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| 1 | Isolation and identification of novel casein-derived bioactive peptides and potential functions in fermented casein with Lactobacillus helveticus显示文摘The present study here establishes a complete and effective method for isolating,purifying and identifying extracellular and intracellular peptides,and also describes the characters and bioactivities of peptides from fermented casein with Lactobacillus helveticus.Intracellular peptides are much larger in quantity and more complex in composition than extracellular peptides,between which the correlation reveals proteolytic and metabolic mechanisms.In addition,totally 241 different peptide sequences were identified by Nano LC–MS/MS from casein(212)and Lactobacillus helveticus proteins(29).These casein-derived peptides mostly originated from-casein,followed byS1-casein,-casein,andS2-casein,and came from extracell(69)and intracell(143),in which common peptides have a total of 27.Forty-four of the identified peptides were previously described as bioactive,including angiotensinconverting enzyme(ACE)-inhibitory,antioxidant,immunomodulating,antimicrobial,DPP-IV inhibitory,antiamnesic and anticancer effects and so on.Thirteen peptides with the potential of some biological activities are obtained,which were described in previous studies.A total of 47 novel peptides of 5 to 26 amino acids that were not disclosed were obtained.The new sources of natural bioactive peptides may have the very high application value as potential new peptide drugs for treatment human diseases.The product peptide DELQDKIHPF found in both extracell and intracell was quantitatively analyzed using the MRM mode of UPLC-U3Q,23.1 and 9.76 ng/mL,respectively.The quantitative analysis of the potential bioactive peptide may also advance the production of peptide products in the future. | Mengzhu Fan Tingting Guo Wanru Li Jing Chen Fushuo Li Chao Wang Yi Shi David Xi-an Li Shaohui Zhang | 2019 | Food Science and Human Wellness2019，8，2： | 5 |
| 2 | Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation显示文摘Objective: To investigate the relationship between the transcription of ANRIL, P15, P14 and P16 at the same locus and the regulation mechanism of ANRIL.Methods: Publicly available database of Cancer Cell Line Encyclopedia(CCLE) was used in bioinformatic analyses. Methylation of Cp G islands was detected by denaturing high performance liquid chromatography(DHPLC). Gene transcript levels were determined using quantitative real-time polymerase chain reaction(q RTPCR) assays. An engineered P16-specific transcription factor and DNA methyltransferase were used to induce P16-specific DNA demethylation and methylation.Results: The expression level of ANRIL was positively and significantly correlated with that of P16 but not with that of P15 in the CCLE database. This was confirmed in human cell lines and patient colon tissue samples. In addition, ANRIL was significantly upregulated in colon cancer tissues. Transcription of ANRIL and P16 was observed only in cell lines in which the P16 alleles were unmethylated and not in cell lines with fully methylated P16 alleles.Notably, P16-specific methylation significantly decreased transcription of P16 and ANRIL in BGC823 and GES1 cells. In contrast, P16-specific demethylation re-activated transcription of ANRIL and P16 in H1299 cells(P<0.001).Alteration of ANRIL expression was not induced by P16 expression changes.Conclusions: ANRIL and P16 are coordinately transcribed in human cells and regulated by the methylation status of the P16 Cp G islands around the transcription start site. | Ying Gan Wanru Ma Xiuhong Wang Juanli Qiao Baozhen Zhang Chenghua Cui Zhaojun Liu Dajun Deng | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 3 | A mumps model with seasonality in China显示文摘Background:Mumps,an infectious viral disease,classically manifested by inflammation of salivary glands and is best known as a common childhood viral disease with no specific treatment.Although it can be protected by vaccine,there are more than 100,000 reported mumps cases according to the Chinese Center for Disease Control and Prevention.However,the factors and mechanisms behind the persistence and prevalence of mumps have not been well understood.Methods:A mumps model with seasonal fluctuation is formulated and investigated.We evaluate the basic reproduction numberℛ0 and analyze the dynamical behavior of the model.We also use the model to simulate the monthly data of mumps cases and carry out some sensitivity analysis ofℛ0 in terms of various model parameters.Results:It is shown that there exists only disease-free solution which is globally asymptotically stable ifℛ0<1,and there exists a positive periodic solution ifℛ0>1.ℛ0 is a threshold parameter,and its magnitude determines the extinction or persistence of the disease.Conclusion:Our analysis shows that vaccination rate and invalid vaccination rate play important roles in the spread of mumps.Hence,Our study suggests to increase the vaccine coverage and make two doses of MMR(Measles,mumps and rubella vaccine)vaccine freely available in China. | Qianqian Qu Cong Fang Le Zhang Wanru Jia Jie Weng Yong Li | 2017 | Infectious Disease Modelling2017，2，1： | 2 |
| 4 | Quantifying the effects of nitrogen on fruit growth and yield of cucumber crop in greenhouses显示文摘 | Jianfeng Dai Shanshan Liu Wanru Zhang Rui Xu Weihong Luo Shengfei Zhang Xinyou Yin Li Han Weiping Chen | 2011 | Scientia Horticulturae2011，，3： | 1 |
| 5 | Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser显示文摘Neural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies.The recently proposed hierarchical platinum-iridium(Pt-Ir)electrodes produced by femtosecond lasers have exhibited superior electrochemical performance in vitro,but their in vivo performance is still unclear.In this study,we explored the electrochemical performance,biological response,and tissue adhesion of hierarchical Pt-Ir electrodes by implantation in adult rat brains for 1,8,and 16 weeks.Regular smooth Pt-Ir electrodes were used as a control.The results showed that the electrochemical performance of both electrodes decreased and leveled off during implantation.However,after 16 weeks,the charge storage capacity of hierarchical electrodes stabilized at~16.8 mC/cm^(2),which was 15 times that of the smooth control electrodes(1.1 mC/cm^(2)).Moreover,the highly structured electrodes had lower impedance amplitude and cutoff frequency values.The similar histological response to smooth electrodes indicated good biocompatibility of the hierarchically structured Pt-Ir electrodes.Given their superior in vivo performance,the femtosecond laser-treated Pt-Ir electrode showed great potential for neuromodulation applications. | Linze Li Changqing Jiang Wanru Duan Zhiyan Wang Feng Zhang Changgeng He Tiangang Long Luming Li | 2022 | Microsystems & Nanoengineering2022，8，5： | 1 |
| 6 | Design and implementation of unmanned aerial vehicle localization and light tracking system显示文摘Unmanned aerial vehicles(UAV)are applied widely and profoundly in various fields.Moreover,high-precision positioning and tracking in multiple scenarios are the core requirements for UAV usage.To ensure stable communication of UAVs in denial environments with substantial electromagnetic interference,a systematic solution is proposed based on a deep learning algorithm for target detection and visible light for UAV tracking.Considering the cost and computational power limitations on the hardware,the you only look once(YOLO)v4-Tiny model is used for static target detection of the UAV model.For UAV tracking,and a light tracker that can adjust the angle of emitted light and focus it on the target is used for dynamic tracking processing.Thus,achieving the primary conditions of UAV optical communication with good secrecy is also suitable for dynamic situations.The UAV tracker positions the UAV model by returning the coordinates and calculating the time delay,and then controls the spotlight to target the UAV.In order to facilitate the deployment of deep learning models on hardware devices,the lighter and more efficient model is selected after comparison.The trained model can achieve 99.25%accuracy on the test set.The dynamic target detection can reach 20 frames per second(FPS)on a computer with an MX520 graphics processing unit(GPU)and 6 GB of random access memory(RAM).Dynamic target detection on a Jetson Nano can reach 5.4 FPS. | Xu Ming Dong Chen Li Hanlu Luo Qiming Wang Lizi Zhang Wanru Liu Huixin | 2023 | The Journal of China Universities of Posts and Telecommunications2023，30，4： | 0 |
| 7 | Organic solar cells based on small molecule donor and polymer acceptor显示文摘Small molecule donor/polymer acceptor(SD/PA)-type organic solar cells(OSCs)have attracted widespread attention in recent years due to the continuing power conversion efficiency(PCE)growth,near 10%,and the excellent thermal stability for the practical applications.However,the development of SD/PA-type OSCs lags far behind that of polymer donor/small molecule acceptor(PD/SA)-type OSCs,which are also based on the combination of small molecule and polymer,with the PCEs exceeding 18%.The reasons accounting for this great gap are well worth exploring.In this review,we have analyzed the key factors affecting the photovoltaic performances of SD/PA-type OSCs,systematically summarized the research progress of SD/PA type OSCs in recent years,and put forward our own views on the future development of SD/PA type OSCs. | Wanru Xu Yilin Chang Xiangwei Zhu Zhenhua Wei Xiaoli Zhang Xiangnan Sun Kun Lu Zhixiang Wei | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 8 | Synaptotagmins: links to human disease显示文摘 | Wanru Li Claire Xi Zhang | 2017 | Journal of Translational Neuroscience2017，2，4： | 0 |
| 9 | An Automated Detection Approach of Protective Equipment Donning for Medical Staff under COVID-19 Using Deep Learning显示文摘Personal protective equipment(PPE)donning detection for medical staff is a key link of medical operation safety guarantee and is of great significance to combat COVID-19.However,the lack of dedicated datasets makes the scarce research on intelligence monitoring of workers’PPE use in the field of healthcare.In this paper,we construct a dress codes dataset for medical staff under the epidemic.And based on this,we propose a PPE donning automatic detection approach using deep learning.With the participation of health care personnel,we organize 6 volunteers dressed in different combinations of PPE to simulate more dress situations in the preset structured environment,and an effective and robust dataset is constructed with a total of 5233 preprocessed images.Starting from the task’s dual requirements for speed and accuracy,we use the YOLOv4 convolutional neural network as our learning model to judge whether the donning of different PPE classes corresponds to the body parts of the medical staff meets the dress codes to ensure their self-protection safety.Experimental results show that compared with three typical deeplearning-based detection models,our method achieves a relatively optimal balance while ensuring high detection accuracy(84.14%),with faster processing time(42.02 ms)after the average analysis of 17 classes of PPE donning situation.Overall,this research focuses on the automatic detection of worker safety protection for the first time in healthcare,which will help to improve its technical level of risk management and the ability to respond to potentially hazardous events. | Qiang Zhang Ziyu Pei Rong Guo Haojun Zhang Wanru Kong Jie Lu Xueyan Liu | 2022 | Computer Modeling in Engineering & Sciences2022，，9： | 0 |
| 10 | Sparse Rev-Shift Coded Modulation with Novel Overhead Bound显示文摘To provide reliability in distributed systems,combination property(CP)is desired,where k original packets are encoded into n≥k packets and arbitrary k are sufficient to reconstruct all the original packets.Shift-and-add(SA)encoding combined with zigzag decoding(ZD)obtains the CP-ZD,which is promising to reap low computational complexity in the encoding/decoding process of these systems.As densely coded modulation is difficult to achieve CP-ZD,research attentions are paid to sparse coded modulation.The drawback of existing sparse CP-ZD coded modulation lies in high overhead,especially in widely deployed setting m | Mingjun Dai Wanru Li Chanting Zhang Xiaohui Lin Bin Chen | 2023 | China Communications2023，20，10： | 0 |
| 11 | Advances in Research on Hypoglycemic Functions of Polysaccharides from Medicinal and Edible Plants显示文摘Plant polysaccharides have an excellent hypoglycemic effect through various ways such as promoting insulin secretion,improving insulin resistance,regulating related enzyme activities,improving sugar,protein and fat metabolism,promoting hepatic glycogen synthesis,inhibiting gluconeogenesis,and improving immune system function and resistance.At present,more than 200 polysaccharides derived from traditional Chinese medicines have been reported,and most of them are isolated and purified from plants.With the deepening of research on plant polysaccharides,more and more attention has been paid to the development of safe and economical natural hypoglycemic products.This paper first introduced the hypoglycemic effects of Folium Mori polysaccharides,Cucurbita moschata polysaccharides,Momordica charantia polysaccharides,Dioscoreae Rhizoma polysaccharides and Camellia sinensis O.Kuntze polysaccharides.Besides,it discussed the utilization ways of hypoglycemic plant polysaccharides,and the prospects of applying polysaccharide hypoglycemic effect to diabetes treatment,so as to provide reference for the research and utilization of plant polysaccharide hypoglycemic effects and the development of natural hypoglycemic foods. | Xiaohan ZHANG Chenghui ZHANG Wenrui YU Wanru XUE Tong TONG Jialin SUN Xuqiao FENG | 2018 | Medicinal Plant2018，9，6： | 0 |
| 12 | Chlorinated phthalimide polymer donor as ultra-wide bandgap and deep HOMO guest for achieving highly efficient polymer solar cells显示文摘Quaternary approach has been receiving more and more attention due to its effectiveness in improving solar cell performance, while synthesis/selection of the fourth component is yet a key issue. Herein, we report a chlorinated phthalimide based donor polymer(namely Ph I-Cl) having an ultra-wide bandgap(2.10 e V) and a deep HOMO(-5.58 e V) level. Addition of Ph I-Cl as the third component of PM6:Y6 and the fourth of PM6:Y6:PC71BM increases both hole and electron mobilities and gives rise to more balanced charge carriers mobilities. Both the short-circuit current-density and fill-factor are increased and open-circuit voltage is well maintained, delivering 17.0% and 18.1% efficiencies, respectively. These results demonstrate that chlorination on the side thiophene of phthalimide-based donor polymer is a way to make deep HOMO and ultra-wide bandgap donor polymer guest used for highly efficient ternary and quaternary strategies. | Weichao Zhang Jianhua Huang Xiaoyu Lv Ming Zhang Wanru Liu Tianzi Xu Jun Ning Alata Hexig Feng Liu Aiju Xu Chuanlang Zhan | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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