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| 1 | Copper ions influence the toxicity of β-amyloid(1-42) in a concen-tration-dependent manner in a Caenorhabditis elegans model of Alzheimer’s disease显示文摘β-amyloid (Aβ) and copper play important roles in the pathogenesis of Alzheimer’s disease (AD).However,the behavioral correlativity and molecular mechanisms of Aβ and copper toxicity have been investigated less often.In the present study,we investigated the interaction and toxicity of Aβ1-42 and copper in the Aβ1-42 transgenic Caenorhabditis elegans worm model CL2006.Our data show that the paralysis behavior of CL2006 worms significantly deteriorated after exposure to 10-3 mol L-1 copper ions.However,the paralysis behavior was dramatically attenuated with exposure to 10-4 mol L-1 copper ions.The exogenous copper treatment also partially changed the homeostatic balance of zinc,manganese,and iron.Our data suggest that the accumulation of reactive oxygen species (ROS) was responsible for the paralysis induced by Aβ and copper in CL2006.The ROS generation induced by Aβ and copper appear to be through sod-1,prdx-2,skn-1,hsp-60 and hsp-16.2 genes. | LUO YunFeng ZHANG Jie LIU NianQing LUO Yuan ZHAO BaoLu | 2011 | Science China(Life Sciences)2011，54，6： | 26 |
| 2 | Antioxidant effects of green tea polyphenols显示文摘The unprecedented interest in the antioxidant activity of green tea polyphenols (GTP) is due to the appar-ent health benefits of tea drinking and the experimental re-sults with the polyphenols. The results suggest that the gal-loylated catechins show stronger antioxidant effect than that of nongalloylated catechins and the double bond in C ring also plays an important role in this effect. There are synergic effects between different catechins and the antioxidant effect of (+)-epimers is stronger than that of (-)-epimers. The active site to scavenge free radicals mainly locates in p-hydroxyl of phenol in gallic acid and hydroxyl of phenol in the pyrane also shows activity. The large p bond in chromane and benzene ring of catechin is the structure base for their anti-oxidant effects. The prevent effect of GTP against diseases and their redox regulation in cell signal pathway are very important to be studied in the future. | ZHAO Baolu Laboratory of Visual Information Processing, Research Centers of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China | 2003 | Chinese Science Bulletin2003，48，4： | 16 |
| 3 | Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors显示文摘Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the anti-obesity mechanisms of green tea catechins (GTCs) through modulation of peroxisome proliferator activated-receptor (PPAR) pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels. Meanwhile, GTCs increased the PPARγ levels in subcutaneous white adipose tissue (SWAT) and decreased the PPAR levels in visceral white adipose tissue (VWAT). In addition, GTC treatment up-regulated the levels of PPARδ in SWAT, VWAT, and brown adipose tissue and increased the expression of genes involved in fatty acid oxidation in brown adipose tissue. Our results suggest that GTCs exert their anti-obesity mechanism in part by modulating PPAR signaling pathways. | YAN JingQi ZHAO Yan ZHAO BaoLu | 2013 | Science China(Life Sciences)2013，56，9： | 8 |
| 4 | Effects of r-HuEPO on the biophysical characteristics of erythrocyte membrane in patients with anemia of chronic renal failure显示文摘Using electron spin resonance (ESR) spin labeling technique, we have studied the conformation of sulfhydryl groups(-SH) binding sites in membrane proteins and membrane fluidity of red blood cells (RBCs) from two groups of patients with anemia of chronic renal failure (ACRF). One of the groups is composed of patients who were untreated with recombinant human erythropoietin(r-HuEPO), and the other is composed of patients who were treated with r-HuEPO. The results indicated: 1) the conformation of SH group binding site in RBC membrane proteins from former group was different from those of health people. 2)the fluidity in the region near the surface of RBC membrane from former group was lower than those of healthy people. 3) However, the above biophysical properties of RBC membrane from later group were normal. We concluded that RBC membrane in patients with ACRF was abnormal, and the treatment of r-HuEPO may promote the production of normal RBCs, thus ameliorate the biophysical properties of RBCs from the patients with ACRF. | SHI HONGLIAN FAJUN YANG BAOLU ZHAO WENJUAN XIN(Institute of Biophysics, Academia Sinica, Beijing, China.) | 1994 | Cell Research1994，4，1： | 8 |
| 5 | L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway显示文摘In this study, the inhibitory effect of L-theanine, an amino acid derivative of tea, on the rewarding effects of nicotine and its underlying mechanisms of action were studied. We found that L-theanine inhibited the rewarding effects of nicotine in a con- ditioned place preference (CPP) model of the mouse and reduced the excitatory status induced by nicotine in SH-SY5Y cells to the same extent as the nicotine receptor inhibitor dihydro-beta-erythroidine (DH E). Further studies using high performance liquid chromatography, western blotting and immunofluorescence staining analyses showed that L-theanine significantly inhibited nicotine-induced tyrosine hydroxylase (TH) expression and dopamine production in the midbrain of mice. L-theanine treatment also reduced the upregulation of the 4, 2 and 7 nicotine acetylcholine receptor (nAChR) subunits induced by nico- tine in mouse brain regions that related to the dopamine reward pathway, thus decreasing the number of cells that could react to nicotine. In addition, L-theanine treatment inhibited nicotine-induced c-Fos expression in the reward circuit related areas of the mouse brain. Knockdown of c-Fos by siRNA inhibited the excitatory status of cells but not the upregulation of TH induced by nicotine in SH-SY5Y cells. Overall, the present study showed that L-theanine reduced the nicotine-induced reward effects via inhibition of the nAChR-dopamine reward pathway. These results may offer new therapeutic strategies for treatment of tobacco addiction. | DI XiaoJing YAN JingQi ZHAO Yan CHANG YanZhong ZHAO BaoLu | 2012 | Science China(Life Sciences)2012，55，12： | 6 |
| 6 | The neuroprotective effect of L-Theanine and its inhibition on nicotine dependence显示文摘The benefits of tea for human health are widely accepted all over the world.L-Theanine,a nonprotein amino acid found in tea plants,is the major tea component that contributes to the unique pleasing taste of tea.L-Theanine has been shown to promote relaxation,enhance cognitive performance and act antagonistically against the excitement induced by caffeine.Recently,it was found that L-Theanine had inhibitory effect on nicotine dependence.This paper reviews the neuroprotective properties of L-Theanine and discusses the inhibitory effects of L-Theanine on nicotine dependence. | Yan Zhao Baolu Zhao | 2014 | Chinese Science Bulletin2014，59，31： | 5 |
| 7 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 8 | Geodynamic processes of the southeastern Neo-Tethys Ocean and the formation mechanism of the curved subduction system in Southeast Asia显示文摘Southeast Asia is located at the intersection of the Tethys and Pacific domains. The superimposed effects of the two tectonic domains have resulted in complicated deep structure, surface magma responses, and dynamic processes of Southeast Asia. Based on the latest long-term passive seismic experiment and numerical modeling, this study reconstructs the dynamic processes of the closure of the Neo-Tethys Ocean and the formation of the curved subduction system in Southeast Asia since the Late Mesozoic. P-wave velocity structure shows a remnant of the Neo-Tethys subducted slab in the lower mantle beneath Southeast Asia at a depth of approximately 1500 km. On the Java-East Timor subduction zone, the remnant slab is coupled with the Indo-Australian subducting slab in the upper mantle with the same direction, while on the Sumatra subduction zone, the remnant slab is decoupled from the Indo-Australian subducting slab in different directions. The formation of the curved subduction system in Southeast Asia is resulted from the northward subdcutions of previous Neo-Tethys and current IndoAustralian Plate, and the westward subduction of the Pacific Plate since Mesozoic. The former is characterized by continuous subduction and subsequent continental block collision, forming the current continental lithosphere in Southeast Asia and the curve-shaped Sumatra-Java subduction zone;the latter is characterized by subduction retreat and back-arc spreading, forming the eastern Philippine subduction zone and a series of marginal sea basins. Since the Early Cretaceous, the opening of the North Australian Sea resulted in stagnation of the Australian Block in the high latitude area of the southern hemisphere for a long time.The North Australian Sea was dominated by out-dipping double subduction from 45 Ma, which resulted in rapid northward drifting of the Australian Block and final collision with the Sundaland. | Weiwei DING Rixiang ZHU Bo WAN Liang ZHAO Xiongwei NIU Pan ZHAO Baolu SUN Yanghui ZHAO | 2023 | Science China Earth Sciences2023，66，4： | 2 |
| 9 | Three-dimensional electron spin resonance imaging of endogenous nitric oxide radicals generated in living plants显示文摘 | Yuanlin Cao Yongsheng Chen Qian Wan Jungai Hu Baolu Zhao | 2018 | Biophysics Reports2018，4，3： | 2 |
| 10 | Protective Effects of Green Tea Polyphenols in the 6-OHDA Rat Model of Parkinson’s Disease Through Inhibition of ROS-NO Pathway显示文摘 | Shuhong Guo Jingqi Yan Tangbin Yang Xianqiang Yang Erwan Bezard Baolu Zhao | 2007 | Biological Psychiatry2007，，12： | 1 |
| 11 | Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface‐Functionalized Gold Nanoparticles显示文摘 | Libo Du Siqingaowa Suo Guangqing Wang Hongying Jia Ke Jian Liu Baolu Zhao Yang Liu | 2012 | Chem Eur J2012，，4： | 1 |
| 12 | Nitric oxide damages neuronal mitochondria and induces apoptosis in neurons显示文摘The cytotoxic effect of nitric oxide on primarily cultured rat cerebellar granule cells was stuatea, and the mechanisms were discussed. The results showed that nitric oxide donor S-nitroso-N-acetyl-penicillamine (SNAP; 500 (imol/L) could induce apoptosis in immature cultures of cerebellar granule cells. Flow cytometry and HPLC analyses revealed that after treatment with SNAP, the mitochondrial transmembrane potential and the cellular ATP content decreased significantly. Nitric oxide scavenger hemoglobin could effectively prevent the neuronal mitochondria from dysfunction and attenuate apoptosis. The results suggested that nitric oxide activated the apoptotic program by inhibiting the activity of mitochondrial respiratory chain and thus decreasing the cellular ATP content. | Taotao Wei Chang Chen Jingwu Hou Baolu Zhao Wenjuan Xin | 2000 | Chinese Science Bulletin2000，45，5： | 1 |
| 13 | Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes显示文摘 | Qiong Guo Baolu Zhao Meifen Li Shengrong Shen Wenjuan Xin | 1996 | Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism1996，，3： | 1 |
| 14 | Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals显示文摘 | Baolu Zhao Xiaojie Li Rungen He Shujun Cheng Xin Wenjuan | 1989 | Cell Biophysics1989，，2： | 1 |
| 15 | Studies on protective mechanisms of four components of green tea polyphenols (GTP) against lipid peroxidation in synaptosomes显示文摘 | Guo Qiong Zhao Baolu Li Neifen | 1996 | Biochem Biophys Acta1996，1304，3： | 1 |
| 16 | Simultaneous de tection of NO and ROS by ESR in biological systems显示文摘 | Yuanlin Cao Pink Guo Baolu Zhao | 2005 | Methods Enzymol2005，396，： | 1 |
| 17 | Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals显示文摘 | Baolu Zhao Xiaojie Li Rungen He Shujun Cheng Xin Wenjuan | 1989 | Cell Biophysics1989，，2： | 1 |
| 18 | Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress显示文摘 | Jingqi Yan Yan Zhao Siqingaowa Suo Yang Liu Baolu Zhao | 2012 | Free Radical Biology and Medicine2012，，9： | 1 |
| 19 | Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress显示文摘 | Jingqi Yan Yan Zhao Siqingaowa Suo Yang Liu Baolu Zhao | 2012 | Free Radical Biology and Medicine2012，，9： | 1 |
| 20 | Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes显示文摘 | Qiong Guo Baolu Zhao Meifen Li Shengrong Shen Wenjuan Xin | 1996 | Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism1996，，3： | 1 |
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