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| 1 | Comparative Analysis of Nutrient Composition of Caulerpa lentillifera from Different Regions显示文摘This study investigated the difference of nutrient composition in Caulerpa lentillifera collected from different regions.The nutrient compositions of C.lentillifera from China's Hainan and Shandong provinces were determined and compared with those from Semporna(Malaysia),Sabah(Malaysia),Petchburi(Thailand),and two other species of seaweeds(Malaysia).The results showed that the polysaccharide and protein contents of C.lentillifera from Hainan(44.82%±0.98%and 12.5%±0.70%),Shandong(43.22%±1.42%and 14.7%±0.72%),Petchburi(59.27%±2.31%and 12.49%±0.30%),and Sabah(44.02%±2.01%and 19.38%±1.48%)were higher than those of Eucheuma cottonii(26.49%±3.01%and 9.76%±1.33%)and Sargassum polycystum(33.49%±1.70%and 5.40%±0.07%),respectively.The polyunsaturated fatty acid contents in C.lentillifera from Hainan(29.98%)and Shandong(22.11%)were higher than that in Semporna(16.76%±0.27%),Sabah(9.49%),and S.polycystum(20.34%±0.43%),but lower than that in E.cottonii(51.55%±0.57%).In Caulerpa lentillifera of Hainan and Shandong provinces,the essential amino acid(EAA)/total amino acid(TAA)ratios were 35.22%and 38.78%,respectively;and the EAA/ETAA ratios were 54.36%and 63.35%,respectively.The EAA composition of C.lentillifera was close to the ideal model of Food and Agriculture Organization/World Health Organization.C.lentillifera was rich in mineral elements,including calcium((3315.85±127.55)mg(100 g)^-1 and(3728.35±92.38)mg(100 g)^-1),magnesium((6715.74±82.58)mg(100 g)^-1 and(8128.59±242.72)mg(100 g)^-1),and trace elements,including iron((510.65±5.47)mg(100 g)^-1 and(1972.97±183.35)mg(100 g)^-1),selenium((1.04±0.08)mg(100 g)^-1 and(0.83±0.15)mg(100 g)^-1),and zinc((33.90±0.13)mg(100 g)^-1 and(11.75±2.05)mg(100 g)^-1).These results showed that C.lentillifera was more nutritious than S.polycystum or E.cottonii in terms of polysaccharide,protein,and fatty acid contents.Furthermore,both C.lentillifera species collected from Hainan and Shandong provinces show more basic nutrients.Therefore,C.lentillifera has important development and application prospects. | ZHANG Meijian MA Yurong CHE Xinyi HUANG Zumei CHEN Peng XIA Guanghua ZHAO Meihui | 2020 | Journal of Ocean University of China2020，19，2： | 8 |
| 2 | Blown sand motion within the sand-control system in the southern section of the Taklimakan Desert Highway显示文摘Although scientists have performed many studies in the Taklimakan Desert, few of them have reported the blown sand motion along the southern edge of the Taklimakan Desert Highway, which differs significantly from the northern region in terms of aeolian sand geomorphology and formation environment. Based on the field observation data of airflow and aeolian sand transport, continuous monitoring data of erosional and depositional processes between 14 April 2009 and 9 April 2011 and data of surface sand grains from the classical section along the southern edge of the Taklimakan Desert Highway, this paper reported the blown sand motion within the sand-control system of the highway. The main results are as follows: 1) The existing sand-control system is highly effective in preventing and controlling desertification. Wind velocities within the sand-control system were approximately 33%–100% of those for the same height above the mobile sand surface. Aeolian sand fluxes were approximately 0–31.21% of those of the mobile sand surface. Sand grains inside the system, with a mean diameter of 2.89 φ, were finer than those(2.15 φ) outside the system. In addition, wind velocities basically followed a logarithmic law, but the airflow along the classical section was mainly determined by topography and vegetation. 2) There were obvious erosional and depositional phenomena above the surface within the sand-control system, and these phenomena have very consistent patterns for all observation points in the two observed years. The total thicknesses of erosion and deposition ranged from 0.30 to 14.60 cm, with a mean value of 3.67 cm. In contrast, the deposition thicknesses were 1.90–22.10 cm, with a mean value of 7.59 cm, and the erosion thicknesses were 3.51–15.10 cm, with a mean value of 8.75 cm. The results will aid our understanding of blown sand within the sand-control system and provide a strong foundation for optimizing the sand-control system. | CHENG Hong HE Jiajia XU Xingri ZOU Xueyong WU Yongqiu LIU Chenchen DONG Yifan PAN Meihui WANG Yanzai ZHANG Hongyan | 2015 | Journal of Arid Land2015，7，5： | 8 |
| 3 | Patterning catalyst via inkjet printing to grow single-walled carbon nanotubes显示文摘Controlled growth of patterned single-walled carbon nanotubes (SWNTs) is an important issue in many applications. Herein, we demonstrated a method to pattern catalyst via inkjet printing for the growth of SWNTs, using metal salt solutions as the inks and an ordinary office-use printer. We printed water solutions of cobalt acetate on hydrophilic Si substrates and grew high quality SWNT films. The composition of the precursor solutions and the hydrophilicity of the substrates were crucial factors to the patterning. | Zeyao Zhang Yitan Li Sheng Zhu Xiyan Liu Xiulan Zhao Meihui Li Haoyu Li Feng Yang Yan Li | 2019 | Chinese Chemical Letters2019，30，2： | 3 |
| 4 | Channel Mismatches Correction in Time-Interleaved ADCs Based on Hybrid Filter Bank Reconstruction显示文摘Time-interleaved analog-to-digital converter(TIADC) is an efficient way to achieve higher sampling rate for medium-to-high resolution applications. The performance of a TIADC suffers from the mismatch errors among the sub-channels. This paper presents a method to estimate the channel mismatches using the sub-channels output data. The proposed method introduces an equivalent transfer function for each channel to model and estimate the mismatch errors. A Hybrid filter bank(HFB)structure is used to both model the TIADC and reconstruct the desired uniformly sampled sequence based on the perfect reconstruction conditions of the HFB system.A four-channel 12-bit 400 MHz TIADC has been implemented in hardware to verify the proposed calibration method. The measured results show that the Spuriousfree dynamic range(SFDR) can be improved up to 74 d B after being corrected with 64-tap Finite-impulse response(FIR) filters. | LIU Sujuan ZHUO Li JIANG Wenshu ZHANG Meihui | 2014 | Chinese Journal of Electronics2014，23，1： | 2 |
| 5 | A micro-nano optogenetic system based on probiotics for in situ host metabolism regulation显示文摘Genetically engineered bacteria have aroused attention as micro-nano drug delivery systems in situ.However,conventional designs of engineered bacteria usually function constantly or autonomously,which might be non-specific or imprecise.Therefore,designing and optimizing in situ control strategy are important methodological progress for therapeutic researches of intestinal engineered bacteria.Here,a micro-nano optogenetic system based on probiotic was developed combining microelectronics,nanotechnology,and synthetic biology to achieve in situ controllable drug delivery.Firstly,optogenetic engineered Lactococcus lactis was orally administrated in the intestinal tract.A wearable optical device was designed to control optical signals remotely.Then,L.lactis could be customized to secrete peptides according to optical signals.As an example,optogenetic L.lactis system can be constructed to secrete glucagon-like peptide-1(GLP-1)under the control of the wearable optical device to regulate metabolism.To improve the half-life of GLP-1 in vivo,Fc-domain fused GLP-1 was optimally used.Using this strategy,blood glucose,weight,and other features were well controlled in rats and mice models.Furthermore,upconversion microcapsules were introduced to increase the excitation wavelength of the optogenetic system for better penetrability.This strategy has biomedical potential to expand the toolbox for intestinal engineered bacteria. | Xinyu Zhang Ning Ma Wei Ling Gaoju Pang Tao Sun Jing Liu Huizhuo Pan Meihui Cui Chunli Han Chun Yang Jin Chang Xian Huang Hanjie Wang | 2023 | Nano Research2023，16，2： | 2 |
| 6 | Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as Potential Antitumor Agents显示文摘 | HU Hao JIANG Mingyan XIE Lijun HU Gang ZHANG Cuirong ZHANG Lixia ZHOU Shunguang ZHANG Meihui GONG Ping | 2015 | Chemical Research in Chinese Universities2015，31，5： | 1 |
| 7 | RESEARCH ON DIVERSIFIED FINANCIAL DISPUTE RESOLUTION MECHANISMS IN CHINA显示文摘在在 2008 的 US Lehman 微型契约危机以后,全球国家一直在探索金融消费者保护立法。这篇论文主要集中于瓷器当前的金融机制的现状和问题,以及怎么构造一个金融争论决定系统和金融搜集意见的人系统(FOS ) ,怎么采用调停,仲裁和处理金融争论的另外的各种各样的争论决定机制。 | Dong Yang Lei Liu Meihui Zhang | 2012 | Frontiers of Law in China-Selected Publications from Chinese Universities2012，7，4： | 1 |
| 8 | Sarcaglarols A-D, Lindenane-Monoterpene Heterodimers from Sarcandra glabra Based on Molecular Networks显示文摘Sarcaglarols A-D(1-4),two pairs of lindenane-monoterpene heterodimers fused by a 1,2-dioxane moiety,were discovered and isolated from the leaves of Sarcandra glabra guided by MS/MS molecular networking-based strategy.Their planar structures,absolute configurations of basic skeleton and flexible polyhydric side chain were established by analysis of HRESIMS,NMR spectroscopic data,ECD spectrum,and the X-ray diffraction study of isopropylidene derivatives.An intermolecular[2+2+2]cycloaddition may play a key role in the biosynthesis pathway of the 1,2-dioxane moiety fused lindenane-monoterpene heterodimer skeleton,which can be recognized as the biogenetic precursors of our previous reported lindenane-normonoterpene conjugates.In addition,compounds 1,3 and 4 exhibited moderate inhibitory effects of lipid accumulation in free fatty acid-exposed L02 cells. | Yongyue Wang Zhirong Cui Jun Chi Pengfei Tang Meihui Zhang Jixin Li Yongyi Li Hao Zhang Jun Luo Lingyi Kong | 2021 | Chinese Journal of Chemistry2021，39，1： | 1 |
| 9 | On multicolumn foreign key discovery显示文摘 | Zhang Meihui Hadjieleftheriou M Ooi B C | 2010 | Proceedings of the VLDB Endowment2010，3，1： | 1 |
| 10 | Organochlorine pesticides (OCPs) in soils of the coastal areas along Sanduao Bay and Xinghua Bay, southeast China显示文摘 | Jiaquan Zhang Xinli Xing Shihua Qi Lingzhi Tan Dan Yang Wei Chen Junhua Yang Meihui Xu | 2012 | Journal of Geochemical Exploration2012，，： | 1 |
| 11 | Organochlorine pesticides (OCPs) in soils of the coastal areas along Sanduao Bay and Xinghua Bay, southeast China显示文摘 | Jiaquan Zhang Xinli Xing Shihua Qi Lingzhi Tan Dan Yang Wei Chen Junhua Yang Meihui Xu | 2012 | Journal of Geochemical Exploration2012，，： | 1 |
| 12 | Material patterning on substrates by manipulation of fluidic behavior显示文摘Patterned materials on substrates are of great importance for a wide variety of applications.In solution-based approaches to material patterning;fluidic flow is inevitable.Here we demonstrate not only the importance of fluidic behavior but also the methodology of engineering the flow pattern to guide the material crystallization and assembly.We show by both experiment and simulation that substrate heating;which is generally used to accelerate evaporation,produces irregular complex vortexes.Instead;a top-heating-bottom-cooling(THBC)set-up offers an inverse temperature gradient and results in a single Marangoni vortex,which is desired for ordered nanomaterial patterning near the contact line.We then realize the fabrication of large-scale patterns of iodide perovskite crystals on different substrates under THBC conditions.We further demonstrate that harnessing the flow behavior is a general strategy with great feasibility to pattern various functional materials ranging from inorganic;organic,hybrid to biological categories on different substrates,presenting great potential for practical applications. | Yitan Li Hao Wang Henglu Xu Shiting Wu Xuemei Li Jiapeng Yu Chaoyu Huang Zeyao Zhang Hao Sun Lu Han Meihui Li Anyuan Cao Zhenhai Pan Yan Li | 2019 | National Science Review2019，6，4： | 0 |
| 13 | An investigation of long-term outcome of rabbit anti-thymocyte globulin and cyclosporine therapy for pediatric severe aplastic anemia显示文摘Children with severe aplastic anemia(SAA)face heterogeneous prognoses after immunosuppressive therapy(IST).There are few models that can predict the long-term outcomes of IST for these patients.The objective of this paper is to develop a more effective prediction model for SAA prognosis based on clinical electronic medical records from 203 children with newly diagnosed SAA.In the early stage,a novel model for long-term outcomes of SAA patients with IST was developed using machine-learning techniques.Among the indicators related to long-term efficacy,white blood cell count,lymphocyte count,absolute reticulocyte count,lymphocyte ratio in bone-marrow smears,C-reactive protein,and the level of IL-6,IL-8 and vitamin B12 in the early stage are strongly correlated with long-term efficacy(P<.05).Taken together,we analyzed the long-term outcomes of rabbit antithymocyte globulin and cyclosporine therapy for children with SAA through machine-learning techniques,which may shorten the observation period of therapeutic effects and reduce treatment costs and time. | Lixian Chang Mingchen Yan Jingliao Zhang Binghang Liu Li Zhang Ye Guo Jing Sun Yang Wan Meihui Yi Yang Lan Yuli Cai Yuanyuan Ren Haihui Zheng Aoli Zhang Zhenyu Li Jian Wang Yingrui Li Xiaofan Zhu | 2023 | Blood Science2023，5，3： | 0 |
| 14 | Three-dimensional quantication of protoporphyrin IX in photodynamic therapy using SFDI/DFT:A pilot experimental validation显示文摘Photodynamic therapy(PDT)dosimetry,induding light dose,photosensitizer dose and tissue oxygen,has been a research focus in PDT.In this work,we present a three-dimensional(3D)quantification of protoporphyrin X(PpIX)using combined spatial frequency domain imaging(SFDI)and diffuse fuorescence tomography(DFT).The SFDI maps both the distributions of tissue absorption and scattering properties at three wavelengths and accordingly provides the optical background for DFT and extracts the tissue oxygenation for assessing the therapeutic outcomes,while DFT dynamically monitors the 3D distribution of PpEX dose from measured fluorescence signals for the procedure optimization.A pilot in vrivo application in tumor nude models showed that the proposed SFDI/DFT is able to dynamically trace changes in the PpX concentration and tissue oaxygen during the treatment,rendering it a potentially powerful tool for PDT to improve clinical eficacy. | Mai Dan Weijie Song Meihui Liu Yaru Zhang Feng Gao | 2022 | Journal of Innovative Optical Health Sciences2022，15，6： | 0 |
| 15 | Study on the Action Mechanism of Isodon suzhouensis Stems in the Treatment of Prostate Cancer Based on UPLC-Q-TOF-MS/MS Combined with Network Pharmacology and Molecular Docking显示文摘[Objectives]This study was conducted to explore the action mechanism of chemical components from stems of Isodon suzhouensis on prostate cancer based on UPLC-Q-TOF-MS/MS technique,network pharmacology,and molecular docking validation.[Methods]UPLC-Q-TOF-MS/MS was applied to search active components in stems of I.suzhouensis,and SwissTargetPrediction and PharmaMapper databases were used to predict their potential targets.The GeneCards database was adopted to screen the targets of prostate cancer,and the targets of the active components and the targets of prostate cancer were intersected to obtain common targets.A protein-protein interaction network was constructed,and also,an'active component-target-disease-pathway'network was constructed using Metascape for gene ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.Moreover,AutoDock was adopted to perform molecular docking verification on key active components and core targets.[Results]Sixty three active components were screened from stems of I.suzhouensis,and they had 233 common targets with prostate cancer,mainly involving biological processes such as protein phosphorylation,response to hormones,active regulation of cell movement,cell response to lipids,and response to oxidative stress,as well as pathways in cancer,prostate cancer,micro ribonucleic acids in cancer,p53 signaling pathway,NF-κB signaling pathway and other signaling pathways,exerting anti-tumor effects.Molecular docking showed that the top 5 key active components had good binding ability with the top 5 core targets.[Conclusions]Active components from stems of I.suzhouensis can exert therapeutic effects on prostate cancer through multiple targets and pathways. | Peigui LIU Weiqing ZHANG Xianji LIU Meihui DUAN Weixian YANG Meiqi WEI | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 16 | Production of XX neo-male mandarin fish, Siniperca chuatsi, after sexual differentiation by oral administration of 17α-methyltestosterone显示文摘A well-known fact about mandarin fish(Siniperca chuatsi)is that females grow faster than males.Mandarin fish that have all-female populations have economic advantages,but traditional neo-male fish are difficult to produce.In this study,indirect feeding of 500 mg/kg 17α-methyltestosterone(MT)to XX mandarin fish(60 dpf,days post fertilization)with completely differentiated ovaries induced secondary sex reversal.At 40 days after MT treatment,14.7%of mandarin fish with complete reversal was produced,which showed for the first time that XX mandarin fishes with differentiated ovaries still have potentially bisexual germ cells and the plasticity of sex reversal.In the MT treatment group,there was no significant difference in survival compared to the control group.The body weight of the MT treatment group was significantly lower than that of the control group 40 days after treatment(dat)(P<0.05).During MT treatment,serum 11-KT and T concentrations increased and serum E2 concentration decreased in the MT treatment group,but there was no significant difference in hormone levels between the MT treatment group and the control group.A masculinization of mandarin fish was also confirmed by the expression patterns of sex-specific genes sox9,dmrt1,cyp19a1a and foxl2.A significant amount of sox9 and dmrt1 was expressed in the fish gonads of the MT treatment group,whereas cyp19a1a and foxl2 were minimally expressed in the fish gonads. | Jingjun Huang Shiyan Liu Haofeng Ouyang Chong Han Meihui Li Linqiang Han Shuisheng Li Guifeng Li Haoran Lin Yong Zhang | 2023 | Water Biology and Security2023，2，1： | 0 |
| 17 | Detecting SARS-CoV-2 BA.2,BA.4,and BA.5 Variants Utilizing a Robust RT-RPA-CRISPR/Cas12a-Based Method-China,2023显示文摘Introduction:Since 2019,numerous variants of concern for severe acute respiratory syndrome virus 2(SARS-CoV-2)have emerged,leading to significant outbreaks.The development of novel,highly accurate,and rapid detection techniques for these new SARSCoV-2 variants remains a primary focus in the ongoing efforts to control and prevent the coronavirus disease 2019(COVID-19)pandemic.Methods:Reverse transcription-recombinase polymerase amplification combined with the clustered regularly interspaced short palindromic repeatsassociated protein 12a(CRISPR/Cas12a)system was used to validate the detection of the Omicron BA.2,BA.4,and BA.5 variants of SARS-CoV-2.Results:Our results demonstrate that the CRISPR/Cas12a assay is capable of effectively detecting the SARS-CoV-2 BA.2,BA.4,and BA.5 variants with a limit of detection of 10,1,and 10 copies/μL,respectively.Importantly,our assay successfully differentiated the three SARS-CoV-2 Omicron strains from one another.Additionally,we evaluated 46 SARS-CoV-2 positive clinical samples consisting of BA.2(n=20),BA.4(n=6),and BA.5(n=20)variants,and the sensitivity of our assay ranged from 90%to 100%,while the specificity was 100%.Discussion:This research presents a swift and reliable CRISPR-based method that may be employed to track the emergence of novel SARS-CoV-2 variants. | Meihui Luo Yang Pan Yaqing He Ruhan A Changcheng Wu Baoying Huang Roujian Lu Li Zhao Bo Peng Fei Ye Huijuan Wang Yuda Chen Zhen Li Daitao Zhang Wenling Wang Wenjie Tan | 2023 | China CDC weekly2023，5，26： | 0 |
| 18 | Structure and optical characterization of GaP-SiO_2 co-sputtered films显示文摘The films of GaP nanocrystals embedded in SiO2 matrix were prepared by radio frequency magnetron co-sputtering and subsequent anneal- ing technology. The structure and morphology of the films were investigated by scanning electron microscope, X-ray diffraction, and energy dispersive spectrum. Raman spectra results showed that the transverse optical phonon model (TO) and the longitudinal optical phonon model (LO) of GaP nanocrystals were both discovered to undergo red shift, broadening, and asymmetry. The red shift degree of the TO model was about 8.8 cm-1. The luminescence spectrum of the GaP/SiO2 film consisted of several emission peaks. 2.84-2.54 eV blue light emission was explained by the quantum confinement-luminescence centers model (QC-LCs). | CHAI Yuesheng YANG Meihui ZHANG Mingang SUN Gang | 2008 | Rare Metals2008，27，6： | 0 |
| 19 | Au nanoparticles based ultra-fast “Turn-On” fluorescent sensor for detection of biothiols and its application in living cell imaging显示文摘Au or other metal nanostructures have the ability to strongly quench the fluorescence of fluorophores.This feature has made AuNP-conjugates attractive for the construction of platforms for various bioanalytes to overcome the limitations of small molecule fluorophores(poor solubility,long reaction time).In this paper,an ultrafast'Turn-On'fluo rescent sensor for biothiols was constructed.The sensor is based on the fluorescent resonance energy transfer(FRET)effect between the fluorophore(PN)and AuNPs,which effectively quenches the fluorescence of the fluorophore.In the presence of thiols,PN is displaced and released from AuNP surfaces,and thus,the fluorescence is rapidly restored.The sensor features appreciable water solubility and ultrafast response time(a few seconds for Cys).In addition,it exhibits high selectivity and a detection limit as low as 12 nmol/L for Hcy.Moreover,the sensor presents good biocompatibility and has been successfully applied for imaging biothiols in living cells. | Hailiang Zhang Pengfei Xu Xintong Zhang Xiaozheng Cao Wenxiu Han Meihui Liu Xiaohui Liu Wenbin Zeng | 2020 | Chinese Chemical Letters2020，31，5： | 0 |
| 20 | Study on the Action Mechanism of Euphorbia peplus in the Treatment of Alzheimer s Disease Based on UPLC-Q-TOF-MS/MS Combined with Network Pharmacology and Molecular Docking显示文摘[Objectives]Based on UPLC-Q-TOF-MS/MS,network pharmacology and molecular docking techniques,the mechanism of Euphorbia peplus in the treatment of Alzheimer s disease(AD)was studied.[Methods]The UPLC-Q-TOF-MS/MS technique was used to rapidly analyze the chemical components of E.peplus.Active components and potential targets of E.peplus were retrieved from TCMSP and Swiss Target Prediction database,and AD targets were screened using GeneCards database.The targets of E.peplus in the treatment of AD were obtained.The PPI network was constructed using String platform,and the network topology of Cytoscape software was used to compute and screen key targets,and the GO and KEGG pathway enrichment analysis was carried out in Metascape database to construct the'component-target-pathway-disease'network.Molecular docking was used to predict the binding properties of active ingredients and targets.[Results]The results of UPLC-Q-TOF-MS/MS showed that 83 compounds were identified from E.peplus,including 19 terpenoids,10 phenolic acids and phenols,16 flavonoids,2 phenylpropanoids,4 coumarins,1 alkaloid,1 anthraquinone and 30 other compounds.The results of network pharmacological analysis showed that 82 active ingredients were screened,and 279 common targets were identified for the treatment of AD,among which the key targets were ALB(albumin),GAPDH(glyceraldehyde triphosphate dehydrogenase),TNF(tumor necrosis factor),AKT1(serine/threonine protein kinase 1),and IL6(interleukin-6).KEGG enrichment analysis showed that key signaling pathways include cancer pathways,lipid and atherosclerosis,Alzheimer s disease,insulin resistance,serotonergic synapses,calcium signaling pathway,cAMP signaling pathway and other signaling pathways.Molecular docking results showed that 14-deoxyandrographolide,dehydroandrographolide,licochalcone B,apigenin and naringenin may be the key components of E.peplus in the treatment of AD.[Conclusions]The results suggest that E.peplus can be used to treat Alzheimer s disease through multi-component,multi-target and multi-pathway. | Liping ZHANG Weiqing ZHANG Weixian YANG Meihui DUAN Meiqi WEI | 2023 | Agricultural Biotechnology2023，12，4： | 0 |
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