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| 1 | Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration显示文摘Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related diseases.Here,we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone(PTH)peptide PTH(1-34)and nano-hydroxyapatite(nHAP).A combination of the positively charged natural polymer chitosan(CS)and negatively charged sodium alginate led to the formation of hydrogels with porous structures,as shown by scanning electron microscopy.Rheological characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1-34).In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34)exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells(rBMSCs)via the Notch signaling pathway,as shown by the upregulated expression of osteogenic-related proteins.We found that increasing the content of PTH(1-34)in the hydrogels resulted in enhanced osteogenic differentiation of BMSCs.Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP,indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process.Both the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration,suggesting a new strategy for tissue engineering and regeneration in the future. | Zhiyuan Zou Le Wang Zhifei Zhou Qing Sun Delong Liu Yan Chen Hao Hu Yu Cai Sixiong Lin Zhengran Yu Bizhi Tan Wei Guo Zemin Ling Xuenong Zou | 2021 | Bioactive Materials2021，6，6： | 7 |
| 2 | Epidemic Characteristics of Human Rabies—China,2016–2020显示文摘Introduction:The epidemiological characteristics of human rabies in China in 2016–2020 were analyzed in order to provide the scientific basis for the formulation of the prevention and control policy of rabies at next stage.Methods:The data of China’s National Notifiable Disease Reporting System(NNDRS)from 2016 to 2020 were collected and analyzed by using a descriptive epidemiology method.Results:A total of 2,074 cases of human rabies were reported from 2016–2020 in China,there were year over year decreases in total number of cases.Human rabies appeared throughout the year,among which the highest in incidence happened from August to October,while March and December months were months in which the epidemic was weakest.Conclusion:Though decreases were observed for human rabies in China,further steps should be taken to maintain these results.Management should be strengthened and the immunity of dogs should be prioritized to control this situation from the source.In addition,all reported cases should be monitored and reported to achieve the accurate prevention and control. | Zhengran Liu Min Liu Xiaoyan Tao Wuyang Zhu | 2021 | China CDC weekly2021，3，39： | 3 |
| 3 | The use of coronary stent in hepatic artery stenosis after orthotopic liver transplantation显示文摘 | Mingsheng Huang Hong Shan Zaibo Jiang Zhengran Li Kangshun Zhu Shouhai Guan Jiesheng Qian Guihua Chen Minqiang Lu Yang Yang | 2006 | European Journal of Radiology2006，，3： | 1 |
| 4 | An isoindigo-bithiazole-based acceptor-acceptor copolymer for balanced ambipolar organic thin-film transistors显示文摘Balanced carrier transport is observed in acceptor-acceptor (A-A′) type polymer for ambipolar organic thin-film transistors B (OTFTs). It is found that the incorporation of two electron-accepting moieties (BTz and IIG) into a polymer main chain to form A-A′ polymer PIIG-BTz could lower highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels and facilitate good molecular stacking of the polymer. Ambipolar transistor behaviour for PIIG-BTz, with the balanced hole and electron mobilities of 0.030 and 0.022 cm2 V-1 s-1 was observed in OTFT devices, respectively. The study in this work reveals that the utilization of acceptor-acceptor (A-A′) structure in polymer main chain can be a feasible strategy to develop ambipolar polymer semiconductors. | Ping Li Hanlin Wang Lanchao Ma Long Xu Fei Xiao Zhengran Yi Yunqi Liu Shuai Wang | 2016 | Science China Chemistry2016，59，6： | 1 |
| 5 | CgVeA, a light signaling responsive regulator, is involved in regulation of chaetoglobosin A biosynthesis and conidia development in Chaetomium globosum显示文摘Cytochalasans,with diverse structures and pharmacological activities,are a class of compounds containing isoindolinone moieties fused to the tricyclic or tetracyclic ring system.Chaetoglobosin A(cheA),mainly produced by Chaetomium globosum,is the most abundant cytochalasan.However,limited understanding of transcriptional regulation of morphological development and cheA biosynthesis in C.globosum has hindered cheA application in agriculture and biomedical field.This study examined the regulatory role of CgVeA gene in C.globosum.CgVeA had significant effect on secondary metabolites production in C.globosum,similar to that reported in other filamentous fungi.Inactivation of CgVeA caused an obvious decrease in cheA production from 51.32 to 19.76 mg/L under dark conditions.In contrast,CgVeA overexpression resulted in a dramatic increase in cheA production,reaching 206.59 mg/L under light conditions,which was higher than that noted under dark condition.The RT-qPCR results confirmed that CgVeA,as a light responsive regulator,positively regulated cheA biosynthesis by controlling the expression of core genes of the cheA biosynthetic gene cluster and other relevant regulators.Electrophoretic mobility shift assays proved that CgVeA directly regulated LaeA,cheR,and p450,and indirectly regulated PKS.Moreover,CgVeA had a significant effect on the regulation of asexual spores production.When compared with wild-type C.globosum,CgVeA-silenced and CgVeA overexpression mutants presented remarkable differences in sporulation,irrespective of light or dark condition.Besides,CgVeA expression was speculated to negatively regulate spore formation.These findings illustrated the regulatory mechanism of a hypothetical global regulator,CgVeA,in C.globosum,suggesting its potential application in industrial-scale cheA biosynthesis. | Zhengran Wang Shanshan Zhao Kai Zhang Congyu Lin Xin Ru Qian Yang | 2022 | Synthetic and Systems Biotechnology2022，7，4： | 1 |
| 6 | Progress in quality control of herbal medicine with IR fingerprint spectra显示文摘 | Zou Huabin Yang Guosheng Qin Zhengran | 2005 | Anal lett2005，38，9： | 1 |
| 7 | Microstructural Evolution and Anisotropic Weakening Mechanism of ZK60 Magnesium Alloy Processed by Isothermal Repetitive Upsetting Extrusion显示文摘The isothermal repetitive upsetting extrusion(RUE)was implemented to process ZK60 magnesium alloy at 380℃.Then,the relationship between the microstructural characters,including grain refinement and texture evolution,and the mechanical performance of the alloy was investigated.Results showed that after 3 passes of RUE,the average grain size was refined from 115.0 to 26.5μm,which was mainly caused by the continuous dynamic recrystallization and discontinuous dynamic recrystallization.Meanwhile,the elongation of the alloy increased from 13.8 to 21.6%,and the superplasticity(142%)of the alloy has been achieved in the following high temperature tensile test,which is very beneficial for the further processing of the alloy into components.In particular,the alloy formed a distinctive texture distributed between<2-1-11>and<2-1-14>,which was greatly related to the Schmid factor of extrusion direction(ED)and transverse direction(TD).This texture changed the initiation ability of basal and prismatic slip in both directions and inhibited the initiation of partial tensile twinning in TD;thus,the anisotropy in both directions was weakened.As expected,the tensile yield strength difference decreased from25.9 to 3.4 MPa,but it was used as the cost of tensile yield strength in ED. | Zhengran Liu Xi Zhao Kai Chen Siqi Wang Xianwei Ren Zhimin Zhang Yong Xue | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，5： | 1 |
| 8 | High-performance and high-thermally stable PSN-PZT piezoelectric ceramics achieved by high-temperature poling显示文摘High piezoelectric properties and superior thermal stability are both important indicators of piezoelectric ceramics serving at high temperature.However,since these properties are usually mutually exclusive,high performance and superior thermal stability are hard to achieve simultaneously.Here we report that a high piezoelectricity(d_(33)∼562 pC/N)and superior thermal stability(the variation is within 7%from 20 to 330℃)were both achieved in 0.4 mol%ZnO-doped 0.02Pb(Sb_(1/2)Nb_(1/2))-0.51PbZrO_(3)-0.47PbTiO_(3) by high-temperature poling.Compared with traditional poling method,high-temperature poling method forms a small-sized and highly oriented domain structure,which can effectively improve the piezoelectric and dielectric properties of piezoelectric ceramics.At the same time,the enhanced pinning effect of defect ions and stabilized domain structure due to high-temperature poling also contribute to the superior temperature stability of the piezoelectric and dielectric properties.This work provides an effective method for designing piezoelectric materials with high performance and good temperature stability for high temperature sensor applications. | Zhengran Chen Ruihong Liang Chi Zhang Zhiyong Zhou Yuchen Li Zhenming Liu Xianlin Dong | 2022 | Journal of Materials Science & Technology2022，，21： | 1 |
| 9 | Electroless ultrasonic funetionalization of diamond nanoparticles using aryl diazonium salts显示文摘 | Mangeney C Qin Zhengran Dahoumane S A | 2008 | Diamond and Related Materials2008，17，11： | 1 |
| 10 | Progress in quality control of herbal medicine with IR fingerprint spectra显示文摘 | ZOU Huabin YANG Guosheng QIN Zhengran | 2005 | Analytical Letters2005，38，9： | 1 |
| 11 | Sludge composition and characteristics shaped microbial community and further determined process performance: A study on full-scale thermal hydrolysis-anaerobic digestion processes显示文摘Anaerobic digestion (AD) with thermal hydrolysis (TH) pretreatment is a promising process for excess sludge treatment,while there lacks of the knowledge from full-scale process about the impact of sludge composition and characteristics on microbial community and performance.The sludge physiochemical indices,microbial community and performance data of four full-scale TH-AD plants were characterized,and their relationships was elucidated.The four plants were operated under almost similar total organic loading rate (OLR)but their methanogenesis performance differentiate into two groups,namely superior group(SupG) and the inferior group (Inf G).In both groups,TH effectively solubilized particulate organic compounds,meanwhile raised the ammonia nitrogen (NH_(4)^(+)-N) and volatile fatty acid (VFA) concentration.Compared with the Sup G,thermal hydrolyzed sludge of Inf G had higher level of VFAs,NH_(4)^(+)-N and total chemical oxygen demand (t COD),which showed higher inhibition effect on microbes,leading to a community with lower diversity,lower abundance of carbohydrate degrading functional guild,higher protein degrading one,and methanogens that adapted to limited substrates,and further declined the methane production rate.Thus,it was recommended that OLR alone was not sufficient for controlling the system in design and operation,the concentration of VFAs,NH_(4)^(+)-N and t COD should be equally considered.Their higher concentration,together with the higher abundance of Defluviitoga and Proteiniphilum were recommended as indicators for inferior running condition.Our results proposed that microbial communities played a role of bridge between environmental factors and performance,provided implications for engineering ecology and operational regulation for full-scale sludge TH-AD process. | Wei Liu Chenxiang Sun Wei Li Tianle Li Zhan Chen Jiawei Wang Zhengran Ren Xianghua Wen | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 12 | Derlin-1 and TER94/VCP/p97 are required for intestinal homeostasis显示文摘Adult stem cells are critical for the maintenance of residential tissue homeostasis and functions. However,the roles of cellular protein homeostasis maintenance in stem cell proliferation and tissue homeostasis are not fully understood. Here, we find that Derlin-1 and TER94/VCP/p97, components of the endoplasmic reticulum(ER)-associated degradation(ERAD) pathway, restrain intestinal stem cell proliferation to maintain intestinal homeostasis in adult Drosophila. Depleting any of them results in increased stem cell proliferation and midgut homeostasis disruption. Derlin-1 is specifically localized in the ER of progenitors, and its Cterminus is required for its function. Interestingly, we find that increased stem cell proliferation is resulted from elevated ROS levels and activated JNK signaling in Derlin-1-or TER94-deficient progenitors. Further removal of reactive oxygen species(ROS) or inhibition of JNK signaling almost completely suppresses increased stem cell proliferation. Together, these data demonstrate that the ERAD pathway is critical for stem cell proliferation and tissue homeostasis. Thus, we provide insights into our understanding of the mechanisms underlying cellular protein homeostasis maintenance(ER protein quality control) in tissue homeostasis and tumor development. | Fuli Liu Hang Zhao Ruiyan Kong Lin Shi Zhengran Li Rui Ma Huiqing Zhao Zhouhua Li | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 13 | The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury显示文摘Chronic compressive spinal cord injury in compressive cervical myelopathy conditions can lead to rapid neurological deterioration in the early phase,followed by partial self-recovery,and ultimately an equilibrium state of neurological dysfunction.Ferroptosis is a crucial pathological process in many neurodegenerative diseases;however,its role in chro nic compressive spinal cord injury remains unclear.In this study,we established a chronic compressive spinal cord injury rat model,which displayed its most severe behavioral and electrophysiological dysfunction at 4 wee ks and partial recovery at 8 weeks after compression.Bulk RNA sequencing data identified enriched functional pathways,including ferroptosis,presynapse,and postsynaptic membrane activity at both 4 and 8 wee ks following chro nic compressive spinal co rd injury.Tra nsmission electron microscopy and malondialdehyde quantification assay confirmed that ferroptosis activity peaked at 4 weeks and was attenuated at 8 weeks after chronic compression.Ferro ptosis activity was negatively correlated with behavioral score.Immunofluorescence,quantitative polymerase chain reaction,and western blotting showed that expression of the anti-ferroptosis molecules,glutathione peroxidase 4(GPX4) and MAF BZIP transcription factor G(MafG),in neuro ns was suppressed at 4 weeks and upregulated at 8 weeks following spinal co rd compression.There was a positive correlation between the expression of these two molecules,suggesting that they may work together to contribute to functional recovery following chronic compressive spinal cord injury.In conclusion,our study determined the genome-wide expression profile and fe rroptosis activity of a consistently compressed spinal cord at different time points.The results showed that anti-fe rroptosis genes,specifically GPX4 and MafG,may be involved in spontaneous neurological recovery at 8 weeks of chronic compressive spinal cord injury.These findings contribute to a better understanding of the mechanisms underlying chronic compressive spinal cord injury and may help identify new therapeutic targets for compressive cervical myelopathy. | Zhengran Yu Xing Cheng Wenxu Pan Cheng Yu Yang Duan | 2023 | Neural Regeneration Research2023，18，11： | 0 |
| 14 | Analysis of the co-seismic responses of the fluid well pattern system in Jiangsu Province to the Wenchuan and Tohoku earthquakes显示文摘This thesis discusses the earthquake reflecting ability of the observation well pattern system of Jiangsu Province, China, which has been digitally renovated, and probes into the cause of the major differences in the earthquake reflecting abilities of well holes at different measurement points. This is achieved through the analysis of the co-seismic responses to the Wenchuan (2008; Ms8.0, China) and Tohoku (2011; Ms9.0, Japan) earthquakes. We found that the co-seismic response of water level from regional well holes in Jiangsu Province was stronger than that of water temperature. The water-level co-seismic response follows a consistent law and is closely related to the earthquake magnitude. The co-seismic response of water temperature strongly varied among well points, and was more often manifested as a slow restorative change. The co-seismic responses also varied based on tectonic elements. The response in central and northern Jiangsu was weaker than that of southern Jiangsu, possibly due to the thicker loess cover layer in central Jiangsu which makes it less effective at capturing the micro-changes of stress-strain states relative to the hilly land in the south. The more complicated geological structure in southern Jiangsu makes it contribute to greater changes in the state of underground water after a minor disturbance. | Jiangrong Zheng1, Haolin Jiang1 and Zhengran He2 1 Earthquake Administration of Jiangsu Province, Nanjing 210014, China 2 School of Information Science and Engineering, Southeast University, Nanjing 210049, China | 2012 | Earthquake Science2012，25，3： | 0 |
| 15 | Free-standing Na_(2)C_(6)O_(6)/MXene composite paper for highperformance organic sodium-ion batteries显示文摘Sodium-ion batteries(SIBs)are regarded as the ideal low-cost choice for next-generation large-scale energy storage system.Carbonyl-based organic salt-disodium rhodizonate(Na_(2)C_(6)O_(6))with high theoretical specific capacity(501 mAh·g−1)is considered as a promising cathode material for SIBs.However,the dissolution of active material in electrolyte and low electronic conductivity lead to rapidly capacity decay and poor rate performance.Herein,a simple method is designed to construct free-standing and flexible Ti3C2Tx Na2C6O6/MXene paper via vacuum-assisted filtration and antisolvent approach.The MXene can form an electronic conductive network,adsorb the active materials,and offer additional active sites for Na storage.The binder-free Na_(2)C_(6)O_(6)/MXene paper delivers excellent electrochemical property with a high rate performance of 231 mAh·g−1 at 1,000 mA·g−1 and a high capacity of 215 mAh·g−1 after 100 cycles.This work provides an attractive strategy for designing high-performance organic electrode materials of SIBs. | Zhengran Wang Yuchan Zhang Huiyu Jiang Chuanliang Wei Yongling An Liwen Tan Shenglin Xiong Jinkui Feng | 2023 | Nano Research2023，16，1： | 0 |
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