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| 1 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Natural Selection and Adaptive Evolution of Leptin in the Ochotona Family Driven by the Cold Environmental Stress 显示文摘 | Wang ZL Zhao XQ Wang DP Qi DL Xu BH Ren YH Tian HF | 2008 | PLoS ONE2008，3，1： | 1 |
| 3 | C-reactive protein induces interleukin-6 and thrombospondin-1 protein and mRNA expression through activation of nuclear factor-xll in HK-2 cells 显示文摘 | Wang HR Chen DL Zhao M | 2012 | Kidney Blood Press Res2012，35，4： | 1 |
| 4 | Role of insulin and insulin receptor in learning and memory显示文摘 | Zhao WQ Alkon DL | 2001 | Mol Cell Endocrinol2001，177，12： | 1 |
| 5 | The evolution of the vertebrate Dlx gene family显示文摘 | Stock DW Ellies DL Zhao Z | 1996 | Proc Natl Acad Sci USA1996，93，10： | 1 |
| 6 | Osteogenic potential of bone marrow stremal cells derived from streptozotocin- induced diabetic rats显示文摘 | Zhao YF Zeng DL Xia LG | 2013 | Int J Mol Med2013，31，3： | 1 |
| 7 | On tension-compression yield asymmetry in an extruded Mg-3AI-IZn alloy显示文摘 | DL Yin JT Wang JQ Liu X Zhao | 2009 | Journal of Alloys and Compounds2009，478，1： | 1 |
| 8 | Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer显示文摘 | Zhao L Wang DL Liu Y | 2013 | Cell Signal2013，25，8： | 1 |
| 9 | Arabidopsis ECERIFERUM9 involvement in cuticle formation and maintenance of plant water status显示文摘 | Lue S Zhao H Des Marais DL Parsons EP Wen X Xu X Bangarusamy DK Wang G Rowland O Juenger T Bressan RA Jenks MA | | 0，，： | 1 |
| 10 | YAP is overexpressed in clear cell renal cell carcinoma and its knockdown reduces cell prolifera- tion mad induces cell cycle arrest and apoptosis显示文摘 | Cao Y Zhao XM Wang DL | 2014 | Oncol Rep2014，32，4： | 1 |
| 11 | Role of insulin and insulin receptor in learning and memory 显示文摘 | Zhao WQ Alkon DL | 2001 | Mol Cell Endocrinol2001，25，1： | 1 |
| 12 | Insulin and the insulin receptor in experimental models of learning and memory显示文摘 | Zhao WQ Chen H Quon MJ Alkon DL | 2004 | Eur J Pharmacol2004，490，13： | 1 |
| 13 | Influence of corporin on BBB in ischemic reperfusion rats brain显示文摘 | Li DL Zhao HG Qi W etal | 2005 | J Apoplexy Nervous Disease2005，18，2： | 1 |
| 14 | Role of insulin and insulin receptor inlearning and memory 显示文摘 | Zhao WQ Alkon DL | 2001 | Mol Cell Endocrinol2001，25，1： | 1 |
| 15 | Myeloid dendritic cells can kill T cells during chronic hepatitis C virus infection 显示文摘 | ZHAO L TYRRELL DL | 2013 | Viral Immunol2013，26，1： | 1 |
| 16 | Effect of montelukast on the expression of interleukin-18, telomerase reverse transcriptase, and Bcl-2 in the brain tissue of neonatal rats with hypoxic-ischemic brain damage显示文摘 | Liu JL Zhao XH Zhang DL | 2015 | Genet Mol Res2015，14，3： | 1 |
| 17 | Stereoselective metabolism of tetrah'/- dropalmatine enantiomers in rat liver microsomes 显示文摘 | Zhao M Li LP Sun DL | 2012 | Chirality2012，24，5： | 1 |
| 18 | Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway 显示文摘 | Fan DL Zhao WJ Wang YX | 2012 | Int J Dermatol2012，51，： | 1 |
| 19 | Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth faetor-IM/Smad signaling pathway 显示文摘 | Fan DL Zhao WJ Wang YX | 2012 | Int J Dermatol2012，51，4： | 1 |
| 20 | Role of insulin and insulin receptors in learning and memory显示文摘 | Zhao WQ Alokon DL | 2001 | Mol Cell Endocrinol2001，177，12： | 1 |
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