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| 1 | Correlation between Waist Circumference and Carotid Intima-Media Thickness in Women from Shanghai, China显示文摘Objective To evaluate whether waist circumference (WC) ≥85 cm is related to asymptomatic preclinical atherosclerosis in women from Shanghai, China. Methods A total of 2365 females aged ≥20 years recruited from 4 communities underwent physical examination and carotid artery scanning. Their carotid intima-media thickness (C-IMT) was measured. Results The C-IMT was significantly higher in overweight or obese women with their BMI ≥25.0 kg/m2 (P<0.01) and in those with their WC ≥85 cm than in those with their WC <85 cm (P<0.01). Spearman and partial correlation analysis showed that the C-IMT was significantly correlated with WC which was independent of menopausal status. The C-IMT significantly increased with the increasing WC and reached to a platform in about 85 cm. An increment tendency was found in the subgroup with its WC < 85 cm (P<0.01) while no significant tendency was found in the subgroup with its WC≥85 cm (P=0.07). Multiple stepwise regression analysis showed that the WC was an independent risk factor for C-IMT. In logistic regression model, the odd ratio of WC ≥80 cm, ≥80 cm and <85 cm and ≥85 cm for evaluating the risk of C-IMT elevation was 1.632, 1.501, and 1.878, respectively. Conclusion WC is significantly correlated with C-IMT in women from Shanghai, China, and WC≥85 cm may be used in identifying the risk of subclinical carotid atherosclerosis. | SHEN Yun ZHANG Lei ZONG Wen Hong WANG Zheng ZHANG Yin YANG Man Jing MA Xiao Jing ZHU Jia An BAO YuQian JIA Wei Ping | 2013 | Biomedical and Environmental Sciences2013，26，7： | 4 |
| 2 | Relationship between time in range and corneal nerve fiber loss in asymptomatic patients with type 2 diabetes显示文摘Background: Corneal confocal microscopy (CCM) is a noninvasive technique to detect early nerve damage of diabetic sensorimotor polyneuropathy (DSPN). Time in range (TIR) is an emerging metric of glycemic control which was reported to be associated with diabetic complications. We sought to explore the relationship between TIR and corneal nerve parameters in asymptomatic patients with type 2 diabetes (T2DM).Methods: In this cross-sectional study, 206 asymptomatic inpatients with T2DM were recruited. After 7 days of continuous glucose monitoring, the TIR was calculated as the percentage of time in the glucose range of 3.9 to 10.0 mmol/L. CCM was performed to determine corneal nerve fiber density, corneal nerve branch density, and corneal nerve fiber length (CNFL). Abnormal CNFL was defined as ≤15.30 mm/mm2.Results: Abnormal CNFL was found in 30.6% (63/206) of asymptomatic subjects. Linear regression analyses revealed that TIR was positively correlated with CCM parameters both in the crude and adjusted models (all P< 0.05). Each 10% increase in TIR was associated with a 28.2% (95% CI: 0.595–0.866,P = 0.001) decreased risk of abnormal CNFL after adjusting for covariates. With the increase of TIR quartiles, corneal nerve fiber parameters increased significantly (allP for trend <0.01). The receiver operating characteristic curve indicated that the optimal cutoff point of TIR was 77.5% for predicting abnormal CNFL in asymptomatic patients.Conclusions: There is a significant independent correlation between TIR and corneal nerve fiber loss in asymptomatic T2DM patients. TIR may be a useful surrogate marker for early diagnosis of DSPN. | Wejing Zhao Jingyi Lu Lei Zhang Wei Lu Wei Zhu Yuqian Bao Jjian Zhou | 2022 | Chinese Medical Journal2022，135，16： | 2 |
| 3 | Effects of AlCoCrFeNiTi high-entropy alloy on microstructure and mechanical properties of pure aluminum显示文摘A new kind of AlCoCrFeNiTi high-entropy alloy(HEA)as a grain refiner was prepared by vacuum arc melting.In this work,the effects of HEA(1.0 wt.%,2.0 wt.%and 3.0 wt.%)on the microstructure and mechanical properties of pure aluminum were studied.The microstructure was characterized and examined by scanning electron microscope(SEM),energy dispersive X-ray spectroscopy(EDS),X-ray diffraction(XRD),electron probe micro-analyzer(EPMA)and transmission electron microscopy(TEM)to indicate the refining abilities and mechanism of HEA on pure aluminum.Results show that the addition of HEA refined both the macrostructure and microstructure of pure aluminum.When 1.0 wt.%HEA was added,most coarse columnar grains were refined into equiaxed crystals,and as the amount of HEA increased to 2.0 wt.%and3.0 wt.%,aluminum grains were further refined,and the grain boundaries were nearly indistinguishable.Moreover,the morphology ofα-Al transformed from coarse columnar crystals to equiaxed grains,and the mean size ofα-Al grains decreased from 374μm to 27μm.The Al3Ti,Al3Ni,and nano-phase precipitated from the aluminum alloy with HEA in the solidification.The typical rod-like nano-phases distributed interdendritic regions ofα-Al.The average length of nano-phases is 2568 nm,4372 nm,and 6907 nm and the average diameter is 112 nm,103 nm,and 92 nm when 1.0 wt.%,2.0 wt.%and 3.0 wt.%HEA were added to the pure aluminum,respectively.The ultimate tensile strength(UTS)and yield strength(YS)were improved in all samples,whereas the elongation(El)was decreased with increasing HEA concentration.When 3.0 wt.%HEA was added into the aluminum melt,the UTS was improved by 145.2%from62 MPa to 152 MPa,the YS was increased by 173.8%from 42 MPa to 115 MPa,and the El was decreased by 33.3%from 39%to 26%. | Qinglin Li Shang Zhao Xuepeng Bao Yushi Zhang Yuqian Zhu Chuangzao Wang Yefeng Lan Yuxin Zhang Tiandong Xia | 2020 | Journal of Materials Science & Technology2020，52，17： | 2 |
| 4 | Insulin sensitivity,βcell function,and adverse pregnancy outcomes in women with gestational diabetes显示文摘Background: The potential impact of β cell function and insulin sensitivity on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) remains uncertain. We aimed to investigate the association between β cell dysfunction, insulin resistance, and the composite adverse pregnancy outcomes.Methods: This observational study included 482 women diagnosed with GDM during pregnancy. Quantitative metrics on β cell function and insulin sensitivity during pregnancy were calculated using traditional equations. The association of β cell dysfunction and insulin resistance with the risk of the composite adverse pregnancy outcomes was investigated using multivariable-adjusted logistic regression models.Results: Multivariable-adjusted odds ratios (ORs) of adverse pregnancy outcomes across quartiles of homeostatic model assessment for insulin resistance (HOMA-IR) were 1.00, 0.95, 1.34, and 2.25, respectively (P for trend = 0.011). When HOMA-IR was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 1.34 (95% confidence interval 1.16-1.56) for each 1-unit increase in HOMA-IR. Multivariable-adjusted ORs of adverse pregnancy outcomes across quartiles of homeostatic model assessment for β cell function (HOMA-β) were 1.00, 0.51, 0.60, and 0.53, respectively (P for trend = 0.068). When HOMA-β was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 0.57 (95% CI 0.24-0.90) for each 1-unit increase in HOMA-β. However, other quantitative metrics were not associated with the composite adverse pregnancy outcomes.Conclusions: We demonstrated a significant association of β cell function and insulin sensitivity with the risk of adverse pregnancy outcomes. We have provided additional evidence on the early identification of adverse pregnancy outcomes besides the glycemic values. | Yun Shen Yanwei Zheng Yingying Su Susu Jiang Xiaojing Ma Jiangshan Hu Changbin Li Yajuan Huang Yincheng Teng Yuqian Bao Minfang Tao Jian Zhou | 2022 | Chinese Medical Journal2022，135，21： | 2 |
| 5 | Serum C-Reactive Protein and Risk of Cardiovascular Events in Middle-Aged and Older Chinese Population显示文摘 | Shan Jiang Yuqian Bao Xuhong Hou Qichen Fang Chen Wang Jiemin Pan Yuhua Zuo Wenhong Zhong Kunsan Xiang Weiping Jia | 2009 | The American Journal of Cardiology2009，，12： | 2 |
| 6 | Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women显示文摘 | Rong Yang Xiaojing Ma Xiaoping Pan Feifei Wang Yuqi Luo Chengchen Gu Yuqian Bao Weiping Jia | 2013 | Menopause: The Journal of The North American Menopause Society2013，，5： | 1 |
| 7 | High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China显示文摘 | Huating Li Kun Dong Qichen Fang Xuhong Hou Mi Zhou Yuqian Bao Kunsan Xiang Aimin Xu Weiping Jia | 2012 | Journal of Hepatology2012，，： | 1 |
| 8 | Glycated haemoglobi- nAlc for diagnosing diabetes in Chinese population: cross section- al epidemiological survey显示文摘 | Yuqian Bao Xiaojing Ma Huating Li | 2010 | BMJ2010，340，： | 1 |
| 9 | The combination of carotid and lower extremity ultrasonography increases the detection of atherosclerosis in type 2 diabetes patients显示文摘 | Lianxi Li Haoyong Yu Jiaan Zhu Xing Wu Fang Liu Feng Zhang Qing Li Songhua Wu Yuqian Bao Weiping Jia | 2012 | Journal of Diabetes and Its Complications2012，，1： | 1 |
| 10 | Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride显示文摘 | Huating Li Qichen Fang Fei Gao Jia Fan Jian Zhou Xiaoying Wang Huizhen Zhang Xiaoping Pan Yuqian Bao Kunsan Xiang Aimin Xu Weiping Jia | 2010 | Journal of Hepatology2010，，5： | 1 |
| 11 | Glycated haemoglobin A1C for diagnosing diabetes in Chinese population:cross sectional epidemiological survey显示文摘 | BAO YUQIAN MA XIAOJING LI HUATING | 2010 | BMJ2010，340，： | 1 |
| 12 | Effectiveness of quality of care for patients with type 2 diabetes in China:findings from the Shanghai Integration Model(SIM)显示文摘This cross-sectional study aimed to investigate the quality of care of diabetes in Shanghai,China.A total of 173235 patients with type 2 diabetes in 2017 were included in the analysis.Profiles of risk factors and intermediate outcomes were determined.The patients had a mean age of 66.43±8.12(standard deviation(SD))years and a mean diabetes duration of 7.95±5.53(SD)years.The percentage of patients who achieved the target level for HbA_(1c)(<7.0%)was 48.6%.Patients who achieved the target levels for blood pressure(BP)<130/80 mmHg and low-density lipoprotein-cholesterol(LDL-c)<2.6 mmol/L reached 17.5%and 34.0%,respectively.A total of 3.8%achieved all three target levels,and the value increased to 6.8%with an adaptation of the BP target level(<140/90 mmHg)for those over 65 years.Multivariable analysis identified the factors associated with a great likelihood of achieving all three target levels:male,young age,short diabetes duration,low body mass index,macrovascular complications,no microvascular complications,prescribed with lipid-lowering medication,and no prescription of antihypertensive medication.In conclusion,nearly 50%and one-third of the patients with diabetes met the target levels for HbA_(1c)and LDL-c,respectively,with a low percentage achieving the BP target level.The percentage of patients who achieved all three target levels needs significant improvement. | Chun Cai Yuexing Liu Yanyun Li Yan Shi Haidong Zou Yuqian Bao Yun Shen Xin Cui Chen Fu Weiping Jia the SIM Study Group | 2022 | Frontiers of Medicine2022，16，1： | 1 |
| 13 | Non–high-density lipoprotein cholesterol is associated more closely with albuminuria in Chinese type 2 diabetic patients with normal renal function, compared with traditional lipid parameters显示文摘 | Jiemin Pan Fei Gao Yuqian Bao Lei Zhang Yinfang Tu Weiping Jia | 2012 | Journal of Clinical Lipidology2012，，4： | 1 |
| 14 | Glycated haemoglobin A1c for diagnosing diabetes in Chinese population:cross sectional epidemiological survey显示文摘 | Yuqian Bao Xiaojing Ma Huating Li etal | 2010 | BMJ2010，，340： | 1 |
| 15 | Additional role of serum 25‐hydroxyvitamin D3 levels in atherosclerosis in C hinese middle‐aged and elderly men显示文摘 | Yaping Hao Xiaojing Ma Yuqi Luo Jie Ni Jianxin Dou Jiaan Zhu Yuqian Bao Weiping Jia | 2014 | Clin Exp Pharmacol Physiol2014，，3： | 1 |
| 16 | Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial显示文摘Lifestyle interventions,including dietary adjustments and exercise,are important for obesity management.This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet(LCD)or exercise is more effective in metabolism improvement.Forty-five eligible subjects were randomly divided into an LCD group(n=22)and an exercise group(EX,n=23).The subjects either adopted LCD(carbohydrate intake<50 g/day)or performed moderate-to-vigorous exercise(≥30 min/day)for 3 weeks.After the interventions,LCD led to a larger weight loss than EX(−3.56±0.37 kg vs.−1.24±0.39 kg,P<0.001),as well as a larger reduction in fat mass(−2.10±0.18 kg vs.−1.25±0.24 kg,P=0.007)and waist circumference(−5.25±0.52 cm vs.−3.45±0.38 cm,P=0.008).Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance.Triglycerides decreased in both two groups,whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group.Various glycemic parameters,including serum glycated albumin,mean sensor glucose,coefficient of variability(CV),and largest amplitude of glycemic excursions,substantially declined in the LCD group.Only CV slightly decreased after exercise.This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance.Compared with exercise,LCD might be more efficient for weight loss and glucose homeostasis in people with obesity. | Lingli Cai Jun Yin Xiaojing Ma Yifei Mo Cheng Li Wei Lu Yuqian Bao Jian Zhou Weiping Jia | 2021 | Frontiers of Medicine2021，15，3： | 1 |
| 17 | Metabolic surgery in China: present and future显示文摘Obesity and its related complications comprise a serious public health problem worldwide,and obesity is increasing in China.Metabolic surgery is a new type of treatment with unique advantages in weight loss and obesity-related metabolic complications.The pathogenesis of obesity is complex and not yet fully understood.Here,we review the current efficacy and safety of metabolic surgery,as well as recent progress in mechanistic studies and surgical procedures in China.The exciting and rapid advances in this field provide new opportunities for patients with obesity and strike a balance between long-term effectiveness and safety. | Yinfang Tu Yuqian Bao Pin Zhang | 2021 | Journal of Molecular Cell Biology2021，13，8： | 1 |
| 18 | Targeted gene panel provides advantages over whole-exome sequencing for diagnosing obesity and diabetes mellitus显示文摘A small fraction of patients diagnosed with obesity or diabetes mellitus has an underlying monogenic cause.Here,we constructed a targeted gene panel consisting of 83 genes reported to be causative for monogenic obesity or diabetes.We performed this panel in 481 patients to detect causative variants and compared these results with whole-exome sequencing(WES)data available for 146 of these patients.The coverage of targeted gene panel sequencing was significantly higher than that of WES.The diagnostic yield in patients sequenced by the panel was 32.9%with subsequent WES leading to three additional diagnoses with two novel genes.In total,178 variants in 83 genes were detected in 146 patients by targeted sequencing.Three of the 178 variants were missed by WES,although the WES-only approach had a similar diagnostic yield.For the 335 samples only receiving targeted sequencing,the diagnostic yield was 32.2%.In conclusion,taking into account the lower costs,shorter turnaround time,and higher quality of data,targeted sequencing is a more effective screening method for monogenic obesity and diabetes compared to WES.Therefore,this approach could be routinely established and used as a first-tier test in clinical practice for specific patients. | Hairong Yu Haoyong Yu Rong Zhang Danfeng Peng Dandan Yan Yunjuan Gu Yuqian Bao Weiping Jia Hong Zhang Cheng Hu | 2023 | Journal of Molecular Cell Biology2023，15，6： | 0 |
| 19 | Robust genome and RNA editing via CRISPR nucleases in PiggyBac systems显示文摘CRISPR/Cas-mediated genome editing in human pluripotent stem cells(hPSCs)offers unprecedented opportunities for developing in vitro disease modeling,drug screening and cell-based therapies.To efficiently deliver the CRISPR components,here we developed two all-in-one vectors containing Cas9/gRNA and inducible Cas13d/gRNA cassettes for robust genome editing and RNA interference respectively.These vectors utilized the PiggyBac transposon system,which allows stable expression of CRISPR components in hPSCs.The Cas9 vector PB-CRISPR exhibited high efficiency(up to 99%)of inducing gene knockout in both protein-coding genes and long non-coding RNAs.The other inducible Cas13d vector achieved extremely high efficiency in RNA knockdown(98%knockdown for CD90)with optimized gRNA designs.Taken together,our PiggyBac CRISPR vectors can serve as powerful toolkits for studying gene functions in hPSCs. | Yuqian Jiang Rachel Catherine Hoenisch Yun Chang Xiaoping Bao Craig E.Cameron Xiaojun Lance Lian | 2022 | Bioactive Materials2022，7，8： | 0 |
| 20 | Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation显示文摘Most information used to evaluate diabetic statuses is collected at a special time-point,such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease risk.As a new parameter for continuously evaluating personal clinical statuses,the newly developed technique“continuous glucose monitoring”(CGM)can characterize glucose dynamics.By calculating the complexity of glucose time series index(CGI)with refined composite multi-scale entropy analysis of the CGM data,the study showed for the first time that the complexity of glucose time series in subjects decreased gradually from normal glucose tolerance to impaired glucose regulation and then to type 2 diabetes(P for trend<0.01).Furthermore,CGI was significantly associated with various parameters such as insulin sensitivity/secretion(all P<0.01),and multiple linear stepwise regression showed that the disposition index,which reflectsβ-cell function after adjusting for insulin sensitivity,was the only independent factor correlated with CGI(P<0.01).Our findings indicate that the CGI derived from the CGM data may serve as a novel marker to evaluate glucose homeostasis. | Cheng Li Xiaojing Ma Jingyi Lu Rui Tao Xia Yu Yifei Mo Wei Lu Yuqian Bao Jian Zhou Weiping Jia | 2023 | Frontiers of Medicine2023，17，1： | 0 |
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