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| 1 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 2 | Short-term Load Prediction of Integrated Energy System with Wavelet Neural Network Model Based on Improved Particle Swarm Optimization and Chaos Optimization Algorithm显示文摘To improve energy efficiency and protect the environment,the integrated energy system(IES)becomes a significant direction of energy structure adjustment.This paper innovatively proposes a wavelet neural network(WNN)model optimized by the improved particle swarm optimization(IPSO)and chaos optimization algorithm(COA)for short-term load prediction of IES.The proposed model overcomes the disadvantages of the slow convergence and the tendency to fall into the local optimum in traditional WNN models.First,the Pearson correlation coefficient is employed to select the key influencing factors of load prediction.Then,the traditional particle swarm optimization(PSO)is improved by the dynamic particle inertia weight.To jump out of the local optimum,the COA is employed to search for individual optimal particles in IPSO.In the iteration,the parameters of WNN are continually optimized by IPSO-COA.Meanwhile,the feedback link is added to the proposed model,where the output error is adopted to modify the prediction results.Finally,the proposed model is employed for load prediction.The experimental simulation verifies that the proposed model significantly improves the prediction accuracy and operation efficiency compared with the artificial neural network(ANN),WNN,and PSO-WNN. | Leijiao Ge Yuanliang Li Jun Yan Yuqian Wang Na Zhang | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，6： | 11 |
| 3 | Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing chemotherapy:China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study显示文摘Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies.In this study,we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset (n=3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression,which included the following variables: male patients,induction chemotherapy for newly diagnosed or relapsed disease,neutropenia,neutropenia longer than 10 days,hypoalbuminemia,central-venous catheter,and history of IFD.The patients were classified into three groups,which had low (0-10,~1.2%),intermediate (11-15,6.4%),and high risk (> 15,17.5%) of IFD.In the validation set (n=1389),the IFD incidences of the groups were ~1.4%,5.0%,and 21.4%.In addition,we demonstrated that antifungal prophylaxis offered no benefits in low-risk patients,whereas benefits were documented in intermediate (2.1% vs.6.6%,P=0.007) and high-risk patients (8.4% vs.23.3%,P=0.007).To make the risk score applicable for clinical settings,a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established,and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD.In conclusion,an objective,weighted risk score for IFD was developed,and it may be useful in guiding antifungal prophylaxis. | Ling Wang Ying Wang Jiong Hu Yuqian Sun He Huang Jing Chen Jianyong Li Jun Ma Juan Li Yingmin Liang Jianmin Wang Yan Li Kang Yu Jianda Hu Jie Jin Chun Wang Depei Wu Yang Xiao Xiaojun Huang | 2019 | Frontiers of Medicine2019，13，3： | 10 |
| 4 | Controllability of Boolean control networks with state-dependent constraints显示文摘This paper investigates the controllability of Boolean control networks(BCNs) with state-dependent constraints. A kind of input transformation is proposed to transfer a BCN with state-dependent input constraints into a BCN with free control input. Based on the proposed technique, a necessary and sufficient condition for controllability is obtained. It is shown that state-dependent constraints for the state can be equivalently expressed as input constraints. When a BCN has both input and state constraints, there is a possibility that the sets of admissible controls for some states are the empty set. To treat this kind of BCN, a variation of the input transformation is proposed and the problem of controllability is solved. An illustrative example is provided to explain the proposed method and results. | Yuqian GUO | 2016 | Science China(Information Sciences)2016，59，3： | 7 |
| 5 | Hybrid Precoding for mm Wave Massive MIMO Systems with Different Antenna Arrays显示文摘In this paper, the performance of hybrid precoding is investigated for mmWave massive MIMO systems with different antenna arrays. The hybrid precoding with partially connected architecture (PCA) is adopted. The spectral efficiency (SE) and received energy efficiency (EE) are investigated by considering four types of antenna arrays, including uniform linear array (ULA), uniform rectangular planar array (URPA), uniform hexagonal planar array (UHPA), and uniform circular planar array (UCPA), respectively. We focus on analysis at the antenna response vector and utilize the idea of orthogonal matching pursuit algorithm to seek the optimal hybrid precoder. Furthermore, the trade-off of precoding architectures is studied between SE and received EE. Simulation results show that if the uniform planar array antenna is more concentrated, the SE and receive EE will be higher. Considering SE and received EE, the performance of planar arrays outperform linear array. There exist different optimal radio-frequency chain numbers to maximize the SE for planar array and linear array. In addition, the PCA can achieve relatively higher received EE while the SE is close to the fully connected architecture and the full digital architecture. | Qingfeng Ding Yuqian Deng Xinpeng Gao Mengxia Liu | 2019 | China Communications2019，16，10： | 6 |
| 6 | Genetic analysis and preimplantation genetic diagnosis of Chinese Marfan syndrome patients显示文摘Marfan syndrome (MFS)(OMIM 154700) is a relatively common autosomal dominant genetic disease that causes skeletal, ocular, and cardiovascular defects and was first described by a French pediatrician in 1896 (Bitterman and Sponseller, 2017). Its prevalence rate is 1/3000—1/5000, and more than 25% of cases are sporadic (Chiu et al., 2014). Studies have shown that about 90% of MFS is caused by variants in the fibrillin-1 gene (FBN1, OMIM 134797). FBN1, located on chromosome 15q21.1, encodes a macromolecular glycoprotein-fibrin 1, which aggregates to form microfibers in the extracellular matrix and distributes in various human connective tissues, such as periosteum, vessel wall, and crystal suspensor ligament. Variants in FNB1 have been reported in 65 exons, but the relationship between genotype and phenotype remains rather unclear (Sakai et al., 2016). Studies have also shown that patients with MFS and similar diseases may have variants in other related genes such as members of the transforming growth factor beta receptor (TGFBR) family (Mizuguchi et al., 2004;Sakai et al., 2006;Bolar et al., 2012;De Cario et al., 2018). For better prevention and treatment of MFS as well as for suspected MFS patients, there is a strong need for efficient genetic testing for early diagnosis and differential diagnoses of patients with related phenotypes (Aubart et al., 2018). | Meng Qin Xiaohui Zhu Zhe Zhang Xuemin Li Zhiqiang Yan Yuqian Wang Shuo Guan Yihua He Wenxin Zhang Liying Yan Jie Qiao Xu Zhi | 2019 | Journal of Genetics and Genomics2019，46，6： | 6 |
| 7 | A study on service capacity of primary medical and health institutions for cervical cancer screening in urban and rural areas in China显示文摘Objective: To provide a decision-making basis for sustainable and effective development of cervical cancer screening.Methods: This cross-sectional study assesses the service capacity to conduct cervical cancer screening with a sample of 310 medical staff, medical institutions and affiliated township health centers from 20 countylevel/district-level areas in 14 Chinese provinces in 2016.Results: The county-level/district-level institutions were the main prescreening institutions for cervical cancer screening. More medical staff have become engaged in screening, with a significantly higher amounts in urban than in rural areas(P<0.05). The number of human papillomavirus(HPV) testers grew the fastest(by 225% in urban and 125% in rural areas) over the course of the project. HPV testing took less time than cytology to complete the same number of screening tasks in both urban and rural areas. The proportion of mid-level professionals was the highest among the medical staff, 40.0% in urban and 44.7% in rural areas(P=0.406), and most medical staff had a Bachelor’s degree, accounting for 76.3% in urban and 52.0% in rural areas(P<0.001). In urban areas, 75.0% were qualified medical staff, compared with 68.0% in rural areas, among which the lowest proportion was observed for rural cytology inspectors(22.7%). The medical equipment for cervical pathology diagnosis in urban areas was better(P<0.001). HPV testing equipment was relatively adequate(typing test equipment was 70% in urban areas, and non-typing testing equipment was 70% in rural areas).Conclusions: The service capacity of cervical cancer screening is insufficient for the health needs of the Chinese population. HPV testing might be an optimal choice to fill the needs of cervical cancer screening given current Chinese medical health service capacity. | Yang Li Li Ma Chunxia Yang Zhangya Chen Yuqian Zhao Le Dang Jinghe Lang Youlin Qiao | 2019 | Chinese Journal of Cancer Research2019，31，5： | 5 |
| 8 | Genetic environment of β-lactamase genes of extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in China显示文摘 | Liu Lin Wang Xiaorong An Shuchang Zhang Xiangyan Chen Lin Li Yuqian Xu Li Zhang Yijie Gao Zhancheng | 2014 | Chinese Medical Journal2014，，13： | 5 |
| 9 | COVID-19: Antiviral Agents, Antibody Development and Traditional Chinese Medicine显示文摘The World Health Organization(WHO) has declared coronavirus disease 2019(COVID-19) is the first pandemic caused by coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). Currently, there is no effective anti-SARS-CoV-2 drug approved worldwide for treatment of patients with COVID-19. Therapeutic options in response to the COVID-19 outbreak are urgently needed. To facilitate the better and faster development of therapeutic COVID-19 drugs, we present an overview of the global promising therapeutic drugs, including repurposing existing antiviral agents,network-based pharmacology research, antibody development and traditional Chinese medicine. Among all these drugs,we focus on the most promising drugs(such as favipiravir, tocilizumab, SARS-CoV-2 convalescent plasma, hydroxychloroquine, Lianhua Qingwen, interferon beta-1 a, remdesivir, etc.) that have or will enter the final stage of human testing—phase Ⅲ–Ⅳ clinical trials. | Wenyi Guan Wendong Lan Jing Zhang Shan Zhao Junxian Ou Xiaowei Wu Yuqian Yan Jianguo Wu Qiwei Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 10 | Extraction of Astaxanthin from Euphausia pacific Using Subcritical 1,1,1,2-tetrafluoroethane显示文摘Euphausia pacific is an important source of natural astaxanthin.Studies were carried out to assess the extractability of astaxanthin from E.pacific using subcritical 1,1,1,2-tetrafluoroethane(R134a).To examine the effects of multiple process variables on the extraction yield,astaxanthin was extracted under various conditions of pressure(30-150 bar),temperature(303-343 K),time(10-50 min),flow rate(2-10 g min-1),moisture content(5.5%-63.61%),and particle size(0.25-0.109 mm).The results showed that the extraction yield increased with temperature,pressure,time and flow rate,but decreased with moisture content and particle size.A maximum yield of 87.74% was obtained under conditions of 100 bar,333 K,and 30 min with a flow rate of 6 g min-1 and a moisture content of 5.5%.The substantial astaxanthin yield obtained under low-pressure conditions demonstrates that subcritical R134a is a good alternative to CO 2 for extraction of astaxanthin from E.pacific. | HAN Yuqian MA Qinchuan WANG Lan XUE Changhu | 2012 | Journal of Ocean University of China2012，11，4： | 5 |
| 11 | The beneficial effects of intermittent fasting:an update on mechanism,and the role of circadian rhythm and gut microbiota显示文摘Importance:There is accumulating evidence that intermittent fasting(IF)is connected to improved health condition and longevity time-restricted feeding(TRF)is the most recognized and extensively studied model of IF.Objective:To investigate the underlying mechanism of pleiotropic benefits of IF and hint the most advantageous feeding pattern for humans.Evidence review:We searched MEDLINE,EMBASE,Cochrane Library and Google Scholar by 2020 April for publications on IF or TRF and their mechanisms.Studies include animal models and human cohorts.Findings:One important mechanism is that IF allows certain period of fasting time,in which our bodies activate pathways of repair and rejuvenation.Moreover,the advantages of IF,especially TRF over total caloric restriction(CR)provided bases for various animal and human studies which suggested that the feeding-fasting rhythm stimulates the fluctuation of our gut microbiota and a series of subsequent molecular alterations,which in turn restored a healthier circadian clock that resembled our inherent clock formed throughout millions of years of homo sapiens history.Conclusions and Relevance for Reviews:Complete understanding of the mechanism leading to the beneficial effects of IF paves the way for tailored dietary regimen to combat a wide range of diseases and ill health conditions. | Dandan Hu Zhibo Xie Yuqian Ye Suhad Bahijri Minshan Chen | 2020 | Hepatobiliary Surgery and Nutrition2020，9，5： | 5 |
| 12 | AlN Precipitates and Microstructure in Non-oriented Electrical Steels Produced by Twin-roll Casting Process显示文摘Aluminum nitride(AlN) precipitates and microstructure of 4 wt.%(Si+Al) non-oriented electrical steel were investigated.The 2.0 mm thick cast strips with three different silicon/aluminum(Si/Al) ratios were produced by twin-roll casting process,then the strips were reheated,warm rolled,cold rolled and annealed.The microstructure and AlN precipitates were characterized using optical microscopy,scanning electron microscopy and transmission electron microscopy.The results showed that with the increase of Si/Al ratio,on the one hand,the casting microstructure changed from columnar grains to equiaxed grains,and the uniformity of annealed microstructure was improved;On the other hand,the number of AlN precipitates in cast strips reduced meanwhile the distribution became dispersed.By the reheat treatment,the size and distribution of the AlN precipitates can be changed.Moreover,the grain size of the annealed strips is in the range of 20-50 μm,at the same time,many AlN precipitates were located at grain boundaries.Therefore,controlling the Si/Al ratio is a simple method to obtain desired microstructure.Then AlN precipitates in non-oriented electrical steel prepared by twin-roll casting process hinder markedly the recrystallized grains growth.A compatible reheat treatment can be an approach worth exploring to control the behavior of AlN precipitates. | Ting ZHANG Xiaoming ZHANG Zhiyuan GUO Yuqian WANG Chenggang LI Liangyun LAN | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，4： | 5 |
| 13 | Genetic testing and PGD for unexplained recurrent fetal malformations with MAGEL2 gene mutation显示文摘Birth defects are caused by multiple factors,such as chromosome abnormality,environmental factors,and maternal factors.In this study,we focused on exploring the genetic causes of a non-consanguineous couple who suffered from four times of unsuccessful pregnancy due to unexplained recurrent fetal malformations with similar symptoms and normal chromosome copy number variations.Using trio-whole exome sequencing(trio-WES) for this couple and one of the affected fetuses,we found a mutation,c.1996 delC on the maternal imprinted gene MAGEL2 that was carried by the affected fetus and husband,leading to Schaaf-Yang syndrome.To screen this mutation,we further performed preimplantation genetic diagnosis(PGD) strategy followed by a gene pedigree validation and pathogenicity analysis.After the transfer of a PGD-screened embryo,a normal newborn without previous abnormal symptoms was born(February 15,2019).We present the first data that identified a pathogenic gene(MAGEL2 c.1996 delC) in a fetus with Schaaf-Yang syndrome in the EAS(East Asian) database and overcame this genetic defect by using processed PGD for this couple based on the WES results. | Wei Guo Yanli Nie Zhiqiang Yan Xiaohui Zhu Yuqian Wang Shuo Guan Ying Kuo Wenxin Zhang Xu Zhi Yuan Wei Liying Yan Jie Qiao | 2019 | Science China(Life Sciences)2019，62，7： | 4 |
| 14 | Identifying normal embryos from reciprocal translocation carriers by whole chromosome haplotyping显示文摘Reciprocal translocation is a chromosomal structural abnormality that arises when two non-homologous chromosomes rearrange and attach with each other, an incidence that occurs in about 1/500to 1/625 newborns (Mackie and Scriven, 2002). This event typically does not lead to any significant loss of genetic material, thus reciprocal translocation carriers do not exhibit any severe | Zhiqiang Yan Yuqian Wang Yanli Nie Xu Zhi Xiaohui Zhu Meng Qin Shuo Guan Yixin Ren Ying Kuo Di Chang Wei Chen Peng Yuan Liying Yan Jie Qiao | 2018 | Journal of Genetics and Genomics2018，45，9： | 4 |
| 15 | Correlation between Waist Circumference and Carotid Intima-Media Thickness in Women from Shanghai, China显示文摘Objective To evaluate whether waist circumference (WC) ≥85 cm is related to asymptomatic preclinical atherosclerosis in women from Shanghai, China. Methods A total of 2365 females aged ≥20 years recruited from 4 communities underwent physical examination and carotid artery scanning. Their carotid intima-media thickness (C-IMT) was measured. Results The C-IMT was significantly higher in overweight or obese women with their BMI ≥25.0 kg/m2 (P<0.01) and in those with their WC ≥85 cm than in those with their WC <85 cm (P<0.01). Spearman and partial correlation analysis showed that the C-IMT was significantly correlated with WC which was independent of menopausal status. The C-IMT significantly increased with the increasing WC and reached to a platform in about 85 cm. An increment tendency was found in the subgroup with its WC < 85 cm (P<0.01) while no significant tendency was found in the subgroup with its WC≥85 cm (P=0.07). Multiple stepwise regression analysis showed that the WC was an independent risk factor for C-IMT. In logistic regression model, the odd ratio of WC ≥80 cm, ≥80 cm and <85 cm and ≥85 cm for evaluating the risk of C-IMT elevation was 1.632, 1.501, and 1.878, respectively. Conclusion WC is significantly correlated with C-IMT in women from Shanghai, China, and WC≥85 cm may be used in identifying the risk of subclinical carotid atherosclerosis. | SHEN Yun ZHANG Lei ZONG Wen Hong WANG Zheng ZHANG Yin YANG Man Jing MA Xiao Jing ZHU Jia An BAO YuQian JIA Wei Ping | 2013 | Biomedical and Environmental Sciences2013，26，7： | 4 |
| 16 | Roles of miR319-regulated TCPs in plant development and response to abiotic stress显示文摘Elaborate regulation of gene expression is required for plants to maintain normal growth,development,and reproduction.MicroRNAs(miRNAs)and transcription factors are key players that control gene expression in plant regulatory networks.The TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR(TCP)family comprises plantspecific transcription factors that contain a conserved TCP domain of 59 amino acids.Some members of this family are targeted by miR319,one of the most ancient and evolutionarily conserved miRNAs in plants.Accumulating evidence has revealed that miR319-regulated TCP(MRTCP)genes participate extensively in plant development and responses to environmental stress.In this review,the structural characteristics and classifications of TCP transcription factors and the regulatory relationships between TCP transcription factors and miRNAs are introduced.Current knowledge of the regulatory functions of MRTCP genes in multiple biological pathways including leaf development,vascular formation,flowering,hormone signaling,and response to environmental stresses such as cold,salt,and drought is summarized.This review will be beneficial for understanding the roles of the MRTCP-mediated regulatory network and its molecular mechanisms in plant development and stress response,and provides a theoretical basis for plant genetic improvement. | Yujie Fang Yuqian Zheng Wei Lu Jian Li Yujing Duan Shuai Zhang Youping Wang | 2021 | The Crop Journal2021，9，1： | 4 |
| 17 | Coupled relationships among anammox,denitrification, and dissimilatory nitrate reduction to ammonium along salinity gradients in a Chinese estuarine wetland显示文摘Salinization in estuarine wetlands significantly alters the balance between their nitrogen(N)removal and retention abilities but these processes have not yet been characterized effectively.In the present study,the potential rates of sediment denitrification,anaerobic ammonium oxidation(anammox),and dissimilatory nitrate reduction to ammonium(DNRA)were mapped using N isotope tracing methods along salinity gradients across the Yellow River Delta wetland(YRDW)in China.The contribution of anammox to total dissimilatory N transformations in YRDW was merely 6.8%,whereas denitrification and DNRA contributed 52.3%and 40.9%,respectively.The potential rate of denitrification(5.82μmol/kg/h)decreased significantly along salinity gradients and markedly exceeded DNRA potential rate(2.7μmol/kg/h)in fresh wetlands,but was lower than that of DNRA in oligohaline wetlands(3.06 and 3.18μmol/kg/h,respectively).Moreover,a significantly positive relationship between salinity and DNRA/denitrification was obeserved,indicating that increased salinity may favor DNRA over denitrification.Furthermore,total sulfur(TS)content and ratio of total organic carbon to total nitrogen(C/N)increased with the salinity gradient and showed evident positive relationships with the DNRA/denitrification ratio.In this study,we proved that increased salinization resulted in the dominance of DNRA over denitrification,possible through the addition of S and alteration of the C/N in estuarine wetlands,leading to increased N retention in estuarine wetlands during salinization,which would enhance the eutrophication potential within wetlands and in downstream ecosystems. | Zijun Zhou Lei Ge Yufang Huang Yuqian Liu Siyang Wang | 2021 | Journal of Environmental Sciences2021，33，8： | 4 |
| 18 | Prevention of diet-induced obesity by safflower oil: insights at the levels of PPARα, Orexin, and Ghrelin gene expression of adipocytes in mice显示文摘这研究的目的是在老鼠由一本高红花油食谱和 adipocytic 基因表示调查导致食谱的肥胖的预防。四十只 3-week-old C57BL/6 老鼠随机被划分成三个组:控制组(反对, 5% 猪油 +5% 红花油) ,高猪油组(LAR, 45% 猪油 +5% 红花油) ,并且高红花油组(SAF, 45% 红花油 +5% 猪油) 。在 10 个星期以后, LAR 组的 10 只老鼠高被换到红花油饮食(LARSAF ) 。十个星期以后,葡萄糖忍耐测试被葡萄糖的 intraperitoneal 注射执行。类脂化合物和胰岛素的传播层次被测量,白脂肪质的纸巾为基因薄片和反向的 transcriptasepolymerase 链反应分析被拿。LAR 组比 CON 组显示出更高的身体重量,脂肪过多索引,胰岛素,和类脂化合物(P < 0.05 ) 。在 LARSAF 组的身体重量在饮食的颠倒以后减少了。血浆生物化学的侧面在 LARSAF 和 SAF 组减少了(P < 0.05 ) 与那些相比 LAR 组。LARSAF 组的血葡萄糖水平与 LAR 组的相比在 intraperitoneal 葡萄糖忍耐测试期间被减少。LARSAF 组有 Orexin 和 Ghrelin 基因表示的底层,而 PPAR 基因表示的水平显著地与 LAR 组的相比被提高。那么, SAF 食谱能改变 adipocytic 在导致食谱的肥胖的有效改善的脂肪过多相关的基因表示和结果。 | Zhong Zhang Qiang Li Fengchen Liu Yuqian Sun Jinchao Zhang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 3 |
| 19 | High-Performance and Hysteresis-Free Perovskite Solar Cells Based on Rare-Earth-Doped SnO_(2) Mesoporous Scaffold显示文摘Tin oxide(SnO_(2)),as electron transport material to substitute titanium oxide(TiO_(2))in perovskite solar cells(PSCs),has aroused wide interests.However,the performance of the PSCs based on SnO_(2) is still hard to compete with the TiO_(2)-based devices.Herein,a novel strategy is designed to enhance the photovoltaic performance and long-term stability of PSCs by integrating rare-earth ions Ln^(3+)(Sc^(3+),Y^(3+),La^(3+))with SnO_(2) nanospheres as mesoporous scaffold.The doping of Ln promotes the formation of dense and large-sized perovskite crystals,which facilitate interfacial contact of electron transport layer/perovskite layer and improve charge transport dynamics.Ln dopant optimizes the energy level of perovskite layer,reduces the charge transport resistance,and mitigates the trap state density.As a result,the optimized mesoporous PSC achieves a champion power conversion efficiency(PCE)of 20.63%without hysteresis,while the undoped PSC obtains an efficiency of 19.01%.The investigation demonstrates that the rare-earth doping is low-cost and effective method to improve the photovoltaic performance of SnO_(2)-based PSCs. | Qiyao Guo Jihuai Wu Yuqian Yang Xuping Liu Zhang Lan Jianming Lin Miaoliang Huang Yuelin Wei Jia Dong Jinbiao Jia Yunfang Huang | 2019 | Research2019，，1： | 3 |
| 20 | Automatic segmentation of foveal avascular zone based on adaptive watershed algorithm in retinal optical coherence tomography angiography images显示文摘The size and shape of the foveal avascular zone(FAZ)have a strong positive correlation with several vision-threatening ret inovascular diseases.The identification,segmentation and analysis of FAZ are of great significance to clinical diagnosis and treatment.We presented an adaptive watershed algorithm to automatically extract F AZ from retinal optical coherence tomography angiography(OCTA)images.For the traditional watershed algorithm,'over-segmentation'is the most common problem.FAZ is often incorrectly divided into multiple regions by redundant'dams'.This paper analyzed the relationship between the'dams'length and the maximum inscribed circle radius of FAZ,and proposed an adaptive watershed algorithm to solve the problem of'over-segmentation'.Here,132 healthy retinal images and 50 diabetic retinopathy(DR)images were used to verify the accuracy and stability of the algorithm.Three ophthal-mologists were invited to make quan titative and qualitative evaluations on the segmentation results of this algorithm.The quantitative evaluation results show that the correlation coffi-cients between the automatic and manual segmentation results are 0.945(in healthy subjects)and 0.927(in DR patients),respectively.For qualitative evaluation,the percentages of'perfect segmentation'(score of 3)and'good segmentation'(score of 2)are 99.4%(in healthy subjects)and 98.7%(in DR patients),respectively.This work promotes the application of watershed algorithm in FAZ segmentation,making it a useful tool for analyzing and diagnosing eye diseases. | Jian Liu Shixin Yan Nan Lu Dongni Yang Chunhui Fan Hongyu Lv Shuanglian Wang in Zhu Yuqian Zhao Yi Wang Zhenhe Ma Yao Yu | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 3 |
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