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| 1 | Wide-steering-angle high-resolution optical phased array显示文摘Optical phased array(OPA)technology is considered a promising solution for solid-state beam steering to supersede the traditional mechanical beam steering.As a key component of the LIDAR system for long-range detection,OPAs featuring a wide steering angle and high resolution without beam aliasing are highly desired.However,a wide steering range requires a waveguide pitch less than half of the wavelength,which is easily subjected to cross talk.Besides,high resolution requires a large aperture,and it is normally achieved by a high count number of waveguides,which complicates the control system.To solve the mentioned issues,we design two high-performance 128-channel OPAs fabricated on a multilayered SiN-on-SOI platform.Attributed to the nonuniform antenna pitch,only 128 waveguides are used to achieve a 4 mm wide aperture.Besides,by virtue of innovative dual-level silicon nitride(Si_(3)N_(4))waveguide grating antennas,the fishbone antenna OPA achieves a 100°×19.4°field of view(FOV)with divergence of 0.021°×0.029°,and the chain antenna OPA realizes a 140°×19.23°FOV with divergence of 0.021°×0.1°.To our best knowledge,140°is the widest lateral steering range in two-dimensional OPA,and 0.029°is the smallest longitudinal divergence.Finally,we embed the OPA into a frequency-modulated continuous-wave system to achieve 100 m distance measurement.The reflected signal from 100 m distance is well detected with 26 dBm input transmitter power,which proves that OPA serves as a promising candidate for transceiving optical signal in a LIDAR system. | YINGZHI LI BAISONG CHEN QUANXIN NA QIJIE XIE MIN TAO LANXUAN ZHANG ZIHAO ZHI YUXUAN LI XIAOBIN LIU XIANSHU LUO GUOQIANG LO FENGLI GAO XUEYAN LI JUNFENG SONG | 2021 | Photonics Research2021，9，12： | 7 |
| 2 | On-chip generation of Bessel–Gaussian beam via concentrically distributed grating arrays for long-range sensing显示文摘Bessel beam featured with self-healing is essential to the optical sensing applications in the obstacle scattering environment.Integrated on-chip generation of the Bessel beam outperforms the conventional structure by small size,robustness,and alignment-free scheme.However,the maximum propagation distance(Z_(max))provided by the existing approaches cannot support long-range sensing,and thus,it restricts its potential applications.In this work,we propose an integrated silicon photonic chip with unique structures featured with concentrically distributed grating arrays to generate the Bessel-Gaussian beam with a long propagation distance.The spot with the Bessel function profile is measured at 10.24m without optical lenses,and the photonic chip’s operation wavelength can be continuously performed from 1500 to 1630 nm.To demonstrate the functionality of the generated Bessel-Gaussian beam,we also experimentally measure the rotation speeds of a spinning object via the rotational Doppler Effect and the distance through the phase laser ranging principle.The maximum error of the rotation speed in this experiment is measured to be 0.05%,indicating the minimum error in the current reports.By the compact size,low cost,and mass production potential of the integrated process,our approach is promising to readily enable the Bessel-Gaussian beam in widespread optical communication and micro-manipulation applications. | Zihao Zhi Quanxin Na Qijie Xie Baisong Chen Yingzhi Li Xiaobin Liu Xuetong Li Lijun Wang Guoqiang Lo Junfeng Song | 2023 | Light(Science & Applications)2023，12，5： | 1 |
| 3 | AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents.Although activator of HSP90 ATPase activity 1(AHA1)is reported to be a potential oncogene,its role in osteosarcoma progression remains largely unclear.Since metabolism reprogramming is involved in tumorigenesis and cancer metastasis,the relationship between AHA1 and cancer metabolism is unknown.In this study,we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma patients.AHA1 promotes the growth and metastasis of osteosarcoma both in vitro and in vivo.Mechanistically,AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in osteosarcoma.Notably,we identifed that isocitrate dehydrogenase 1(IDH1)is a novel client protein of Hsp90 AHA1.Furthermore,the IDH1 protein level was positively correlated with AHA1 in osteosarcoma.And IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of osteosarcoma.Moreover,high IDH1 level was also associated with poor prognosis of osteosarcoma patients.This study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis,which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients. | Diwei Zheng Weihai Liu Wenlin Xie Guanyu Huang Qiwei Jiang Yang Yang Jiarong Huang Zihao Xing Mengling Yuan Mengning Wei Yao Li Junqiang Yin Jingnan Shen Zhi Shi | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 4 | GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer显示文摘Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer. | Qiwei Jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan Chen Zhesheng Chen Zhi Shi | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 5 | Three-terminal germanium-on-silicon avalanche photodiode with extended p-charge layer for dark current reduction显示文摘Germanium-on-silicon(Ge-on-Si) avalanche photodiodes(APDs) are widely used in near-infrared detection, laser ranging, free space communication, quantum communication, and other fields. However, the existence of lattice defects at the Ge/Si interface causes a high dark current in the Ge-on-Si APD, degrading the device sensitivity and also increasing energy consumption in integrated circuits. In this work, we propose a novel surface illuminated Ge-on-Si APD architecture with three terminals. Besides two electrodes on Si substrates, a third electrode is designed for Ge to regulate the control current and bandwidth, achieving multiple outputs of a single device and reducing the dark current of the device. When the voltage on Ge is -27.5 V, the proposed device achieves a dark current of 100 n A, responsivity of 9.97 A/W at -40 d Bm input laser power at 1550 nm, and optimal bandwidth of 142 MHz. The low dark current and improved responsivity can meet the requirements of autonomous driving and other applications demanding weak light detection. | XIAOBIN LIU XUETONG LI YUXUAN LI YINGZHI LI ZIHAO ZHI MIN TAO BAISONG CHEN LANXUAN ZHANG PENGFEI GUO GUOQIANG LO XUEYAN LI FENGLI GAO BONAN KANG JUNFENG SONG | 2022 | Photonics Research2022，10，8： | 0 |
| 6 | Selective harvesting at rational intervals promotes carbon sequestration in temperate coniferous and broad-leaved mixed forests in China显示文摘Evidence-based selective cutting at prescribed intervals as part of good forest management can enhance the carbon sequestration capacity of the forest.The effect of forest management on carbon sequestration has,however,not been quantified.Thus,carbon content of various organs was measured for 323 tree species,247 shrub species,and233 herb species in seven temperate coniferous and broadleaved mixed forests that were subjected to selective cutting with restoration durations of 100,55,45,36,25,14,and6 years to explore dynamic changes in carbon storage.The results showed that biomass carbon allocation in different organs followed a pattern:trunk>root>branch>leaf for all forests.With longer restoration durations,more carbon accumulated in different organs and in soils.Interestingly,when the restoration duration exceeded 50 years,carbon storage in ecosystem was larger than that in primary forests with 100-year cutting intervals,suggesting that a reasonable selective cutting interval can increase forest carbon sequestration.Mean diameter at breast height(DBH)and forest carbon storage were significantly positively correlated,and carbon storage of selectively cut forests exceeded that of primary forests when the stand mean DBH exceeded 15.66 cm.Therefore,mean DBH of forests can be an indicator for combining sustainable forest management and forest carbon sequestration.Additionally,the classic coefficients of 0.45 and 0.50 used to estimate carbon sequestration underestimated values by 2.65%and overestimated by 8.16%,respectively,in comparison with the measured carbon content from different plant organs. | Jihua Hou Junxia Tian Li Xu Zihao Zhang Zhi Chen Nianpeng He | 2021 | Journal of Forestry Research2021，32，3： | 0 |
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