|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression显示文摘MicroRNAs (miRNAs ) 是小非编码的规章的 RNA 的一个班,并且在 miRNAs 的变化涉及肿瘤起源和前进。研究证明了 miR-20a 是在人的卵巢的癌症纸巾的 overexpressed 并且这 miRNA 提高长期的细胞的增长和侵略能力。在这研究,在浆液 miR-20a 表示和卵巢的癌症舞台之间的积极关联被观察。我们发现 miR-20a 直接绑,导致它的降级并且减少它 MICA/B mRNA 的 -untranslated 区域在血浆膜上铺平的蛋白质 3 ′。膜界限 MICA/B 蛋白质的减小,是 2 成员 D (NKG2D ) 受体在生来的杀手(NK ) 上发现了房间的生来的迷人的组的 ligands, γ δ + T 房间和 CD8 + T 房间,允许肿瘤房间躲避调停免疫者的杀死。尤其是,反对 miR-20a 行动提高了在 vitro 并且在肿瘤的 vivo 模型的在两个的肿瘤房间的调停 NKG2D 的杀死。一起拿,我们的数据显示在肿瘤房间的 miR-20a 的增加的层次可以间接地由 downregulating MICA/B 压制 NK 房间 cytotoxicity 表达式。这些数据提供在转移能力和 NK 房间的肿瘤房间的有免疫力的逃跑之间的一个潜在的连接。 | Jingyan Xie Mengna Liu Yujuan Li Yunzhong Nie Qiongyu Mi Shuli Zhao | 2014 | Cellular & Molecular Immunology2014，11，5： | 10 |
| 2 | Wetting behaviors and interfacial characteristics of molten Al_(x)CoCrCuFeNi high-entropy alloys on a WC substrate显示文摘The wettability of molten Al_(x)CoCrCuFeNi(x is from 0 to 1.5,mol.%)high-entropy alloys(HEA)on a WC substrate was measured using a modified sessile drop method at 1823 K in an argon atmosphere.The wetting behaviors and interfacial characteristics between HEAs and WC were studied.Good wettability with final equilibrium contact angles of 0.5°-4.6°is obtained,and addition of Al deteriorates the wettability of the HEAs.The wetting of Al_(x)CoCrCuFeNi/WC system can be roughly divided into an initially sharp spreading stage and a subsequent steady-state phase.In the first stage,the adsorption of Cr atoms at the solid-liquid interface primarily contributes to the wetting,and the contact angle drastically reduces.However,both the wetting behavior and interfacial microstructure are determined by the Al content of the HEA in the next stage.For x≤0.5,the wetting is mainly driven by the dissolution of WC,although a few reaction products of(W,Cr)_(2)C are observed.Moreover,an obvious dissolution pit appears at the surface of the substrate.When the Al content of x≥1,the interfacial reaction is dominant in competition with the dissolution of WC,and massive reaction products precipitate at the HEA/WC interface,which leads to the formation of a continuous reaction layer. | Wenyan Luo Yunzhong Liu Cheng Tu | 2021 | Journal of Materials Science & Technology2021，，19： | 7 |
| 3 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 4 | Health Inequalities during 20 Years of Rapid Economic Development in China (1980-2000):A Mortality Analysis显示文摘Objective To examine the influence of China's economic reforms on population health and regional mortality rates.Methods Longitudinal study measuring the mortality trends and their regional variations.Using data from the three most recent national censuses,we used the model life table to adjust the mortality levels within the population for each census,and to calculate life expectancy.We then examined the variation in patterns of mortality and population health by economic status,region and gender from 1980-2000.Results Life expectancy varied with economic status,province,and gender.Results showed that,although life expectancy in China had increased overall since the early 1980s,regional differences became more pronounced.Life expectancy for populations who live in the eastern coastal provinces are greater than those in the western regions.Conclusion Differences in life expectancy are primarily related to differences in regional economic development,which in turn exacerbate regional health inequalities.Therefore,it is necessary to improve economic development in less developed regions and to improve health policies and the public health system that address the needs of everyone. | ZHENG XiaoYing SONG XinMing CHEN Gong YOU YunZhong REN Qiang LIU JuFen ZHANG Lei TAN LingFang WEI JiHong CHEN QiuYuan | 2011 | Biomedical and Environmental Sciences2011，24，4： | 2 |
| 5 | Enhanced strength and ductility in Al-Zn-Mg-Cu alloys fabricated by laser powder bed fusion using a synergistic grain-refining strategy显示文摘Grain refinement is critical to surpassing the bottlenecks of inherent hot tearing of high-strength aluminum alloys fabricated by additive manufacturing(AM).In this study,a synergistic grain-refining strategy including heterogeneous nucleation,solute-driven growth restriction and nanoparticle-induced growth restriction was introduced to control the microstructure of Al-Zn-Mg-Cu alloys during the laser powder bed fusion(LPBF)process.Crack-free Al-Zn-Mg-Cu alloys with significantly refined grains were safely fabricated via LPBF by coincorporation of Ti C and TiHparticles.In-situ L1-AlTi particles were produced to promote the heterogeneous nucleation.The grain growth was restricted by adding Ti solute,while introduced TiC nanoparticles(NPs)improved the density of heterogeneous nucleation sites and blocked grain growth physically.The resultant elimination of columnar grains and hot cracks in the(1 wt.%)TiC-and(0.8 wt.%)TiH-modified Al-Zn-Mg-Cu alloy resulted in excellent ultimate tensile strength(UTS)of 593±24 MPa,yield strength(YS)of 485±41 MPa and elongation(EL)of 10.0%±2.5%under the T6 condition.This study provides new insights into improving the grain microstructure and mechanical properties of high-strength aluminum alloys during LPBF. | Xiaohui Liu Yunzhong Liu Zhiguang Zhou Qiangkun Zhan | 2022 | Journal of Materials Science & Technology2022，，29： | 2 |
| 6 | Technology transfer from higher education institutions to industry in China:nature and implications显示文摘 | HONG LIU YUNZHONG JIANG | | 0，，21： | 1 |
| 7 | Estima- bility analysis of variance and covariance components显示文摘 | Peiliang Xu Yumei Liu Yunzhong Shen | 2007 | Journal of Geodesy2007，81，： | 1 |
| 8 | Estimability analysis of variance and covariance components显示文摘 | XU Peiliang LIU Yumei SHEN Yunzhong | 2007 | Journal of Geodesy2007，81，： | 1 |
| 9 | Variance Component Estimation in Linear Inverse Ill-posed Models显示文摘 | Peiliang Xu Yunzhong Shen Yoichi Fukuda Yumei Liu | 2006 | Journal of Geodesy2006，，2： | 1 |
| 10 | Estimability analysis of variance and covariance components显示文摘 | Peiliang Xu Yumei Liu Yunzhong Shen Yoichi Fukuda | 2007 | Journal of Geodesy2007，，9： | 1 |
| 11 | Variance Component Estimation in Linear Inverse Ill-posed Models显示文摘 | Peiliang Xu Yunzhong Shen Yoichi Fukuda Yumei Liu | 2006 | Journal of Geodesy2006，，2： | 1 |
| 12 | A comparison of99mTc-MIBI myocardial SPET with electron beam computed tomography in the assessment of coronary artery disease显示文摘 | Zhiming Yao Xiu Jie Liu MD. Rongfang Shi Ruping Dai Shaoxiong Zhang Yunzhong Liu Shengting Li Yueqin Tian Xiaoli Zhang | 1997 | European Journal of Nuclear Medicine1997，，9： | 1 |
| 13 | Technology Transfer from Higher Education Institution to Industry in China: Nature and Implications显示文摘 | Yunzhong Jiang | 2001 | Technovation2001，21，： | 1 |
| 14 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 15 | Technology Transfer from Higher Education Institutions to Industry in China:Nature and Implications显示文摘 | Hong Liu Yunzhong Jiang | 2001 | Technovation2001，，21： | 1 |
| 16 | Simulation study of transfer in multi- stage rapid solidification显示文摘 | Liu Yunzhong Chen Zhenhua Wang Jian N | 2000 | Mater Sci and Eng2000，，280： | 1 |
| 17 | Variance Component Estimation in Linear Inverse Ill-posed Models显示文摘 | Peiliang Xu Yunzhong Shen Yoichi Fukuda Yumei Liu | 2006 | Journal of Geodesy2006，，2： | 1 |
| 18 | Technovation显示文摘 | Yunzhong J iang Technology transfer from higher education institutions to industry in China: nature and implications | 2001 | (21): 175 - 1882001，，21： | 1 |
| 19 | Estimability Analysis of Variance and Covariance Components 显示文摘 | XU Peiliang LIU Yumei SHEN Yunzhong | 2007 | Journal of Geodesy2007，，81： | 1 |
| 20 | Estiinability Analysis of Variance and Covariance Components 显示文摘 | XU Peiliang LIU Yumei SHEN Yunzhong | 2007 | Journal of Geodesy2007，81，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员