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| 1 | Characterization of PM_(2.5)/PM_(2.5-10) and source tracking in the juncture belt between urban and rural areas of Beijing显示文摘Coarse (PM2.5-10) and fine (PM2.5) atmospheric particulate samples were collected in summer and winter during 2005―2007 in the juncture belt between urban and rural areas of Beijing. Elements, ions, organic/elemental carbon (OC/EC) and polynuclear aromatic hydrocarbons (PAHs) were determined to obtain some latest information about the particulate pollution in the juncture belt of Beijing. Particulate matter levels at this site were high as compared with the levels at other sampling sites in Beijing. Pollution elements, secondary ions and PAHs were enriched in fine particles rather than in coarse particles. An obvious seasonal variation of the chemical composition of PM was observed. Source apportionment results showed that secondary components were the largest mass contributor of PM2.5, accounting for 28%; whereas soil-related sources were the largest contributor of PM2.5-10, explaining about 49% of the total mass. The abnormal levels of soil heavy metals at the electronic waste disassembly site in the upwind villages suggested the potential impact of such activities to the environment. | WANG HaiLin ZHOU YuMin ZHUANG YaHui WANG XiaoKe HAO ZhengPing | 2009 | Chinese Science Bulletin2009，54，14： | 11 |
| 2 | K-ras^G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis显示文摘增加的氧气的 glycolysis 和氧化应力是癌症房间新陈代谢的重要特征,但是内在的生物化学、分子的机制留下逃犯。用四圜素可诱导的模型,我们显示出 K 地岬 G12V 原因 mitochondrial 机能障碍,导致反应的氧的减少的呼吸,提高的 glycolysis,和增加的产生种类。K 地岬蛋白质与线粒体被联系,并且导致呼吸的链建筑群的快速的抑制 -- 我和在由影响 cyclosporin 敏感的渗透的 mitochondrial transmembrane 潜力的减少转移毛孔。而且, K 地岬 在 vitro 的 G12V 表示提高转变房间的能力允许新陈代谢的改编到高 glycolytic 新陈代谢在 vivo 形成肿瘤。我们的学习建议 mitochondrial 机能障碍的那正式就职是由 K 地岬 G12V 在癌症房间引起新陈代谢的变化和 ROS 应力,并且支持肿瘤开发。 | Yumin Hu Weiqin Lu Gang Chen Peng Wang Zhao Chen Yan Zhou Marcia Ogasawara Dunyaporn Trachootham Li Feng Helene Pelicano Paul J Chiao Michael J Keating Guillermo Garcia-Manero Peng Huang | 2012 | Cell Research2012，22，2： | 6 |
| 3 | Effectiveness of flesh-moistening paste in psoriasis vulgaris patients with symptom pattern of blood stasis:a randomized and parallel-controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on both the left and right side of the same patients with psoriasis vulgaris,diagnosed via TCM as blood stasis pattern,were selected as the targeted skin lesions.A randomized,double-blind,parallel-controlled,multicenter controlled trial was conducted.The targeted skin lesions were categorized into either the treatment or control group.The treatment group used the flesh-moistening paste;the control group used a placebo.Both the paste and the placebo were topically applied twice daily for eight weeks.The patients were examined biweekly to evaluate the effects.The two groups were compared in terms of the psoriasis area and severity index(PASI)of the targeted skin lesions,which is scored according to erythema,desquamation,infiltration,area,pruritus,and improvement of skin barrier function.Adverse events were recorded during the study period.SPSS 21.0 was used to analyze the data.RESULTS:Fifty-six patients were enrolled between February 2016 and October 2017.Two were complicated by cardio-cerebrovascular disease and were excluded;thus,54 outpatients were finally enrolled in the study.Four dropped out during the study period:three failed to complete their follow-up visits for unknown reasons,and one exited due to an adverse event.The final trial comprised 50 of the 56 originally selected patients,with a 92.6%completion rate.After 8 weeks of treatment,the targeted skin lesion scores differed significantly(P<0.05).The PASI scores of the targeted skin lesions differed significantly beginning at week 6(P<0.05).The treatment group presented better results than those of the control group.Only one patient had an adverse reaction associated with the treatment.Improvements in skin barrier function differed significantly(P<0.05).CONCLUSION:The flesh-moistening paste demonstrated a reliable curative effect and safety for treating psoriasis vulgaris in patients with blood stasis patterns.The topical paste improved the barrier function of the skin lesions. | Guo Xinwei Lang Na Li Guanru Li Ping Qu Jianhua Zhou Dongmei Wang Ping Cang Zhang Deng BingXu Lou Weihai Xu Jingna Lan Haibing Liu Yumin Zhang Weishu Sun Liyun | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 4 |
| 4 | Adaptive PMD Compensation in 10 Gbit/s RZ Optical Communication System显示文摘We report an experiment of adaptive compensation for polarization mode dispersion (PMD) in 10Gbit/s return zero (RZ) optical communication system. The quasi-real-time PMD compensation is realized. The algorithm so-called particle swarm optimization (PSO) is used to control feedback compensation system. | Yu Li Zhang Xiaoguang Zhou Guangtao Shen Yu Zheng Yuan Li Chaoyang Liu Yumin Chen Lin Yang Bojun | 2003 | 光学学报2003，23，S1： | 3 |
| 5 | Nanoparticle mediated controlled delivery of dual growth factors显示文摘Peripheral nerve functional recovery after nerve injury generally requires multiple growth factors by synergistic effect.However,the optical combination of multiple synergistic growth factors for axonal regeneration has been scarcely considered up to now.Meanwhile,the use of growth factors in promoting nerve regeneration was limited by its short biological half-life in vivo,its vulnerability to structure disruption or hydrolyzation,leading to loss of bioactivity.Herein,a novel polymeric nanoparticle delivery system composed of heparin andε-poly-L-lysine(PL)was prepared for control release of nerve growth factor(NGF)and basic fibroblast growth factor(bFGF).The nanoparticles were synthesized by polyelectrolyte complexation in aqueous solution at room temperature,followed by cross-linking with biological genipin.The obtained nanoparticles had a spherical shape,with a mean diameter of about 246 nm,and high growth factors encapsulation efficiency as well as good stability.NGF and bFGF were encapsulated in the nanoparticles and showed a continuous and slow release behavior in vitro.The bioactivities of the released growth factors were evaluated,and exhibited the synergistic effect.The controlled release of the dual synergistic growth factors would improve the treatment of peripheral nerve injury to mimic the natural cellular microenvironments. | ZHANG LuZhong ZHOU YouLang LI GuiCai ZHAO YaHong GU XiaoSong YANG YuMin | 2014 | Science China(Life Sciences)2014，57，2： | 3 |
| 6 | Aquaporin 4 expression and ultrastructure of the blood-brain barrier following cerebral contusion injury显示文摘This study aimed to investigate aquaporin 4 expression and the ultrastructure of the blood-brain barrier at 2-72 hours following cerebral contusion injury,and correlate these changes to the formation of brain edema.Results revealed that at 2 hours after cerebral contusion and laceration injury,aquaporin 4 expression significantly increased,brain water content and blood-brain barrier permeability increased,and the number of pinocytotic vesicles in cerebral microvascular endothelial cells increased.In addition,the mitochondrial accumulation was observed.As contusion and laceration injury became aggravated,aquaporin 4 expression continued to increase,brain water content and blood-brain barrier permeability gradually increased,brain capillary endothelial cells and astrocytes swelled,and capillary basement membrane injury gradually increased.The above changes were most apparent at 12 hours after injury,after which they gradually attenuated.Aquaporin 4 expression positively correlated with brain water content and the blood-brain barrier index.Our experimental findings indicate that increasing aquaporin 4 expression and blood-brain barrier permeability after cerebral contusion and laceration injury in humans is involved in the formation of brain edema. | Xinjun Li Yangyun Han Hong Xu Zhongshu Sun Zengjun Zhou Xiaodong Long Yumin Yang Linbo Zou | 2013 | Neural Regeneration Research2013，8，4： | 2 |
| 7 | A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe^(2+)in vivo显示文摘Iron is one of the essential trace elements in the human body.It plays an important role in human biology and pathology.Deregulation of iron levels in cells is associated with disease development.In this work,we synthesized a novel near-infrared intramolecular charge transfer(ICT)based ratiometric fluorescent probe to detect Fe^(2+),by using naphthalimide and indole moieties as building blocks.Our work showed that the radiometric probe has excellent selectivity,sensitivity and rapid response.Moreover,we could successfully perform real-time monitoring of Fe^(2+) in He La cells and C.elegans. | Lina Huang Yu Chen Yuqiang Zhao Yumin Wang Junwei Xiong Junfeng Zhang Xianghua Wu Ying Zhou | 2020 | Chinese Chemical Letters2020，31，11： | 2 |
| 8 | Ubiquitin-specific protease 24 promotes EV71 infection by restricting K63-linked polyubiquitination of TBK1显示文摘TANK-binding kinase 1(TBK1)is an essential protein kinase for activation of interferon regulatory factor 3(IRF3)and induction of the type I interferons(IFN-I).Although the biochemical regulation of TBK1 activation has been studied,little is known about how enterovirus 71(EV71)employs the deubiquitinases(DUBs)to regulate TBK1 activation for viral immune evasion.Here,we found that EV71 infection upregulated the expression of ubiquitinspecific protease 24(USP24).Further studies revealed that USP24 physically interacted with TBK1,and can reduce K63-linked polyubiquitination of TBK1.Knockdown of USP24 upregulated TBK1 K63-linked polyubiquitination,promoted the phosphorylation and nuclear translocation of IRF3,and in turn improved IFN-I production during EV71 infection.As a consequence,USP24 knockdown dramatically inhibited EV71 infection.This study revealed USP24 as a novel regulator of TBK1 activation,which promotes the understanding of immune evasion mechanisms of EV71 and could provide a potential strategy for treatment of EV71 infection. | Lichao Zang Jin Gu Xinyu Yang Yukang Yuan Hui Guo Wei Zhou Jinhong Ma Yan Chen Yumin Wu Hui Zheng Weifeng Shi | 2023 | Virologica Sinica2023，38，1： | 2 |
| 9 | Study on the fluorescence spectra and electrochemical behavior of ZnL2 and morin with DNA显示文摘 | SONG Yumin KANG Jingwan ZHOU Jing | 2000 | Spectrochim Acta: A2000，56，： | 1 |
| 10 | Hepatectomy in Elderly Patients: Does Age Matter?显示文摘 | Yanming Zhou Xiaofeng Zhang Zuobing Zhang Xiaobin Liu Lupeng Wu Yumin Li Bin Li | 2013 | World Journal of Surgery2013，，12： | 1 |
| 11 | 显示文摘 | Zongyao Rui Richard J. Goldfarb Yumin Qiu Taihe Zhou Renyi Chen Franco Pirajno Grace Yun | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 12 | Generalization of DEM for Terrain Analysis Using a Compound Method 显示文摘 | ZHOU Qiming CHEN Yumin | 2011 | Remote sensing2011，，1： | 1 |
| 13 | 显示文摘 | Yumin Qiu David I. Groves Neal J. McNaughton Liang-gen Wang Taihe Zhou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 14 | Cyclooxygenase-2 ?765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population显示文摘 | Jianhong He Quanbao Zhang Zhijian Ren Yumin Li Xun Li Wence Zhou Hui Zhang Wenbo Meng Jun Yan Wenting He | 2012 | Molecular Biology Reports2012，，4： | 1 |
| 15 | 显示文摘 | Yumin Qiu David I. Groves Neal J. McNaughton Liang-gen Wang Taihe Zhou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 16 | Study on the fluorescence spectra and electro-chemical behavior of ZnL2 and Morin with DNA显示文摘 | SONG Yumin KANG Jingwan ZHOU Jing | 2000 | Spectrochimica Acta: A2000，56，： | 1 |
| 17 | Generalization of DEM for Terrain Analysis Using a Compound Method显示文摘 | Zhou Qiming Chen Yumin | 2011 | Remote Sensing2011，，1： | 1 |
| 18 | 显示文摘 | Zongyao Rui Richard J. Goldfarb Yumin Qiu Taihe Zhou Renyi Chen Franco Pirajno Grace Yun | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 19 | Influence of cementite spheroidization on relieving the micro-galvanic effect of ferrite-pearlite steel in acidic chloride environment显示文摘The corrosion behavior of the as-received steel and the spheroidized steel in acidic chloride environment was investigated. The results indicate the corrosion mode and corrosion rate of two steels are diverse due to their difference in microstructure. For as-received steel with ferrite-pearlite microstructure, severe localized corrosion happens on the pearlite regions, and plenty of cathodic cementite remains in the pits, further strengthening the micro-galvanic effect and accelerating the corrosion rate. While for spheroidized steel with tempered martensite microstructure, the nanosized cementite particles evenly distributed on the ferrite substrate are easy to fall off, which can significantly reduce the cementite accumulation on the steel surface, relieving the acceleration effect of micro-galvanic corrosion. | Hu Liu Jie Wei Junhua Dong Yiqing Chen Yumin Wu Yangtao Zhou Subedi Dhruba Babu Wei Ke | 2021 | Journal of Materials Science & Technology2021，，2： | 1 |
| 20 | Gelcasting of silicon carbide ceramics using phenolic resin and furfuryl alcohol as the gel former显示文摘 | Yumin Zhang Zhiyong Yuan Yufeng Zhou | 2013 | Ceramics International2013，，： | 1 |
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