitory activity against Coxsackie virus B3 with IC50 values of 3.70 μmol/L and 6.41 μmol/L and SI values of 7.8 and 12.1,respectively. | Yang Yu Zhibo Jiang Weixia Song Yongchun Yang Yuhuan Li Jiandong Jiang Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 23 |
| 2 | CO_2 Emissions Embodied in China's Foreign Trade:An Investigation from the Perspective of Global Vertical Specialization显示文摘In light of the growth in vertically specialized in global trade,the present paper uses input-output tables from the World Input-Output Database to construct an environmental multiregional input-output model to calculate the CO_2 emissions embodied in China's international trade during 1995-2009.The advantage of this model lies in its incorporation of the reexported CO_2emissions component embodied in trade and its ability to differentiate domesticsourcedCO_2 emissions from foreign-sourced CO_2 emissions in trade.The results show that carbon emissions embodied in both China's exports and imports increased significantly during 1995-2009.One important reason for this is that the re-exported carbon emissions embodied in China's imported intermediate inputs increased substantially during this period.Our research reveals that accelerating the transformation of trade pattern and upgrading processing trade should be emphasized in the formulation of policy to prompt CO_2 emissions abatement in China. | Yuhuan Zhao Zhonghua Zhang Song Wang Shaojun Wang | 2014 | China & World Economy2014，22，4： | 21 |
| 3 | Recent Progress on Functional Genomics Research of Enterovirus 71显示文摘Enterovirus 71(EV71) is one of the main pathogens that causes hand-foot-and-mouth disease(HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Studying EV71 protein function is essential for elucidating the EV71 replication process and developing anti-EV71 drugs and vaccines. In this review, we summarized the recent progress in the studies of EV71 noncoding regions(50 UTR and 30 UTR) and all structural and nonstructural proteins, especially the key motifs involving in viral infection, replication, and immune regulation. This review will promote our understanding of EV71 virus replication and pathogenesis, and will facilitate the development of novel drugs or vaccines to treat EV71. | Huiqiang Wang Yuhuan Li | 2019 | Virologica Sinica2019，34，1： | 14 |
| 4 | Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity显示文摘Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95(H3N2), respectively. | Lingjie Meng Qinglan Guo Yufeng Liu Minghua Chen Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 14 |
| 5 | Fixed Ammonium in Major Types of Paddy Soils in Hunan Province, China显示文摘The contents, affecting factors, seasonal changes and availability of fixed ammonium in major types ofpaddy soils derived from different parent materials in Hunan Province, China, were studied using the Silva-Bremner method by laboratory and pot experiments. Results showed that the content of fixed ammoniumin the plough horizons ranged from 88.3 mg kg-1 to 388.1 mg kg-1, with 273.2 ± 77.7 mg kg-1 on average,accounting for 11.2% of total soil N on average. Content of fixed ammonium decreased in the order of newlylacustrine clayey paddy soil > alluvial sandy paddy soil > purple clayey paddy soil > newly alluvial sandypaddy soil > yellow clayey paddy soil > reddish-yellow clayey paddy soil > granitic sandy paddy soil. Therewere four distribution patterns of fixed ammonium in the profiles to 1-m depth, i.e., increase with the depth,decrease with increasing depth, no distinct change with the depth, and abrupt increase or decrease in somehorizon. Percentage of fixed ammonium in total N increased with the depth in most of the soils. Fixationof NH4+ by soil was higher at 30 ℃ than at 20 ℃ and 40 ℃, and continuous submergence benefited thefixation of NH4+ in newly alluvial sandy paddy soil, purple clayey paddy soil and alluvial sandy paddy soil,while alternating wetting and drying contributed to the fixation of NH4+ in yellow clayey paddy soil mostly.Fixed ammonium content in the test paddy soils was significantly correlated with < 0.01 mm clay content(P < 0.05), but not with < 0.001 mm clay content, total N, organic N and organic matter. Fixed ammoniumcontent varied with rice growth stages. Application of N fertilizer promoted fixation of NH4+ by soil, and Nuptake by rice plant promoted release of fixed ammonium from the soil. Recently fixed ammonium in paddysoil after N fertilizer application was nearly 100% available to rice plant, while native fixed ammonium wasonly partly available, varying with the soil type and rice type. | ZHANG YANGZHU, LIAO JIPEI, SUN YUHUAN, FENG YUEHUA and HUANG YUNXIANGCollege of Resources and Environment, Hunan Agricultural University, Changsha 410128 (China) | 2003 | Pedosphere2003，13，3： | 11 |
| 6 | Review of the biological and engineering aspects of algae to fuels approach显示文摘Current biofuel production relies on limited arable lands on the earth,and is impossible to meet the biofuel demands.Oil producing algae are alternative biofuel feedstock with potential to meet the world’s ambitious goal to replace fossil fuels.This review provides an overview of the biological and engineering aspects in the production and processing technologies and recent advances in research and development in the algae to fuels approach.The article covers biology,selection and genetic modification of algae species and strains,production systems design,culture media and light management,harvest and dewatering,downstream processing,and environment and economic assessment.Despite the many advances made over several decades,commercialization of algal fuels remains challenging chiefly because of the techno-economic constraints.Technological breakthroughs in all major aspects must take place before commercial production of algal fuels becomes economically viable. | Paul Chen Min Min Yifeng Chen Liang Wang Yecong Li Qin Chen Chenguang Wang Yiqin Wan Xiaoquan Wang Yanling Cheng Shaobo Deng Kevin Hennessy Xiangyang Lin Yuhuan Liu Yingkuan Wang Blanca Martinez Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 9 |
| 7 | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities显示文摘A pair of new diphenyl glycerol ether enantiomers(-)-l and(+)-l and two new methyl benzamidobenzoates 2 and 3,named(-)-(R)-and(+)-(S)-isatindigotrioic acid[(-)-l and(+)-l]and isatindigoticamides A(2) and B(3),respectively,were isolated from an aqueous decoction of the roots of Isatis indigotica(ban lan gen).Their structures were elucidated by spectroscopic data analysis including2 D NMR experiments.The absolute configurations of(-)-l and(+)-l were assigned based on the CD exciton chirality method.Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC_(50)values of 4.87 and 25.87μmol/L,respectively.Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production. | Yufeng Liu Minghua Chen Qinglan Guo Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 8 |
| 8 | Sulfur-enriched alkaloids from the root of Isatis indigotica显示文摘Five new sulfur-enriched alkaloids isatithioetherins A–E(1–5), and two pairs of scalemic enantiomers(t)-and( à)-isatithiopyrin B(6 a and 6 b) and isoepigoitrin and isogoitrin(7 a and 7 b), along with the known scalemic enantiomers epigoitrin and goitrin(8 a and 8 b), were isolated and characterized from an aqueous extract of the Isatis indigotica roots. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and theoretical calculations of electronic circular dichroism(ECD) spectra based on the quantum-mechanical time-dependent density functional theory(TDDFT). Compounds 1–5 represent a novel group of sulfur-enriched alkaloids, biogenetically originating from stereoselective assemblies of epigoitrin-derived units. Isolation and structure characterization of 6 a and 6 b support the postulated biosynthetic pathways for the diastereomers 9 a and 9 b via a rare thio-Diels–Alder reaction. Compounds 2 and 4 showed antiviral activity against the influenza virus A/Hanfang/359/95(H3 N2, IC500.60 and 1.92 μmol/L) and the herpes simplex virus 1(HSV-1, IC503.70 and 2.87 μmol/L), and 2 also inhibited Coxsackie virus B3(IC500.71 μmol/L).& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/). | Qinglan Guo Chengbo Xu Minghua Chen Sheng Lin Yuhuan Li Chenggen Zhu JiANDong Jiang Yongchun Yang Jiangong Shi | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 8 |
| 9 | Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots显示文摘A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A(1), was isolated from an aqueous extract of the Isatis indigotica roots 'ban lan gen'. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism(CD) data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated. | Lingjie Meng Qinglan Guo Minghua Chen JiANDong Jiang Yuhuan Li Jiangong Shi | 2018 | Chinese Chemical Letters2018，29，8： | 7 |
| 10 | Bounds of Solutions of a Kind of Hyper-Chaotic Systems and Application显示文摘This paper investigates the boundedness of a kind of hyper-chaotic systems that have wide applications in the secure communications. In particular, an accurate bound estimation is attained for this kind of hyper-chaotic systems. Then, the result is applied to the chaos synchronization. Some numerical simulations are also given to verify the corresponding theoretical results. | Fuchen ZHANG Yuhuan LI Chunlai MU | 2013 | Journal of Mathematical Research with Applications2013，33，3： | 6 |
| 11 | Incidence and clinical characteristics of inflammatory bowel disease in a developed region of G uangdong P rovince, C hina: A prospective population‐based study显示文摘 | Zhirong Zeng Zhenhua Zhu Yuyu Yang Weishan Ruan Xiabiao Peng Yuhuan Su Lin Peng Jinquan Chen Quan Yin Chao Zhao Haihua Zhou Shuai Yuan Yuantao Hao Jiaming Qian Siew Chien Ng Minhu Chen Pinjin Hu | 2013 | J Gastroenterol Hepatol2013，，7： | 5 |
| 12 | Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients显示文摘Dear Editor,An acute viral pneumonia(COVID-19),caused by the novel coronavirus known as SARS-CoV-2,was first identified during December 2019 in China(Zhu et al.,2020).SARSCoV-2 was found to be highly transmissible in humans(Wang et al.,2020)and is now a pandemic spreading to over 140 countries and causing over 150,000 infections and 6,000 deaths as of March 15,2020.Diagnosis is critical for confirmation and treatment of COVID-19.Currently the primary criterion for diagnosis of COVID-19 is viral RNA detection for respiratory samples.Recently,two studies on virus loads in clinical samples reported that viral loads in nasal and throat swabs and sputum specimens peaked at 3–7 days after illness onset(d.a.o.)and virtually disappeared before 15 d.a.o.(Pan et al.,2020;Zou et al.,2020).Another study showed that the median duration of virus shedding in throat swabs was 20 d.a.o.in survivors and was detectable until death in non-survivors(Zhou et al.,2020).Additionally,live viruses have been isolated in the feces and urine samples of COVID-19 patients.However,the viral dynamics in these types of specimens has not yet been clearly elucidated,as well as comparative studies on virus shedding in the upper respiratory,intestinal,and urinary tracts. | Ning Zhang Yuhuan Gong Fanping Meng Yi Shi Jun Wang Panyong Mao Xia Chuai Yuhai Bi Penghui Yang Fusheng Wang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 13 | Catalytic microwave assisted pyrolysis of aspen显示文摘The effect of catalysts on the microwave pyrolysis of aspen pellets was studied.A range of chlorides,nitrates and metal-oxides were added at 2%of the aspen mass(air dry aspen pellet weight basis).Chlorides in particular were found to favor liquid yield,especially the yield of water phase residue.Average liquid yield with added chlorides was 41%mass of the total biomass input,compared to 35%mass without catalyst.Metal-oxides were found to favor pyrolysis heavy oil,and thus total oil yield,since the yield of light oils seemed to be fairly constant.Nitrates were found to favor pyrolysis gas production.Pure light oils and light oils blended with diesel were found to be a potential diesel fuel substitute. | Johannes Moen Changyan Yang Bo Zhang Hanwu Lei Kevin Hennessy Yiqin Wan Zhiping Le Yuhuan Liu Paul Chen Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 5 |
| 14 | Microwave-Assisted Decarboxylation of Sodium Oleate and Renewable Hydrocarbon Fuel Production显示文摘The carboxyl terminal of sodium oleate has a stronger polarity than that of oleic acid;this terminal is more likely to be dipole polarized and ionically conductive in a microwave field.Sodium oleate was used as the model compound to study the decarboxylation of oleic acid leading to hydrocarbon formation via microwave-assisted pyrolysis technology.The pyrolysis gas,liquid,and solid products were precisely analyzed to deduce the mechanism for decarboxylation of sodium oleate.Microwave energy was able to selectively heat the carboxyl terminal of sodium oleate.During decarboxylation,the double bond in the long hydrocarbon chain formed a p-πconjugated system with the carbanion intermediate.The resulting p-πconjugated system was more stable and beneficial to the pyrolysis reaction(decarboxylation,terminal allylation,isomerization,and aromatization).The physical properties of pyrolysis liquid were generally similar to those of diesel fuel,thereby demonstrating the possible use of microwaves for controlling the decarboxylation of sodium oleate in order to manufacture renewable hydrocarbon fuels. | Wang Yunpu Liu Yuhuan Ruan Rongsheng Wen Pingwei Wan Yiqin Zhang Jinsheng | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，3： | 5 |
| 15 | Accuracy Improvement of GTEM Cells for EMI Noise Measurement显示文摘针对吉赫兹横电磁波fgigahertz transverse electromagnetic,GTEMl小室用于辐射电磁干扰(electromagnetic interference,EMI)测量精度不高的问题,提出一种GTEM小室测量EMI噪声的的校准方法,采用多项式模型提取辐射噪声,利用方差对该模型的计算误差进行补偿,并基于高阶矩分析校准后的GTEM小室和3m电波暗室测量辐射电场值分布的相似性。实验结果表明,采用该文所提方法可显著提高GTEM小室的测量精度,验证了方法的有效性。 | ZHAO Yang RONG Rong ZHANG Yuhuan YAN Wei ZHAO Bo WANG Enrong QIU Xiaohui | 2012 | 中国电机工程学报2012，32，27： | 5 |
| 16 | Aircraft Measurements of Cloud–Aerosol Interaction over East Inner Mongolia显示文摘To investigate the potential effects of aerosols on the microphysical properties of warm clouds, airborne observational data collected from 2009 to 2011 in Tongliao, Inner Mongolia, China, were statistically analyzed in this study. The results demonstrated that the vertical distribution of the aerosol number concentration(N_a) was similar to that of the clean rural continent. The average aerosol effective diameter(D_e) was maintained at approximately 0.4 μm at all levels. The data obtained during cloud penetrations showed that there was a progressive increase in the cloud droplet concentration(N_c) and liquid water content(LWC) from outside to inside the clouds, while the Nawas negatively related to the Ncand LWC at the same height. The fluctuation of the N_a, Ncand LWC during cloud penetration was more obvious under polluted conditions(Type 1) than under clean conditions(Type 2). Moreover, the wet scavenging of cloud droplets had a significant impact on the accumulation mode of aerosols, especially on particles with diameters less than 0.4 μm. The minimum wet scavenging coefficient within the cloud was close to 0.02 under Type 1 conditions, while it increased to 0.1 under Type 2 conditions,which proved that the cloud wet scavenging effect under Type 1 conditions was stronger than that under Type 2 conditions.Additionally, cloud droplet spectra under Type 1 conditions were narrower, and their horizontal distributions were more homogeneous than those under Type 2 conditions. | Yuhuan Lü Hengchi LEI Jiefan YANG | 2017 | Advances in Atmospheric Sciences2017，34，8： | 4 |
| 17 | Economic Benefits and Environmental Costs of China's Exports: A Comparison with the USA Based on Network Analysis显示文摘 | Ya Liu Yuhuan Zhao Hao Li Song Wang Yongfeng Zhang Ye Cao | 2018 | China & World Economy2018，26，4： | 4 |
| 18 | An AGAMOUS-like factor is associated with the origin of two domesticated varieties in Cymbidium sinense (Orchidaceae)显示文摘Cymbidium has been artificially domesticated for centuries in Asia,which produced numerous cultivated varieties.Flowers with stamenoid tepals or those with multiple tepals have been found in different species of Cymbidium;however,the molecular basis controlling the formation of these phenotypes is still largely unknown.Previous work demonstrated that AGAMOUS/AG lineage MADS genes function in floral meristem determinacy as well as in reproductive organs development in both dicots and monocots,indicating a possible relationship with the origin of two flower varieties in Cymbidium.Here,we characterized and analyzed two AG lineage paralogues,CsAG1 and CsAG2,from Cymbidium sinense,both of which were highly expressed in the gynostemium column of a standard C.sinense.Interestingly,we detected ectopic expression of CsAG1 rather than CsAG2 in all floral organs of a stamenoid-tepal variety and significant down-regulation of CsAG1 in a variety with multiple tepals.Over-expression of CsAG1 in wild type Arabidopsis resulted in petal-to-stamen homeotic conversion,suggesting a conserved C-function of CsAG1 in the development of Cymbidium flower.Altogether,our results supported a hypothesis that disruption of a single AG-like factor would be associated with the formation of two domesticated varieties in C.sinense. | Shihao Su Xiaoyu Shao Changfa Zhu Jiayin Xu Yuhuan Tang Da Luo Xia Huang | 2018 | Horticulture Research2018，5，1： | 4 |
| 19 | Investigation and Reduction on Conducted Electromagnetic Interference Noise Mechanism for Complex Power Electronics Systems显示文摘针对复杂电子系统产生的传导EMI噪声,该文分别利用电偶极子模型、电路分析方法和散射参数方法提出了3种传导EMI噪声理论模型及其等效电路,包括因串扰引起的传导噪声模型,因接地不良引起的传导噪声模型,以及因PCB线缆阻抗失配引起的传导噪声模型。同时,还设计了一种串扰扼流圈以有效抑制因串扰引起的传导EMI噪声。实验结果表明,采用文中方法,某型商用车载导航和刷卡器能够通过GB 9254标准测试,噪声抑制效果分别可达44.8和29.28 dB V,从而验证了方法的有效性。 | YAN Wei ZHAO Yang WANG Ertrong ZHANG Yuhuan QIU Xiaohui SUN Hongyan CHEN Xueli | 2012 | 中国电机工程学报2012，32，30： | 4 |
| 20 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
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