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| 1 | Seismic damage of highway bridges during the 2008 Wenchuan earthquake显示文摘Many highway bridges were severely damaged or completely collapsed during the 2008 Wenchuan earthquake.A fi eld investigation was carried out in the strongly affected areas and over 320 bridges were examined.Damage to some representative highway bridges is briefly described and a preliminary analysis of the probable causes of the damage is presented in this paper.The most common damage included shear-flexural failure of the pier columns,expansion joint failure,shear key failure,and girder sliding in the transversal or longitudinal directions due to weak connections between girder and bearings.Lessons learned from this earthquake are described and recommendations related to the design of curved and skewed bridges,design of bearings and devices to prevent girder collapse,and ductility of bridge piers are presented.Suggestions for future seismic design and retrofi tting techniques for bridges in moderate to severe earthquake areas are also proposed. | Han Qiang Du Xiuli Liu Jingbo Li Zhongxian Li Liyun Zhao Jianfeng | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 60 |
| 2 | Dried earth layers of artificial forestland in the Loess Plateau of Shaanxi Province显示文摘由在 Shaanxi 省的黄土高原深处决定在 0 和 6 m 之间的人工的林地的地球潮湿内容,潮湿内容,分发和弄干的地球层的形成原因的垂直变化被研究。结果证明平均潮湿内容是在在在 Guanzhong 的超过 10 年鈥檚 生长的人工的森林下面的 2 和 4 m 之间的 9.3% 鈥 ?.5% 平凡、长期的弱弄干的地球层被开发它证明弄干的地球层在黄土高原上广泛地是分布式的。弄干的陆地层的南部的边界到达了 Qinling 山脉的北脚。当降水到达 600 公里时,在在超过 10 岁的人工的森林下面的 2 和 4 m 之间有弱弄干的地球层。当降水在 400 和 500 公里之间时,有中等弄干的地球层。当降水在 800 公里上面时,没有弄干的地球层。在草地土地,玉米陆地和在黄土高原的中央、南部的部分的人工的林地的不到 5 岁下面没有弄干的地球层。在柏树森林下面的弄干的地球层的发展比阔叶的森林弱。在一样的气候的条件下面,在黄土台地下面的弄干的地球层的发展是将近在象第二 and 的一样的水平第三个河平台。弄干的地球层在膜水地区,和埋葬的深度发展了是小的,运动速度在黄土高原是慢的,它是弄干的地球层的形成的直接的水因素,当树年龄和树种类的差别是消费了许多潮湿的植物因素时。从水和膜在 Guanzhong 平原浇的严肃的深度,弄干的地球层的形成原因主要由于自然因素,是清楚的。弄干的层通常在消费了太多潮湿的中年的人工的林地发展,它是在 subhumid 和半干旱的地区的地球潮湿的一般特性。弄干的层 doesn 鈥檛 的外观证明森林 doesn 鈥檛 在这个区域发展;这被取决于他们的发展紧张。在弄干的地球层微弱地发展了的地方,消费更少的水的中国白杨,蝗虫树和中国 scholartree 的人工的森林能在区域被种,但是在弄干的地球层强烈地发展了的地方,不能在区域被种。 | ZHAO Jingbo DU Juan CHEN Baoqun | 2007 | Journal of Geographical Sciences2007，17，1： | 17 |
| 3 | Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus显示文摘胃肠(官方补给) 感觉马达的畸形在有糖尿病的病人是普通的并且可以包含官方补给的道的任何部分。畸形经常是无临床症状的,并且幸好,严重、威胁生活的问题仅仅很少发生。在糖尿病的反常上面的官方补给的感觉马达的功能的致病不完全地被理解并且是最可能的起源多因素。糖尿病的自治神经病以及糖尿病的尖锐非最优的控制被显示了损害官方补给的马达和感觉功能。词法并且官方补给的墙的机械改变在糖尿病的持续时间期间开发的简历,并且可以贡献马达和感觉机能障碍。在感觉的这评论和活动性,在糖尿病的上面的官方补给的道的混乱被讨论;并且与感觉马达的机能障碍有关的机械改变也是的词法变化和简历探讨了。 | Jingbo Zhao Jens Brφndum Frφkjaer Asbjφrn Mohr Drewes Niels Ejskjaer | 2006 | World Journal of Gastroenterology2006，12，18： | 15 |
| 4 | Tillage Pedogenesis of Purple Soils in Southwestern China显示文摘Land cultivation and tillage process, and their consequent impacts on soil erosion, have been criticized as the main cause of degradation of land or soil quality. However, purple soils, classified as Regosols in FAO Taxonomy or Entisols in USDA Taxonomy, are formed from purple rocks of the Trias-Cretaceous system, have been developed or at least accelerated the development due to continual tillage operation, especially digging and ridging. The present study took micromorphological investigation on the sedimentary rocks and the soils under different operations of tillage. Results show that the purple rock of Feixiangguan Formation of the Trias system (T1f) is the easiest to physical weathering and the most fertile soil material enriched in nutrients, and it has been, therefore, mostly cultivated and intensively tilled around the year. It has the fastest soil formation rate. Soil formation rate in the cropland with conventional tillage is higher than that in the forestland and the grassland. It implies that the artificial brokenness and tillage disturbance play a great role in physical weathering and initiating soil formation processes. | HE Xiubin BAO Yuhai NAN Hongwei XIONG Donghong WANG Li LIU Yanfeng ZHAO Jingbo | 2009 | Journal of Mountain Science2009，6，2： | 10 |
| 5 | Climate and soil moisture environment during develop-ment of the fifth palaeosol in Guanzhong Plain显示文摘Based on weathering characteristics of the fifth palaeosol layer (S5) of four sections in Guanzhong Plain, the thickness of the weathered profile of the paleosol is determined to be greater than the ordi- nary soil, a weathered and leached loess layer thicker than 2 m. The distribution depth of the red argil- lans, the weathered and leached loess layer, Fe2O3, CaCO3 and Sr content under the S5 all indicate that the precipitation in Guanzhong Plain was over 900 mm at that time. The distribution depth of gravity water zone reached 4.2 m at least, and the soil moisture content was generally more than 20% within the range of 4.2 m. At that time there was sufficient soil moisture and no dried earth layer developed in Guanzhong Plain, suitable for the forest to develop. When this soil developed, the mean annual pre- cipitation was more than the annual soil moisture evaporation. The value of soil moisture balance was positive and the atmospheric precipitation could supply the underground water normally. Soil water was weak acidic in the middle and late stages when S5 developed in Guanzhong Plain. It was a kind of subtropical climate and even more humid and warmer than the northern edge of the subtropical climate zone in Guanzhong Plain when the S5 developed. At that time the subtropical climate was prevailing over the northern side and southern side of Qingling Mountains, showing the Mountains no longer to be the boundary between the subtropical zone and the temperate zone in China. The summer monsoon acted intensely and could go over Qingling Mountains frequently bring abundant precipitation. | ZHAO JingBo GU Jing DU Juan | 2008 | Science China Earth Sciences2008，51，5： | 9 |
| 6 | The new basic theory on Quaternary environmental research显示文摘On the basis of extensive survey to the Quaternary paleosols, soils and weathering layers in the vast northern China and the Loess Plateau, we found some unusually special phenomena of chemical components such as unsuccessive illuvium, twin illuviums, unusually thick illuvium and multi-illuviums etc. According to the analysis on the content of CaCO 3 and the data of penetrating experiment, a new theory of illuvial depth or removal depth of CaCO 3 in weathering and leaching belt was constructed, which indicates that the time of CaCO 3 removing to the illuvial depth is very short, and the effect of time factor on illuvial depth can be ignored. The theory can be taken as a credible foundation for studying many geological and geographical problems in weathering and leaching belt. When the illuvial depth of CaCO 3 is bigger than the thickness of developing belt of soil or paleosol, it can be determined that the paleosol has turned into weathering crust. When the illuvial depth of CaCO 3 is bigger than the thickness of paleosol, paleosol is leaching moderately acid soil. When two, three layers or unusually thick CaCO 3 illuviums exist in the same weathering section or at the bottom of the same paleosol, there were two or more periods forming paleosol and corresponding climatic stages at that time. On the basis of the equation of relationship between mean annual rainfall (y) and illuvial depth of CaCO 3 (x) (y = 305.5x + 168.5) determined in the paper, mean annual precipitation during the development of paleosol can be calculated. | ZHAO Jingbo 1, 2, 3 (1. Department of Geography, Shaanxi Normal University, Xi’an 710062, China 2. Center for Historical Environment and Socio-Economic Development in Northwest China, Shaanxi Normal University, Xi’an 710062, China 3. State Key Laboratory of Loess and Quaternary, Institute of Earth Environment, CAS, Xi’an 710075, China) | 2004 | Journal of Geographical Sciences2004，14，2： | 9 |
| 7 | Recharge sources and chemical composition types of groundwater and lake in the Badain Jaran Desert, northwestern China显示文摘在 Badain Jaran 沙漠基于湖水和浅地下水的离子化学药品作文的分析,这份报纸在荒芜的区域讨论了离子化学药品作文,湖水的空间变化,和湖水和地下水的可能的供应来源的特征。结果证明 pH,咸度, TDS 和湖水的电的电导率比地下水的那些大。水样品的离子内容被 Na+ 和 Cl 统治。大多数更高的咸度湖是 Na (K)-Cl-(SO4) 类型,并且低咸度湖的一些属于 Na-(Mg )-(Ca)-Cl-(SO4)-(HCO3) 类型。大多数地下水是 Na-(Ca )-(Mg)-Cl-(SO4)-(HCO3) 类型,把湖,和仅仅在场的一些归因于 subsaline Na-Cl-SO4 类型,流动在盐的湖下面。在东南的湖的 pH,咸度, TDS 和电的电导率是相对低的,并且有稍微碱的湖。在北湖的 pH,咸度, TDS 和电的电导率比东南的湖的那些大得多,并且北湖是中等碱、盐的。在 Badain Jaran 沙漠的东南的部分,到北方表演的来自南方的湖水的离子化学药品特征 subsaline salinehypersaline 的一个变化趋势。离子在的化学作文的变化趋势最近 9 年显示大多数离子内容在 Boritaolegai, Badain, Nuoertu 和 Huhejilin 湖有一点儿减小,它清楚地声明新鲜的水供应的数量在 9 年的时期正在增加。湖水的离子化学药品作文表明湖水的流动方向从东南到在 Badain Jaran 沙漠的西北。离子化学药品作文,沙层水水平高度的潮湿内容和湖水和地下水的层次簇分析证明湖水被降水的本地降雨和渗入主要在 Yabulai 山和 Heishantou 山供应,并且从 Qilian 山的供应是几乎不可能的。 | SHAO Tianje ZHAO Jingbo ZHOU Qi DONG Zhibao MA Yandong | 2012 | Journal of Geographical Sciences2012，22，3： | 7 |
| 8 | Diabetes-induced mechanophysiological changes in the small intestine and colon显示文摘The disorders of gastrointestinal(GI) tract including intestine and colon are common in the patients with diabetes mellitus(DM). DM induced intestinal and colonic structural and biomechanical remodeling in animals and humans. The remodeling is closely related to motor-sensory abnormalities of the intestine and colon which are associated with the symptoms frequently encountered in patients with DM such as diarrhea and constipation. In this review, firstly we review DM-induced histomorphological and biomechanical remodeling of intestine and colon. Secondly we review motor-sensory dysfunction and how they relate to intestinal and colonic abnormalities. Finally the clinical consequences of DMinduced changes in the intestine and colon including diarrhea, constipation, gut microbiota change and colon cancer are discussed. The final goal is to increase the understanding of DM-induced changes in the gut and the subsequent clinical consequences in order to provide the clinicians with a better understanding of the GI disorders in diabetic patients and facilitates treatments tailored to these patients. | Mirabella Zhao Donghua Liao Jingbo Zhao | 2017 | World Journal of Diabetes2017，8，6： | 6 |
| 9 | Identification and molecular mechanism of angiotensin-converting enzyme inhibitory peptides from Larimichthys crocea titin显示文摘This study aimed to identify novel ACEI peptides from Larimichthys crocea titin using in silico approaches and to clarify the molecular interaction mechanism.The hydrolyzed peptides of titin were compared with known ACEI peptides in the AHTPDB and BIOPEP-UWM database.Furthermore,peptides were evaluated for their solubility,ADMET properties,ΔG(kcal/mol)values,and in vitro ACEI activity.Molecular mechanism of ACE-peptide was performed by molecular interactions and binding orientation study.The results revealed that IC50 values of Trp-Ala-Arg(WAR)and Trp-Gln-Arg(WQR)were(31.2±0.8)and(231.33±0.02)mol/L,respectively.The docking interactions result suggested that ACE-WAR and ACEWQR complexes have same binding site,including the residues LYS511,TYR520,TYR523,HIS353,and HIS513.Molecular docking of two tripeptides WAR and WQR with ACE studies predicted their binding site and clarified the interaction between ACE and its inhibitors.The molecular docking data are consistent with the ACE inhibitory activity of the studied peptides.The results showed that Larimichthys crocea titin may be a valuable source for developing nutraceutical food. | Yue Fan Zhipeng Yu Wenzhu Zhao Long Ding Fuping Zheng Jianrong Li Jingbo Liu | 2020 | Food Science and Human Wellness2020，9，3： | 5 |
| 10 | Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase显示文摘Abstract:Ulcerative Colitis(UC)has been reported to be related to Porphyromonas gingivalis(P.gingivalis).Porphyromonas gingivalis peptidylarginine deiminase(PPAD),a virulence factor released by P.gingivalis,is known to induce inflammatory responses.To explore the pathological relationships between PPAD and UC,we used homologous recombination technology to construct a P.gingivalis strain in which the PPAD gene was deleted(Δppad)and aΔppad strain in which the PPAD gene was restored(comΔppad).C57 BL/6 mice were orally gavaged with saline,P.gingivalis,Δppad,or comΔppad twice a week for the entire 40 days(days 0-40),and then,UC was induced by dextran sodium sulfate(DSS)solution for 10 days(days 31-40).P.gingivalis and comΔppad exacerbated DDS-induced colitis,which was determined by assessing the parameters of colon length,disease activity index,and histological activity index,butΔppad failed to exacerbate DDS-induced colitis.Flow cytometry and ELISA revealed that compared withΔppad,P.gingivalis,and comΔppad increased T helper 17(Th17)cell numbers and interleukin(IL)-17 production but decreased regulatory T cells(Tregs)numbers and IL-10 production in the spleens of mice with UC.We also cocultured P.gingivalis,Δppad,or comΔppad with T lymphocytes in vitro and found that P.gingivalis and comΔppad significantly increased Th17 cell numbers and decreased Treg cell numbers.Immunofluorescence staining of colon tissue paraffin sections also confirmed these results.The results suggested that P.gingivalis exacerbated the severity of UC in part via PPAD. | Xida Zhao Jingbo Liu Chong Zhang Ning Yu Ze Lu Shuwei Zhang Yuchao Li Qian Li Junchao Liu Dongjuan Liu Yaping Pan | 2021 | International Journal of Oral Science2021，13，3： | 5 |
| 11 | Application of the Material Balance Method in Paleoelevation Recovery: A Case Study of the Longmen Mountains Foreland Basin on the Eastern Margin of the Tibetan Plateau显示文摘We applied the material balance principle of the denudation volume and sedimentary flux to study the denudation-accumulation system between the Longmen Mountains(Mts.) and the foreland basin. The amount of sediment in each sedimentation stage of the basin was estimated to obtain the denudation volume,erosion thickness and deposit thickness since the Late Triassic Epoch,to enable us to recover the paleoelevation of the provenance and the sedimentary area. The results show the following:(1) Since the Late Triassic Epoch,the elevation of the surface of the Longmen Mts. has uplifted from 0 m to 2751 m,and the crust of the Longmen Mts. has uplifted by 9.8 km. Approximately 72% of the materials introduced have been denuded from the mountains.(2) It is difficult to recover the paleoelevation of each stage of the Longmen Mts. foreland basin quantitatively by the present-day techniques and data.(3) The formation of the Longmen Mts. foreland basin consisted of three stages of thrust belt tectonic load and three stages of thrust belt erosional unload. During tectonic loading stages(Late Triassic Epoch,Late Jurassic–Early Cretaceous,Late Cretaceous–Miocene),the average elevation of Longmen Mts. was lower(approximately 700–1700 m). During erosional unloading stages(Early and Middle Jurassic,Middle Cretaceous and Jiaguan,Late Cenozoic),the average elevation of Longmen Mts. was high at approximately 2000–2800m. | YAN Zhaokun LI Yong LI Haibing DONG Shunli ZHAO Guohua LI Jingbo LI Fensheng YAN Liang ZHENG Lilong | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 4 |
| 12 | Si/MgO composite anodes for Li-ion batteries显示文摘A Si/MgO composite anode material was prepared by a simple magnesium reduction process using silicon oxide and magnesium as starting reactants.The feasibility of this process is discussed from the thermodynamic viewpoint.The resultant composite material is mainly composed of Si and MgO components.MgO,acting as a buffer layer,can accommodate the large volume change of active Si during the charge/discharge process,thus the cycling stability is improved.Electrochemical tests demonstrate that the first charge and discharge capacities of the synthesized Si/MgO composite anode are ca.1380 and 1046 mAh g-1,respectively,with an initial coulomb efficiency of ca.76%.The magnesium reduction process provides a novel idea for the synthesis of Si-based anode materials. | CHEN Jingbo ZHAO Hailei HE Jianchao WANG Jing | 2011 | Rare Metals2011，30，2： | 3 |
| 13 | Optimization of test resources for 3D SoC based on game theory显示文摘The ever-increasing complexity of on-chip interconnection poses great challenges for the architecture of conventional system-on-chip(SoC) in semiconductor industry. The rapid development of process technology enables the creation of stacked 3-dimensional(3 D) SoC by means of through-silicon-via(TSV). Stacked 3 D SoC testing consists of two major issues, test architecture optimization and test scheduling. This paper proposed game theory based optimization of test scheduling and test architecture to achieve win-win result as well as individual rationality for each player in a game. Game theory helps to achieve equilibrium between two correlated sides to find an optimal solution. Experimental results on handcrafted 3 D SoCs built from ITC'2 benchmarks demonstrate that the proposed approach achieves comparable or better test times at negligible computing time. | Shao Jingbo Zhao Yue Liu Xiaoxiao | 2019 | The Journal of China Universities of Posts and Telecommunications2019，26，1： | 3 |
| 14 | The discovery of surface runoff in the megadunes of Badain Jaran Desert,China,and its significance显示文摘The Badain Jaran Desert exhibits the greatest difference in altitude of all of the world's deserts.On the slopes of megadunes in the desert,there are physical and chemical deposits produced by surface runoff.In addition,we have observed rarely-seen infiltration-excess surface runoff in the megadune depressions as well as spring streams at the base of megadunes.We used electron microscopy,energy spectrum analysis,infiltration experiments,moisture content determinations and grain-size analysis to study the mineral and chemical composition of the runoff precipitates,and grain-size of the deposits associated with the runoff,together with the hydrological balance in the megadune area,and the atmospheric precipitation mechanism responsible for groundwater recharge and for supplying water to lakes.The observations of shallow runoff and infiltration-excess surface runoff indicate the occurrence of strong and effective precipitation in summer,which would provide an important source for groundwater recharge.Several lines of evidence,such as the physical and chemical deposits resulting from shallow subsurface runoff,spring streams,infiltration-excess runoff,and gravity capillary water with a moisture content of 3-6%,demonstrate that precipitation reaches the base of the megadunes through infiltration and subsequently becomes groundwater.The chemical deposits,such as newly-formed calcite and gypsum,and gray-black physical deposits,as well as different stages in the development of fan-shaped landforms resulting from shallow subsurface runoff,indicate that groundwater recharge in the area is the result of long-term precipitation,rather than intermittent individual major rainfall events.Fine sand layers with a low infiltration capacity lead to subsurface runoff emerging at the ground surface.Five factors play an important role in maintaining a positive water balance and in replenishing groundwater via rainfall:effective rainfall as a water source,the high infiltration capacity of the sands enabling rainfall to rapidly become capillary water in the dunes,low evapotranspiration rates due to the sparse vegetation,the fact that the depth of the sand layer influenced by evaporation is shallow enough to maximize the deep infiltration of rainfall,and rapidly-moving gravity capillary water in the sandy dunes.These five factors together constitute a mechanism for groundwater recharge from rainfall,and explain the origin of the groundwater and lakes in the area.Our findings represent a significant advance in research on the hydrological cycle,including groundwater recharge conditions and recharge mechanisms,in this desert region. | ZHAO JingBo MA YanDong LUO XiaoQing YUE DaPeng SHAO TianJie DONG ZhiBao | 2017 | Science China Earth Sciences2017，60，4： | 3 |
| 15 | Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett's esophagus显示文摘Barrett's esophagus (BE) is characterized by intestinal metaplasia with the differentiated epithelium replaced by another type of epithelium morphologically similar to normal intestinal epithelium. The metaplasia is preceded by bile and acid reflux into the esophagus. BE is a premalignant condition associated with increased risk of esophageal cancer, especially esophageal adenocarcinoma. The Caudal-related homeodomain transcription factors Caudal-related homeodomain transcription factor CDX1 and CDX2 are expressed exclusively in the small and large intestine, playing important roles in proliferation and differentiation of intestinal epithelial cells. Ectopic expression of CDX1 and CDX2 occurs in BE. The apical sodium-dependent bile acid transporter (ASBT) is expressed primarily in terminal ileum where it is a key factor for intestinal reabsorption of bile salts. In addition to upregulation of CDX1 and CDX2, ASBT expression is up-regulated in BE. Furthermore, both CDX1/CDX2 and ASBT expressions are down-regulated in high-grade esophageal dysplasia. The alteration of the above-mentioned factors calls for attention: what is the relationship between CDXs and ASBT aberrant expression in BE? In this commentary, we discuss this issue on basis of the recent study done by Ma et al . | Jingbo Zhao Hans Gregersen | 2013 | World Journal of Gastroenterology2013，19，18： | 3 |
| 16 | Identifi cation of egg protein-derived peptides as xanthine oxidase inhibitors:virtual hydrolysis,molecular docking,and in vitro activity evaluation显示文摘The purpose of this study was to screen the xanthine oxidase(XO)inhibitory peptides from egg white proteins through virtual hydrolysis,in vitro activity validation,and molecular docking.The results demonstrated that tripeptide EEK from ovalbumin exhibited potent XO inhibitory activity with an IC50 value of 141μmol/L.The molecular docking results showed that tripeptide EEK bound with the active center of XO via 3 carbon hydrogen bond interactions,2 salt bridges,5 conventional hydrogen bond interactions,and 4 attractive charge interactions.The residues Glu802,Phe1009,and Arg880 may play key roles in the XO catalytic reaction.Especially,the key intermolecular forces of inhibiting XO activity may be special type of hydrogen bonds including carbon hydrogen bond interactions and attraction charge interactions.The novel tripeptide EEK is potential candidates for controlling hyperuricemia. | Zhipeng Yu Yaxin Cao Ruotong Kan Huizhuo Ji Wenzhu Zhao Sijia Wu Jingbo Liu David Shiuan | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 17 | 0il bleed from elastomeric thermal silicone conductive pads显示文摘 | Yuqi Chen Yakai Feng Jingqi Zhao Jingbo Shen Menghuang Feng | 2016 | Frontiers of Chemical Science and Engineering2016，10，4： | 3 |
| 18 | Preparation of high concentration polyaluminum chloride with high content of Al_b or Al_c显示文摘A novel membrane distillation concentration method was used to prepare high concentration polyaluminum chloride (PACl) with high content of Alb or Alc. 2.52 mol/L PACl1 with 88% Alb and 2.38 mol/L PACl2 with 61% Alc were successfully prepared. Three coagulants, AlCl3, PACl1 and PACl2 were investigated on their hydrolysis behavior and speciation under different conditions. The effects of pH and dilution ratio on Al species distribution were investigated by ferron assay. Experimental result showed that pH had a significant effect on Al species distribution for the three coagulants. Dilution ratio had little effects on Alb and Alc distribution in whole dilution process except the beginning for PACl1 and PACl2. The results indicated that transformation of Al depends largely on their original composition. AlCl3 was the most unstable coagulant among these three coagulants during hydrolysis process. PACl1 and PACl2 with significant amounts of highly charged and stable polynuclear aluminum hydrolysis products were less affected by the hydrolysis conditions and could maintain high speciation stability under various conditions. | ZHAO Changwei ZHANG Jingbo LUAN Zhaokun PENG Xianjia REN Xiaojing | 2009 | Journal of Environmental Sciences2009，21，10： | 3 |
| 19 | Karst subzone division in vertical cycle zone and its significance显示文摘Vertical cycle karst zone has been studied for more than 100 years, however karst subzones in the zone have never been divided and affected depth of CO2 from rainwater in the zone has never been studied. On the basis of field observation, survey and chemical analysis, the difference of karst processes indicated by CaCO3 and pH values in fine and loose sedimentary strata as well as limestone strata, and the vertical cycle zone ascertained by predecessors can be divided into three subzones, that is, the upper first subzone, characterized by unsaturated water solution and strong dissolution processes, the middle second subzone, characterized by supersaturated water solution and precipitation, and the lower third subzone, characterized by unstable water solution and weak dissolution or weak precipitation. The three subzones can indicate the vertical CO2 cycle. In fine and loose sediment strata, the bottom of the first subzone is the lower boundary strongly influenced by CO2 from rainwater, soil and air; all CO2 from rainwater, soil and air is almost exhausted in the second subzone. In the early developmental period of karst process in limestone strata, karst funnels and vertical caves do not form, vertical seeping of rainwater and soil water is very slow, and CO2 from soil, rainwater and air almost can reach the third subzone, but in the middle and late developmental periods, karst funnels and vertical caves occur, CO2 from soil, rainwater and air can reach deep seasonal change zone and horizontal cycle zone and quicken development of karst morphology. Deep karst morphology near groundwater level under vertical cycle zone develops better in the middle and late periods of karst process. | ZHAO Jingbo CHEN Baoqun YUE Yingli DU Juana | 2006 | Journal of Geographical Sciences2006，16，4： | 3 |
| 20 | Biological evaluation and interaction mechanism of beta-site APP cleaving enzyme 1 inhibitory pentapeptide from egg albumin显示文摘Inhibition of beta-site APP cleaving enzyme1(BACE1)is one of the most promising therapeutic approaches for Alzheimer’s disease.To find natural products for the treatment of Alzheimer’s disease,absorption,distribution,metabolism,excretion and toxicity(ADMET)properties and in vitro BACE1 inhibitory activity of the peptides isolated from egg albumin were evaluated.Then,molecular docking and molecular dynamics simulation were used to explain the molecular mechanism of the interactions between BACE1 and peptides.The IC50 value of peptide KLPGF,with satisfactory ADMET properties,against BACE1 was(8.30±0.56)mmol/L.Molecular docking revealed that KLPGF contacted with the residues of BACE1’s active sites through twelve hydrogen bonds interactions,two hydrophobic interactions,one electrostatic interaction,and two Pi-cation interactions.The 5 ns molecular dynamics simulations confirmed that the structure of KLPGF with BACE1 was stable.Peptide KLPGF contacted the residues Lys321,Asp228,and Asn233 with stable hydrogen bonds.KLPGF may be a potential anti-BACE1 candidate. | Zhipeng Yu Sijia Wu Wenzhu Zhao Long Ding David Shiuan Fuping Zheng Jianrong Li Jingbo Liu | 2020 | Food Science and Human Wellness2020，9，2： | 2 |
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