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| 1 | Echinococcus Granulosus 14-3-3 Protein:A Potential Vaccine Candidate Against Challenge with Echinococcus Granulosus in Mice显示文摘Objective To investigate the protective immunity against Echinococcus granulosus in mice immunized with rEg14-3-3.Methods ICR mice were subcutaneously immunized three times with rEg14-3-3,followed by the challenge with Echinococcus granulosus protoscoleces intraperitoneally and then sacrificed after six months of post-challenge to detect the proliferation of splenocytes by MTT assay,and to measure the secretion of IL-2,IL-4,IL-10,and IFN-γ by ELISA.The rate of reduced hydatid cyst and the levels of IgE,IgG and IgG subclasses in sera were examined.Results Mice vaccinated with rEg14-3-3 and challenged with protoscoleces revealed significant protective immunity of 84.47%.ELISA analysis indicated that the immunized mice generated specific high levels of IgG and the prevailing isotypes of IgG were IgG1 and IgG2a.Splenocytes from mice immunized with rEg14-3-3 showed a significant proliferation response.The secretion of IFN-γ and IL-2 increased significantly in the vaccinated mice whereas there was no significant difference in IL-4 and IL-10 levels between vaccinated and control mice.Conclusion The results indicate that the rEg14-3-3 vaccine could induce a high level of protective immunity as a promising vaccine candidate to prevent cystic echinococcosis. | LI Zong Ji WANG Ya Na WANG Qi ZHAO Wei | 2012 | Biomedical and Environmental Sciences2012，25，3： | 18 |
| 2 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 3 | Geochemical characteristics and their significances of rare-earth elements in deep-water well core at the Lingnan Low Uplift Area of the Qiongdongnan Basin显示文摘A geochemical analysis of rare-earth elements(REEs) in 97 samples collected from the core of deep-water Well LS-A located at the Lingnan Low Uplift Area of the Qiongdongnan Basin is conducted, with the purpose of revealing the changes of sedimentary source and environment in the study region since Oligocene and evaluating the response of geochemical characteristics of REEs to the tectonic evolution. In the core samples, both ∑REE and ∑LREE(LREE is short for light-group REEs) fluctuate in a relatively wide range, while ∑HREE(HREE is short for heavy-group REEs) maintains a relatively stable level. With the stratigraphic chronology becoming newer, both ∑REE and ∑LREE show a gradually rising trend overall. The ∑REE of the core is relatively high from the bottom of Yacheng Formation(at a well depth of 4 207 m) to the top of Ledong Formation, and the REEs show partitioning characteristics of the enrichment of LREE, the stable content of HREE, and the negative anomaly of Eu to varying degrees. Overall the geochemical characteristics of REEs are relatively approximate to those of China's neritic sediments and loess, with significant 'continental orientation'. The ∑REE of the core is relatively low in the lower part of Yacheng Formation(at a well depth of 4 207–4 330 m), as shown by the REEs partitioning characteristics of the depletion of LREE, the relative enrichment of HREE, and the positive anomaly of Eu; the geochemical characteristics of REEs are approximate to those of oceanic crust and basalt overall, indicating that the provenance is primarily composed of volcanic eruption matters. As shown by the analyses based on sequence stratigraphy and mineralogy, the provenance in study region in the early Oligocene mainly resulted from the volcanic materials of the peripheral uplift areas; the continental margin materials from the north contributed only insignificantly; the provenance developed to a certain extent in the late Oligocene. Since the Miocene, the provenance has ceaselessly expanded from proximal to distal realm, embodying a characteristic of multi-source sedimentation. In the core strata with 31.5, 28.4, 25.5, 23, and 16 Ma from today, the geochemical parameters of REEs and Th/Sc ratio have significant saltation, embodying the tectonic movement events in the evolution of the Qiongdongnan Basin. In the tectonic evolution history of the South China Sea, the South China Sea Movement(34–25 Ma BP, early expansion of the South China Sea), Baiyun Movement(23 Ma BP), late expansion movement(23.5–16.5 Ma BP), expansion-settlement transition, and other important events are all clearly recorded by the geochemical characteristics of REEs in the core. | SUN Zhipeng ZHAI Shikui XIU Chun LIU Xinyu ZONG Tong LUO Wei LIU Xiaofeng CHEN Kui LI Na | 2014 | Acta Oceanologica Sinica2014，33，12： | 7 |
| 4 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 5 | Template-free synthesis of hollow TiO2 nanospheres supported Pt for selective photocatalytic oxidation of benzyl alcohol to benzaldehyde显示文摘Heterogeneous photocatalytic system are widely applied to degrade organic pollutants or converse into high value-added chemicals. Both environmental and energy aspects should be considered to improve these chemical processes, favoring reaction conditions that involve room temperature and ambient O2 pressure. In the present work, hollow titanium dioxide nanospheres were fabricated via template-free method. The prepared samples were characterized by X-ray diffraction, N2 adsorption–desorption isotherms, transmission electron microscopy, and X-ray photoelectron spectroscopy. The photocatalytic activity was evaluated by photocatalytic oxidation of benzyl alcohol to benzaldehyde with visible light under atmospheric pressure at room temperature. The designed hollow structure(2%Pt–TiO2–5) not only exhibited a very high surface area,but also promoted photonic behavior and multiple light scattering, which as an efficient photocatalyst performed moderate conversion(about 20%) and high selectivity(> 99%) for oxidation of benzyl alcohol to benzaldehyde at room temperature with visible light in solvent of toluene.This work suggests that both hollow structure and Pt nanoparticles have great potential for execution of oxidative transformations under visible light. | Hongbing Song Zong Liu Yongjie Wang Na Zhang Xiaofei Qu Kai Guo Meng Xiao Hengjun Gai | 2019 | Green Energy & Environment2019，4，3： | 2 |
| 6 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 7 | Green synthesis of enantiomerically pure l -lactide and d -lactide using biogenic creatinine catalyst显示文摘 | Wei Huang Yunbiao Qi Na Cheng Xupeng Zong Tianrong Zhang Wei Jiang Hong Li Quanxing Zhang | 2014 | Polymer Degradation and Stability2014，，： | 1 |
| 8 | Reduced graphene oxide-CoFe204 composite: Synthesis and electromagnetic absorption properties 显示文摘 | Meng Zong Ying Huang Na Zhang | 2015 | Applied Surface Science2015，345，： | 1 |
| 9 | Molecular mechanism of crystal nucleation from solution显示文摘Nucleation from solution is fundamental to many natural and industrial processes.The understanding of molecular mechanism of nucleation from solution is conducive to predict crystal structure,control polymorph and design desired crystal materials.In this review,the nucleation theories,including classical nucleation theory(CNT),nonclassical nucleation theory,as well as other new proposed theories,were reprised,and the molecular mechanism of these theories was compared.Then,the molecular process of nucleation,including the current study techniques,the effect of molecular self-assembly in solutions,desolvation process,as well as the properties of solvent and crystal structure on nucleation from solution were summarized.Furthermore,the relationship of molecular conformation in solution and in crystal,and the effect of solute molecular flexibility on nucleation were discussed.Finally,the current challenges and future scopes of crystal nucleation from solution were discussed. | Xin Li Jingkang Wang Ting Wang Na Wang Shuyi Zong Xin Huang Hongxun Hao | 2021 | Science China Chemistry2021，64，9： | 1 |
| 10 | The Impact of Lipid-metabolizing Genetic Polymorphisms on Body Mass Index and Their Interactions with Soybean Food Intake: A Study in a Chinese Population显示文摘Objective To evaluate the association of known polymorphisms in the lipid metabolic pathway with body mass index(BMI), and estimate their interactions with soybean food intake. Methods A community-based cross-sectional survey was conducted in a Chinese Han population. BMI, soybean food intake, and single nucleotide polymorphisms of rs599839, rs3846662, rs3846663, rs12916, rs174547, rs174570, rs4938303, and rs1558861 were measured in 944 subjects. A multivariate logistic regression was used to analyze the association of the studied polymorphisms with BMIs. The expectation-maximization algorithm was employed to evaluate the extent of linkage disequilibrium between pairwise polymorphisms. The gene-environment interaction was assessed in the general multifactor dimensionality reduction model. Results The polymorphisms of rs3846662 and rs3846663 were associated with 10% highest BMIs when comparing to the 10% lowest values both in individuals and haplotype-based association tests. Although no statistically significant gene-environment interactions were found, people with the haplotype composed of C allele in rs3846662 and T allele in rs3846663 and low frequency of soybean intake had significantly higher risk to overweight and obesity as compared with those with the haplotype consisting of T allele in rs3846662 and C allele in rs3846663 and highly frequent soybean food intake, with an odds ratio of 1.64(95% confidence interval: 1.15-2.34, P<0.01) after adjusting for the common confounders. Conclusion Our study has suggested that rs3846662 and rs3846663 may be the potential candidate polymorphisms for obesity, and their effect on the pathogenesis could be mediated by the frequency of soybean food intake. | WANG Jin Wei TANG Xun LI Na WU Yi Qun LI Shuai LI Jin QIN Xue Ying ZHANG Zong Xin HU Yong Hua CHEN Da Fan | 2014 | Biomedical and Environmental Sciences2014，27，3： | 1 |
| 11 | Pseudomonas syringae Effector AvrPto Blocks Innate Immunity by Targeting Receptor Kinases显示文摘 | Tingting Xiang Na Zong Yan Zou Yong Wu Jie Zhang Weiman Xing Yan Li Xiaoyan Tang Lihuang Zhu Jijie Chai Jian-Min Zhou | 2008 | Current Biology2008，，1： | 1 |
| 12 | Protein Supplementation for the Prevention and Management of Sarcopenia in the Elderly显示文摘Sarcopenia is common in patients with many physiological or pathological conditions, especially in aging people. Nutrition plays an important role in the prevention and treatment of sarcopenia. Sarcopenia is often related to insufficient protein intake in the elderly. Muscle protein synthesis occurs mainly through mTORC1 pathway, and degradation occurs by ubiquitination-mediated pathways. This review summarizes the growing body of evidence, including substantial clinical trials, which increasing the protein intake can serve as the basis for preventing and managing muscle loss in patients with sarcopenia. Supplementation of essential amino acids (EAA), branched chain amino acids (BCAA), and especially leucine-rich whey protein may promote muscle protein synthesis by activating the mTORC1 signaling pathway, and may inhibit protein degradation by decreasing ubiquitin-mediated degradation. Taking in sufficient energy and protein and engaging in active exercise are the main methods of stimulating muscle protein synthesis and preventing or managing sarcopenia. Therefore, it is necessary to strengthen research on the use of protein supplements for not only elderly patients, but also those with tumor cachexia and other diseases related to sarcopenia. | Na Li Jia Jia Wang Zong Liang Lu Ming Xing Zhu Hong Xia Xu Jie Liu | 2019 | Journal of Nutritional Oncology2019，4，2： | 1 |
| 13 | Investigations on control algorithm of steady-state cornering and control strategy for dynamical correction in a steer-by-wire system显示文摘To improve the handling performance of a steer-by-wire (SBW) vehicle, a series of control logics are proposed. Firstly, an algorithm for enhancing the maneuvering in steady-state cornering is presented. On this basis, two categories of control strategies are used to dynamically correct and compensate the transient state steering responses and vehicle behaviors. Simulator tests including subjective evaluations and virtual field tests are both conducted to make comprehensive investigations on the series of control logics. The subjective evaluations demonstrate that the SBW vehicle with a specifically selected value of steering sensitivity tends to be more desirable for driving than a conventional one in which a fixed steering ratio exists. The virtual field tests indicate that the control strategies for dynamical correction and compensation could effectively improve the handling per-formances of an SBW vehicle by reducing the work load of drivers, enhancing the track-holding performance, and improving steering response properties. | Ying XU Chang-fu ZONG Hsiao-hsiang NA Lei LIU | 2009 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2009，10，6： | 1 |
| 14 | Study on control strategy of nonlinear systems with hysteresis inverse model feed-forward compensation based on Preisach显示文摘 | ZONG Xiaoping ZHANG Na WANG Peiguang | 2013 | Advance Materials Research2013，823，25： | 1 |
| 15 | Visible light driven H2 production in molecular systems employing colloidal MoS2 nanoparticles as catalyst 显示文摘 | Zong X Na Y Wen F | 2009 | Chemical Communications2009，，30： | 1 |
| 16 | Larval feeding induced defensive responses in tobacco: comparison of two sibling species of Helicoverpa with different diet breadths显示文摘 | Na Zong Chen-Zhu Wang | 2007 | Planta2007，，1： | 1 |
| 17 | Mechanical design of the horizontal collimator for HEPS storage ring显示文摘Background Horizontal collimators in the storage ring of high energy photon source(HEPS)are used to localize the majority of the particle loss,making it possible to set local shields.Moreover,movable jaws of the collimators are also designed as beam dumps for the machine protection,to absorb and scatter the mis-steered beam.Because of the compact lattice,each collimator should be installed between the limited space of 240 mm in the beam direction.It is necessary for the collimators to have good thermal dissipation ability to endure the synchrotron radiation and HOM load,as well as good resistance to thermal-shock from sudden beam loss simultaneously,which brings great challenges to the design.Purpose The purpose of this paper is to introduce the designing scheme of the collimators in HEPS,including the structure design and the analyses of the key components.Method Thermal and mechanical calculation has been done,based on which the jaw structure has been optimized.Besides,the modal analysis of the whole magnet-collimator-support assembly has been studied to optimize the shields structure.Result Graphite will be used as the tip for movable jaws in the collimators,which is attached to copper by vacuum brazing.The maximum temperature of the jaw during normal operation is 131°C,while maximum stress of the graphite–copper weld joint is 15.6 MPa.Graphite tip can resist thermal shock caused by whole mis-steered beam.Eigen frequency of the standard assembly is acceptable for HEPS.Conclusion The results of calculations indicate that the present structure can work well for considered operating modes. | Liuxu Zong Haijing Wang Chunhua Li Huamin Qu Lei Wu Zihao Wang Yaliang Zhao Guangyi Tang Hao Yang Na Wang Haoyu Shi | 2022 | Radiation Detection Technology and Methods2022，6，4： | 1 |
| 18 | Larval feeding induced defensive re- sponses in tobacco : comparison of two sibling species of Helicov- erpa with different diet breadths显示文摘 | Zong Na Wang Chenzhu | 2007 | Planta2007，226，1： | 1 |
| 19 | Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia显示文摘Aberrant self-renewal of leukemia initiation cells(LICs)drives aggressive acute myeloid leukemia(AML).Here,we report that UHRF1,an epigenetic regulator that recruits DNMT1 to methylate DNA,is highly expressed in AML and predicts poor prognosis.UHRF1 is required for myeloid leukemogenesis by maintaining self-renewal of LICs.Mechanistically,UHRF1 directly interacts with Sin3A-associated protein 30(SAP30)through two critical amino acids,G572 and F573 in its SRA domain,to repress gene expression.Depletion of UHRF1 or SAP30 derepresses an important target gene,MXD4,which encodes a MYC antagonist,and leads to suppression of leukemogenesis.Further knockdown of MXD4 can rescue the leukemogenesis by activating the MYC pathway.Lastly,we identified a UHRF1 inhibitor,UF146,and demonstrated its significant therapeutic efficacy in the myeloid leukemia PDX model.Taken together,our study reveals the mechanisms for altered epigenetic programs in AML and provides a promising targeted therapeutic strategy against AML. | Cheng-Long Hu Bing-Yi Chen Zijuan Li Tianbiao Yang Chun-Hui Xu Ruirui Yang Peng-Cheng Yu Jingyao Zhao Ting Liu Na Liu Bin Shan Qunling Zhang Junhong Song Ming-Yue Fei Li-Juan Zong Jia-Ying Zhang Ji-Chuan Wu Shu-Bei Chen Yong Wang Binhe Chang Dan Hou Ping Liu Yilun Jiang Xiya Li Xinchi Chen Chu-Han Deng Yi-Yi Ren Roujia Wang Jiacheng Jin Kai Xue Ying Zhang Meirong Du Jun Shi Ling-Yun Wu Chun-Kang Chang Shuhong Shen Zhu Chen Sai-Juan Chen Xiaolong Liu Xiao-Jian Sun Mingyue Zheng Lan Wang | 2022 | Cell Research2022，32，12： | 1 |
| 20 | Larval feeding induced defensive re- sponses in tobacco : comparison of two sibling species of Helicov- erpa with different diet breadths显示文摘 | Zong Na Wang Chenzhu | 2007 | Planta2007，226，1： | 1 |
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