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| 1 | Engineering T cells for immunotherapy of primary human hepatocellular carcinoma显示文摘Liver cancers, majority of which are primary hepatocellular carcinoma(HCC), continue to be on the rise in the world. Furthermore, due to the lack of effective treatments, liver cancer ranks the 4th most common cause of male cancer deaths. Novel therapies are urgently needed. Over the last few years,immunotherapies, especially the checkpoint blockades and adoptive cell therapies of engineered T cells,have demonstrated a great potential for treating malignant tumors including HCC. In this review, we summarize the current ongoing research of antigen-specific immunotherapies including cancer vaccines and adoptive cell therapies for HCC. We briefly discuss the HCC cancer vaccine and then focus on the antigen-specific T cells genetically engineered with the T cell receptor genes(TCRTs) and the chimeric antigen receptor genes(CARTs). We first review the current options of TCRTs and CARTs immunotherapies for HCC, and then analyze the factors and parameters that may help to improve the design of TCRTs and CARTs to enhance their antitumor efficacy and safety. Our goals are to render readers a panoramic view of the current stand of HCC immunotherapies and provide some strategies to design better TCRTs and CARTs to achieve more effective and durable antitumor effects. | Leidy DCaraballo Galva Lun Cai Yanxia Shao Yukai He | 2020 | Journal of Genetics and Genomics2020，47，1： | 8 |
| 2 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 3 | Analysis of the Internal Characteristics of a De ector Jet Servo Valve显示文摘In current research on deflector jet servo valves, the receiver pressure estimated using traditional two-dimensional simulation and theoretical calculation is always lower than the experimental data; therefore, credible information about the flow field in the prestage part of the valve can hardly be obtained. To investigate this issue and understand the internal characteristics of the deflector jet valve, a realistic numerical model is constructed and a three-dimensional simulation carried out that displays a complex flow pattern in the deflector jet structure. Then six phases of the flow pattern are presented, and the defects of the two-dimensional simulation are revealed. Based on the simulation results, it is found that the jet in the deflector has a longer core area and the fluid near the shunt wedge cannot resist the impact of the high-speed fluid. Therefore, two assumptions about the flow distribution are presented by which to construct a more complete theoretical model. The receiver pressure and prestage pressure gain are significantly enhanced in the calculations. Finally, special experiments on the prestage of the servo valve are performed, and the pressure performance of the numerical simulation and the theoretical calculation agree well with the experimental data. Finally, the internal mechanism described by the theoretical and numerical models is verified. From this research,more accurate numerical and theoretical models are proposed by which to figure out the internal characteristics of the deflector jet valve. | Hao Yan Yukai Ren Lei Yao Lijing Dong | 2019 | Chinese Journal of Mechanical Engineering2019，32，2： | 5 |
| 4 | An enhanced anti-disturbance control law for systems with multiple disturbances显示文摘Dear editor,The requirements for control performances(e.g.,the control accuracy)are highly increasing in practical engineering systems.However,multiple disturbances,which consist of internal disturbances,external disturbances,and model uncertainties in complex control systems may degrade the control performance[1]. | Yukai ZHU Lei GUO Xiang YU Yuan YUAN | 2020 | Science China(Information Sciences)2020，63，10： | 2 |
| 5 | Design of a Lightweight Force-Feedback Glove with a Large Workspace显示文摘A wearable force-feedback glove is a promising way to enhance the immersive sensation when a user interacts with virtual objects in virtual reality scenarios.Design challenges for such a glove include allowing a large fingertip workspace,providing a desired force sensation when simulating both free-and constrained-space interactions,and ensuring a lightweight structure.In this paper,we present a forcefeedback glove using a pneumatically actuated mechanism mounted on the dorsal side of the user’s hand.By means of a triple kinematic paired link with a curved sliding slot,a hybrid cam-linkage mechanism is proposed to transmit the resistance from the pneumatic piston rod to the fingertip.In order to obtain a large normal component of the feedback force on the user’s fingertip,the profile of the sliding slot was synthesized through an analysis of the force equilibrium on the triple kinematic paired link.A prototype five-fingered glove with a mass of 245 g was developed,and a wearable force-measurement system was constructed to permit the quantitative evaluation of the interaction performance in both free and constrained space.The experimental results confirm that the glove can achieve an average resistance of less than 0.1 N in free-space simulation and a maximum fingertip force of 4 N in constrained-space simulation.The experiment further confirms that this glove permits the finger to move freely to simulate typical grasping gestures. | Yukai Zheng Dangxiao Wang Ziqi Wang Yu Zhang Yuru Zhang Weiliang Xu | 2018 | Engineering2018，4，6： | 2 |
| 6 | Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis显示文摘 | Wei Li Baoyang Hu XuepengWang Tianda Li Tongtong Cui Dawei Yu Chao Liu Liyuan Jiang Guihai Feng Lei wang Rui Fu Xinxin Zhang Jie Hao Yukai Wang Liu Wang Qi Zhou | 2018 | Cell Research2018，28，1： | 2 |
| 7 | A Comparative Overview of Indirect Field Oriented Control (IFOC) and Deadbeat-Direct Torque and Flux Control (DB-DTFC) for AC Motor Drives显示文摘Indirect field oriented control(IFOC)has become a widely adopted solution for AC motor drives.Standard IFOC controls torque and rotor flux linkage via q-and d-axis current.Alternatively,deadbeat-direct torque and flux control(DB-DTFC)has emerged as a promising motor control strategy for the future,which manipulates Volt-sec.vector directly.Air-gap torque and stator flux linkage are decoupled and independently controlled over each switching period.Stator flux linkage is used as a separated degree-of-freedom to manipulate losses dynamically without compromising torque dynamics and torque ripple.In voltage-limited operations,direct selection of Volt-sec.allows DB-DTFC to fully utilize the dc bus voltage and produce fast torque.A single control law is used over a wide speed range.This paper aims to provide a comparative overview of the two motor controls regarding their sensitivity to parameters,current-and voltage-limited operation,loss manipulation,and torque ripple during signal injection.Based on the comparison,the ultimate objective is to demonstrate the opportunities and remaining challenges in DB-DTFC. | Yukai Wang Yuying Shi Yang Xu Robert D.Lorenz | 2015 | Chinese Journal of Electrical Engineering2015，1，1： | 2 |
| 8 | Cryptococcus neoformans,a global threat to human health显示文摘Background Emerging fungal pathogens pose important threats to global public health. The World Health Organization has responded to the rising threat of traditionally neglected fungal infections by developing a Fungal Priority Pathogens List (FPPL). Taking the highest-ranked fungal pathogen in the FPPL,Cryptococcus neoformans, as a paradigm, we review progress made over the past two decades on its global burden, its clinical manifestation and management of cryptococcal infection, and its antifungal resistance. The purpose of this review is to drive research efforts to improve future diagnoses, therapies, and interventions associated with fungal infections.Methods We first reviewed trends in the global burden of HIV-associated cryptococcal infection, mainly based on a series of systematic studies. We next conducted scoping reviews in accordance with the guidelines described in the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews using PubMed and ScienceDirect with the keywordCryptococcus neoformans to identify case reports of cryptococcal infections published since 2000. We then reviewed recent updates on the diagnosis and antifungal treatment of cryptococcal infections. Finally, we summarized knowledge regarding the resistance and tolerance ofC. neoformans to approved antifungal drugs.Results There has been a general reduction in the estimated global burden of HIV-associated cryptococcal meningitis since 2009, probably due to improvements in highly active antiretroviral therapies. However, cryptococcal meningitis still accounts for 19% of AIDS-related deaths annually. The incidences of CM in Europe and North America and the Latin America region have increased by approximately two-fold since 2009, while other regions showed either reduced or stable numbers of cases. Unfortunately, diagnostic and treatment options for cryptococcal infections are limited, and emerging antifungal resistance exacerbates the public health burden.Conclusions The rising threat ofC. neoformans is compounded by accumulating evidence for its ability to infect immunocompetent individuals and the emergence of antifungal-resistant variants. Emphasis should be placed on further understanding the mechanisms of pathogenicity and of antifungal resistance and tolerance. The development of novel management strategies through the identification of new drug targets and the discovery and optimization of new and existing diagnostics and therapeutics are key to reducing the health burden. | Youbao Zhao Leixin Ye Fujie Zhao Lanyue Zhang Zhenguo Lu Tianxin Chu Siyu Wang Zhanxiang Liu Yukai Sun Min Chen Guojian Liao Chen Ding Yingchun Xu Wanqing Liao Linqi Wang | 2023 | Infectious Diseases of Poverty2023，12，2： | 2 |
| 9 | A Structural Approach to Synthesizing Soft Switching PWM Converters显示文摘 | WU Tsaifu LIANG Shihan CHEN Yukai | 2003 | IEEE Transactions on Power Electronics2003，18，1： | 1 |
| 10 | Research and Application on EngineeringCases based Three Stages Teaching Methodology 显示文摘 | Bihong Lu Yukai Li | 2013 | AdvancedMaterials Research2013，，： | 1 |
| 11 | The regulation of hematopoietic stem cell fate in the context of radiation显示文摘Hematopoietic system is one of the main target organs of irradiation injury.Exposure to radiation can cause acute myelosuppression and long-term hematopoietic injury due to the direct and indirect damage of hematopoietic stem cells(HSCs)that can self-renew and differentiate into all types of blood cells.So far,many factors in the modulation of HSC biology at steady status have been revealed,while how to orchestrate HSCs in the context of radiation has not been well established.Recently,an increasing number of studies focus on the underlying mechanisms involved in regulating HSC fate after radiation exposure by affecting DNA damage response(DDR),including DNA-damage repair,cell-cycle arrest,apoptosis and senescence,or bone marrow(BM)microenvironment.In this review,we summarize recent findings on intrinsic and extrinsic factors in the regulation of HSC fate after radiation exposure,which may further deepen our understanding of the radioprotection of HSCs. | Yukai Lu Mengjia Hu Zihao Zhang Yan Qi Junping Wang | 2020 | Radiation Medicine and Protection2020，1，1： | 1 |
| 12 | A comparative analysis of maxillary tooth movement produced by cervical headgear and pend-x appliance显示文摘 | Taner TE Yukay F Pehlivanoglu M | 2003 | Angle Orthod2003，73，6： | 1 |
| 13 | The effect of premolar extractions on tooth-aize discrepancy显示文摘 | Saatci P Yukay F | | 0，，： | 1 |
| 14 | A structural approach to synthesizing soft switching PWM converters显示文摘 | Wu Tsai Fu Liang Shih An Chen Yukai | 2003 | IEEE Transactions on Power Electronics2003，18，1： | 1 |
| 15 | 3C strategy for inverters in parallel operation achieving an equal current distribution 显示文摘 | WU Tsaifu CHEN Yukai | 2000 | IEEE Trans on Industrial Applications Electronics 20002000，17，2： | 1 |
| 16 | The effect of iron on the sound velocities ofδ-AlOOH up to 135 GPa显示文摘δ-(Al,Fe)OOH is considered to be one of the most important hydrous phases on Earth,remaining stable under the extreme conditions throughout the mantle.The behavior ofδ-(Al,Fe)OOH at high pressure is essential to understanding the deep water cycle.δ-(Al_(0.956)Fe_(0.044))OOH crystals synthesized at 21 GPa and 1473 K were investigated by high-pressure Brillouin light scattering spectroscopy and synchrotron X-ray diffraction up to 135.4 GPa in diamond anvil cells.The incorporation of 5 mol%FeOOH increases the unit-cell volume ofδ-AlOOH by~1%and decreases the shear-wave velocity(VS)by~5%at 20–135 GPa.In particular,the compressional(V_(P))and shear(VS)wave velocities ofδ-(Al_(0.956)Fe_(0.044))OOH are 7%–16%and 10%–24%greater than all the major minerals in the mantle transition zone including wadsleyite,ringwoodite,and majorite.The distinctly high sound velocities ofδ-(Al_(0.956)Fe_(0.044))OOH at 20–25 GPa may contribute to the seismic anomalies observed at~560–680 km depths in the cold and stagnant slab beneath Izu-Bonin and/or Korea.Furthermore,the VS ofδ-(Al_(0.956)Fe_(0.044))OOH is about 10%and 4%–12%lower than iron-bearing bridgmanite Mg_(0.96)Fe_(0.05)Si_(0.99O3)and ferropericlase(Mg_(0.92)Fe_(0.08))O,respectively,under the lowermost mantle conditions,which might partially contribute to the large low-shear-velocity provinces and ultralow velocity zones at the bottom of the lower mantle. | Xiaowan Su Chaoshuai Zhao Chaojia Lv Yukai Zhuang Nilesh Salke Liangxu Xu Hu Tang Huiyang Gou Xiaohui Yu Qiang Sun Jin Liu | 2021 | Geoscience Frontiers2021，12，2： | 1 |
| 17 | K-SVM: An effec- tive SVM algorithm based on K-means clustering显示文摘 | Yukai Yao Yang Liu Yongqing Yu etal | 2013 | Jour- nal of computers2013，8，10： | 1 |
| 18 | The effect of premolar extraction on tooth-size discrepancy显示文摘 | Saatci P Yukay F | 1997 | Am JOrthod Dentofacial Orthop1997，111，4： | 1 |
| 19 | The effect of premolar extractions on tooth size discrepancy显示文摘 | Saatci P Yukay F | 1997 | Angle Orthod Dentofac Orthod1997，111，4： | 1 |
| 20 | Prediction on deflection of truss - core sandwich panels in weak direc- tion显示文摘 | WANG Yamin SHAO Yongbo LIU Yukai | 2013 | The Open Ocean Engineering Journal2013，6，： | 1 |
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