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| 1 | Fe-N co-doped coral-like hollow carbon shell toward boosting peroxymonosulfate activation for efficient degradation of tetracycline: Singlet oxygen-dominated non-radical pathway显示文摘Fe-N co-doped coral-like hollow carbon shell (Fe-N-CS) was synthesized via a simply impregnation-pyrolysis method.The Fe-N-CS showed an excellent ability for activating peroxymonosulfate (PMS),which could degrade about 93.74%tetracycline (20 mg/L) in 12 min.The Fe-N-CS/PMS system exhibited a good anti-interference capacity of various pH,inorganic anions,HA and different water qualities.More importantly,the Fe nanoparticles were anchored uniformly in the carbon layer,effectively limiting the metal leaching.The quenching tests and electron spin resonance (ESR) manifested that non-radical singlet oxygen (1O_(2))was the main reactive oxygen species (ROS) for TC degradation.The mechanism study showed that Fe nanoparticles,defect and graphite N played a key role in activating PMS to produce ROS.Moreover,three probable degradation pathways were proposed by using LC-MS measurements.Generally,this work had a new insight for the synthesis of heterogeneous Fe-N-C catalysts in the advanced oxidation process based on PMS. | Wenjin Chen Jin Huang Yaqian Shen Ke Zhu Lele Lei Hongmei He Yushi Ai | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 2 | Establishment of organoid models based on a nested array chip for fast and reproducible drug testing in colorectal cancer therapy显示文摘The conventional microwell-based platform for construction of organoid models exhibits limitations in precision oncology applications because of low-speed growth and high variability. Here, we established organoid models on a nested array chip for fast and reproducible drug testing using 50% matrigel. First, we constructed mouse small intestinal and colonic organoid models. Compared with the conventional microwell-based platform, the mouse organoids on the chip showed accelerated growth and improved reproducibility due to the nested design of the chip. The design of the chip provides miniaturized and uniform shaping of the matrigel that allows the organoid to grow in a concentrated and controlled manner. Next, a patient-derived organoid(PDO) model from colorectal cancer tissues was successfully generated and characterized on the chip. Finally, the PDO models on the chip, from three patients, were implemented for high-throughput drug screening using nine treatment regimens. The drug sensitivity testing on the PDO models showed good quality control with a coefficient of variation under 10% and a Z’ factor of more than 0.7. More importantly, the drug responses on the chip recapitulate the heterogeneous response of individual patients, as well as showing a potential correlation with clinical outcomes. Therefore,the organoid model coupled with the nested array chip platform provides a fast and reproducible means for predicting drug responses to accelerate precise oncology. | Yancheng Cui Rongrong Xiao Yushi Zhou Jianchuang Liu Yi Wang Xiaodong Yang Zhanlong Shen Bin Liang Kai Shen Yi Li Geng Xiong Yingjiang Ye Xiaoni Ai | 2022 | Bio-Design and Manufacturing2022，5，4： | 0 |
| 3 | Peroxymonosulfate activation by Fe-N-S co-doped tremella-like carbocatalyst for degradation of bisphenol A: Synergistic effect of pyridine N, Fe-Nx, thiophene S显示文摘Bisphenol A(BPA)has received increasing attention due to its long-term industrial application and persistence in environmental pollution.Iron-based carbon catalyst activation of peroxymonosulfate(PMS)shows a good prospect for effective elimination of recalcitrant contaminants in water.Herein,considering the problem about the leaching of iron ions and the optimization of heteroatoms doping,the iron,nitrogen and sulfur co-doped tremellalike carbon catalyst(Fe-NS@C)was rationally designed using very little iron,S-C_(3)N_(4) and low-cost chitosan(CS)via the impregnation-calcination method.The as-prepared Fe-NS@C exhibited excellent performance for complete removal of BPA(20 mg/L)by activating PMS with the high kinetic constant(1.492 min^(−1))in 15 min.Besides,the Fe-NS@C/PMS system not only possessed wide pH adaptation and high resistance to environmental interference,but also maintained an excellent degradation efficiency on different pollutants.Impressively,increased S-C_(3)N_(4) doping amount modulated the contents of different N species in Fe-NS@C,and the catalytic activity of Fe-NS@C-1-x was visibly enhanced with increasing SC_(3)N_(4) contents,verifying pyridine N and Fe-Nx as main active sites in the system.Meanwhile,thiophene sulfur(C-S-C)as active sites played an auxiliary role.Furthermore,quenching experiment,EPR analysis and electrochemical test proved that surface-bound radicals(·OH and SO_(4)^(·−))and non-radical pathways worked in the BPA degradation(the former played a dominant role).Finally,possible BPA degradation route were proposed.This work provided a promising way to synthesize the novel Fe,N and S co-doping carbon catalyst for degrading organic pollutants with low metal leaching and high catalytic ability. | Wenjin Chen Lele Lei Ke Zhu Dongdong He Hongmei He Xiulan Li Yumeng Wang Jin Huang Yushi Ai | 2023 | Journal of Environmental Sciences2023，，7： | 0 |
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