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| 1 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 2 | Photocatalytic oxidation of phenol in aqueous solutions with oxygen catalyzed by supported metallophthalocyanine catalyst显示文摘In this paper, zinc tetraaminophthalocyanine (Zn-APc) was immobilized on cellulosic fiber by covalent bond to obtain a novel cellulosic fiber supported metallophthalocyanine, named Zn-TDTAPc-F. At pH 11, upon visible light irradiation for 6 h in the presence of O2, Zn-TDTAPc-F was found to be highly effective for the degradation of phenol in aqueous solution, and the degradation rate of phenol was more than 95%. HPLC was used to confirm formic acid, fumaric acid and maleic acid as its main degradation products. | CHEN WenXing CHEN ShiLiang LüShenShui YAO YuYuan XU MinHong | 2007 | Science China Chemistry2007，50，3： | 8 |
| 3 | Synthesis, Nematicidal Activity, and 3D-QSAR of Novel 1,3,4-Oxadiazole/ Thiadiazole Thioether Derivatives显示文摘 | Jixiang Chen Xiuhai Gan Chongfen Yi Shaobo Wang Yuyuan Yang Fangcheng He Deyu Hu Baoan Song | 2018 | Chinese Journal of Chemistry2018，36，10： | 5 |
| 4 | Preparation and photoactivity of thermosensitive polymer supported metallophthalocyanine显示文摘A novel reactive metallophthalocyanine derivative,zinc tetra(2,4-dichloro-1,3,5-triazine)aminophthalo-cyanine(Zn-TDTAPc),was prepared and immobilized on poly(N-isopropylacrylamide)(PNIPAAm) by covalent bonding to obtain a thermosensitive polymer(Zn-TDTAPc-g-PNIPAAm).Compared with zinc tetraaminophthalocyanine(Zn-TAPc),Zn-TDTAPc-g-PNIPAAm exhibits excellent solubility in water and in most organic solvents.Furthermore,it has a special thermosensitive property in water and the lower critical solution temperature(LCST) is 34.1℃.It was found that both dissolved and precipitated Zn-TDTAPc-g-PNIPAAm present high photoactivity evidenced by the experiment of photocatalytic degra-dation of 1,3-diphenylisobenzofuran(DPBF) in the presence of Zn-TDTAPc-g-PNIPAAm.These proper-ties suggest that it can be used potentially in photodynamic therapy(PDT). | CHEN WenXing LIU Fan LU WangYang SHEN XiaoYuan YAO YuYuan XU MinHong | 2008 | Science China Chemistry2008，51，6： | 5 |
| 5 | Rice metabolic regulatory network spanning the entire life cycle显示文摘As one of the most important crops in the world,rice(Oryza sativa)is a model plant for metabolome research.Although many studies have focused on the analysis of specific tissues,the changes in metab-olite abundance across the entire life cycle have not yet been determined.In this study,combining both tar-geted and nontargeted metabolite profiling methods,a total of 825 annotated metabolites were quantified in rice samples from different tissues covering the entire life cycle.The contents of metabolites in different tissues of rice were significantly different,with various metabolites accumulating in the plumule and radicle during seed germination.Combining these data with transcriptome data obtained from the same time period,we constructed the Rice Metabolic Regulation Network.The metabolites and co-expressed genes were further divided into 12 clusters according to their accumulation patterns,with members within each cluster displaying a uniform and clear pattern of abundance across development.Using this dataset,we established a comprehensive metabolic profile of the rice life cycle and used two independent strategies to identify novel transcription factors-namely the use of known regulatory genes as bait to screen for new networks underlying lignin metabolism and the unbiased identification of new glycerophospholipid metabolism regulators on the basis of tissue specificity.This study thus demonstrates how guilt-by-association analysis of metabolome and transcriptome data spanning the entire life cycle in cereal crops provides novel resources and tools to aid in understanding the mechanisms underlying important agro-nomic traits. | Chenkun Yang Shuangqian Shen Shen Zhou Yufei Li Yuyuan Mao Junjie Zhou Yuheng Shi Longxu An Qianqian Zhou Wenju Peng Yuanyuan Lyu Xuemei Liu Wei Chen Shouchuang Wang Lianghuan Qu Xianqing Liu Alisdair R.Fernie Jie Luo | 2022 | Molecular Plant2022，15，2： | 3 |
| 6 | Mesoporous carbon-supported cobalt catalyst for selective oxidation of toluene and degradation of water contaminants显示文摘 | Yuan Zhuang Qisong Lin Li Zhang Lianshun Luo Yuyuan Yao Wangyang Lu Wenxing Chen | 2016 | Particuology2016，14，1： | 3 |
| 7 | Enhanced electrocatalytic oxidation of dyes in aqueous solution using cobalt phthalocyanine modified activated carbon fiber anode显示文摘Cobalt tetra(2,4-dichloro-1,3,5-triazine)aminophthalocyanine(CoPc)was immobilized covalently on activated carbon fiber(ACF)felt to obtain CoPc-modified ACF(CoPc-ACF)catalyst,and an electrocatalytic oxidation system using CoPc-ACF as the anode was constructed.The electrocatalytic oxidation of Acid Red 1(AR1)was investigated in aqueous solution by an UV-vis spectrophotometer and UPLC.The results indicated that AR1 could be eliminated efficiently in this electrocatalytic oxidation system.In addition,the results of FTIR,TOC and GC-MS suggested that the electrocatalytic oxidation experienced the decoloration achieved by destroying the azo linkage and the further mineralization due to the cleavages of benzene ring and naphthalene ring.The intermediates were mainly small molecular compounds such as maleic acid and succinic acid,etc.Repetitive tests showed that CoPc-ACF can maintain high electrocatalytic activity over several cycles.The further EPR spin-trap experiments indicated that the hydroxyl radicals did not dominate the reaction in this electrocatalytic system,which was completely different from the traditional electro-Fenton system.Based on the non-radical reaction mechanism,the CoPc-modified ACF electrocatalyst has potential application in treating actual dyestuffs wastewaters,which are accompanied with high concentration of hydroxyl radical scavengers such as chlorine ions and additives in the textile printing and dyeing industry. | LI Nan DONG SuSu LV WangYang HUANG SanQing CHEN HaiXiang YAO YuYuan CHEN WenXing | 2013 | Science China Chemistry2013，56，12： | 2 |
| 8 | Study on catalytic oxidation of planar binuclear copper phthalocyanine on 2-mercaptoethanol显示文摘Mononuclear copper phthalocyanine (CuPc) and binuclear copper phthalocyanine (Cu2Pc2) were synthesized by the phenylanhydride-urea route, and their catalytic oxidation activity on 2-mercaptoethanol was studied. Based on the experimental results, a catalytic mechanism of Cu2Pc2 on 2-mercaptoethanol has been proposed. Furthermore, the effects of pH, Cu2Pc2 concentration, and temperature on the catalytic oxidation activity were evaluated. The results showed that CuPc has no catalytic activity, while Cu2Pc2 has high catalytic oxidation activity towards 2-mercaptoethanol with the optimal activity at pH 11. The reaction can further be enhanced by increasing Cu2Pc2 concentration and temperature, due to its endothermic characteristics. | CHEN Wenxing, WEI Lili, WANG Jinqian, YAO Yuyuan, Lü Shenshui & CHEN Shiliang Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, Zhejiang Sci-Tech Univer- sity, Hangzhou 310018, China | 2006 | Science China Chemistry2006，49，6： | 2 |
| 9 | Glucose metabolism controls humanγδ-cell-mediated tumor immunosurveillance in diabetes显示文摘Patients with type 2 diabetes mellitus(T2DM)have an increased risk of cancer.The effect of glucose metabolism onγδT cells and their impact on tumor surveillance remain unknown.Here,we showed that high glucose induced Warburg effect type of bioenergetic profle in Vy9vδ2 T cells,leading to excessive lactate accumulation,which further inhibited lytic granule secretion by impairing the traffcking of cytolytic machinery to the Vy9vδ2 T-cell-tumor synapse by suppressing AMPK activation and resulted in the loss of antitumor activity in vitro,in vivo and in patients.Strikingly,activating the AMPK pathway through glucose control or metformin treatment reversed the metabolic abnormalities and restored the antitumor activity of Vy9vδ2 T cells.These results suggest that the impaired antitumor activity of Vy9vδ2 T cells induced by dysregulated glucose metabolism may contribute to the increased cancer risk in T2DM patients and that metabolic reprogramming by targeting the AMPK pathway with metformin may improve tumor immunosurveillance. | Xiaofeng Mu Zheng Xiang Yan Xu Jing He Jianwen Lu Yuyuan Chen Xiwei Wang Chloe Ran Tu Yanme Wenyue Zhang Zhinan Yin Wing-hang Leung Yu-Lung Lau Yinping Liu Wenwei Tu | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 10 | The bacterial abundance and production in the East China Sea: seasonal variations and relationships with the phytoplankton biomass and production显示文摘The East China Sea is a productive marginal sea with a wide continental shelf and plays an important role in absorbing atmospheric carbon dioxide and transferring terrigenous organic matter to the open ocean. To investigate the roles of heterotrophic bacteria in the biogeochemical dynamics in the East China Sea, bacterial biomasses(BB) and productions(BP) were measured in four cruises. The spatial distributions of the BB and the BP were highly season-dependent. Affected by the Changjiang River discharge, the BB and the BP were high in shelf waters(bottom depth not deeper than 50 m) and generally decreased offshore in August 2009. In December 2009 to January 2010, and November to December 2010, the BB and the BP were high in waters with medium bottom depth. The onshore-offshore decreasing trends of the BB and the BP also existed in May–June 2011, when the BB was significantly higher than in other cruises in shelf break waters(bottom depth deeper than 50 m but not deeper than 200 m). The results of generalized additive models(GAM) suggest that the BB increased with the temperature at a range of 8-20°C, increased with the chlorophyll concentration at a range of 0.02–3.00 mg/m3 and then declining, and decreased with the salinity from 28 to 35. The relationship between the temperature and the log-transformed bacterial specific growth rate(SGR) was linear. The estimated temperature coefficient(Q10) of the SGR was similar with that of the phytoplankton growth. The SGR also increased with the chlorophyll concentration. The ratio of the bacterial to phytoplankton production ranged from less than 0.01 to 0.40, being significantly higher in November–December 2010 than in May–June 2011. Calculated from the bacterial production and growth efficiency, the bacterial respiration consumed, on average, 59%, 72% and 23% of the primary production in August 2009, November–December 2010, and May–June 2011, respectively. | CHEN Bingzhang HUANG Bangqin XIE Yuyuan GUO Cui SONG Shuqun LI Hongbo LIU Hongbin | 2014 | Acta Oceanologica Sinica2014，33，9： | 2 |
| 11 | Application of extracorporeal membrane oxygenation in the endoscopic treatment of severe benign airway stenosis:A case report and literature review显示文摘Ventilation strategies in patients with severe tracheal stenosis should be tailored to the patient according to the underlying cause and narrowing location.This report is on a case of a 68-year-old male patient,who was admitted for radiotherapy because of esophageal cancer and then developed severe stenosis at the cervical trachea.We used venovenous extracorporeal membrane oxygenation to secure the airway and ensure adequate oxygenation.Then urgent endoscopic balloon dilation of airway stenosis was successfully performed under general anesthesia.This case shows that venovenous extracorporeal membrane oxygenation can be used in endoscopic tracheal procedures for patients with severe benign stenosis in the upper-trachea who are unable to tolerate conventional ventilation. | Yuyuan Liang Jihong Zhu Xing Zheng Qing Qiao Yaolin Guan Jisong Zhang Enguo Chen | 2021 | Laparoscopic, Endoscopic and Robotic Surgery2021，4，2： | 2 |
| 12 | Compounds from Kadsura ananosma显示文摘 | Chen Yegao Xie Yuyuan Cheng Kinfai | 2001 | Phytochemstry2001，58，： | 1 |
| 13 | Highly efficient decomposition of organic dyes by aqueous-fiber phase transfer and in situ catalytic oxidation using fiber supported cobalt phthaloc- yanine显示文摘 | CHEN Wenxing LU Wangyang YAO Yuyuan | 2007 | Environmental Science and Technology2007，41，17： | 1 |
| 14 | Direct displacement-based design for seismic retrofit of existing buildings using nonlinear viscous dampers 显示文摘 | LIN Yuyuan CHANG Kuochun CHEN Changyu | | Bull Earthquake Engineering0，6，： | 1 |
| 15 | Preparation and photocatalytic performance of anatase/rutilemixed-phase Ti O2nanotubes显示文摘 | ZHANG Yuyuan CHEN Jinzhu LI Xinjun | 2010 | Catalysis Letters2010，139，34： | 1 |
| 16 | The characteristics of soil water cycle and water bal- ance on steep grassland under natural and simulated rainfall conditions in the Loess Plateau of China 显示文摘 | Chen Hongsong Shao Mingan Li Yuyuan | 2008 | Hydrology2008，360，12： | 1 |
| 17 | Soil desiccation in the Loess Plateau of China Original Research Article显示文摘 | Chen Hongsong Shao Mingan Li Yuyuan | 2008 | Geoderma2008，143，： | 1 |
| 18 | A secure data hiding scheme for two-color images显示文摘 | Chen Yuyuan Pan Hsiangkuang Tseng Yuchee | 2002 | IEEE Transactions on Communications2002，50，8： | 1 |
| 19 | Dammarane-type glycosides from Gynostemma pentaphyllum显示文摘 | Hu Lihong Chen Zhongliang Xie Yuyuan | 1997 | Phytochemistry1997，44，4： | 1 |
| 20 | Preparation and Photocatalytic Performance of Anatase/Rutile Mixed-Phase TiO 2 Nanotubes显示文摘 | Yuyuan Zhang Jinzhu Chen Xinjun Li | 2010 | Catalysis Letters2010，，3： | 1 |
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