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| 1 | A review on completing arsenic biogeochemical cycle: Microbial volatilization of arsines in environment显示文摘Arsenic(As) is ubiquitous in the environment in the carcinogenic inorganic forms, posing risks to human health in many parts of the world. Many microorganisms have evolved a series of mechanisms to cope with inorganic arsenic in their growth media such as transforming As compounds into volatile derivatives. Bio-volatilization of As has been suggested to play an important role in global As biogeochemical cycling, and can also be explored as a potential method for arsenic bioremediation. This review aims to provide an overview of the quality and quantity of As volatilization by fungi, bacteria, microalga and protozoans. Arsenic bio-volatilization is influenced by both biotic and abiotic factors that can be manipulated/elucidated for the purpose of As bioremediation. Since As biovolatilization is a resurgent topic for both biogeochemistry and environmental health, our review serves as a concept paper for future research directions. | Peipei Wang Guoxin Sun Yan Jia Andrew A Meharg Yongguan Zhu | 2014 | Journal of Environmental Sciences2014，26，2： | 22 |
| 2 | Reemergent Cases of COVID-19--Xinjiang Uygur Autonomous Region,China,July 16,2020显示文摘Before the coronavirus disease 2019(COVID-19)outbreak on July 16,2020,no new COVID-19 cases were reported in Urumqi City of Xinjiang for 150 consecutive days.During this outbreak,826 confirmed COVID-19 cases have been reported in Urumqi.The phylogenetic characteristics of COVID-19 virus from clinical specimens of the initial 4 cases in the Urumqi outbreak were sequenced. | Cao Chen Hemuti Ma Zhiyuan Jia Xiang Zhao Dayan Wang Jun Zhao Zhenguo Gao Peipei Liu Yang Song Zhixiao Chen Yuchao Wu Yao Meng Guizhen Wu Wenbo Xu Xucheng Fan Yong Zhang | 2020 | China CDC weekly2020，2，39： | 5 |
| 3 | Uniform single atomic Cu_(1)-C_(4)sites anchored in graphdiyne for hydroxylation of benzene to phenol显示文摘For single-atom catalysts(SACs),the catalyst supports are not only anchors for single atoms,but also modulators for geometric and electronic structures,which determine their catalytic performance.Selecting an appropriate support to prepare SACs with uniform coordination environments is critical for achieving optimal performance and clarifying the relationship between the structure and the property of SACs.Approaching such a goal is still a significant challenge.Taking advantage of the strong d-πinteraction between Cu atoms and diacetylenic in a graphdiyne(GDY)support,we present an efficient and simple strategy for fabricating Cu single atoms anchored on GDY(Cu_(1)/GDY)with uniform Cu_(1)-C_(4)single sites under mild conditions.The Cu atomic structure was confirmed by combining synchrotron radiation X-ray absorption spectroscopy,X-ray photoele ctron spectroscopy and density functional theory(DFT)calculations.The as-prepared Cu1/GDY exhibits much higher activity than state-of-the-art SACs in direct benzene oxidation to phenol with H_(2)O_(2)reaction,with turnover frequency values of 251 h^(-1)at room temperature and 1889 h^(-1)at 60℃,respectively.Furthermore,even with a high benzene conversion of86%,high phenol sele ctivity(96%)is maintaine d,which can be ascribed to the hydrophobic and oleophyllic surface nature of Cu1/GDY for benzene adsorption and phenol desorption.Both experiments and DFT calculations indicate that Cu_(1)-C_(4)single sites are more effective at activating H_(2)O_(2)to form Cu=O bonds,which are important active intermediates for benzene oxidation to phenol. | Jia Yu Changyan Cao Hongqiang Jin Weiming Chen Qikai Shen Peipei Li Lirong Zheng Feng He Weiguo Song Yuliang Li | 2022 | National Science Review2022，9，9： | 3 |
| 4 | Small-molecule fluorescent probes for the detection of carbon dioxide显示文摘During the last few years, the preparation of novel fluorescent probes for the detection of carbon dioxide has attracted considerable attention since carbon dioxide plays extremely important roles in widespread fields including chemical, environmental, clinical analysis, and agri-food industry. This review focuses on the recent advances in the design principles, recognition mechanisms, and preparation of small-molecule fluorescent probes for the selective detection and monitoring of CO_2. Moreover, their properties and functions will be discussed detailedly as well. | Junlong Zhu Peipei Jia Nuo Li Shaoying Tan Junhai Huang Lin Xu | 2018 | Chinese Chemical Letters2018，29，10： | 2 |
| 5 | The Killing Forms and Decomposition Theorems of Lie Supertriple Systems显示文摘 | ZHANG Zhixue JIA Peipei | 2009 | Acta Math Scientia2009，29，： | 1 |
| 6 | Effects of carbon sources on growth and extracellular polysaccharide production of Nostoc flagelliforme under heterotrophic high-cell-density fed-batch cultures显示文摘 | Zhen Ding Shiru Jia Peipei Han Nannan Yuan Ning Tan | 2013 | Journal of Applied Phycology2013，，4： | 1 |
| 7 | Comparisonof bacterial community structures of terrestrial cyanobacteriumNostoc flagelliforme in three different regions ofChina using PCR-DGGE analysis显示文摘 | Han Peipei Shen Shigang Jia Shiru | 2015 | World Journal ofMicrobiololy & Biotechnology2015，31，7： | 1 |
| 8 | Metabolomic approachto optimizing and evaluating antibiotic treatmentin the axenic culture of cyanobacterium Nostoc flagelliforme显示文摘 | Han Peipei Jia Shiru Sun Ying | 2014 | World Journal of Microbiology & Biotechnology2014，30，9： | 1 |
| 9 | Alkaline activation of endogenous latent TGFβ1 by an injectable hydrogel directs cell homing for in situ complex tissue regeneration显示文摘Utilization of the body’s regenerative potential for tissue repair is known as in situ tissue regeneration.However,the use of exogenous growth factors requires delicate control of the dose and delivery strategies and may be accompanied by safety,efficacy and cost concerns.In this study,we developed,for the first time,a biomaterial-based strategy to activate endogenous transforming growth factor beta 1(TGFβ1)under alkaline conditions for effective in situ tissue regeneration.We demonstrated that alkaline-activated TGFβ1 from blood serum,bone marrow fluids and soaking solutions of meniscus and tooth dentin was capable of increasing cell recruitment and early differentiation,implying its broad practicability.Furthermore,we engineered an injectable hydrogel(MS-Gel)consisting of gelatin microspheres for loading strong alkaline substances and a modified gelatin matrix for hydrogel click crosslinking.In vitro models showed that alkaline MS-Gel controllably and sustainably activated endogenous TGFβ1 from tooth dentin for robust bone marrow stem cell migration.More importantly,infusion of in vivo porcine prepared root canals with alkaline MS-Gel promoted significant pulp-dentin regeneration with neurovascular stroma and mineralized tissue by endogenous proliferative cells.Therefore,this work offers a new bench-to-beside translation strategy using biomaterial-activated endogenous biomolecules to achieve in situ tissue regeneration without the need for cell or protein delivery. | Sainan Wang Yuting Niu Peipei Jia Zheting Liao Weimin Guo Rodrigo Cotrim Chaves Khanh-Hoa Tran-Ba Ling He Hanying Bai Sam Sia Laura J.Kaufman Xiaoyan Wang Yongsheng Zhou Yanmei Dong Jeremy J.Mao | 2022 | Bioactive Materials2022，7，9： | 1 |
| 10 | Melphalan-loaded methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer nanomicelles in the treatment of multiple myeloma显示文摘Multiple myeloma(MM)is the second most common hematological tumor characterized by the proliferation of monoclonal plasma cells.Melphalan(MEL)is commonly used in the treatment of MM and is especially essential for patients undergoing autologous stem cell transplantation(ASCT).Although many drugs for MM have been developed in recent years,chemotherapy followed by ASCT remains the optimal option.Melphalan,the backbone of the conditioning regimen,brings severe toxicities at a high dose.Nanodrug delivery systems enable drugs to be highly effective and have low toxicity.In this study,methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(MPEG-PDLLA)was chosen to encapsulate melphalan,and the characteristics,effectiveness,and safety of MEL/MPEG-PDLLA in vitro and in vivo were investigated.MEL/MPEG-PDLLA showed slow release and was easily engulfed by MM cells despite a result of the antitumor assay comparable to that of free melphalan in vitro.The in vivo results showed that MEL/MPEG-PDLLA could significantly alleviate tumor burden and prolong survival time without increasing the toxicity to vital organs.In addition,MEL/MPEG-PDLLA could significantly reduce the damage to the intestinal mucosa caused by melphalan.In conclusion,MEL/MPEG-PDLLA shows improved antitumor activity and has the potential to alleviate pains of MM patients undergoing ASCT. | Yingying Chen Qiang Zeng Bingyang Chu Zhigang Liu Xue Wei Mengran Chen Peipei Yang Minghai Tang Ting Niu Yongqian Jia Ying Qu Zhiyong Qian | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 11 | High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors显示文摘The global COVID-19 coronavirus pandemic has infected over 109 million people,leading to over 2 million deaths up to date and still lacking of effective drugs for patient treatment.Here,we screened about 1.8 million small molecules against the main protease(M^(pro))and papain like protease(PL^(pro)),two major proteases in severe acute respiratory syndrome-coronavirus 2 genome,and identified 1851M^(pro)inhibitors and 205 PL^(pro)inhibitors with low nmol/l activity of the best hits.Among these inhibitors,eight small molecules showed dual inhibition effects on both M^(pro)and PL^(pro),exhibiting potential as better candidates for COVID-19 treatment.The best inhibitors of each protease were tested in antiviral assay,with over 40%of M^(pro)inhibitors and over 20%of PL^(pro)inhibitors showing high potency in viral inhibition with low cytotoxicity.The X-ray crystal structure of SARS-CoV-2 M^(pro)in complex with its potent inhibitor 4a was determined at 1.8Åresolution.Together with docking assays,our results provide a comprehensive resource for future research on anti-SARS-CoV-2 drug development. | Yi Zang Mingbo Su Qingxing Wang Xi Cheng Wenru Zhang Yao Zhao Tong Chen Yingyan Jiang Qiang Shen Juan Du Qiuxiang Tan Peipei Wang Lixin Gao Zhenming Jin Mengmeng Zhang Cong Li Ya Zhu Bo Feng Bixi Tang Han Xie Ming-Wei Wang Mingyue Zheng Xiaoyan Pan Haitao Yang Yechun Xu Beili Wu Leike Zhang Zihe Rao Xiuna Yang Hualiang Jiang Gengfu Xiao Qiang Zhao Jia Li | 2023 | Protein & Cell2023，14，1： | 0 |
| 12 | Freestanding metal nanohole array for high-performance applications显示文摘Plasmonic devices using periodic metallic nanostructures have recently gained tremendous interest for color filters,sensing,surface enhanced spectroscopy,and enhanced photoluminescence,etc.However,the performance of such plasmonic devices is severely hampered by the solid substrates supporting the metallic nanostructures.Here,a strategy for freestanding metallic nanomembranes is introduced by taking advantages of hollow substrate structures.Large-area and highly uniform gold nanomembranes with nanohole array are fabricated via a flexible and simple replication-releasing method.The hollow structures include a hollow core fiber with 30μm core diameter and two ferrules with their hole diameter as 125 and 500μm,respectively.As a proof-of-concept demonstration,2 times higher sensitivity of the bulk refractive index is obtained with this platform compared to that of a counterpart on a solid silica substrate.Such a portable and compact configuration provides unique opportunities to explore the intrinsic properties of the metal nanomembranes and paves a new way to fabricate high-performance plasmonic devices for biomolecule sensing and color filter. | Bobo Du Yinlan Ruan Dexing Yang Peipei Jia Shoufei Gao Yingying Wang Pu Wang Heike Ebendorff-Heidepriem | 2020 | Photonics Research2020，8，11： | 0 |
| 13 | NO_(2) sensing with CdS nanowires at room temperature under green light illumination显示文摘Detection of ppb-level NO_(2) gas under atmosphere is urgent to meet the requirements of the rapidly developing internet of things.Compared with traditional sensing methods,light illumination has been considered as a key approach for excellent gas sensor performance under moderate conditions.Herein,we developed a green-light-assisted gas sensor based on cadmium sulfide nanowires(CdS NWs)that has good NO_(2) sensing capability at ambient temperature.The response values of NO_(2) are 236%and 11%to 10 ppm and 12.5 ppb,respectively.Furthermore,the CdS NWs sensor has a high selectivity for NO_(2) over a variety of interference gases,as well as good stability.The cleaning light activation and the sulfur vacancy-trapped charge behavior of CdS NWs are observed,which suggest a light-assisted sensing mechanism.These results suggest that light-induced charge separation behavior might significantly improve gas-sensing characteristics. | Peipei Li Hongqiang Jin Jia Yu Weiming Chen Runqing Zhao Changyan Cao Weiguo Song | 2022 | Materials Futures2022，1，2： | 0 |
| 14 | 2-25 Interpretation on the Mass Dependent Behavior of Transverse Flow Using Collective-thermal Competition (Percolation) Model显示文摘According to the interplay model proposed in Ref. [1], an improved model, Collective-thermal Competition(Percolation) Model (CTCPM) is developed. The improvements are made by adding the momentum conservationinto the interplay of the thermal motion and the collective motion and limiting the emitting system to be finite.For a nuclear system at a thermal equilibrium, the momentum of the thermal motion distributes isotropically in x,y, z directions (z is the beam direction) and make no effect on the flow (Px) in average. | Liu Xingquan Wada Roy Chen Zhiqiang Huang Meirong Lin Weiping Ren Peipei Zhang Suyalatu Jin Zengxue Jia Baolu Han Rui Liu Jianli Shi Fudong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 15 | 2-26 Effect on Transverse Flow Definition from Different Reaction Mechanisms in AMD and CoMD — Semi-transparency显示文摘In general, the definition of the transverse flow can be classified into the slope flow[1] and the average flow[2]in the certain mid-rapidity region. For a given type of isotope with mass number A, these two definitions are,respectively, expressed | Liu Xingquan Wada Roy Chen Zhiqiang Huang Meirong Lin Weiping Ren Peipei Zhang Suyalatu Jin Zengxue Jia Baolu Han Rui Liu Jianli Shi Fudong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 16 | Effects of Different Raw Materials and Additions on Wave Transparency of Alumina Fiber Products显示文摘Fiber products for microwave kilns were prepared using alumina fibers with alumina contents of 72 mass%and 80 mass%,and calcined alumina powder(4-6μm)as the main raw materials,silica sol as the binder,and cationic starch as the flocculant.Effects of different raw materials and their additions on the wave transparency of fiber products were researched.The results show that as the alumina fiber(72%)addition increases,the heating rate of the samples first decreases and then increases,and the corresponding wave transparency of the sample first increases and then decreases.When the alumina fibers addition is 40 mass%and the alumina powder addition is 30 mass%,the prepared microwave kiln lining material has a higher mullite content,which improves the wave transparency of the sample.The sample prepared from alumina fibers with an alumina content of 80%has a suitable glass-mullite phase ratio,performs lower overall dielectric constant and good wave transparency,and is a suitable lining material for microwave kilns. | WANG Jia SUN Xiaofei XU Jianfeng XU Peipei | 2024 | China's Refractories2024，33，1： | 0 |
| 17 | In-situ doping nickel single atoms in two-dimensional MXenes analogue support for room temperature NO_(2) sensing显示文摘MXenes are promising supports for anchoring metal single atoms due to their versatile composition,well-defined nanostructures,and suitable conductivity.However,metal single atoms are usually coordinated with surface terminal groups(-O,-OH,-Cl,etc.)of MXenes via conventional wet-impregnation,resulting in limited electronic structure modification.Through a NiCl2 molten salt etching method,we observed that Ni single atoms could be in-situ doped in the lattice of MXenes analogue TiC_(0.5)N_(0.5) support(denoted as Ni1/TiC0.5N0.5),resulting in much larger charge transfer from Ni atoms to adjacent Ti atoms,and thus increasing the electronic density of these Ti atoms.When used for NO_(2) sensing,Ni_(1)/TiC_(0.5)N_(0.5) exhibited excellent response sensitivity(ultra-low limit of detection~10 ppb),selectivity,and good stability at room temperature.This study provides an effective strategy for producing MXenes analogue supported metal single atoms for potential application in gas sensing. | Weiming Chen Peipei Li Jia Yu Peixin Cui Xiaohu Yu Weiguo Song Changyan Cao | 2022 | Nano Research2022，15，10： | 0 |
| 18 | Graphdiyne:a Highly Sensitive Material for ppb-Level NO_(2) Gas Sensing at Room Temperature显示文摘Detection of a trace amount of NO_(2) at room temperature has very important applications in air quality monitoring,protection of human health and medical diagnose.However,the existing NO_(2) sensors often suffer from low sensitivity when the concentration at the ppb-level.Here,we report a new kind of materials based on graphdiyne(GDY)for highly sensitive detection of ppb-level(ppb:part per billion)NO_(2) at room temperature.After thermal treatment of the as-prepared GDY at 600℃under argon atmosphere for 2 h(the obtained sample denoted as GDY-600),the prepared sensor with GDY-600 displays excellent sensitivity with a response value of 6.2%towards 250 ppb NO_(2) at room temperature,which is better than most of reported sensing materials.In addition,the sensor exhibits significantly high selectivity to NO_(2) against typical interfering gases including CO,CO_(2),NH_(3),H_(2),H_(2)S and toluene.Moreover,the sensor shows remarkable stability after repetitive measurements.The superior sensing performance of GDY-600 can be ascribed to the highlyπ-conjugated structure with special acetylenic bonds and abundant oxygen-containing functional groups,which are all beneficial for the gas adsorption and redox reaction on the surface. | LI Peipei YU Jia CAO Changyan SONG Weiguo | 2021 | Chemical Research in Chinese Universities2021，37，6： | 0 |
| 19 | A novel mesenchymal stem cell-based regimen for acute myeloid leukemia differentiation therapy显示文摘Currently the main treatment of acute myeloid leukemia(AML)is chemotherapy combining hematopoietic stem cell transplantation.However,the unbearable side effect of chemotherapy and the high risk of life-threatening infections and disease relapse following hematopoietic stem cell transplantation restrict its application in clinical practice.Thus,there is an urgent need to develop alternative therapeutic tactics with significant efficacy and attenuated adverse effects.Here,we revealed that umbilical cord-derived mesenchymal stem cells(UC-MSC)efficiently induced AML cell differentiation by shuttling the neutrophil elastase(NE)-packaged extracellular vesicles(EVs)into AML cells.Interestingly,the generation and release of NE-packaged EVs could be dramatically increased by vitamin D receptor(VDR)activation in UC-MSC.Chemical activation of VDR by using its agonist 1a,25-dihydroxyvitamin D3 efficiently enhanced the pro-differentiation capacity of UC-MSC and then alleviated malignant burden in AML mouse model.Based on these discoveries,to evade the risk of hypercalcemia,we synthetized and identified sw-22,a novel non-steroidal VDR agonist,which exerted a synergistic prodifferentiation function with UC-MSC on mitigating the progress of AML.Collectively,our findings provided a non-gene editing MSC-based therapeutic regimen to overcome the differentiation blockade in AML. | Luchen Sun Nanfei Yang Bing Chen Yuncheng Bei Zisheng Kang Can Zhang Nan Zhang Peipei Xu Wei Yang Jia Wei Jiangqiong Ke Weijian Sun Xiaokun Li Pingping Shen | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 20 | Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2显示文摘Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2.Here we report that nelfinavir,an FDA approved drug for the treatment of HIV infection,is effective against SARS-CoV-2 and COVID-19.Preincubation of nelfinavir could inhibit the activity of the main protease of the SARS-CoV-2(IC50=8.26μM),while its antiviral activity in Vero E6 cells against a clinical isolate of SARS-CoV-2 was determined to be 2.93μM(EC50).In comparison with vehicle-treated animals,rhesus macaque prophylactically treated with nelfinavir had significantly lower temperature and significantly reduced virus loads in the nasal and anal swabs of the animals.At necropsy,nelfinavir-treated animals had a significant reduction of the viral replication in the lungs by nearly three orders of magnitude.A prospective clinic study with 37 enrolled treatment-naive patients at Shanghai Public Health Clinical Center,which were randomized(1:1)to nelfinavir and control groups,showed that the nelfinavir treatment could shorten the duration of viral shedding by 5.5 days(9.0 vs.14.5 days,P=0.055)and the duration of fever time by 3.8 days(2.8 vs.6.6 days,P=0.014)in mild/moderate COVID-19 patients.The antiviral efficiency and clinical benefits in rhesus macaque model and in COVID-19 patients,together with its well-established good safety profile in almost all ages and during pregnancy,indicated that nelfinavir is a highly promising medication with the potential of preventative effect for the treatment of COVID-19. | Zhijian Xu Danrong Shi Jian-Bao Han Yun Ling Xiangrui Jiang Xiangyun Lu Chuan Li Likun Gong Guangbo Ge Yani Zhang Yi Zang Tian-Zhang Song Xiao-Li Feng Ren-Rong Tian Jia Ji Miaojin Zhu Nanping Wu Chunhui Wu Zhen Wang Yechun Xu Cheng Peng Min Zheng Junling Yang Feifei Du Junliang Wu Peipei Wang Jingshan Shen Jianliang Zhang Yong-Tang Zheng Hangping Yao Weiliang Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
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