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| 1 | An improved trust region method for unconstrained optimization显示文摘In this paper,we propose an improved trust region method for solving unconstrained optimization problems.Different with traditional trust region methods,our algorithm does not resolve the subproblem within the trust region centered at the current iteration point,but within an improved one centered at some point located in the direction of the negative gradient,while the current iteration point is on the boundary set.We prove the global convergence properties of the new improved trust region algorithm and give the computational results which demonstrate the effectiveness of our algorithm. | ZHOU QingHua ZHANG YaRui XU FengXia GENG Yan SUN XiaoDian | 2013 | Science China Mathematics2013，56，2： | 5 |
| 2 | A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo显示文摘Laboratory research and pharmacoepidemiology provide support for metformin as a potential antitumor agent.However,the lack of a clear understanding of the indications of metformin limits its efficacy.Here,we performed a genome-wide CRISPR knockout negative screen to identify potential targets that might synergize with metformin.Next-generation sequencing of pooled genomic DNAs isolated from surviving cells after 18 days of metformin treatment(T18)compared to those of the untreated cells at day 0(T0)yielded candidate genes.Knockdown of a group of cyclin-dependent kinases(CDKs),including CDK1,CDK4,and CDK6,confirmed the results of the screen.Combination treatment of the CDKs inhibitor abemaciclib with metformin profoundly inhibited tumor viability in vitro and in vivo.Although cell cycle parameters were not further altered under the combination treatment,investigation of the metabolome revealed significant changes in cell metabolism,especially with regard to fatty acid oxidation,the tricarboxylic acid cycle and aspartate metabolism.Such changes appeared to be mediated through inhibition of the mTOR pathway.Collectively,our study suggests that the combination of CDKs inhibitor with metformin could be recognized as a potential therapy in future clinical applications. | Yarui Ma Qing Zhu Junbo Liang Yifei Li Mo Li Ying Zhang Xiaobing Wang Yixin Zeng Yuchen Jiao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 3 | AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma显示文摘Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma(HCC)in individuals infected with the hepatitis virus.However,the molecular pathways leading to its bioactivation and subsequent toxicity in hepatocytes have not been well-defined.Here,we carried out a genome-wide CRISPR-Cas9 genetic screen to identify aflatoxin B1(AFB1)targets.Among the most significant hits was the aryl hydrocarbon receptor(AHR),a ligand-binding transcription factor regulating cell metabolism,differentiation,and immunity. | Qing Zhu Yarui Ma Junbo Liang Zhewen Wei Mo Li Ying Zhang Mei Liu Huan He Chunfeng Qu Jianqiang Cai Xiaobing Wang Yixin Zeng Yuchen Jiao | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 4 | Correction: AHR mediates the Aflatoxin B1 toxicity associated with hepatocellular carcinoma显示文摘Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-021-00713-1 z published online 9 August 2021 After online publication of the article^(1),the authors noticed one inadvertent mistake occurred during the production process in Fig.7 that needs to be corrected.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected. | Qing Zhu Yarui Ma Junbo Liang Zhewen Wei Mo Li Ying Zhang Mei Liu Huan He Chunfeng Qu Jianqiang Cai Xiaobing Wang Yixin Zeng Yuchen Jiao | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 5 | Knockdown Wiskott-Aldrich syndrome protein family member 3(WASF3)inhibits colorectal cancer metastasis and sensitizes to cisplatin through targeting ZNF471显示文摘:Colorectal cancer(CRC)is a heterogeneous cancer,and many risk factors for colorectal cancer have been established.For CRC metastasis,tumor cell migration,adhesion as well as invasion are important processes.Wiskott-Aldrich syndrome protein family member 3(WASF3)is necessary for metastasis of various types of cancers.However,its role in CRC progression has not been fully elucidated.This study examined the in vitro functional roles of WASF3 in the CRC and explored the underlying molecular mechanisms.We used siRNA-WASF3 to gene silence WASF3 in colon cancer cell(HCT116)in vitro.The effects of WASF3 silencing on HCT116 cell apoptosis,proliferation,migration,as well as invasion were assessed by flow cytometry,CCK-8,and transwell assays.ZNF471 protein expressions were detected by immunofluorescence staining and RT-PCR.Moreover,the effects of ZNF471 were studied on a series of in vitro antitumor-promoting assays using HCT116.WASF3 knockdown expression using small interfering RNA(siRNA)ameliorated CRC cell proliferation,anchorage-independent growth,invasion,and metastasis.Furthermore,we observed that WASF3 contributed to upregulating the metastasis signaling pathway through inhibiting the expression of ZNF471.Our study suggests that targeting WASF3 signaling might be a novel therapeutic strategy for treating CRC. | ZHIYONG ZHANG YAN PAN YAN ZHAO MUDAN REN YARUI LI YUN FENG GUIFANG LU SHUIXIANG HE | 2022 | BIOCELL2022，46，8： | 0 |
| 6 | Synergistic effects of plant hormones on spontaneous late-ripening mutant of'Jinghong'peach detected by transcriptome analysis显示文摘Objectives:Peach(Prunus persica L.)is an ancient fruit tree that originated from China.It is the climacteric fruit belonging to genus Prunus in family Rosaceae.Ethylene,which is produced during ripening,accelerates fruit softening,and therefore peaches cannot be stored for a long time.Materials and Methods:To study the mechanism of fruit late ripening,transcriptome analysis of the fruit of a late-ripening mutant of'Jinghong'peach was performed to identify genes and pathways involved in fruit late ripening.Results:A total of 1805,1511,and 2309 genes were found to be differentially expressed in W2_vs_M1,W3_vs_M2,and W3_vs_M3,respectively.Functional enrichment analysis of the differentially expressed genes showed they were related to carotenoid biosynthesis,starch and sucrose metabolism plant hormone signal transduction,flavonoid biosynthesis,and photosynthesis.The expression trends of ripening-related genes that encode transcription factors and plant hormone signal transduction-related genes that encode enzymes were similar.Conclusions:It will help to elucidate the transcriptional regulatory network of fruit development in the spontaneous late-ripening mutant of‘Jinghong’peach and provide a theoretical basis for understanding the molecular regulatory mechanism of fruit ripening. | Man Zhang Tingting Du Yarui Yin Hongyan Cao Zhihua Song Mao Ye Yating Liu Yanhong Shen Libin Zhang Qing Yang Dong Meng Junkai Wu | 2022 | Food Quality and Safety2022，6，1： | 0 |
| 7 | Quaternary Stratigraphic Division and Paleoenvironmental Evolution Observed from Core LZK1 on Hengsha Island, Shanghai显示文摘The Quaternary sediments in the Yangtze delta are loose and lack precise stratification marks in the lithology. Moreover, due to the limitations of dating methods, it is difficult for Quaternary cores to deliver accurate age constraints. Thus, it is a challenge to establish the Quaternary stratigraphic framework. Gravity core LZK1 was drilled on Hengsha Island, Shanghai, in the Yangtze delta, in 2012. The core was terminated at 403.83 m below the local land surface, the uppermost 291.2 m comprising a thick sequence of Quaternary sediments. This study investigated the stratigraphic subdivision and paleoenvironmental change of the Quaternary sediments. From bottom to top, the Quaternary stratigraphic sequence can be subdivided into the lower Pleistocene Anting Formation, Middle Pleistocene Jiading Formation, Upper Pleistocene Chuansha Formation and Nanhui Formation, Holocene Loutang Formation, Shanghai Formation, and Rudong Formation. According to this study, the Hengsha Island area was dominated by a freshwater lacustrine environment during the early Pleistocene, an alternation of shallow lake and shore lake environment during the Middle Pleistocene, a delta plain to lagoonal environment during the early Upper Pleistocene, a fluvial channel to floodplain environment from the LGM(Last Glacial Maximum) to the end of the Upper Pleistocene, and a delta environment during the Holocene. | KE Xue XIE Jianlei ZHANG Zongyan ZOU Yarui WANG Guoquan | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 0 |
| 8 | GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma显示文摘Treating patients with esophageal squamous cell carcinoma(ESCC)is challenging due to the high chemoresistance.Growth differentiation factor 15(GDF15)is crucial in the development of various types of tumors and negatively related to the prognosis of ESCC patients according to our previous research.In this study,the link between GDF15 and chemotherapy resistance in ESCC was further explored.The relationship between GDF15 and the chemotherapy response was investigated through in vitro and in vivo studies.ESCC patients with high levels of GDF15 expression showed an inferior chemotherapeutic response.GDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation via TGFBR2.Through an in vivo study,we further validated that the anti-GDF15 antibody improved the tumor inhibition effect of cisplatin.Metabolomics showed that GDF15 could alter cellular metabolism and enhance the expression of UGT1A.AKT and TGFBR2 inhibition resulted in the reversal of the GDF15-induced expression of UGT1A,indicating that TGFBR2-AKT pathway-dependent metabolic pathways were involved in the resistance of ESCC cells to cisplatin.The present investigation suggests that a high level of GDF15 expression leads to ESCC chemoresistance and that GDF15 can be targeted during chemotherapy,resulting in beneficial therapeutic outcomes. | Yingxi Du Yarui Ma Qing Zhu Yong Fu Yutong Li Ying Zhang Mo Li Feiyue Feng Peng Yuan Xiaobing Wang | 2023 | Frontiers of Medicine2023，17，1： | 0 |
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