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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Friction stir welding of high-strength aerospace aluminum alloy and application in rocket tank manufacturing显示文摘Friction stir welding(FSW) has been widely adopted in aerospace industry for fabricating high-strength aluminum alloy structures, such as large volume fuel tanks, due to its exceptional advantages including low distortion, less defects and high mechanical properties of the joint. This article systematically reviews the key technical issues in producing large capacity aluminum alloy fuel tanks by using FSW,including tool design, FSW process optimization, nondestructive testing(NDT) techniques and defect repairing techniques, etc. To fulfill the requirements of Chinese aerospace industry, constant-force FSW,retractable tool FSW, lock joint FSW, on-line NDT and solid-state equal-strength FSW techniques, as well as a complete set of aerospace aluminum FSW equipment, have been successfully developed. All these techniques have been engineered and validated in rocket tanks, which enormously improved the fabrication ability of Chinese aerospace industry. | Guoqing Wang Yanhua Zhao Yunfei Hao | 2018 | Journal of Materials Science & Technology2018，34，1： | 33 |
| 3 | A preventive control strategy for static voltage stability based on an efficient power plant model of electric vehicles显示文摘With the increasing integration of wind farms and electric vehicles(EVs)in power systems,voltage stability is becoming more and more serious.Based on vehicle-to-grid(V2G),an efficient power plant model of EVs(E-EPP)was developed to estimate EV charging load with available corresponding response capacity under different charging strategies.A preventive control strategy based on E-EPP was proposed to maintain the static voltage stability margin(VSM)of power system above a predefined security level.Two control modes were used including the disconnection of EV charging load(‘V1G’mode)and the discharge of stored battery energy back to power grid(‘V2G’mode).A modified IEEE 14-bus system with high penetration of wind power and EVs was used to verify the effectiveness of preventive control strategy.Simulation results showed that the proposed strategy can not only improve the static voltage stability of power system with considerable wind generation,but also guarantee the travelling comfort for EV owners. | Mingshen WANG Yunfei MU Hongjie JIA Jianzhong WU Xiuping YAO Xiaodan YU Janaka EKANAYAKE | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 25 |
| 4 | Characterization of Arabidopsis MYB transcription factor gene AtMYB17 and its possible regulation by LEAFY and AGL15显示文摘MYB transcription factors compose one of the largest transcription factor families in Arabidopsis, which play important roles in various developmental processes as well as defense responses against environmental stresses.In this study, we report the characterization of AtMYB17 gene, a putative R2R3 type MYB gene family member in Arabidopsis.AtMYB17 was found exclusively localized in nuclear, with an activation domain at its C-terminus.AtMYB17 was highly expressed in inflorescences and siliques, especially at early flower developmental stages.The level of AtMYB17 transcripts was also found to increase after imbibition during seed germination and gradually concentrate to the shoot apex.Bioinformatics analysis identified several binding sites of LEAFY(LFY) and AGL15 in the promoter re-gion of AtMYB17.Promoter-GUS fusion analysis showed that the LFY binding sites were important in fine-tuning regulation of the spatio-temporal expression of AtMYB17 in transgenic plants.Moreover, AtMYB17 was up-regulated in 35S::AGL15 plants.Taken together, our data suggest that LFY may be involved in the regulation of AtMYB17, possibly together with AGL15, and thereafter in early inflorescence development and seed germination. | Yunfei Zhang Guangyu Cao Li-Jia Qu Hongya Gu | 2009 | Journal of Genetics and Genomics2009，36，2： | 24 |
| 5 | The C_2H_2 -type Zinc Finger Protein ZFP182 is Involved in Abscisic Acid-Induced Antioxidant Defense in Rice显示文摘C2H2 -type zinc finger proteins (ZFPs) are thought to play important roles in modulating the responses of plants to drought, salinity and oxidative stress. However, direct evidence is lacking for the involvement of these ZFPs in abscisic acid (ABA)-induced antioxidant defense in plants. In this study, the role of the rice (Oryza sativa L. sub. japonica cv. Nipponbare) C 2 H 2 -type ZFP ZFP182 in ABA-induced antioxidant defense and the relationship between ZFP182 and two rice MAPKs, OsMPK1 and OsMPK5 in ABA signaling were investigated. ABA treatment induced the increases in the expression of ZFP182, OsMPK1 and OsMPK5, and the activities of superoxide dismutase (SOD) and ascorbate peroxidase (APX) in rice leaves. The transient gene expression analysis and the transient RNA interference (RNAi) analysis in protoplasts showed that ZFP182, OsMPK1 and OsMPK5 are involved in ABA-induced up-regulation in the activities of SOD and APX. Besides, OsMPK1 and OsMPK5 were shown to be required for the up-regulation in the expression of ZFP182 in ABA signaling, but ZFP182 did not mediate the ABA-induced up-regulation in the expression of OsMPK1 and OsMPK5. These results indicate that ZFP182 is required for ABA-induced antioxidant defense and the expression of ZFP182 is regulated by rice MAPKs in ABA signaling. | Hong Zhang Lan Ni Yanpei Liu Yunfei Wang Aying Zhang Mingpu Tan Mingyi Jiang | 2012 | Journal of Integrative Plant Biology2012，54，7： | 23 |
| 6 | Frequency response of autonomous microgrid based on family-friendly controllable loads显示文摘Frequency is a key issue for the stable operation of autonomous microgrid(AMG) with a large penetration of intermittent renewable energy resources.The fast development of demand-side response technology provides a new solution for the frequency control of the AMG.In this paper,a novel decentralized demand control strategy(DDC) for family-friendly controllable refrigerators considering customer comfort level is proposed to regulate the frequency of AMG in coordination with the energy storage system(ESS).The refrigerator under DDC responds to the local frequency signals quickly and adjusts its operation cycle dynamically.Meanwhile,a customer participation degree which is proportional to the frequency deviation is introduced to evaluate the customer comforts when responding to the frequency of AMG.Finally,a benchmark low voltage AMG is established as a test system to verify the effectiveness of the proposed DDC strategy.Simulation results show that the DDC strategy can not only improve the frequency control effect of AMG effectively but also guarantee the customer comforts as well as reduce the capacity of ESS. | JIA HongJie QI Yan MU YunFei | 2013 | Chinese Science Bulletin2013，58，7： | 21 |
| 7 | Genetic analysis and gene mapping of a dominant presenescing leaf gene PSL3 in rice (Oryza sativa L.)显示文摘Leaf senescence as an active process is essential for plant survival and reproduction.However,premature senility is harmful to agricultural production.In this study,a rice mutant,named as psl3 (presescing leaf 3) isolated from EMS-treated Jinhui 10,displays obvious premature senility features both in morphological and physiological level.Genetic analysis showed that mutant trait was controlled by a single dominant gene (PSL3),which was located on rice chromosome 7 between SSR marker c7sr1 and InDel marker ID10 with an interval of 53.5 kb.The result may be useful for the isolation of the PSL3 gene. | FANG LiKui LI YunFeng GONG XiaoPing SANG XianChun LING YingHua WANG XiaoWen CONG YunFei HE GuangHua | 2010 | Chinese Science Bulletin2010，55，23： | 20 |
| 8 | USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors显示文摘(K63 ) 离氨酸 63 连接了 RIG-I 戏的 ubiquitination 在类型的激活的一个关键角色我干扰素小径,然而,为它的 deubiquitination 负责的分子的机制仍然糟糕被理解。这里,我们报导 deubiquitination 酶 ubiquitin 特定的朊酶(USP3 ) 3 否定地调整类型的激活我干扰素由指向 RIG-I 发信号。USP3 击倒 RIG-I 的明确地提高的连接 K63 的 ubiquitination, upregulated IRF3 的 phosphorylation 并且扩充了类型的生产我干扰素 cytokines 和抗病毒的免疫。我们进一步证明在 unstimulated 或 uninfected 房间在 USP3 和 RIG-I-like 受体( RLR )之间没有相互作用,但是在病毒的感染或 ligand 刺激之上, USP3 绑在 RLR 的 caspase 激活招募领域然后通过它的锌手指的合作劈开 polyubiquitin 链Ub有约束力的领域和 USP 催化领域。变化分析表明到 RIG-I 上的 polyubiquitin 链的 USP3 的那绑定是为它 polyubiquitin 链的劈开的前提步。我们的调查结果在 RIG-I 激活识别 USP3 的一个以前未被认出的角色并且提供卓见进 USP3 由禁止 RIG-I 发信号和抗病毒的免疫的机制。 | Jun Cui Yanxia Song Yinyin Li Qingyuan Zhu Peng Tan Yunfei Qin Helen Y Wang Rong-Fu Wang | 2014 | Cell Research2014，24，4： | 20 |
| 9 | Salidroside inhibits H2O2-induced apoptosis in PC12 cells by preventing cytochrome c release and inactivating of caspase cascade显示文摘我们使用了老鼠 pheochromocytoma (PC 12 ) 在氢过氧化物上学习 salidroside 的效果的房间线(H 2 O 2)-induced apoptosis。在 PC12 房间, H 2 O 2-induced apoptosis 被 Bcl-2, Bax 的起来规定,到 cytosol 的 mitochondrial 细胞色素 c 的版本,和 caspase-3, -8 和 -9 的激活的下面规定伴随。然而, salidroside 压制了 Bcl-2, Bax 的起来规定和 mitochondrial 细胞色素 c 的版本的下面规定到 cytosol。而且, salidroside 对 H 2 O 2-induced apoptosis。总起来说,这些结果建议有 salidroside 的 PC12 房间的处理能堵住 H 2 由调整 Bcl-2 家庭成员并且由压制细胞色素 c 版本和 caspase 串联激活的 O 2-induced apoptosis。 | Lei Cai Hua Wang Qin Li Yunfei Qian Wenbing Yao | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 18 |
| 10 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 11 | Observation and analysis of near-surface atmospheric aerosol optical properties in urban Beijing显示文摘Year-round measurements of the mass concentration and optical properties of fine aerosols(PM_(2.5)) from June 2009 to May 2010 at an urban site in Beijing were analyzed.The annual mean values of the PM_(2.5) mass concentration,absorption coefficient(Ab),scattering coefficient(Sc) and single scattering albedo(SSA)at 525 nm were 67±66μg/m^3,64 ±62 Mm^(-1),360 ±405 Mm^(-1) and 0.82 ±0.09,respectively.The bulk mass absorption efficiency and scattering efficiency of the PM_(2.5) at 525 nm were 0.78 m^2/g and 5.55 m^2/g,respectively.The Ab and Sc showed a similar diurnal variation with a maximum at night and a minimum in the afternoon,whereas SSA displayed an opposite diurnal pattern.Significant increases in the Ab and Sc were observed in pollution episodes caused by the accumulation of pollutants from both local and regional sources under unfavorable weather conditions.Aerosol loadings in dust events increased by several times in the spring,which had limited effects on the Ab and Sc due to the low absorption and scattering efficiency of dust particles.The frequency of haze days was the highest in autumn because of the high aerosol absorption and scattering under unfavorable weather conditions.The daily PM_(2.5)concentration should be controlled to a level lower than 64 μg/m^3 to prevent the occurrence of haze days according to its exponentially decreased relationship with visibility. | Junshan Jing Yunfei Wu Jun Tao Huizheng Che Xiangao Xia Xiaochun Zhang Peng Yan Deming Zhao Leiming Zhang | 2015 | Particuology2015，13，1： | 16 |
| 12 | An examination of summer precipitation over Asia based on TRMM/TMI显示文摘A 6-year dataset of summer monthly mean precipitation derived from Tropical Precipitation Measure-ment Mission (TRMM)-Microwave Imager (TMI) was used to delineate the spatial distribution patterns of precipitation throughout Asian areas, which indicates that there are three rainfall centers located at the northern coast of the Bay of Bengal, the South China Sea and the western equatorial Pacific Warm Pool, respectively. Based upon the analysis of horizontal distribution, the capability of TMI for characterizing terrestrial and maritime precipitation has been evaluated and compared with Global Precipitation Climatology Project (GPCP) dataset. It was found that TMI and GPCP are well consistent with each other, while a few significant differences occur at several regions over land. By investigating rainfall esti-mates over six specific locations in Asia, a systematic underestimation of TMI was demonstrated, which could be explained by the inherent deficiency within TMI terrestrial algorithm relying on scat-tering signal from ice particles in a precipitation system. A further analysis shows that the highly in-homogeneous distribution of rain gauges employed by GPCP contributes a great deal to the significant discrepancy between GPCP and TMI, especially over regions surrounding the Tibetan Plateau where rain gauges are quite scarce. | LIU Qi FU Yunfei | 2007 | Science China Earth Sciences2007，50，3： | 16 |
| 13 | Rice Transcription Factor OsDOFll Modulates Sugar Transport by Promoting Expression of Sucrose Transporter and SWEET Genes显示文摘 | Yunfei Wu Sang-Kyu Lee Youngchul Yoo Jinhuan Wei Suk-Yoon Kwon Sang-Won Lee Jong-Seong Jeon Gynheung An | 2018 | Molecular Plant2018，11，6： | 15 |
| 14 | An approach to determining the local boundaries of voltage stability region with wind farms in power injection space显示文摘A new approach to determining the local boundaries of voltage stability region in power injection space (IVSR) for power system with wind farms is presented. It can be used for power system voltage stability analysis and on-line security assessment with considering the output uncertainty of the wind farms. Firstly, power flow tracing and double dispatching are used to determine the generators that are closely related to the wind farms, in order to balance the power fluctuations caused by the wind speed variation. Then, modal analysis is used to get the key generators to achieve an effective dimension reduction for IVSR. Finally, the forecasting output power (or wind speed) of wind farms is divided into several intervals. For each interval, the corresponding local IVSR boundaries can be calculated by the method based on small disturbance. Moreover, parallel process is used to accelerate the computing speed. The presented approach is validated by several power systems. It can be revealed that the approach can give the local IVSR boundaries at different wind speeds and has a good engineering application prospect. | MU YunFei & JIA HongJie Key Laboratory of Power System Simulation and Control of Ministry of Education, Tianjin University, Tianjin 300072, China | 2010 | Science China(Technological Sciences)2010，53，12： | 13 |
| 15 | Climatic characteristics of convective and stratiform precipitation over the Tropical and Subtropical areas as derived from TRMM PR显示文摘Climatic characteristics of convective and stratiform precipitation over the Tropical and Subtropical areas are investigated based on the measurements of Tropical Rainfall Measuring Mission's(TRMM) Precipitation Radar(PR) from 1998 to 2007.Results indicate that convective precipitation are distributed mainly over the Intertropical Convergence Zone(ITCZ),the South Pacific Convergence Zone(SPCZ),the Asian Monsoon Region,regions between the South America and the Mid-America,and the Tropical Africa where the frequencies lie between 1% and 2%.But in four seasons,total area fractions of convective precipitation frequencies less than 1% all exceed 85%.The frequencies of stratiform precipitation are much higher than those of convective precipitation,and total area fractions of stratiform precipitation frequencies >1% are over 55% during four seasons.However,frequencies of the two rain types show not only remarkable regionality,but also distinct seasonal variations.Conditional rain rates of convective precipitation range from 6 to 14 mm/h whereas those of stratiform precipitation are smaller than 4 mm/h.Meanwhile,rain tops of convective precipitation are higher than those of stratiform precipitation.The mean profiles of the two rain types show significant latitudinal dependency.And the seasonal variations of precipitation profiles are displayed mainly in the variations of rain tops.The frequencies and conditional rain rates of both rain types over ocean are higher than those over land,but rain tops are just the opposite.Moreover,the seasonal variations of both rain types over ocean are weaker than those over land because of the different stable states of underlying surfaces. | LIU Peng LI ChongYin WANG Yu FU YunFei | 2013 | Science China Earth Sciences2013，56，3： | 11 |
| 16 | Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels显示文摘The present study was designed to investigate the protective effects of leonurine, a compound purified from Herba Leonuri that is active on ischemic rat behavior and cortical neurons, and explore the underlying mechanism. The general rat activity, cortical neuron morphology, superoxide dismutase (SOD), malondialdehyde (MDA),γ- aminobutyric acid (GABA) and glutamate decarboxylase 67 (GAD67) levels were measured. We found leonurine significantly improve the general activity of rats in an opefield test, which was associated with attenuated neuronal damage induced by ischemia. Moreover, serum SOD activity was significantly greater, MDA level lower in the leonurine group as compared with ischemia group. In addition, GABA content in the cerebral cortex was significantly greater in high-dose leonurine group. Correspondingly, GAD67 protein level coincided with the GABA level. Taken together, our results demonstrated that leonurine attenuated brain injury during ischemia via antioxidative and anti-excitotoxicity effects by targeting GABA and leonurine might become a useful adjuvant neuroprotective agent. | Shilei ZHENG Jingru ZHU Jiao LI Shuang ZHANG Yunfei MA | 2019 | Frontiers of Agricultural Science and Engineering2019，6，2： | 11 |
| 17 | β-diversity Patterns of Plant Community in Fragmented Habitat in a Degenerated Meadow in Songnen Plain,China显示文摘A number of isolated islands of Leymus chinensis + herbosa community were investigated in fragmented habitat islands,by Braun-Blanquet field survey approach,in a degenerated meadow in the Songnen Plain,China in 2007.These islands were classified as large,medium,and small scales on the basis of the island area(100-1000m2,large island;50-100m2,middle island;10-50m2,small island).Each scale of the investigation involved eight islands.The responses of β-diversity patterns of plant taxon to the habitat fragmentation at local community and metacommunity levels were analyzed on different scales of 24 isolated islands.The results indicated that at the local community level,there were 57 species belonging to 20 families and 49 genera in large islands,49 species belonging to 16 families and 40 genera in middle islands,and 27 species belonging to eight families and 23 genera in small islands.β-diversity indexes for species,genus and family in large,middle,and small islands varied greatly,and the highest value of the indexes was not noted in the largest island.However,the average of the data obtained at the three scales showed that across large islands,Whittaker indexes were low and Bray-Curtis similarity indexes were high,while across small islands,Whittaker indexes were high and Bray-Curtis similarity indexes were low.At the metacommunity level,Whittaker indexes for species and genus showed a great significantly negative double logarithmic correlation(p<0.01) with the island area,whereas the Bray-Curtis indexes for species,genus and family showed a great significantly positive double logarithmic correlation(p<0.01) with the island area.At both local community and metacommunity levels,turnovers of species and genus could respond more sensitively to spatial changes of plant diversity patterns than that of family.Hence,the species and the genus could be used for the analysis of β-diversity patterns of plant community. | HAN Dayong LI Haiyan YANG Yunfei | 2009 | Chinese Geographical Science2009，19，4： | 11 |
| 18 | Effects of Cl- Ions on the Corrosion Behaviour of Low Alloy Steel in Deaerated Bicarbonate Solutions显示文摘The effect of Cl-ions on corrosion evolution of Ni Cu low alloy steel during immersion tests(up to 70days) in deaerated 0.05 mol/L bicarbonate solutions was investigated by in-situ electrochemical measurements combined with X-ray diffraction(XRD), scanning electron microscopy(SEM) and electron probe microanalysis(EPMA) characterisations. The results showed that due to the acceleration of substrate dissolution in the presence of Cl-, corrosion of Ni Cu low alloy steel underwent only two stages, i.e., a quick oxidation process followed by a final metastable passive state, without the initial slow anodic dissolution as observed in the Cl--free bicarbonate solution. The main components of the formed rust layer in the Cl--free bicarbonate solution were α-Fe OOH and Fe)_3O_4 , while apart from α-Fe OOH, (Fe)_6(OH)_(12)(CO)_3 was found evident instead of (Fe)_3O_4 in the Cl--containing solution. Metastable pits were only found in the Cl--containing solution where Cl-accumulated after the immersion test, confirming the attack of Cl-on the substrate after penetrating the formed corrosion product layer. | Yunfei Lu Junhua Dong Wei Ke | 2016 | Journal of Materials Science & Technology2016，32，4： | 11 |
| 19 | Numerical Simulation of Typhoon Muifa(2011) Using a Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST) Modeling System显示文摘The newly developed Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST) Modeling System is applied to investigate typhoon-ocean interactions in this study. The COAWST modeling system represents the state-of-the-art numerical simulation technique comprising several coupled models to study coastal and environmental processes. The modeling system is applied to simulate Typhoon Muifa(2011), which strengthened from a tropical storm to a super typhoon in the Northwestern Pacific, to explore the heat fluxes exchanged among the processes simulated using the atmosphere model WRF, ocean model ROMS and wave model SWAN. These three models adopted the same horizontal grid. Three numerical experiments with different coupling configurations are performed in order to investigate the impact of typhoon-ocean interaction on the intensity and ocean response to typhoon. The simulated typhoon tracks and intensities agree with observations. Comparisons of the simulated variables with available atmospheric and oceanic observations show the good performance of using the coupled modeling system for simulating the ocean and atmosphere processes during a typhoon event. The fully coupled simulation that includes a ocean model identifies a decreased SST as a result of the typhoon-forced entrainment. Typhoon intensity and wind speed are reduced due to the decrease of the sea surface temperature when using a coupled ocean model. The experiments with ocean coupled to atmosphere also results in decreased sea surface heat flux and air temperature. The heat flux decreases by about 29% compared to the WRF only case. The reduction of the energy induced by SST decreases, resulting in weakening of the typhoon. Coupling of the waves to the atmosphere and ocean model induces a slight increase of SST in the typhoon center area with the ocean-atmosphere interaction increased as a result of wave feedback to atmosphere. | LIU Na LING Tiejun WANG Hui ZHANG Yunfei GAO Zhiyi WANG Yi | 2015 | Journal of Ocean University of China2015，14，2： | 10 |
| 20 | Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy显示文摘The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent fashion.To date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed. | Dongdong Ti Yunfei Niu Zhiqiang Wu Xiaobing Fu Weidong Han | 2018 | Science China(Life Sciences)2018，61，11： | 10 |
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