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| 1 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 2 | Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg显示文摘 | He XW Wang F Jiang L Li J Liu SK Xiao ZY Jin XQ Zhang YN He Y Li K Guo YJ Sun SH | 2005 | 第二军医大学学报2005，26，10： | 5 |
| 3 | Structure of nano-copper and nano-conductive fibers显示文摘VARIOUS small inorganic solid grain catalysts, alloys and films consisting of various nano-size particles were prepared by chemical methods. The study of catalytic properties of nanostructured materials integrated material physics with chemistry, which promoted the development of materials science. | Zhang, ZK Cui, ZL Chen, KZ Wang, YN Ning, YP | 1997 | Chinese Science Bulletin1997，42，18： | 4 |
| 4 | Overexpression of miR- 125b, a novel regulator of innate immunity, in eosinophilie chronic rhinosinusitis with nasal polyps 显示文摘 | Zhang XH Zhang YN Li HB | 2012 | Am J Respir Crit Care Med2012，185，2： | 1 |
| 5 | Effect of hysteroscopy on the peritoneal dissemination of endometrial cancer cells : a meta- analysis 显示文摘 | Chang YN Zhang Y Wang Y J | 2011 | Fertil steril2011，96，： | 1 |
| 6 | The application of mind mapping in the teaching of pharmaceutics 显示文摘 | Jiang YN Zhang JH Wang L | 2007 | Education Science & Culture Magazine2007，，2： | 1 |
| 7 | Immunohistocheraical localization of huntingtin- associated protein 1 in endocrine system of the rat 显示文摘 | Liao M Shen JY Zhang YN | 2005 | J Histochem Cytochem2005，53，12： | 1 |
| 8 | Identification of novel chromosomal abnormalities,inv(5)(p13q13) and t(7; 8)(q23;q21),associated with autism显示文摘 | Chert Z Zhou XB Zhang YN | 2007 | Am J Biochem & Biotech2007，3，3： | 1 |
| 9 | Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat 显示文摘 | Liao M Shen JY Zhang YN | 2005 | J Histochem Cytochem2005，53，12： | 1 |
| 10 | Distribution and flo- ristics of desert plant communities in the lower rea- ches of Tarim River, southern Xinjiang, People's Republic of China显示文摘 | Zhang YM Chen YN Pan BR | 2005 | JAridEnvir2005，63，4： | 1 |
| 11 | Wounding-induced WRKY8 is involved in basal defense in Arabidopsis 显示文摘 | Chen LG Zhang LP Yn DQ 2010 | 2010 | Molecular Plant- Microbe Interactions2010，23，： | 1 |
| 12 | Antagonistic effects of ultra-low-molecular-weight heparin against cerebral ischemia/reperfusion injury in rats显示文摘 | Zhang ZG Zhang QZ Cheng YN | | 0，，： | 1 |
| 13 | Increased local TgE production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic,but not non- eosinophilic,chronic rhinosinusitis with nasal polyps显示文摘 | Cao PP Zhang YN Liao B | 2014 | Clin Exp Allergy2014，44，5： | 1 |
| 14 | Peroxynitrite mediates high glucose-induced osteoblast apoptosis显示文摘 | Qi J S Li Yn Zhang B S | 2008 | J Endocrinol Invest2008，31，4： | 1 |
| 15 | Inhibition of infection of incoming HIV-1 virus by RNA-cleaving DNA enzyme显示文摘 | Zhang XY Xu YN Ling H | 1999 | FEBS Lett1999，458，2： | 1 |
| 16 | Microsatellite alterations in human hepatocetlular carcinoma infected with hepatitis B virus: associated with the elevation of serum alpha-fetoprotein 显示文摘 | Yang EB Zhao YN Zhang K | 2001 | Int J Oncol2001，19，3： | 1 |
| 17 | Characterization of the ge- nomic structure and tissue-specific promoter of the human nuclear receptor NR5A2(hB1F)显示文摘 | Zhang C K Lin W Cai YN | 2001 | Gene2001，273，2： | 1 |
| 18 | Effect and mechanisms of rutaecarpine on treating atopic dermatitis in mice 显示文摘 | Tong M Guo YN Zhang GY | 2011 | Sichuan Da Xue Xue Bao Yi Xue Ban2011，42，23： | 1 |
| 19 | MicroRNA miR-886-5p inhibits apoptosis by down-regulating Bax expression in human cervical carcinoma cells显示文摘 | Li JH Xiao X Zhang YN | 2011 | Gynecol Oncol2011，120，1： | 1 |
| 20 | AI-40 injected into the bilateral hippocampus can induce neurotoxic effect in AD rats显示文摘 | JIANG LH ZHANG YN SONG FF et aI | 2007 | ACTA UNNERSITATIS MEDICIN ALIS NAN?JlNG (Natural Science)2007，27，12： | 1 |
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