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| 1 | First-line pemetrexed-platinum doublet chemotherapy with or without bevacizumab in non-squamous non-small cell lung cancer: A real-world propensity score-matched study in China显示文摘Objective: To evaluate the efficacy and safety profile of first-line bevacizumab(Bev)-containing pemetrexedplatinum chemotherapy in a real-world Chinese cohort with advanced non-squamous non-small cell lung cancer(NS-NSCLC).Methods: A total of 415 eligible patients with NS-NSCLC who received first-line pemetrexed-platinum chemotherapy at National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College between February 2010 and September 2017 were reviewed retrospectively: 309 Bev(-) and 106 Bev(+) cases. Bev was administered at 7.5 mg/kg every 3 weeks in the Bev(+) group. To reduce the risk of a selection bias, a propensity score-matching(PSM) was conducted and 105 pairs of Bev(-) and Bev(+) cases were identified.Results: The median duration of follow-up was 15.8 months. The median progression-free survival(PFS) was prolonged significantly in the Bev(+) group than in the Bev(-) group in overall(9.8 vs. 7.8 months, P=0.006) and PSM pairs(9.8 vs. 6.6 months, P<0.001). Moreover, patients receiving maintenance therapy with pemetrexed plus Bev had longer PFS than those interrupted after induction chemotherapy, or those receiving mono-maintenance with pemetrexed(12.3 vs. 4.8 vs. 8.6 months;P<0.001). Multivariate analyses revealed Bev to be one of the favorable prognostic factors for PFS, along with the predictor of maintenance therapy.Conclusions: First-line induction and maintenance therapy with Bev(7.5 mg/kg every 3 weeks) combined with pemetrexed-platinum chemotherapy was efficacious and superior to non-Bev chemotherapy in Chinese patients with advanced NS-NSCLC. | Fei Qi Xingsheng Hu Yutao Liu Zhijie Wang Jianchun Duan Jie Wang Mei Dong | 2019 | Chinese Journal of Cancer Research2019，31，5： | 4 |
| 2 | In-Situ Chemosynthesis of ZnO Nanoparticles to Endow Wood with Antibacterial and UV-Resistance Properties显示文摘Hybrid wood materials have attracted considerable attention because they have combined advantages of both wood and inorganic compounds. This work investigated the microstructural morphology, thermal stability, ultraviolet(UV) stability, and antibacterial property of composites made from wood/ZnO hybrid materials through a facile in-situ chemosynthesis methods. The X-ray diffraction(XRD) and thermogravimetric analysis(TGA) results indicated that the synthesized ZnO particles had an average grain size of about 10.8 nm. The scanning electron microscopy(SEM) observations showed that ZnO nanoflowers self-assembled with nanosheets were presented in wood cell lumens and increased with increasing Zn^(2+)concentrations. ZnO nanoparticles were also generated in the wood cell wall, which was confirmed by the results of energy-dispersive spectroscopy(EDS). The TGA tests also indicated that the thermal stability of wood/ZnO hybrid materials was improved after the formation of ZnO inorganic particles. Finally, the results of antibacterial efficacy tests and UV resistance tests revealed that ZnO nanoparticles showed a promising future as antimicrobial agents against Escherichia coli(E.coli) and UV resistance agents for wood protection. | Youming Dong Yutao Yan Huandi Ma Shifeng Zhang Jianzhang Li Changlei Xia Sheldon Q.Shi Liping Cai | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 3 | Insights into the sandwich-like ultrathin Ni-doped MoS_(2)/rGO hybrid as effective sulfur hosts with excellent adsorption and electrocatalysis effects for lithium-sulfur batteries显示文摘The design of sulfur hosts with high conductivity,large specific surface area,strong adsorption and electrocatalytic ability is crucial to advance high performance lithium-sulfur batteries.Herein,a novel ultrathin sandwich-type Ni-doped MoS_(2)/reduced graphene oxide(denote as Ni-doped MoS_(2)/rGO) hybrid is developed as a sulfur host through a simple one-step hydrothermal route.The two-dimensional layered structure Ni-doped MoS_(2)/rGO hybrid with heterostructure and heteroatom architecture defects not only plays a key role in adsorption of lithium polysulfide but also catalyzes on redox kinetics of sulfur and polysulfide species.Meanwhile,it can contribute to the large specific surface area for Li_(2) S/S_8 deposition,fast Li-ion and electron transportation,thus enhancing the electrocatalytic properties,as confirmed firstly by cyclic voltammetry(CV) results.Due to the adsorption-catalytic synergistic effect,the Ni-doped MoS_(2)/rGO cathode exhibits high specific capacity(1343.6 mA h g^(-1) at 0.2 C,921.6 mA h g^(-1) at 1 C),high coulombic efficiency and an outstanding cycle stability(with the low attenuation rate of 0.077% per cycle over 140 cycles at 0.5 C and 0.11% per cycle over 400 cycles at 1 C,respectively).This work proposes some inspiration for exploring the construction of advanced lithium-sulfur batteries through the rational design defects of atomic structure and electronic states of MoS_(2) as sulfur host. | Ran Zhang Yutao Dong Mohammed AAl-Tahan Yingying Zhang Ruipeng Wei Yuhang Ma Changchun Yang Jianmin Zhang | 2021 | Journal of Energy Chemistry2021，30，9： | 2 |
| 4 | Hollow cubic MnS-CoS_(2)-NC@NC designed by two kinds of nitrogen-doped carbon strategy for sodium ion batteries with ultraordinary rate and cycling performance显示文摘In order to obtain an advanced anode material that exhibits excellent electrochemical performance in sodium ion batteries,a hollow nanocube MnS-CoS_(2)-NC@NC(NC=nitrogen-doped carbon)with two kinds of nitrogen-doped carbon was synthesized by simple one-step calcination.One of the two kinds of nitrogen-doped carbon comes from the organic ligands in the precursor being mixed in the sulfide after calcination,and the other comes from the calcination of the coated polydopamine(PDA)to form a carbon shell wrapped outside the sulfide.The characteristic nanostructure with two kinds of nitrogen-doped carbon can not only improve the overall conductivity of the electrode material,which is obviously beneficial to the rapid transmission of sodium ions and thus outstanding rate performance,but also can alleviate volume expansion to maintain battery cycle stability.In the half-cell,the MnS-CoS_(2)-NC@NC electrode not only provides an ultra-high specific capacity of 608.5 mA·h·g^(-1)at 0.2 A·g^(-1)for 100 cycles,but also shows an outstanding rate performance of 560.5 mA·h·g^(-1)at 5.0 A·g^(-1)for 1,100 cycles.Even in a full-cell composed with Na3V2(PO4)3 as the positive material,it can still maintain a capacity of 436.7 mA·h·g^(-1)after 900 cycles at 1.0 A·g^(-1).In order to explore its sodium storage mechanism,in-situ and ex-situ X-ray diffraction(XRD)tests were carried out to prove that CoS_(2)and MnS were reduced to produce metallic Co and metallic Mn during the discharging process,respectively,and reversibly returned during the charging process. | Ruipeng Wei Yutao Dong Yingying Zhang Xiyang Kang Xia Sheng Jianmin Zhang | 2022 | Nano Research2022，15，4： | 1 |
| 5 | Prepara- tion and wear properties of TiB/A1-30Si compsites via in-si- tu melt reactions under high-energy ultrasonic field 显示文摘 | Zhang Songli Dong Xianwei Zhao Yutao | 2014 | Trans Nonferous Met Soc2014，24，： | 1 |
| 6 | Nanoparticle-Decorated Ultrathin La2O3 Nanosheets as an Effcient Electrocatalysis for Oxygen Evolution Reactions显示文摘Electrochemical catalysts for oxygen evolution reaction are a critical component for many renewable energy applications. To improve their catalytic kinetics and mass activity are essential for sustainable industrial applications. Here, we report a rare-earth metal-based oxide electrocatalyst comprised of ultrathin amorphous La2O3 nanosheets hybridized with uniform La2O3 nanoparticles(La2O3@NP-NS). Significantly improved OER performance is observed from the nanosheets with a nanometer-scale thickness. The as-synthesized 2.27-nm La2O3@NP-NS exhibits excellent catalytic kinetics with an overpotential of 310 mV at 10 m A cm^-2, a small Tafel slope of 43.1 mV dec^-1, and electrochemical impedance of 38 Ω. More importantly, due to the ultrasmall thickness, its mass activity, and turnover frequency reach as high as 6666.7 A g^-1 and 5.79 s^-1, respectively, at an overpotential of 310 mV. Such a high mass activity is more than three orders of magnitude higher than benchmark OER electrocatalysts, such as IrO2 and RuO2. This work presents a sustainable approach toward the development of highly e cient electrocatalysts with largely reduced mass loading of precious elements. | Guangyuan Yan Yizhan Wang Ziyi Zhang Yutao Dong Jingyu Wang Corey Carlos Pu Zhang Zhiqiang Cao Yanchao Mao Xudong Wang | 2020 | Nano-Micro Letters2020，12，4： | 1 |
| 7 | Experimental study on the vitrification and xenotransplantation of human ovarian tissue显示文摘Background:Cryopreservation of ovarian tissue is a promising method for preserving fertility.Transmission electron microscopy(TEM)is an evaluation system for cryo-injury during the cooling and warming process which is very laborious and needs to be optimized.Objective:In this study,we evaluated that serum 17β-oestradiol(E2)may be used as an indicator of vitrified ovarian tissue.Methods:Immunodeficient nude mice were used as hosts for xenografting of vitrified-warmed human ovarian tissues.A total of 54 mice were divided into two group:vitrified ovarian xenotransplant(VOX)group(n?45)and non-transplant control group(n?9).The transplanted mice were grouped into vitrified/warmed grafted-4 weeks(VOX-4w,n?15),vitrified/warmed grafted-6weeks(VOX-6w n?15)and vitrified/warmed grafted-12 weeks(VOX-12w n?15)according to the time after transplantation.The viable and functional recovery of grafted ovarian tissue was assessed by light microscopy,transmission electron microscopy,and hormone(E2)assays.Results:Serum E2 concentration was significantly higher in VOX-6w(group(21.07 pg/ml)than that of VOX-12w group(15.59 pg/ml).VOX-12w group showed a lower value(12.61 pg/ml)for E2 concentration.The trend for E2 concentration was consistent with the morphological identification of the grafts.Conclusion:In vivo serum hormone E2 released by cortical biopsies can be used as a functional marker for xenotransplanted vitrified-warmed human ovarian tissue reserve. | Jinghui Zhao Yuping Ge Jingyi Li Yucui Zeng Guoyi Dong Liping Zeng Juanjuan Dai Hui Du Mumin Shao Xuewen Yu Huan Li Fang He Zhouchun Shang Chun Wang Gabor Vajt Huiru Tang Ruifang Wu Yutao Du | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，1： | 1 |
| 8 | Enhanced Q-switching performance of magnetite nanoparticle via compositional engineering with Ti_(3)C_(2) MXene in the near infrared region显示文摘In this work,we reported a new strategy to improve the nonlinear saturable absorption performance of magnetite(Fe_(3)O_(4))nanoparticles(FONPs)via the compositional engineering with the Ti_(3)C_(2) MXene in the near-infrared(NIR)region.Based on the DFT simulation,the band structures and work function were significantly modified by the Ti_(3)C_(2) MXene doping.By using the open-aperture Z-scan technology,the nonlinear optical features of the FONPs@Ti_(3)C_(2) nanocomposite were significantly improved,showing the great potential as the saturable absorber in the pulsed laser.With the nanocomposite as the saturable absorber,the passively Q-switched Nd:GdVO4 lasers emitted much shorter pulse durations when compared with the pristine FONP saturable absorber.These findings indicated that FONPs@Ti_(3)C_(2) heterostructure was a promising saturable absorber for the short pulse generation in the NIR region. | Yutao Hu Hongwei Chu Daozhi Li Ying Li Shengzhi Zhao Li Dong Dechun Li | 2021 | Journal of Materials Science & Technology2021，，22： | 1 |
| 9 | Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped RNA betacoronavirus,1 that has spread globally since December 2019.As of July 22,2020,more than 14,000,000 confirmed cases and 607,781 deaths from COVID-19 have been reported to the World Health Organization from 216 areas and territories.2 Patientswithmore prominent laboratory abnormalities may develop acute respiratory distress syndrome(ARDS),which potentially leads tomultiple organ failure and death.1,3 However,at present,there are no regulatory approved antiviralmedicines,vaccines,or specific clinical treatments for COVID-19. | Junping Wu Cherie S.Tan Hongzhi Yu Youwei Wang Yutao Tian Wenwei Shao Yifei Zhang Kuo Zhang Hongxia Shao Guangjian Ni Jun Shen Antonio Carlo Galoforo Qi Wu Dong Ming | 2020 | The Innovation2020，1，3： | 1 |
| 10 | Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC显示文摘Anaplastic lymphoma kinase(ALK)is the most common fusion gene involved in non-small cell lung cancer(NSCLC),and remarkable response has been achieved with the use of ALK tyrosine kinase inhibitors(ALK-TKIs).However,the clinical efficacy is highly variable.Pre-existing intratumoral heterogeneity(ITH)has been proven to contribute to the poor treatment response and the resistance to targeted therapies.In this work,we investigated whether the variant allele frequencies(VAFs)of ALK fusions can help assess ITH and predict targeted therapy efficacy.Through the application of next-generation sequencing(NGS),7.2%(326/4548)of patients were detected to be ALK positive.On the basis of the adjusted VAF(adjVAF,VAF normalization for tumor purity)of four different threshold values(adjVAF<50%,40%,30%,or 20%),the association of ALK subclonality with crizotinib efficacy was assessed.Nonetheless,no statistical association was observed between median progression-free survival(PFS)and ALK subclonality assessed by adjVAF,and a poor correlation of adjVAF with PFS was found among the 85 patients who received first-line crizotinib.Results suggest that the ALK VAF determined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy prediction in NSCLC. | Wei Rao Yutao Liu Yan Li Lei Guo Tian Qiu Lin Dong Jianming Ying Weihua Li | 2023 | Frontiers of Medicine2023，17，3： | 0 |
| 11 | Modulating of MoSe_(2)functional plane via doping-defect engineering strategy for the development of conductive and electrocatalytic mediators in Li-S batteries显示文摘The lithium polysulfide shuttle and sluggish sulfur reaction kinetics still pose significant challenges to lithium-sulfur(Li-S)batteries.The functional plane of Fe-MoSe_(2)@r GO nanohybrid with abundant defects has been designed and applied in Li-S batteries to develop the functional separator and multi-layer sulfur cathode.The cell with a functional separator exhibits a retention capacity of 462 m Ah g^(-1)after the 1000th at 0.5 C and 516 m Ah g^(-1)after the 600th at 0.3 C.Even at low electrolyte conditions(7.0μL_(mgsulfur)^(-1)and 15μL_(mgsulfur)^(-1))under high sulfur loadings(3.46 mg cm^(-2)and 3.73 mg cm^(-2)),the cell still presents high reversible discharge capacities 679 and 762 m Ah g^(-1)after 70 cycles,respectively.Further,at sulfur loadings up to 8.26 and 5.2 mg cm^(-2),the cells assembled with the bi-layers sulfur cathode and the tri-layers sulfur cathode give reversible capacities of 3.3 m Ah cm^(-2)after the 100th cycle and 3.0 m Ah cm^(-2)after the 120th cycle,respectively.This research not only demonstrates that the FeMoSe_(2)@r GO functional plane is successfully designed and applied in Li-S batteries with superior electrochemical performances but also paves the novel way for developing a unique multi-layer cathode technique to enhance and advance the electrochemical behavior of Li-S cells at a high-sulfur-loading cathode under lean electrolyte/sulfur(E/S)ratio. | Mohammed A.Al-Tahan Yutao Dong Aml E.Shrshr Xiyang Kang Hui Guan Yumiao Han Zihao Cheng Weihua Chen Jianmin Zhang | 2022 | Journal of Energy Chemistry2022，，12： | 0 |
| 12 | A novel secreted protein, NISP1, is phosphorylated by soybean Nodulation Receptor Kinase to promote nodule symbiosis显示文摘Nodulation Receptor Kinase(NORK) functions as a co-receptor of Nod factor receptors to mediate rhizobial symbiosis in legumes, but its direct phosphorylation substrates that positively mediate root nodulation remain to be fully identified.Here, we identified a GmNORK-Interacting Small Protein(GmNISP1) that functions as a phosphorylation target of GmNORK to promote soybean nodulation. GmNORKα directly interacted with and phosphorylated GmNISP1. Transcription of GmNISP1 was strongly induced after rhizobial infection in soybean roots and nodules. GmNISP1 encodes a peptide containing 90 amino acids with a “DY” consensus motif at its N-terminus.GmNISP1 protein was detected to be present in the apoplastic space. Phosphorylation of GmNISP1 by GmNORKα could enhance its secretion into the apoplast. Pretreatment with either purified GmNISP1 or phosphorylation-mimic GmNISP1~(12D) on the roots could significantly increase nodule numbers compared with the treatment with phosphorylation-inactive GmNISP1~(12A).The data suggested a model that soybean GmNORK phosphorylates GmNISP1 to promote its secretion into the apoplast, which might function as a potential peptide hormone to promote root nodulation. | Baolan Fu Zhipeng Xu Yutao Lei Ru Dong Yanan Wang Xiaoli Guo Hui Zhu Yangrong Cao Zhe Yan | 2023 | Journal of Integrative Plant Biology2023，65，5： | 0 |
| 13 | 葛根异黄酮对MPP^+诱导的PC12细胞ppENK,PDYN和DRD2 mRNA表达的影响(英文)显示文摘Objective: The aim of the study was to observe the effect of total isoflavones from pueraria lobata (TIP) on D2 dopamine receptor mRNA, preproenkephalin mRNA and prodynorphin mRNA expressions in Parkinson’s disease (PD) model cells induced by 1-methyl-4-phenylpyridinium ion (MPP+). Methods: TIP was dissolved in 0.1 M NaOH and added to the culture medium at a final concentrations of 50 mg/L, 100 mg/L and 200 mg/L. Some cells (control) were exposed to 0.001 M NaOH. TIP was added to PC12 cells 30 min prior to the administration of MPP+. TIP and MPP+ remained in the culture medium for 96 h. D2 dopamine receptor mRNA, preproenkephalin mRNA and prodynorphin mRNA expressions were assayed by real-time quantitative reverse transcription-PCR. Results: The D2 dopamine receptor mRNA and preproenkephalin mRNA expressions were up-regulated in MPP+ group compared with the control group, and prodynorphin mRNA expression was down-regulated in that. The D2 dopamine receptor mRNA expression being down-regulated and prodynorphin mRNA expression being up-regulated in TIP group compared with the MPP+ group. And there was no effect of TIP on preproenkephalin gene expression in PC12 cells induced by MPP+. Conclusion: The results suggest that TIP down-regulates the D2 dopamine receptor mRNA expression, up-regulates prodynorphin mRNA expression and not affects preproenkephalin gene expression in PC12 cells induced by MPP+. | Miaoxian Dong Chengchong Li Yutao Gen Chun Zhang Xiaoming Li Yingcai Niu | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 0 |
| 14 | Intelligent power distribution live‐line operation robot systems based on stereo camera显示文摘Maintenance tasks in distribution networks are often accompanied by hazards associated with high altitudes and high voltages.By utilising robots instead of human operators to perform these tasks,potential risks can be avoided,while productivity can be increased.This research proposes an intelligent power distribution live‐line operation robot(PDLOR)system based on a stereo camera to replace human to complete work.The PDLOR system consists of several key components,including dual manipulators,wireless tools,a visual perception system,an insulated bucket truck,and a ground control ter-minal.Once the task is confirmed,the real‐time vision system identification and posi-tioning enable the adjustment of the insulated bucket to position the robot correctly for its intended work.The stereo camera plays a crucial role in accurately recognising and estimating the object's orientation.Additionally,a simplified reconstruction is performed within a virtual simulation environment,which aids in collision detection during path planning.After obtaining the optimal path,it is then communicated to the real manip-ulator for execution.To validate the feasibility of the PDLOR system,field experiments were conducted in actual distribution network scenarios.The results demonstrate that the PDLOR effectively completes single‐phase power‐line connection tasks within a remarkable 10‐min timeframe. | Yutao Chen Yahao Wang Xuming Tang Kai Wu Shaolei Wu Rui Guo Yu Feng Erbao Dong | 2023 | High Voltage2023，8，6： | 0 |
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