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| 1 | Genetic correction of p-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice显示文摘 | Yixuan Wang Chen-Guang Zheng Yonghua Jiang Jiqin Zhang Jiayu Chen Chao Yao Qingguo Zhao Sheng Liu Ke Chen Juan Du Ze Yang Shaorong Gao | 2012 | Cell Research2012，22，4： | 27 |
| 2 | Xinglou Chengqi Decoction improves neurological function in experimental stroke mice as evidenced by gut microbiota analysis and network pharmacology显示文摘The current study was designed to explore the brain protection mechanism of Xinglou Chengqi Decoction(XCD)based on gut microbiota analysis and network pharmacology. A transient middle cerebral artery occlusion(MCAO) model of mice was established, followed by behavioral evaluation, TTC and TUNEL staining. Additionally, to investigate the effects of gut microbiota on neurological function after stroke, C57BL/6 mice were treated with anti-biotic cocktails 14 days prior to ischemic stroke(IS) to deplete the gut microbiota. High-throughput 16S rDNA gene sequencing, metabonomics technique, and flow multifactor technology were used to analyze bacterial communities, SCFAs and inflammatory cytokines respectively. Finally, as a supplement, network pharmacology and molecular docking were applied to fully explore the multicomponent-multitarget-multichannel mechanism of XCD in treating IS, implicated in ADME screening, target identification, network analysis, functional annotation, and pathway enrichment analysis.We found that XCD effectively improved neurological function, relieved cerebral infarction and decreased the neuronal apoptosis.Moreover, XCD promoted the release of anti-inflammatory factor like IL-10, while down-regulating pro-inflammatory factors such as TNF-α, IL-17A, and IL-22. Furthermore, XCD significantly increased the levels of short chain fatty acids(SCFAs), especially butyric acid. The mechanism might be related to the regulation of SCFAs-producing bacteria like Verrucomicrobia and Akkermansia, and bacteria that regulate inflammation like Paraprevotella, Roseburia, Streptophyta and Enterococcu. Finally, in the network pharmacological analysis, 51 active compounds in XCD and 44 intersection targets of IS and XCD were selected. As a validation, components in XCD docked well with key targets. It was obviously that biological processes were mainly involved in the regulation of apoptotic process, inflammatory response, response to fatty acid, and regulation of establishment of endothelial barrier in GO enrichment. XCD can improve neurological function in experimental stroke mice, partly due to the regulation of gut microbiota. Besises, XCD has the characteristic of 'multi-component, multi-target and multi-channel' in the treatment of IS revealed by network pharmacology and molecular docking. | GAO Qiang HAN Zhen-Yun TIAN Dan-Feng LIU Gan-Lu WANG Zhen-Yi LIN Jing-Feng CHANG Ze ZHANG Dan-Dan XIE Ying-Zhen SUN Yi-Kun YAO Xing-Wei MA Da-Yong | 2021 | Chinese Journal of Natural Medicines2021，19，12： | 6 |
| 3 | The Pollution Character Analysis and Risk Assessment for Metals in Dust and PM_(10) around Road from China显示文摘INTRODUCTION In recent years,with the gradual improvement of road construction,the rapid increase of the number of motor vehicles,vehicle emissions and the current poor vehicle performance,poor vehicle maintenance,higher emission factor[1]and so on,air pollution caused by the traffic issues becomes the focus of people attention[2-6].The harmful substances are gradually accumulated | CHEN Rong Hui WANG Bao Qing WANG Ze Bei YAO Shu | 2015 | Biomedical and Environmental Sciences2015，28，1： | 5 |
| 4 | Magnetostratigraphy of a Loess-Paleosol Sequence from Higher Terrace of the Daduhe River in the Eastern Margin of the Tibetan Plateau and Its Geological Significance显示文摘The eolian deposits distributed in the river valleys in the eastern margin of the Tibetan Plateau(TP)are very useful in neotectonic and paleoclimatic studies.Firstly,the climate in the eastern margin of the TP is mainly controlled by the Indian summer monsoon,and detailed studies on the loess-paleosol sequences in this region can provide valuable terrestrial evidence of past changes in the Indian summer monsoon.Secondly,the river terraces in the eastern margin of the TP are considered to be a sensitive recorder of neotectonism to reflect the timing and amplitude of the TP uplift.The formation ages of | QIAO Yansong WANG Yan YAO Haitao QI Lin HE Ze Xin CHENG Yu PENG Shasha GE Junyi | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 5 |
| 5 | Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes显示文摘编码 adiponectin 受体 1 的基因( ADIPOR1 )和小象ubiquitin一样修饰词( SUMO4 ) 4 被连接了到 anti-atherogenic 效果,但是很少对是否被知道在二基因的多型性,独立行动或交往,没有 diabetes.MethodsWe genotyped ,影响冠的动脉疾病( CAD )的风险没有糖尿病的 200 个 CAD 病人和没有 CAD 的 200 控制,它被选择基于前一个没有 diabetes.ResultsRisk 等位基因,协会也是的潜力在 ADIPOR1 (rs7539542-G, rs7514221-C 和 rs3737884-G ) 在三 SNP 在这些 SNP 和 CAD 的临床的特征之间探索了,没有糖尿病,在在 SUMO4 的 SNP rs237025 的 G 等位基因显著地增加了 CAD 的风险,与从 1.79 ~ 4.44 的 ORs。任何这四风险等位基因的搬运人出现了类似不利 ? 临床的特征。与有 CC 或 GC 遗传型的个人相比,有在 rs3737884 的 GG 遗传型的那些在影响了左前面的下降冠的动脉的 CAD 的显著地更高的风险(或:6.77, P = 0.009 ) ,恰好冠的动脉(或:4.81, P = 0.028 ) 或容器的一个相对大的数字(P = 0.04 ) 。没有糖尿病,在 SUMO4 在 SNP 象风险等位基因一样在 ADIPOR1 在三 SNP 中的至少一个带风险等位基因的个人比不带任何风险等位基因的个人在 CAD 的显著地更高的风险(或:5.82, 95% CI:1.2327.7, P = 0.013 ) 没有糖尿病,在 ADIPOR1 和 SUMO4 的 .ConclusionsSNPs 与 CAD 的提高的风险被联系,并且在二基因的 SNP 可以交往联合影响疾病风险。 | Hong LI Ze YANG Lian-Mei PU Xiang LI Yang RUAN Fan YANG Shuai MENG Duo YANG Wei YAO Hao FU Feng ZHANG Ze-Ning JIN | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 6 | Bi_2Se_3/C Nanocomposite as a New Sodium-Ion Battery Anode Material显示文摘Bi_2Se_3 was studied as a novel sodium-ion battery anode material because of its high theoretical capacity and high intrinsic conductivity. Integrated with carbon,Bi_2Se_3/C composite shows excellent cyclic performance and rate capability. For instance, the Bi_2Se_3/C anode delivers an initial capacity of 527 mAh g^(-10) at 0.1 A g^(-1) and maintains 89% of this capacity over 100 cycles. The phase change and sodium storage mechanism are also carefully investigated. | Lixin Xie Ze Yang Jingying Sun Haiqing Zhou Xiaowei Chi Hailong Chen ANDy X.Li Yan Yao Shuo Chen | 2018 | Nano-Micro Letters2018，10，3： | 2 |
| 7 | Annexin A5 regulates Leydig cell testosterone production via ERK1/2 pathway显示文摘这研究是从主要老鼠 Leydig 房间和内在的机制在睾丸激素分泌物上调查 annexin A5 的效果。孤立的老鼠 Leydig 房间与 annexin A5 被对待。睾丸激素生产被化合光试金检测。Steroidogenic 的蛋白质和 mRNA 尖锐规章(星) , P450scc, 3 β -hydroxysteroid 脱氢酶(3 β -HSD), 17 β -hydroxysteroid 脱氢酶(17 β -HSD), 和 17 α -hydroxylase 被分别地的西方的弄污和半量的 RT-PCR 检验。Annexin A5 显著地在剂量依赖者和时间依赖者礼貌从老鼠 Leydig 房间刺激了睾丸激素分泌物并且增加了 mRNA 和星的蛋白质表示, P450scc, 3 β -HSD, 和 17 β -HSD 然而并非 17 α -hydroxylase。由 siRNA 击倒的 Annexin A5 显著地减少了睾丸激素和 P450scc 的蛋白质表示的水平, 3 β -HSD, 和 17 β -HSD。ERK1/2 发信号的重要激活在 annexin A5 处理以后在 5, 10,和 30 min 被观察。在有英皇家空军之阶级最低之兵禁止者 PD98059 的 Leydig 房间的预告的处理以后(50 μ为 20 min 的摩尔 l −1) ,支持睾丸激素分泌物并且增加 P450scc 的表示上的 annexin A5 的效果, 3 β -HSD, 和 17 β -HSD 完全被废除(P <0.05 ) 。因此,发信号的 ERK1/2 在调停涉及 annexin A5 的角色睾丸激素生产和 P450scc 的表示, 3 β -HSD, 和 17 β在 Leydig 房间的 -HSD。 | Ze He Qin Sun Yuan-Jiao Liang Li Chen Yi-Feng Ge Shi-Feng Yun Bing Yao | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 8 | A stable oxygen evolution splitting electrocatalysts high entropy alloy FeCoNiMnMo in simulated seawater显示文摘Stabilizing anode for oxygen evolution(OER)in chlorine-containing electrolytes is a significant challenge.Adding corrosion inhibitors in electrolytes can alleviate this problem,but the type and dosage of cor-rosion inhibitors need a lot of exploration,and side reactions may occur to reduce current efficiency.Herein,we prepared a FeCoNiMnMo High entropy alloy(HEA)electrode for OER in simulated seawa-ter without corrosion inhibitors.It exhibits great electrocatalytic activity(overpotential(η)=237 mV at 10 mA cm^(-2))and excellent stability(200 h at 100 mA cm^(-2)).Experiments and Density Functional The-ory(DFT)calculation show that the protective layer containing K_(2)MoO_(4)is the crucial factor for chlorine resistance of FeCoNiMnMo electrode.The tightly adsorbed state of Cl-and K_(2)MoO_(4)ensures that other oxides are not corroded.And the externally added K_(2)MoO_(4)cannot protect the electrode.In addition,the high-entropy effect of HEA reduces the dissolution of the alloy.This work provides an efficient way to prepare a noble-free HEA catalyst that can stabilize oxygen evolution in corrosive electrolytes. | Peng Li Yuanpeng Yao Wengen Ouyang Ze Liu Huayi Yin Dihua Wang | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 9 | Robust UV/moisture dual curable PDMS-microcapsule-silica functional material for self-healing,antifouling,and antibacterial applications显示文摘Polydimethylsiloxane containing methacryloyloxy and methoxy silane groups(MAPDMS)-microcapsule-SiO_(2)(MPMS)functional materials were prepared by constructing micro-nano hierarchical structures on the surface of MAPDMS matrix.Herein,MAPDMS@1,1-stilbene-modified hydrolyzed polyglycidyl methacrylate/graphene oxide/dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride(MAPDMS@PGMA_(m)/GO/QC18)self-healing microcapsules with compact multi-shell structure were synthesized and combined with nano-SiO_(2)to construct the hierarchical structures.Furthermore,ultraviolet(UV)/moisture dual curing mode was introduced into deep curing reaction and efficient self-healing reaction of the MPMS.The results show that the introduction of UV/moisture dual curing mode and micro-nano hierarchical structure gives MPMS functional materials excellent mechanical properties,antifouling properties,self-healing properties,antibacterial properties.The shear strength and tensile strength of MPMS increase from 3.32 and 4.26 MPa of MAPDMS to 3.81 and 5.06 MPa,respectively.Its static contact angle increases from 115.9°of MAPDMS to 156.5°,its slide angle decreases from 68.5°of MAPDMS to 7.8°,respectively.The antifouling performance of MPMS against seawater,soy sauce,juice,coffee,protein,other contaminants is effectively improved compared with MAPDMS matrix.At the same time,the tensile strength and elongation at break of MPMS after healing reach 98.22%and 96.57%of those in original state,respectively.In addition,the antibacterial rates of MPMS against Escherichia coli and Staphylococcus aureus reach 99.85%and 100%,respectively.The MPMS prepared in this paper is expected to be widely used in marine antifouling,pipeline network,anti-icing,microfluidics,wearable devices,medical devices,electrochemical biosensors,other fields. | Nan Zheng Jie Liu Guoqing Wang Pan Yao Lihong Dang Ze Liu Jiufu Lu Wenge Li | 2023 | Nano Research2023，16，5： | 2 |
| 10 | Salmonella-mediated blood-brain barrier penetration,tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy显示文摘Chemotherapy is an important adjuvant treatment of glioma,while the efficacy is far from satisfactory,due not only to the biological barriers of blood-brain barrier(BBB)and blood-tumor barrier(BTB)but also to the intrinsic resistance of glioma cells via multiple survival mechanisms such as upregulation of P-glycoprotein(P-gp).To address these limitations,we report a bacteria-based drug delivery strategy for BBB/BTB transportation,glioma targeting,and chemo-sensitization.Bacteria selectively colonized into hypoxic tumor region and modulated tumor microenvironment,including macrophages repolarization and neutrophils infiltration.Specifically,tumor migration of neutrophils was employed as hitchhiking delivery of doxorubicin(DOX)-loaded bacterial outer membrane vesicles(OMVs/DOX).By virtue of the surface pathogen-associated molecular patterns derived from native bacteria,OMVs/DOX could be selectively recognized by neutrophils,thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.Moreover,the P-gp expression on tumor cells was silenced by bacteria typeⅢsecretion effector to sensitize the efficacy of DOX,resulting in complete tumor eradication with 100%survival of all treated mice.In addition,the colonized bacteria were finally cleared by anti-bacterial activity of DOX to minimize the potential infection risk,and cardiotoxicity of DOX was also avoided,achieving excellent compatibility.This work provides an efficient trans-BBB/BTB drug delivery strategy via cell hitchhiking for enhanced glioma therapy. | Ze Mi Qing Yao Yan Qi Jinhai Zheng Jiahao Liu Zhenguo Liu Hongpei Tan Xiaoqian Ma Wenhu Zhou Pengfei Rong | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 11 | Total Synthesis of Three New Dihydrostilbenes from Bulbophllum odoratissimum显示文摘A total synthesis of three new dihydrostilbenes, 1, 2 and 3, which were isolated from Bulbophyllum odoratissimum Lindl. with significant cytotoxicity toward human cancer cell lines, was developed via Horner reaction etc. The natural products 1, 2 and 3 were obtained in 5.8%, 6.6% and 5.9%, respectively. | Jin Guang LIN Wei Ge ZHANG Rui ZHAO Ze Yu NIU Kai BAO Dai Lin LIU Nai Li WANG Xin Shen YAO | 2006 | Chinese Chemical Letters2006，17，3： | 1 |
| 12 | Characterization of low-pathogenic H6N6 avian influenza viruses in central China显示文摘 | Yanfeng Yao Huadong Wang Quanjiao Chen Hongbo Zhang Tao Zhang Jianjun Chen Bing Xu Hanzhong Wang Bing Sun Ze Chen | 2013 | Archives of Virology2013，，2： | 1 |
| 13 | Photonic generation ofprecisely it phase-shifted binary phase-coded micro-wave signal 显示文摘 | LI Ming LI Ze YAO Jian-ping | 2012 | IEEE Photonics Technology Letters2012，24，22： | 1 |
| 14 | A New Dammarane Glycoside, Ginsenoside Ⅲ from the Flower-buds of Panax ginseng C.A. Meyer显示文摘From the dried flower-buds of Panax ginseng C.A. Meyer, a new ndnor dammaranetype triterpene saponin named ginsenoside III was iso1ated. On the basis of spectral and chemical evidence, the structure of the new saponin was elucidated as 3 -O- [β-D -glucopyranosyl (1→2 ) - βD- glucopyranosyl] - 20-O-β-D-glucopyranosyl 3 β, 12β- 20(S) -trihydroxydammar- 25 - en- 24-one. | Feng QIU Zhong Ze MA Yu Ping PEI Sui Xu XU Xin Sheng YAO Ying Jie CHEN Zhen Tao CHE(Shenyang Pharmaceutical University, Shenyang, 110015)(The Hongkong University of Science & Technology, Hong Kong) | 1998 | Chinese Chemical Letters1998，9，7： | 1 |
| 15 | Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge显示文摘Human cytomegalovirus virions contain three major glycoprotein complexes (gC I, II, III), all of which are required for CMV infectivity. These complexes also represent major antigenic targets for anti-viral immune responses. The gC II complex consists of two glycoproteins, gM and gN. In the current study, DNA vaccines expressing the murine cytomegalovirus (MCMV) homologs of the gM and gN proteins were evaluated for protection against lethal MCMV infection in a mouse model. Humoral and cellular immune responses, spleen viral titers, and mice survival and body-weight changes were examined. The results showed that immunization with gM or gN DNA vaccine alone was not able to offer good protection, whereas co-immunization with both gM and gN induced an effective neutralizing antibody response and cellular immune response, and provided mice with complete protection against a lethal MCMV challenge. This study provides the first in vivo evidence that the gC II (gM-gN) complex may be able to serve as a protective subunit antigen for future HCMV vaccine development. | Huadong Wang Yanfeng Yao Chaoyang Huang Quanjiao Chen Jianjun Chen Ze Chen | 2013 | Virologica Sinica2013，28，3： | 1 |
| 16 | Component fractionation of wood-tar by column chromatography with the packing material of silica gel显示文摘Bio-oil can be an important fuel resource for automobiles in the future,while its complex composition restricts the direct application of the bio-oil extremely.So it is necessary to separate the complex mixture to relatively simplified fractions for goal directed specific treatments to reach the fuel quality for automobiles,and meanwhile different functional chemical materials and fine chemicals can be obtained.So it is significant to investigate the bio-oil component separating methods.Herein the method of column chromatography by the packing material of silica gel with two series of eluants of cyclohexane-benzene-methanol and cyclohexane-dichloromethane-methanol were investigated for component fractionation of the raw wood tar (oil fraction of the liquid product by slow pyrolysis of wood).The analytical results show that the components in cyclohexane are rich in alkoxyl-monophenols;the components of alkyl-monophenols and five ring oxygen-containing compounds are abundant in benzene and in dichloromethane similarly;in the methanol fraction,the components are diverse and diphenols are relatively in higher content,comparatively small polar molecules and five ring oxygen-containing compounds are more abundant in the methanol fraction after being eluted by dichloromethane,and the content of 1-(4-hydroxy-3-methoxyphenyl)-2-propanone is higher after being eluted by benzene. | WANG Ze LIN WeiGang SONG WenLi DU Lin LI ZhengJie YAO JianZhong | 2011 | Chinese Science Bulletin2011，56，14： | 1 |
| 17 | An Improved Method for Predicting Linear B-cell Epitope Using Deep Maxout Networks显示文摘To establish a relation between an protein amino acid sequence and its tendencies to generate antibody response,and to investigate an improved in silico method for linear B-cell epitope(LBE)prediction.We present a sequence-based LBE predictor developed using deep maxout network(DMN)with dropout training techniques.A graphics processing unit(GPU)was used to reduce the training time of the model.A 10-fold cross-validation test on a large,non-redundant | LIAN Yao HUANG Ze Chi GE Meng PAN Xian Ming | 2015 | Biomedical and Environmental Sciences2015，28，6： | 1 |
| 18 | Simulation of calcium oxalate stone in vitro 显示文摘 | OUYANG Jian - ruing YAO Xiu - qiong SU Ze - xuan | 2003 | Science in China (Series B))2003，33，1： | 1 |
| 19 | Evaluation of D(d,n)^3 He reaction neutron source models for BNCT irradiation system design显示文摘<正>A mathematical method was developed to calculate the yield,energy spectrum and angular distribution of neutrons from D(d,n)~3He(D-D)reaction in a thick deuterium-titanium target for incident deuterons in energies lower than 1.0MeV.The data of energy spectrum and angular distribution were applied to set up the neutron source model for the beam-shaping-assembly(BSA)design of Boron-Neutron-Capture-Therapy(BNCT)using MCNP-4C code. Three cases of D-D neutron source corresponding to incident deuteron energy of 1000,400 and 150 key were inves- tigated.The neutron beam characteristics were compared with the model of a 2.45 MeV mono-energetic and isotropic neutron source using an example BSA designed for BNCT irradiation.The results show significant differences in the neutron beam characteristics,particularly the fast neutron component and fast neutron dose in air,between the non-isotropic neutron source model and the 2.5 MeV mono-euergetic and isotropic neutron source model. | YAO Ze'en LUO Peng Tooru KOBAYASHI Gerard BENGUA | 2007 | Nuclear Science and Techniques2007，18，6： | 1 |
| 20 | Instantaneous microwave fre- quency measurement using a special fiber bragg grating 显示文摘 | Li Ze Chi H Yao J P | 2011 | IEEE Microwave and Wireless Components Let- ters2011，21，1： | 1 |
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