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| 1 | Identification and differentiation of major components in three different “Sheng-ma” crude drug species by UPLC/Q-TOF-MS显示文摘Cimicifugae Rhizoma(Sheng ma) is a Ranunculaceae herb belonging to a composite family and well known in China,has been widely used in traditional Chinese medicine.The Pharmacopoeia of the People's Republic of China contains three varieties(Cimicifuga dahurica(Turcz.),Cimicifuga foetida L.and Cimicifuga heracleifolia Kom.) which have been used clinically as 'Sheng-ma'.However,the chemical constituents of three components of 'Sheng-ma' have never been documented.In this study,a rapid method for the analysis of the main components of 'Sheng-ma' was developed using ultra-high performance liquid chromatography with quadrupole-time-of-flight mass spectrometry(UPLC/Q-TOF-MS).The present study reveals the major common and distinct chemical constituents of C.dahurica,C.foetida and C.heracleifolia and also reports principal component and statistical analyses of these results.The components were identified by comparing the retention time,accurate mass,mass spectrometric fragmentation characteristic ions and matching empirical molecular formula with that of the published compounds.A total of 32 common components and 8 markers for different 'Sheng-ma' components were identified.These findings provide an important basis for the further study and clinical utilities of the three 'Sheng-ma' varieties. | Mengxue Fan Kunming Qin Fei Ding Yuting Huang Xiaoli Wang Baochang Cai | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 4 |
| 2 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 3 | Multi-scenario Simulation for 2060 and Driving Factors of the Eco-spatial Carbon Sink in the Beibu Gulf Urban Agglomeration, China显示文摘Since China announced its goal of becoming carbon-neutral by 2060, carbon neutrality has become a major target in the development of China's urban agglomerations. This study applied the Future Land Use Simulation(FLUS) model to predict the land use pattern of the ecological space of the Beibu Gulf urban agglomeration, in 2060 under ecological priority, agricultural priority and urbanized priority scenarios. The Integrated Valuation of Ecosystem Services and Trade-offs(In VEST) model was employed to analyse the spatial changes in ecological space carbon storage in each scenario from 2020 to 2060. Then, this study used a Geographically Weighted Regression(GWR) model to determine the main driving factors that influence the changes in land carbon sinking capacity. The results of the study can be summarised as follows: firstly, the agricultural and ecological priority scenarios will achieve balanced urban expansion and environmental protection of resources in an ecological space. The urbanized priority scenario will reduce the carbon sinking capacity. Among the simulation scenarios for 2060, carbon storage in the urbanized priority scenario will decrease by 112.26 × 10^(6) t compared with that for 2020 and the average carbon density will decrease by 0.96 kg/m^(2) compared with that for 2020. Carbon storage in the agricultural priority scenario will increase by 84.11 × 10^(6) t, and the average carbon density will decrease by 0.72 kg/m^(2). Carbon storage in the ecological priority scenario will increase by 3.03 × 10^(6) t, and the average carbon density will increase by 0.03 kg/m^(2). Under the premise that the population of the town will increases continuously, the ecological priority development approach may be a wise choice.Secondly, slope, distance to river and elevation are the most important factors that influence the carbon sink pattern of the ecological space in the Beibu Gulf urban agglomeration, followed by GDP, population density, slope direction and distance to traffic infrastructure.At the same time, urban space expansion is the main cause of the changes of this natural factors. Thirdly, the decreasing trend of ecological space is difficult to reverse, so reasonable land use policy to curb the spatial expansion of cities need to be made. | QIN Menglin ZHAO Yincheng LIU Yuting JIANG Hongbo LI Hang ZHU Ziming | 2023 | Chinese Geographical Science2023，33，1： | 3 |
| 4 | Experimental investigation of the isothermal section at 400℃of the Mgsingle bondCesingle bondSr ternary system显示文摘The objective of this study is to determine the isothermal section at 400℃ of the Mgsingle bondCesingle bondSr system.In this study,the constitution of the Cesingle bondSr system and the Mgsingle bondCesingle bondSr system have been investigated over the entire composition range using X-ray diffraction(XRD),field emission scanning electron microscope(SEM)and energy dispersive spectroscopy(EDS).No any new binary compound has been found in the Cesingle bondSr system and no ternary compound has been found in the Mgsingle bondCesingle bondSr system also.Nine three-phase regions have been experimentally observed.Six binary phases Mg_(2)Sr,Mg_(23)Sr_(6),Mg_(38)Sr_(9),Mg_(17)Sr_(2),Mg_(12)Ce,Mg_(41)Ce_(5) are detected dissolving about 3-7 at.%the third element.This study first detected the experimental data of the Cesingle bondSr binary system and determined the isothermal section at 400℃ of the Mgsingle bondCesingle bondSr ternary system. | Songxiang Sun Yuting Qin Hua Zhou Yong Du Cuiyun He | 2016 | Journal of Magnesium and Alloys2016，4，1： | 1 |
| 5 | High-performance bulk thermoelectric materials and devices显示文摘Thermoelectric technology has intrigued wide-spread interests with a direct conversion between electricity and heat.The study on thermoelectric materials ultimately comes down to improving electrical properties and reducing lattice thermal conductivity,thus leading to a considerable thermoelectric figure of merit(zT).In this paper,we summarize our recent progress in skutterudites,diamond-like compounds,liquid-like materials,thermoelectric critical phenomena and mosaic crystals,and thermoelectric devices.The significant improvement in thermoelectric materials and devices greatly promotes thermoelectric technology as an important role in future energy solution. | QIN YuTing ZHANG QiHao QIU PengFei BAI ShengQiang SHI Xun CHEN LiDong | 2016 | Science Foundation in China2016，24，4： | 1 |
| 6 | FeCo alloy/N,S co-doped carbon aerogel derived from directionalcasting cellulose nanofibers for rechargeable liquid flow and flexible Zn–air batteries显示文摘Bifunctional oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)electrocatalysts with the advantages of excellent activity and stability are the vital components of air cathodes for rechargeable Zn–air batteries(ZABs).Herein,the carbon aerogel with honeycomb-like structure,N and S double doping and loaded with FeCo alloy nanoparticles(NSCA/FeCo)was prepared successfully as cathodes for rechargeable liquid flow and two-dimensional flexible ZABs by clever directional casting.The interaction between the bimetallic alloy and the double-doped carbon with specifical structure,large surface,great conductivity endows NSCA/FeCo with effective ORR/OER active sites and small charge/mass transport barrier,thus achieving outstanding bifunctional catalytic performance.The NSCA/FeCo displays a half-wave potential of+0.85 V(vs.reversible hydrogen electrode(RHE))for ORR and an overpotential of 335 mV at a current density of 10 mA·cm^(−2)for OER,which is even comparable to the performance of noble-metal catalysts in relevant fields(Pt/C for ORR and RuO_(2)for OER).Consequently,the rechargeable liquid flow ZABs assembled with NSCA/FeCo showed excellent performance(maximum power density:132.0 mW·cm^(−2),specific capacity:804.5 Wh·kg^(−1)at 10 mA·cm^(−2),charge and discharge cycle stability of more than 250 cycles).Furthermore,the flexible NSCA/FeCo-based ZABs have a maximum power density of 43.0 mW·cm^(−2),outstanding charging–discharge stability of more than 450 cycles,exhibit good flexibility under different bending conditions.Therefore,this work has provided an efficient bifunctional electrocatalyst for OER/ORR and a promising strategy of air cathodes for rechargeable and wearable ZABs. | Yiwen Zhang Xifeng Zhang Yuting Li Juan Wang Sibudjing Kawi Qin Zhong | 2023 | Nano Research2023，16，5： | 1 |
| 7 | Natural Mesoporous Activated Carbon from Toxic Plant Stellera Chamaejasme Roots by Chemical Methods显示文摘Stellera chamaejasme,widely distributed on the Qinghai-Tibet Plateau,is a poisonous plant causing serious harm to grassland.Activated carbons have been prepared from the roots of Stellera chamaejasme via phosphoric acid and zinc chloride activation at500°C for 60 min with an impregnation ratio of 3:1.Yield(25.1%-27.6%),ash(4.5%-4.9%),methylene blue(195.0 mg/g-254.5 mg/g),iodine value(720.4 mg/g-810.5 mg/g),specific surface area(1023.3 m2/g-1216.7 m2/g),specific pore volume(2.13 cm3/g-2.26 cm3/g),mesopore volume(1.30 cm3/g-1.59 cm3/g)and average pore size(5.88nm-7.45 nm)of the products were determined.The results from both the zinc chloride and phosphoric acid activation processes showed that the activated carbons of S.chamaejasme roots exhibit a characterization of natural developed mesopores. | Huizhen Sun Yute Qin Xiaohui Liu Haichao Li | 2018 | Journal of Bioresources and Bioproducts2018，3，2： | 0 |
| 8 | Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune microenvironment显示文摘Human lung adenosquamous cell carcinoma(LUAS),containing both adenomatous and squamous pathologies,harbors strong plasticity and is significantly associated with poor prognosis.We established an up-to-date comprehensive genomic and transcriptomic landscape of LUAS in 109 Chinese specimens and demonstrated LUAS development via adeno-to-squamous transdifferentiation.Unsupervised transcriptomic clustering and dynamic network biomarker analysis identified an inflammatory subtype as the critical transition stage during LUAS development.Dynamic dysregulation of the counteracting lineage-specific transcription factors(TFs),containing adenomatous TFs NKX2-1 and FOXA2,and squamous TFs TP63 and SOX2,finely tuned the lineage transition via promoting CXCL3/5-mediated neutrophil infiltration.Genomic clustering identified the most malignant subtype featured with STK11-inactivation,and targeting LSD1 through genetic deletion or pharmacological inhibition almost eradicated STK11-deficient lung tumors.These data collectively uncover the comprehensive molecular landscape,oncogenic driver spectrum and therapeutic vulnerability of Chinese LUAS. | Shijie Tang Yun Xue Zhen Qin Zhaoyuan Fang Yihua Sun Chongzhe Yuan Yunjian Pan Yue Zhao Xinyuan Tong Jian Zhang Hsinyi Huang Yuting Chen Liang Hu Dasong Huang Ruiqi Wang Weiguo Zou Yuan Li Roman KThomas Andrea Ventura Kwok-Kin Wong Haiquan Chen Luonan Chen Hongbin Ji | 2023 | National Science Review2023，10，4： | 0 |
| 9 | Distribution Patterns of Synechococcus Indicated Their Environmental Constraints and Related Geochemical Processes in the Yellow Sea显示文摘Synechococcus is a widely distributed photosynthetic pico-phytoplankton,which contributes mainly to carbon fixation and maintains the stability of the marine ecosystem.To investigate its distribution patterns in the Yellow Sea,seawater samples were collected during September 2018.Results of flow cytometry analysis showed that the Synechococcus abundance ranged from 6.36×10^(2) to 4.51×10^(4) cells mL^(−1),which correlated with salinity(P<0.01)and temperature(P<0.05).At deeper off-shore sites,Synecho-coccus showed high abundance at the subsurface thermo-halocline,which was in accordance with chlorophyll a(Chl a)content along the vertical column.Based on the high-throughput sequencing data of rpoC1(partial gene encoding RNA polymerase),two Synechococcus subclusters,S5.1 and S5.2,were found to coexist in the studied area.Several clades of S5.1,including Clades I,II,and III,were the dominant components,accounting for 6.63%,26.11%,and 45.5%of the total genus,respectively.Redundancy analysis(RDA)showed that nitrite was the main environmental factor that explained the genus composition among samples.Fur-thermore,co-occurrence network revealed that the main phyla that coexisted with Synechococcus were Proteobacteria,Bacteroidetes,Actinobacteria,Planctomycetes,and Verrucomicrobia,which were involved in the carbon(C),nitrogen(N),sulfur(S),and manga-nese(Mn)cycles.Overall,Synechococcus exhibited biogeographic distribution correlated with temperature-salinity and nitrite in the Yellow Sea,and their geochemical function showed diverse but should be further verified in the future. | ZHOU Yuting WANG Ting CHEN Xi QIN Song ZHAO Zhenjun GUO Xinyi LI Jialin | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
| 10 | ICAM-1 depletion in the center of immunological synapses is important for calcium releasing in T-cells显示文摘T-cell activation requires the formation of the immunological sy napse(IS)bet ween a T-cll and anantigen-presenting cell(AP C)to control the development of the adaptive immune response.How-ever,calcium release,an initial signal of T-cell activation,has been found to occur before IS for-mation.The mechanism for triggering the calcium signaling and relationship bet ween calciumrelease and IS format ion remains unclear.Herein,using live-cell imaging,we found that int ercellularadhesion molecule 1(ICAM-1),an essential mdlecule for IS formation,accumulated and then wasdepleted at the center of the synapse before complete IS formation.During the proces of ICAM1depletion,calcium was released.if ICAM-1 failed to be depleted from the center of the synapse,thesustained calcium signaling could not be induced.Moreover,depletion of ICAM-1 in ISs preferen-tially ccurred with the contact of antigen-specific T-cels and dendritic clls(DCs).Blocking thebinding ofICA M-1 and lymphocy te finction-associated antigen 1(LFA-1),ICAM-1 failed to depleteat the center of the synapse,and calcium release in T-clls decreased.In studying the mechanism ofhow the depletion ofiCA M1 could influence calcium release in T-clls,we found that the movementof ICAM-1 was associat ed with the localization of LFA-1 in the IS,which afected the localization ofcalcium microdomains,ORAIl and mitochondria in IS.Therefore,the depletion of ICAM-1 in the center of the synapse is an important factor for an initial sust ained calcium release in T-cells. | Yuanzhen Suo Wei Lin Yuting Deng Zhichao Fan Lizeng Qin Guosheng Jiang Yiwei Chu Xunbin Wei | 2018 | Journal of Innovative Optical Health Sciences2018，，2： | 0 |
| 11 | Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization显示文摘Due to their broad functional plasticity,myeloid cells contribute to both liver injury and recovery during acetaminophen overdose-induced acute liver injury(APAP-ALI).A comprehensive understanding of cellular diversity and intercellular crosstalk is essential to elucidate the mechanisms and to develop therapeutic strategies for APAP-ALI treatment.Here,we identified the function of IFN-I in the myeloid compartment during APAP-ALI.Utilizing single-cell RNA sequencing,we characterized the cellular atlas and dynamic progression of liver CD11b+cells post APAP-ALI in WT and STAT2 T403A mice,which was further validated by immunofluorescence staining,bulk RNA-seq,and functional experiments in vitro and in vivo.We identified IFN-I-dependent transcriptional programs in a three-way communication pathway that involved IFN-I synthesis in intermediate restorative macrophages,leading to CSF-1 production in aging neutrophils that ultimately enabled Trem2+restorative macrophage maturation,contributing to efficient liver repair.Overall,we uncovered the heterogeneity of hepatic myeloid cells in APAP-ALI at single-cell resolution and the therapeutic potential of IFN-I in the treatment of APAP-ALI. | Qiaoling Song Shyamasree Datta Xue Liang Xiaohan Xu Paul Pavicic Xiaonan Zhang Yuanyuan Zhao Shan Liu Jun Zhao Yuting Xu Jing Xu Lihong Wu Zhihua Wu Minghui Zhang Zhan Zhao Chunhua Lin Yuxin Wang Peng Han Peng Jiang Yating Qin Wei Li Yingying Zhang Yonglun Luo Ganes Sen George R.Stark Chenyang Zhao Thomas Hamilton Jinbo Yang | 2023 | Cellular & Molecular Immunology2023，20，2： | 0 |
| 12 | Radiological biomarkers of idiopathic normal pressure hydrocephalus:new approaches for detecting concomitant Alzheimer’s disease and predicting prognosis显示文摘Idiopathic normal pressure hydrocephalus(iNPH)is a clinical syndrome characterized by cognitive decline,gait disturbance,and urinary incontinence.As iNPH often occurs in elderly individuals prone tomany types of comorbidity,a differential diagnosis with other neurodegenerative diseases is crucial,especially Alzheimer’s disease(AD).A growing body of published work provides evidence of radiological methods,including multimodal magnetic resonance imaging and positron emission tomography,which may help noninvasively differentiate iNPH from AD or reveal concurrent AD pathology in vivo.Imaging methods detecting morphological changes,white matter microstructural changes,cerebrospinal fluid circulation,and molecular imaging have been widely applied in iNPH patients.Here,we review radiological biomarkers using different methods in evaluating iNPH pathophysiology and differentiating or detecting concomitant AD,to noninvasively predict the possible outcome postshunt and select candidates for shunt surgery. | Hanlin Cai Yinxi Zou Hui Gao Keru Huang Yu Liu Yuting Cheng Yi Liu Liangxue Zhou Dong Zhou Qin Chen | 2022 | Psychoradiology2022，2，4： | 0 |
| 13 | Characterisation of IL-21 and IL-21Rαin grass carp:IL-21-producing cells are upregulated during Flavobacterium columnare infection显示文摘Interleukin-21(IL-21)is produced mainly by activated CD4^(+)T cells and promotes the proliferation,survival and differentiation of immune cells.This study characterised a high affinity binding receptor of IL-21(IL-21 Rα)from grass carp(Ctenopharyngodon idella,Ci)and analyzed the expression of CiIL-21 and CiIL-21 Rα.It has been shown that they were modulated by PAMPs and during infection with bacterial and viral pathogens.Recombinant CiIL-21 protein produced in bacteria was active in inducing the expression of genes involved in Th responses.A monoclonal CiIL-21 antibody was generated against the rCiIL-21 and showed good reactive specificity with the rCiIL-21 proteins expressed in E.coli cells,and HEK293 T cells and the native protein from PHA-stimulated kidney leukocytes.In addition,the IL-21-producing cells detected by the CiIL-21 monoclonal antibody were found to be increased to in the kidney,spleen and hindgut after infection with Flavobacterium columnare.Our data indicate that IL-21 is involved in the regulation of immune response to bacterial and viral infection. | Jiawen Xu Junya Wang Qingyu Min Wei Wang Yuting Qin Lina Lei Qian Gao Jun Zou | 2024 | Aquaculture and Fisheries2024，9，2： | 0 |
| 14 | Production and characterization of monoclonal antibodies against grass carp CD4-1 and CD4-2显示文摘CD4 T helper cells are an important group of cells in the immune system of vertebrates and express CD4 receptor on the cell surface.In mammals,the CD4 receptor is encoded by a single copy gene,whilst in fish,two copies of cd4 genes,namely cd4-1 and cd4-2,are found.In this study,the ectodomains of grass carp(Ctenopharyngodon idella,Ci)CD4-1 and CD4-2 were expressed in the E.coli cells and used to generate monoclonal antibodies in mice.Western blotting,confocal microscopy and flow cytometry were performed to characterize the monoclonal antibodies.It has been shown that the CiCD4-1 and CiCD4-2 monoclonal antibodies had good specificity to react with the recombinant ectodomains of CiCD4-1 and CiCD4-2 expressed in the CHO-S cells and the native CD4 molecules of grass carp.The CiCD4-1 monoclonal antibody did not recognize CiCD4-2 and verse versa.In addition,the CD4-1 and CD4-2 monoclonal antibodies specifically recognized the CD4-1 and CD4-2 receptors expressed in the HEK293 cells and native molecules of fish cells.Further,the percentages of lymphocytes in immune tissues of healthy fish were analyzed by flow cytometry.It was found that 17.6%of lymphocytes were CD4-1^(+)cells and 22.5%were CD4-2^(+)in the head kidney.In the spleen,13.1%of lymphocytes were CD4-1^(+)and 18.6%were CD4-2^(+)while 7.3%of blood lymphocytes were CD4-1^(+)cells and 8.8%were CD4-2^(+)cells.The availability of the CD4-1 and CD4-2 monoclonal antibodies provides antibody-based tools for further elucidation of the functions of CD4 T cells in grass carp. | Bangjie Wang Yuting Qin Zhaosheng Sun Xiaozhen Zhu Zhao Jia Kangyong Chen Danjie Liu Junya Wang Jun Zou | 2024 | Aquaculture and Fisheries2024，9，2： | 0 |
| 15 | Graphene foam/hydrogel scaffolds for regeneration of peripheral nerve using ADSCs in a diabetic mouse model显示文摘The functional recovery of peripheral nerve injury(PNI)is unsatisfactory,whereas diabetes mellitus(DM)and its related complications further attenuate the restoration of diabetic PNI(DPNI).Adipose-derived stem cells(ADSCs)are promising candidates for treatment of DPNI due to their abundant source,excellent differentiation and paracrine ability.Our results showed that ADSCs remarkably enhanced the proliferation and migration of Schwann cells and endothelial cells,and tube formation.Mechanistically,ADSCs could regulate Nrf2/HO-1,NF-κB and PI3K/AKT/mTOR signaling pathways,showing multiple functions in reducing oxidative stress and inflammation,and regulating cell metabolism,growth,survival,proliferation,angiogenesis,differentiation of Schwann cell and myelin formation.In current study,novel graphene foam(GF)/hydrogel-based scaffold was developed to deliver ADSCs for treatment of DPNI.GF/hydrogel scaffold exhibited excellent mechanical strength,suitable porous network,superior electrical conductivity,and good biocompatibility.In vitro results revealed that GF/hydrogel scaffold could obviously accelerate proliferation of Schwann cells.Moreover,in vivo experiments demonstrated that ADSCs-loaded GF/hydrogel scaffold significantly promoted the recovery of DPNI and inhibited the atrophy of targeted muscles,thus providing a novel and attractive therapeutic approach for DPNI patients. | Qun Huang Yuting Cai Xinrui Yang Weimin Li Hongji Pu Zhenjing Liu Hongwei Liu Mohsen Tamtaji Feng Xu Liyuan Sheng Tae-Hyung Kim Shiqing Zhao Dazhi Sun Jinbao Qin Zhengtang Luo Xinwu Lu | 2022 | Nano Research2022，15，4： | 0 |
| 16 | Controllable NO Release for Catheter Antibacteria from Nitrite Electroreduction over the Cu-MOF显示文摘Implant-associated infections caused by biomedical catheters severely threaten patients'health.The use of electrochemical control on NO release from benign nitrite equipped in the catheter can potentially resolve this issue with excellent biocompatibility.Inspired by nitrite reductase,a Cu-BDC(BDC:benzene-1,4-dicarboxylic acid)catalyst with coordinated Cu(Ⅱ)sites was constructed as a heterogeneous electrocatalyst to control nitrite reduction to nitric oxide for catheter antibacteria.The combined results of in situ and ex situ tests unveil the key function of interconversion between Cu(Ⅱ)and Cu(Ⅰ)species in NO_(2)^(-)reduction to NO.After being incorporated into the actual catheter,the Cu-BDC catalyst exhibits high electrocatalytic activity toward NO_(2)^(-)reduction to NO and excellent antibacteria efficacy with a sterilizing rate of 99.9%,paving the way for the development of advanced metal-organic frameworks(MOFs)electrocatalysts for catheter antibacteria. | Yibo Wang Yutian Qin Wei Li Yuting Wang Lina Zhu Meiting Zhao Yifu Yu | 2023 | Transactions of Tianjin University2023，29，4： | 0 |
| 17 | mRNA-based therapeutics:powerful and versatile tools to combat diseases显示文摘The therapeutic use of messenger RNA(mRNA)has fueled great hope to combat a wide range of incurable diseases.Recent rapid advances in biotechnology and molecular medicine have enabled the production of almost any functional protein/peptide in the human body by introducing mRNA as a vaccine or therapeutic agent.This represents a rising precision medicine field with great promise for preventing and treating many intractable or genetic diseases.In addition,in vitro transcribed mRNA has achieved programmed production,which is more effective,faster in design and production,as well as more flexible and cost-effective than conventional approaches that may offer.Based on these extraordinary advantages,mRNA vaccines have the characteristics of the swiftest response to large-scale outbreaks of infectious diseases,such as the currently devastating pandemic COVID-19.It has always been the scientists’desire to improve the stability,immunogenicity,translation efficiency,and delivery system to achieve efficient and safe delivery of mRNA.Excitingly,these scientific dreams have gradually been realized with the rapid,amazing achievements of molecular biology,RNA technology,vaccinology,and nanotechnology.In this review,we comprehensively describe mRNA-based therapeutics,including their principles,manufacture,application,effects,and shortcomings.We also highlight the importance of mRNA optimization and delivery systems in successful mRNA therapeutics and discuss the key challenges and opportunities in developing these tools into powerful and versatile tools to combat many genetic,infectious,cancer,and other refractory diseases. | Shugang Qin Xiaoshan Tang Yuting Chen Kepan Chen Na Fan Wen Xiao Qian Zheng Guohong Li Yuqing Teng Min Wu Xiangrong Song | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 0 |
| 18 | BODIPY-based supramolecular fluorescent metallacages显示文摘During the past few years, the construction of BODIPY-based supramolecular fluorescent metallacages through coordination-driven self-assembly has gained increasing interest due to their unique photophysical properties and applications in catalysis, sensing, and bioimaging. In consideration of the rapid development of this field, it is time to summarize recent developments involving BODIPY-based metallacages.In this review, a comprehensive summary of the construction of BODIPY-based metallacages as well as their photophysical properties and applications will be presented. | Yute Wang Yi Qin Xiaoli Zhao Peipei Jia Zhiyong Zeng Lin Xu | 2023 | Chinese Chemical Letters2023，34，3： | 0 |
| 19 | Intermetallic PdBi aerogels with improved catalytic performance for the degradation of organic pollutants in water显示文摘It is always highly pursued to develop efficient and durable catalysts for catalytic applications.Herein,intermetallic PdBi aerogels with tunable activity were prepared successfully via a surfactant-free spontaneous gelation process.The prepared PdBi aerogels have a three-dimensional high porous structure and plentiful active sites pervaded on the ultrathin interlinked nanowires network.These unique structures,as well as the synergistic effect between Pd and Bi,can accelerate mass and electron transfer,and improve the atom utilization ratio of Pd atoms to promote the catalytic efficiency.As a proofof-concept application,the optimized Pd_(2) Bi_(1) aerogels exhibit 4.2 and 6.2 times higher catalytic activity for the reduction of 4-nitrophenol(4-NP)and methylene blue(MB)than those of commercial Pd/C,respectively.With the introduction of non-noble metal of Bi,the cost of the resulted Pd Bi aerogels can be dropped signi ficantly while the catalytic capability of Pd Bi aerogel will be improved sharply.This strategy will bring good hints to rationally design fine catalysts for various applications. | Xiaofeng Tan Jun Qin Yan Li Yuting Zeng Jindi Gong Gengxiu Zheng Feng Feng He Li | 2021 | Chinese Chemical Letters2021，32，4： | 0 |
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