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| 1 | 中国及世界风资源变化研究进展显示文摘20世纪以来,随着能源需求成倍增长,风能资源因其安全、清洁、丰富的特性已成为世界上增长最快的能源方式。有关风能资源可持续利用的近地层风和风能资源变化研究也逐渐开展起来。20世纪观测事实研究表明,①全球高纬度地区风速呈增大趋势,而中低纬度地区风速呈减小趋势变化;②中国近50年来年平均风速呈明显的减小趋势变化;③中国区域城市化发展、测站迁址及测风仪器的变更都对中国年平均风速的长期变化产生了一定影响,但都不是近50年来中国年平均风速呈显著减小趋势的主因;大气环流的变化才是造成中国年平均风速呈显著减小趋势的最可能原因。与风和风能资源预估相关的研究表明,21世纪由于人为温室气体排放增加和全球变暖,中国年平均和冬季平均风速和风功率密度将可能减小,夏季平均风速和风功率密度的变化不确定性较大。目前,利用气候模式模拟和预估近地层风速方面的研究才刚刚开始,今后还需要做大量和长时间的研究试验,才能得到更可靠的结论。 | 江滢 罗勇 赵宗慈 ZHU Jinhong | 2009 | 科技导报2009，27，13： | 30 |
| 2 | Significant relationship between spring AO and the summer rainfall along the Yangtze River显示文摘The influence of spring AO on the summer rainfall along the Yangtze River is investigated. The long-term rainfall observations are filtered to remove the low-frequency variations longer than 10 years. The inter-annual components show a high correlation to AO in the last hundred years. The strongest correlation appears for May AO and summer rainfall with a value of -0.39, significant above the 99% confidence level. Associated with one standard deviation stronger May AO index, the rainfall over the Yangtze River to the southern Japan decreases by about 3%-9%, while, at the same time increases by about 3%-6% in the northern China and far-eastern Russia. The coherent changes in rainfall are significantly related to the East Asian summer jet stream in the upper troposphere. When there is stronger AO in spring, the jet stream tends to move polarward in summer, and leads the rainfall-belt to move northward too. That gives rise to a drier condition in the Yangtze River valley, wetter anomalies in northern China. | GONG Daoyi ZHU Jinhong WANG Shaowu | 2002 | Chinese Science Bulletin2002，47，11： | 22 |
| 3 | Projections of Wind Changes for 21st Century in China by Three Regional Climate Models显示文摘This paper examines the capability of three regional climate models (RCMs), i.e., RegCM3 (the International Centre for Theoretical Physics Regional Climate Model), PRECIS (Providing Regional Climates for Impacts Studies) and CMM5 (the fifth-generation Pennsylvania State University-the National Center for Atmospheric Research of USA, NCAR Mesoscale Model) to simulate the near-surface-layer winds (10 m above surface) all over China in the late 20th century. Results suggest that like global climate models (GCMs), these RCMs have the certain capability of imitating the distribution of mean wind speed and fail to simulate the greatly weakening wind trends for the past 50 years in the country. However, RCMs especially RegCM3 have the better capability than that of GCMs to simulate the distribution and change feature of mean wind speed. In view of their merits, these RCMs were used to project the variability of near-surface-layer winds over China for the 21st century. The results show that 1) summer mean wind speed for 2020-2029 will be lower compared to those in 1990-1999 in most area of China; 2) annual and winter mean wind speed for 2081-2100 will be lower than those of 1971-1990 in the whole China; and 3) the changes of summer mean wind speed for 2081-2100 are uncertain. As a result, although climate models are absolutely necessary for projecting climate change to come, there are great uncertainties in projections, especially for wind speed, and these issues need to be further explored. | JIANG Ying Luo Yong ZHAO Zongci SHI Ying XU Yinlong ZHU Jinhong | 2010 | Chinese Geographical Science2010，20，3： | 13 |
| 4 | Evidence and modeling study of droughts in China during 4―2 ka BP显示文摘Four periods with predominated droughts are identified in 4―2 ka BP according to documentary data, namely 3.6―3.5, 3.1―3.0, 2.8―2.7, and 2.45―2.35 ka BP. Palaeo-environmental data indicated that droughts were predominated in 4―2 ka BP in the south of Northeast China, Inner-Mongolia, east of Qinghai-Tibetan Plateau, and South China. Modeling study shows that precession may be responsible for the occurrence of droughts in 4―2 ka BP, integrating the GCM with forcing of insolation. | WANG ShaoWu HUANG JianBin WEN XinYu ZHU JinHong | 2008 | Chinese Science Bulletin2008，53，14： | 10 |
| 5 | Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition显示文摘改变的新陈代谢是癌症房间的特点之一。戊糖磷酸盐小径(PPP ) 是细胞的新陈代谢的一个基本部件。Glucose-6-phosphate 脱氢酶(G6PD ) , PPP 的限制率的酶,在许多癌症被提高并且由通过 PPP 生产 ribose-5-phosphate 和 NADPH 贡献肿瘤生长。然而,在 hepatocellular 的 G6PD 的角色癌(HCC ) 转移和在 HCC 前进和预后的 G6PD 的临床的意义一直不是很好坚定的。在这研究,由从 HCC 病人和 HCC 房间线调查织物样品,我们发现那提高的 G6PD 表情显著地与 HCC 转移和差的预后被联系 HCC,和那 G6PD 击倒在 vitro 禁止 HCC 房间线的增长,移植和侵略。进一步的研究表明 G6PD 由通过信号变换器的激活和抄写 3 的使活跃之物(STAT3 ) 导致上皮间充质的转变贡献 HCC 移植和 hepatocellular 癌房间的侵略小径。我们的调查结果建议那指向的 G6PD 能为转移干预开创可能性并且为 HCC 改进病人结果。 | Ming Lu Lu Lu Qiongzhu Dong Guangyang Yu Jinhong Chen Lunxiu Qin Lianxin Wang Wenwei Zhu Huliang Jia | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 10 |
| 6 | Atmospheric oscillations over the last millennium显示文摘The variations of global atmospheric oscillations over the last millennium, including the North Atlantic Oscillation (NAO), the North Pacific Oscillation (NPO) highly associated with the Pacific Decadal Oscillation (PDO), the Southern Oscillation (SO) and the Antarctic Oscillation (AAO), are studied and compared in this paper based on observations and reconstructed data. The cross correlation analysis of AAO, NAO and NPO shows that there is no significant relationship on interannual variation among them. However, the consistency on decadal variability is prominent. During A.D.1920–1940 and A.D.1980–2000, the positive (strong) phase was dominant and the negative (weak) one noticeable during A.D.1940–1980. In addition, the reconstructed atmospheric oscillations series demonstrate that the positive phase existed in the early of the last millennium for NAO and in the late of the last millennium for AAO, respectively; while it occurred in the mid-late of the last millennium for PDO and ENSO. | HUANG JianBin WANG ShaoWu GONG DaoYi ZHOU TianJun WEN XinYu ZHANG ZiYin ZHU JinHong | 2010 | Chinese Science Bulletin2010，55，22： | 6 |
| 7 | Down-regulation of SDFI-α expression in tumor microenvironment is associated with aspirin- mediated suppression of the pro-metastasis effect of sorafenib in hepatocellular carcinoma显示文摘 | Lu Lu Ming Lu Yuan Pei Jinhong Chen Lunxiu Gin Wenwei Zhu Huliang Jia | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 6 |
| 8 | GOLM1 exacerbates CD8^(+)T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages显示文摘The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses.Golgi membrane protein 1(GOLM1)is correlated to hepatocellular carcinoma(HCC)progression and metastasis.However,little is known about the role of GOLM1 in regulating the immunosuppressive environment and its impact on immunotherapeutic efficacy in HCC.In this study,GOLM1 was positively correlated with infiltrating tumor-associated macrophages(TAMs)expressed high levels of programmed death-ligand 1(PD-L1)and CD8^(+)T cell suppression in HCC tissues.Both gain-and loss-of-function studies determined a close correlation between GOLM1 and immunosuppression.In the mechanism,GOLM1 promoted COP9 signalosome 5-mediated PD-L1 deubiquitination in HCC cells and increased the transport of PD-L1 into exosomes via suppression of Rab27b expression.Furthermore,co-culture with exosomes derived from HCC cells upregulated the expression of PD-L1 on macrophages.Zoledronic acid in combination with anti-PD-L1 therapy reduced PD-L1^(+)TAMs infiltration and alleviated CD8^(+)T cell suppression,resulting in tumor growth inhibition in the mouse HCC model.Together,our study unveils a mechanism by which GOLM1 induces CD8^(+)T cells suppression through promoting PD-L1 stabilization and transporting PD-L1 into TAMs with exosome dependent.Targeting PD-L1^(+)TAM could be a novel strategy to enhance the efficacy of anti-PD-L1 therapy in HCC. | Jinhong Chen Zhifei Lin Lu Liu Rui Zhang Yan Geng Minghao Fan Wenwei Zhu Ming Lu Lu Lu Huliang Jia Jubo Zhang Lun-Xiu Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 5 |
| 9 | Modeling studies on the changes of the Subtropical High over the Western Pacific during the last 100 years显示文摘Intensity index series of Subtropical High over the Western Pacific was constructed according to modeling results by using of CCM3.6 atmospheric model with cli-matologically SST forcing for 30 years, and with observed SST forcing from 1900 to 2000. The index series constructed by modeling closely correlated to the observations for 1951-1999 (c.c. 0.72) and to the statistically reconstructed one for 1900-1950 (c.c. 0.51). The index series for 1900-1999 showed significant 80 a and 40 a periodicity. A minimum of persistence in seasonal variations of the index occurred in Autumn, which was called 'Autumn Barrier'. It may relate to the 'Spring Barrier', found in the seasonal variations of SST over the Eastern Equatorial Pacific. The increasing trend shown in the index series for the 20th century may associate with the global warming caused by enhancement of greenhouse effect. | Qiaozhen Mu Shaowu Wang Jingning Cai Zhihui Xie Jinhong Zhu | 2002 | Chinese Science Bulletin2002，47，11： | 4 |
| 10 | Feasibility study on the use of near-infrared spectroscopy for rapid and nondestructive determination of gossypol content in intact cottonseeds显示文摘Background:Gossypol found in cottonseeds is toxic to human beings and monogastric animals and is a primary parameter for the integrated utilization of cottonseed products.It is usually determined by the techniques relied on complex pretreatment procedures and the samples after determination cannot be used in the breeding program,so it is of great importance to predict the gossypol content in cottonseeds rapidly and nondestructively to substitute the traditional analytical method.Results:Gossypol content in cottonseeds was investigated by near-infrared spectroscopy(NIRS)and high-performance liquid chromatography(HPLC).Partial least squares regression,combined with spectral pretreatment methods including Savitzky-Golay smoothing,standard normal variate,multiplicative scatter correction,and first derivate were tested for optimizing the calibration models.NIRS technique was efficient in predicting gossypol content in intact cottonseeds,as revealed by the root-mean-square error of cross-validation(RMSECV),root-mean-square error of prediction(RMSEP),coefficient for determination of prediction(R_(p)^(2)),and residual predictive deviation(RPD)values for all models,being 0.05∼0.07,0.04∼0.06,0.82∼0.92,and 2.3∼3.4,respectively.The optimized model pretreated by Savitzky-Golay smoothing+standard normal variate+first derivate resulted in a good determination of gossypol content in intact cottonseeds.Conclusions:Near-infrared spectroscopy coupled with different spectral pretreatments and partial least squares(PLS)regression has exhibited the feasibility in predicting gossypol content in intact cottonseeds,rapidly and non destructively.It could be used as an alternative method to substitute for traditional one to determi ne the gossypol content in intact cottonseeds. | LI Cheng SU Bangsong ZHAO Tianlun LI Cong CHEN Jinhong ZHU Shuijin | 2021 | Journal of Cotton Research2021，4，2： | 4 |
| 11 | Performance enhancement of paper-based SERS chips by shell-isolated nanoparticle-enhanced Raman spectroscopy显示文摘Paper-based flexible surface-enhanced Raman scattering(SERS) chips have been demonstrated to have great potential for future practical applications in point-of-care testing(POCT) due to the potentials of massive fabrication, low cost, efficient sample collection and short signal acquisition time. In this work,common filter paper and Ag@Si O2 core-shell nanoparticles(NP) have been utilized to fabricate SERS chips based on shell-isolated nanoparticle-enhanced Raman spectroscopy(SHINERS). The SERS performance of the chips for POCT applications was systematically investigated. We used crystal violet as the model molecule to study the influence of the size of the Ag core and the thickness of the Si O2 coating layer on the SERS activity and then the morphology optimized Ag@Si O2 core-shell NPs was employed to detect thiram. By utilizing the smartphone as a miniaturized Raman spectral analyzer, high SERS sensitivity of thiram with a detection limit of 10^-9 M was obtained. The study on the stability of the SERS chips shows that a Si O2 shell of 3 nm can effectively protect the as-prepared SERS chips against oxidation in ambient atmosphere without seriously weakening the SERS sensitivity. Our results indicated that the SERS chips by SHINERS had great potential of practical application, such as pesticide residues detection in POCT. | Mingze Sun Binghan Li Xiaojia Liu Jiayin Chen Taotao Mu Lianqing Zhu Jinhong Guo Xing Ma | 2019 | Journal of Materials Science & Technology2019，35，10： | 3 |
| 12 | Influence of stress on the creep behavior of Cu particle enhancement SnPb based composite solder joints显示文摘Lap joints with a 1 mm2 cross-sectional area were fabricated using Cu particle enhancement 63Sn37Pb based composite solder and 63Sn37Pb eutectic solder to examine the influence of stress on the creep behavior of the solder joints. The results indicate that the creep resistance of the composite solder joints is generally superior to that of the conventional 63Sn37Pb solder joints. At the same time, the creep rupture life of the composite solder joints is declined with increasing stress and drops faster than that of the 63Sn37Pb eutectic solder joints. | YAN Yanfu YAN Hongxing CHEN Fuxiao ZHANG Keke ZHU Jinhong | 2007 | Rare Metals2007，26，1： | 3 |
| 13 | Correlation between the genetic variants of base excision repair (BER) pathway genes and neuroblastoma susceptibility in eastern Chinese children显示文摘Dear Editor,Neuroblastoma is the most common non-central nerve system(CNS)solid tumor in pediatrics[1].Neuroblastoma accounts for approximately 8%of all pediatric cancers but disproportionally causes a high cancer mortality(15%)in children[2].Pediatric patients with low-risk neuroblastoma witness a 5-year overall survival rate>90%,whereas the 5-year overall survival rate in high-risk neuroblastoma pediatric patients is<40%[3]. | Zhenjian Zhuo Chunlei Zhou Yuan Fang Jinhong Zhu Hongting Lu Haixia Zhou Haiyan Wu Yizhen Wang Jing He | 2020 | Cancer Communications2020，40，11： | 2 |
| 14 | 在自从 1980s: ,伪造在人口之间的连接学习的中国的人口地理和人的地理显示文摘自从 1980 年代,这篇论文在中国考察人口地理的进步。评论结果建议与它这个领域里的看不见和排斥地位的普通感觉相反,自从 1980 年代,巨大的进步在中国在人口地理被取得了。人口地理学者用地理观点做了重要贡献到大量人口问题的理解,包括移植,都市化,人口分发,在人口之间的关系,环境和资源,变老,婚姻模式,和候鸟罪,尽管如此的贡献经常没出现在地理圆。而且,人口地理学者在使新生起了一个不可缺少的作用在中国的人口研究并且伪造它的连接到人的地理,在这个多学科的领域里占据一个重要位置。对移植和都市化研究的区域的人口地理学者贡献是特别地重要的,在这些区域研究在他们的主角思考了。论文证明作为在超过 20 年隔离以后的领域里的迟到者,在中国的人口地理学者通过了自从 1980 年代,在与社会科学家一起的社会科学和增加的相互作用追上来和与开发的增加的约会的一个过程,并且极大地得益于它;然而,为逐渐地从主要溪流人地理要离间的人口地理有一个趋势,类似于然而并非象在 1990 年代末和 2000 年代初的祖籍英国的美国人地理一模一样的现象。论文主张人口地理仅仅是在菜的半路伪造在人口研究和人的地理之间的连接,并且它需要回到地理科学寻求在人口研究和人的地理的领域之间的健康平衡,并且在一个多学科的领域里支持它的进一步的开发。 | ZHU Yu DING Jinhong WANG Guixin SHEN Jianfa LIN Liyue KE Wenqian | 2016 | Journal of Geographical Sciences2016，26，8： | 2 |
| 15 | Dasatinib inhibits proliferation of liver cancer cells,but activation of Akt/mTOR compromises dasatinib as a cancer drug显示文摘Dasatinib is a multi-target protein tyrosine kinase inhibitor.Due to its potent inhibition of Src,Abl,the platelet-derived growth factor receptor(PDGFR)family kinases,and other oncogenic kinases,it has been investigated as a targeted therapy for a broad spectrum of cancer types.However,its efficacy has not been significantly extended beyond leukemia.The mechanism of resistance to dasatinib in a wide array of cancers is not clear.In the present study,we investigated the effect of dasatinib on hepatocellular carcinoma cell growth and explored the underlying mechanisms.Our results showed that dasatinib potently inhibited the proliferation of SNU-449 cells,but not that of other cell lines,such as SK-Hep-1,even though it inhibited the phosphorylation of Src on both negative and positive regulation sites in all these cells.Dasatinib activated the phosphoinositide-dependent protein kinase1(PDK1)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway in SK-Hep-1 cells,but not in SNU-449 cells.Blocking the Akt/mTOR signaling pathway strongly promoted the efficacy of dasatinib in SK-Hep-1 cells.In SNU-449 cells,dasatinib promoted apoptosis and the cleavage of caspase-3 and caspase-7,induced cell cycle arrest in the G1 phase,and inhibited the expression of Cyclin-dependent kinase(CDK4)/6/CyclinD1 complex.These findings demonstrate that dasatinib exerts its anti-proliferative effect on hepatocellular cell proliferation by blocking the Src family kinases;however,it causes Akt activation,which compromises dasatinib as an anti-cancer drug. | Chang Liu Xiaoxia Zhu Yuqi Jia Fenqing Chi Keru Qin Jinhong Pei Chan Zhang Xiuli Mu Hongwei Zhang Xiushan Dong Jun Xu Baofeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 16 | Re-characterization of an extrachromosomal circular plasmid in the pathogenic Leptospira interrogans serovar Lai strain 56601显示文摘在中国,(str.56601 ) 螺旋体 interrogans serovar Lai 紧张 56601 是在人和动物引起严重细螺旋体病的主要病原的紧张之一。完全在 2003 定序的这 organismwas 的染色体。在 2011,然而,我们由于广泛地在螺旋体染色体散布的重复序列在 str.56601 染色体识别了并且改正一些集会错误。在这研究,我们重新分析以前报导在染色体 andrectified 的活动、噬菌体相关的 genomic 岛用各种各样的试验性的方法在 plasmid 和染色体详细说明了顺序信息。分开的圆形的 extrachromosomal plasmid 也是的 presenceof 证实岛在 L 报导了,并且它在 genomic 区域的地点是到 genomic 的 determinedrelative。由基于的脉搏地胶化电气泳动和 plasmid 的联合的 interrogans serovar Lai 基于抽取的南部的污点 analysis.This 报告证实分开的 extrachromosomal 通报 plasmid 不集成于 L 的染色体。interrogans str.56601 并且显著地改进了我们 L 的 genomic 组织,进化,和致病的理解。interrogans。特别地,这 extrachromosomal 通报 plasmid 的描述将在病原的螺旋体种类贡献 geneticmanipulation 系统的开发。 | Lili Huang Weinan Zhui Ping He Yan Zhang Xuran Zhuang Guoping Zhao Xiaokui Guo Jinhong Qin Yongzhang Zhu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 1 |
| 17 | Development of Maweizhan cytoplasmic male-sterile line in rice(Oryza sativa L.)显示文摘A male sterile mutant plant was found from the rice field of the local rice variety which was cultivated for a long time in the west of Hubei Province. The plant has more vigorous tillering ability. Its plant height of 95 cm was a bit shorter than that of the normal ones. | ZHU Yingguo YU Jinhong,and ZHANG Xiaoguo,College of Life Sci,Wuhan Univ,Wuhan 430072,China | 1996 | Chinese Rice Research Newsletter1996，4，4： | 1 |
| 18 | Twentieth-century climatic wanning in China in the context of the Holocene 显示文摘 | Wang Shaowu Gong Daoyi Zhu Jinhong | 2001 | The Holocene2001，11，3： | 1 |
| 19 | Tight gas sandstone reservoirs in China: characteristics and recognition criteria显示文摘 | Caineng Zou Rukai Zhu Keyu Liu Ling Su Bin Bai Xiangxiang Zhang Xuejian Yuan Jinhong Wang | 2012 | Journal of Petroleum Science and Engineering2012，，： | 1 |
| 20 | Twentieth-century climatic warming in China in the context of the Holocene显示文摘 | Gong Daoyi Zhu Jinhong | 2001 | The Holocene2001，11，： | 1 |
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