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| 1 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 2 | GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system显示文摘Distinctively different metabolism between tumor cells and normal cells endows tumor tissues unique microenvironment.In this regard,we have successfully prepared a sequential catalytic platform based on Au/Pt star for tumor theragnostic.The multifunctional probes consisted of a gold/platinum star-shaped core(Au/Pt star)conjugated with a GSH-sensitive disulfide bond(S–S),a targeting ligand(rHSA-FA),a near-infrared fluorophore(IR780)and glucose oxidase(GOx).When systemically administered in a xenografted murine model,the probes specifically targeted the tumor sites.As the disulfide linker was cleaved by intracellular GSH,the IR780 molecules could be released for photo-thermal therapy&photodynamic therapy(PTT&PDT)and imaging.Subsequently,the Pt nanolayer of the Au/Pt star and the GOx formed a sequential catalytic system:GOx effectively catalyzed intracellular glucose by consuming oxygen to generate H2O2 and enhance the local acidity,and the Pt layer exhibited peroxidase-like property to catalyze H2O2 producing toxic·OH for tumor oxidative damage.Here we demonstrated that our probes simultaneously possessed a GSH-sensitive release,real-time imaging ability,and synergetic cancer starving-like therapy/enzyme oxidative therapy/PTT/PDT features,which provides a potential strategy for effective tumor theragnostic. | Amin Zhang Qian Zhang Gabriel Alfranca Shaojun Pan Zhicheng Huang Jin Cheng Qiang Ma Jie Song Yunxiang Pan Jian Ni Lijun Ma Daxiang Cui | 2020 | Nano Research2020，13，1： | 4 |
| 3 | Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator显示文摘包含 12 基因(ZCCHC12 ) 的老鼠锌手指 CCHC 领域作为骨头的 transcriptional 激活剂被识别了发信号的形态基因的蛋白质(BMP ) ,和人的 ZCCHC12 被报导与 non-syndromic X 连接智力迟钝(NS-XLMR ) 有关。然而,的细节人的 ZCCHC12 在 NS-XLMR 包含仍然保持不清楚。在这研究,我们在为原子本地化负责的人的 ZCCHC12 蛋白质的中间识别了一个新奇原子本地化信号(NLS ) 。多重织物的北污点分析显示 ZCCHC12 高度在人的大脑被表示。而且,在 situ,杂交证明 ZCCHC12 明确地在老鼠 E10.5 胚胎的前脑,中脑,和间脑区域的 neuroepithelium 被表示。酶记者试金证明 ZCCHC12 作为激活剂提高了使活跃之物蛋白质 1 的 transcriptional 活动(AP-1 ) 和营地反应元素绑定蛋白质(CREB ) 。在结论,我们在 ZCCHC12 识别了新 NLS 并且弄明白 ZCCHC12 作为 AP-1 和 CREB 的 transcriptional 激活剂工作。 | Hong Li Qian Liu Xiang Hu Du Feng Shuanglin Xiang Zhicheng He Xingwang Hu Jianlin Zhou Xiaofeng Ding Chang Zhou Jian Zhang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 3 |
| 4 | Fluid-Structure Interaction Simulation of Aqueous Outflow System in Response to Juxtacanalicular Meshwork Permeability Changes with a Two-Way Coupled Method显示文摘Elevated intraocular pressure appears to have a broader impact on increased resistance to aqueous humor outflow through the conventional aqueous outflow system(AOS).However,there is still no consensus about exact location of the increased outflow resistance of aqueous humor,and the mechanism is not perfect.In addition,it is difficult to accurately obtain hydrodynamic parameters of aqueous humor within the trabecular meshwork outflow pathways based on the current technology.In this paper,a two-way fluid-structure interaction simulation was performed to study the pressure difference and velocity in the superficial trabecular meshwork,juxtacanalicular meshwork(JCM)and Schlemm’s canal in response to JCM permeability changes.We obtained the JCM permeability of normal intraocular pressure varied between 1×10?15 m2 and 10×10?15 m2 while permeability of the JCM ranged from 2×10?16 m2 and 3×10?16 m2 under conditions of high intraocular pressure.The study indicated that the fluid dynamics parameters in trabecular meshwork and Schlemm’s canal are most significantly affected by the changes of JCM permeability.Moreover,the study demonstrates that the finite element modeling of AOS provides a practical means for studying the outflow dynamics and the biomechanical environment of the AOS. | Jing Zhang Xiuqing Qian Haixia Zhang Zhicheng Liu | 2018 | Computer Modeling in Engineering & Sciences2018，，8： | 3 |
| 5 | Facile preparation of monodisperse hollow cress-linked chitosan microspheres 显示文摘 | Zhen Qian Zhicheng Zhang Haiming Li | 2008 | J Polym SCI Part A: Polym Chem2008，46，： | 1 |
| 6 | One-step synthesis of manganese dioxide/polystyrene nanocomposite foams via high internal phase emulsion and study of their catalytic activity显示文摘 | Shufen Wang Zhicheng Zhang Huarong Liu Wei Zhang Zhen Qian Bibo Wang | 2010 | Colloid and Polymer Science2010，，9： | 1 |
| 7 | Anovel approach to raspberry-like particles for superhydro- phobic materials 显示文摘 | QIAN Zhen ZHANG Zhicheng SONG Linyong | 2009 | Journal of Materials Chemistry2009，19，9： | 1 |
| 8 | One-step solid state reaction to selectively fabricate cubic and tetragonal CuFe 2 O 4 anode material for high power lithium ion batteries显示文摘 | Zheng Xing Zhicheng Ju Jian Yang Huayun Xu Yitai Qian | 2013 | Electrochimica Acta2013，，： | 1 |
| 9 | Identification and molecular characterization of twin-arginine translocation system (Tat) in Xanthomonas oryzae pv. oryzae strain PXO99显示文摘 | Lei Chen Baishi Hu Guoliang Qian Chen Wang Wanfeng Yang Zhicheng Han Fengquan Liu | 2009 | Archives of Microbiology2009，，2： | 1 |
| 10 | Experimental Study of Aqueous Humor Flow in a Transparent Anterior Segment Phantom by Using PIV Technique显示文摘Pupillary block is considered as an important cause of primary angle-closure glaucoma(PACG).In order to investigate the effect of pupillary block on the hydrodynamics of aqueous humor(AH)in anterior chamber(AC)and potential risks,a 3D printed eye model was developed to mimic the AH flow driven by fluid generation,the differential pressure between AC and posterior chambers(PC)and pupillary block.Particle image velocimetry technology was applied to visualize flow distribution.The results demonstrated obvious differences in AH flow with and without pupillary block.Under the normal condition(without pupillary block),the flow filed of AH was nearly symmetric in the AC.The highest flow velocity located at the central of AC when the differential pressure between AC and PC was under 5.83 Pa,while it appeared near the cornea and iris surface when the differential pressure was greater than 33.6 Pa.Once pupillary block occurred,two asymmetric vortices with different sizes were observed and the shear stress in the paracentral cornea and iris epithelium increased greatly.It can be concluded that the pupillary block and the elevated differential pressure between AC and PC could change the flow distribution and thus increase the risk of corneal endothelial cells detachment.This study could make a further understanding of the pathogenesis of PACG. | Wenjia Wang Xiuqing Qian Qi Li Gong Zhang Huangxuan Zhao Tan Li Yang Yu Hongfang Song Zhicheng Liu | 2019 | Molecular & Cellular Biomechanics2019，16，1： | 1 |
| 11 | One-pot synthesis of Bi2Se3 nanostructures with rationally tunable morphologies显示文摘形状控制证明了是定制双性人 2 为许多应用程序的 Se 3 nanostructures。这里,三不同双性人 2 Se 3 nanostructures,即,螺线类型 nanoplates,光滑的 nanoplates,和树枝状的 nanostructures,被在合成系统操作过度饱和水平准备。这机制研究显示在低过度饱和,那在生长能引起在双性人 2 Se 3 粒子连续地被增加,导致螺线类型 nanoplates 的形成。在中间的过度饱和,非结晶的双性人 2 Se 3 粒子和随后的再结晶导致了光滑的 nanoplates 的形成。而且在高过度饱和,多晶的双性人 2 开始形成的 Se 3 核心,在哪个双性人 2 Se 3 发生了。这个工作不仅推进我们生长机制的理解而且提供一条新途径控制双性人 2 Se 3 nanostructures。 | Xianli Liu Jinwei Xu Zhicheng Fang Lin Lin Yu Qian Youcheng Wang Chunmiao Ye Chao Ma Jie Zeng | 2015 | Nano Research2015，8，11： | 0 |
| 12 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 13 | Robust sequential design for piecewise-stationary multi-armed bandit problem in the presence of outliers显示文摘The multi-armed bandit(MAB)problem studies the sequential decision making in the presence of uncertainty and partial feedback on rewards.Its name comes from imagining a gambler at a row of slot machines who needs to decide the best strategy on the number of times as well as the orders to play each machine.It is a classic reinforcement learning problem which is fundamental to many online learning problems.In many practical applications of the MAB,the reward distributions may change at unknown time steps and the outliers(extreme rewards)often exist.Current sequential design strategies may struggle in such cases,as they tend to infer additional change points to fit the outliers.In this paper,we propose a robust change-detection upper confidence bound(RCD-UCB)algorithm which can distinguish the real change points from the outliers in piecewise-stationary MAB settings.We show that the proposed RCD-UCB algorithm can achieve a nearly optimal regret bound on the order of O(√SKT log T),where T is the number of time steps,K is the number of arms and S is the number of stationary segments.We demonstrate its superior performance compared to some state-of-the-art algorithms in both simulation experiments and real data analysis.(See https://github.com/woaishufenke/MAB_STRF.git for the codes used in this paper.) | Yaping Wang Zhicheng Peng Riquan Zhang Qian Xiao | 2021 | Statistical Theory and Related Fields2021，5，2： | 0 |
| 14 | Consecutive topological transitions of helical Fermi arcs at saddle points in CoSi显示文摘The CoSi family hosts unconventional topological nodes with nonzero Chern numbers.The nontrivial topology is manifested by conspicuous surface Fermi arcs connecting surface projections of the nodes.Here,using angle-resolved photoemission spectroscopy,we have systematically investigated the(001)surface states of pristine and Ni-doped Co Si.The surface states form saddle-like band structures at/near the time-reversal invariant point near the Fermi level.The Fermi arcs undergo consecutive Lifshitz transitions at the saddle points X,leading to changes of the Fermi arc configuration.As the density of states has a van Hove singularity at the saddle points,exotic many-body physical phenomena may emerge accompanied by the topological transitions of surface Fermi arcs. | Zhicheng Rao Shangjie Tian Shunye Gao Quanxin Hu Wenhui Fan Jierui Huang Cenyao Tang Yaobo Huang Hechang Lei Yujie Sun Tian Qian Hong Ding | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，5： | 0 |
| 15 | Insights into the Ti^(4+) doping in P2-type Na_(0.67)Ni_(0.33)Mn_(0.52)Ti_(0.15)O_(2) for enhanced performance of sodium-ion batteries显示文摘Due to the sodium abundance and availability,sodium-ion batteries(SIBs)have the potential to meet the worldwide growing demand of electrical energy storage.P2-type sodium transition-metal layer oxides with a high energy density are considered as the most promising cathode materials for SIBs.We present here a detailed study of the enhanced rate capability and cyclic stability of the Ti-doped Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2)cathode material.The combined analysis of ex-situ X-ray absorption fine structure(XAFS)spectroscopy,aberration-corrected high resolution transmission electron microscopy(AB-HRTEM)and X-ray diffraction(XRD)show that the strong Ti–O bond in the transition metal layers stabilizes the local structure,destroy the Na+-vacancy ordering and arrest the irreversible multiphase transformation that occurs during the intercalation/deintercalation process.Actually,Na_(0.67)Ni_(0.33)Mn_(0.52)Ti_(0.15)O_(2)exhibits a reversible capacity of 89.6 mA h g^(-1)even at 5 C,an excellent cyclability with 88.78%capacity retention after 200 cycles at 0.5 C.This study provides a better understanding in optimization of the design of high-energy cathode materials based on titanium doped layered oxides for SIBs. | Shi Tao Wei ZhouaDajun Wu Zhicheng Wang Bin Qian Wangsheng Chu Augusto Marcelli Li Song | 2021 | Journal of Materials Science & Technology2021，，15： | 0 |
| 16 | Efficacy of early prone or lateral positioning in patients with severe COVID-19:a single-center prospective cohort显示文摘Background:Position intervention has been shown to improve oxygenation,but its role in non-invasively ventilated patients with severe COVID-19 has not been assessed.The objective of this study was to investigate the efficacy of early position intervention on non-invasively ventilated patients with severe COVID-19.Methods:This was a single-center,prospective observational study in consecutive patients with severe COVID-19 managed in a provisional ICU at Renmin Hospital of Wuhan University from 31 January to 15 February 2020.Patients with chest CT showing exudation or consolidation in bilateral peripheral and posterior parts of the lungs were included.Early position intervention(prone or lateral)was commenced for>4 hours daily for 10 days in these patients,while others received standard care.Results:The baseline parameters were comparable between the position intervention group(n=17)and the standard care group(n=35).Position intervention was well-tolerated and increased cumulative adjusted mean difference of SpO_(2)/FiO_(2)(409,95%CI 86 to 733)and ROX index(26,95%CI 9 to 43)with decreased Borg scale(−9,95%CI−15 to−3)during the first 7 days.It also facilitated absorption of lung lesions and reduced the proportion of patients with high National Early Warning Score 2(≥7)on days 7 and 14,with a trend toward faster clinical improvement.Virus shedding and length of hospital stay were comparable between the two groups.Conclusions:This study provides the first evidence for improved oxygenation and lung lesion absorption using early position intervention in non-invasively ventilated patients with severe COVID-19,and warrants further randomized trials. | Zhong Ni Kaige Wang Ting Wang Yuenan Ni Wei Huang Ping Zhu Tao Fan Ye Wang Bo Wang Jun Deng Zhicheng Qian Jiasheng Liu Wenhao Cai Shanling Xu Yu Du Gang Wang Zongan Liang Weimin Li Jianfei Luo Fengming Luo Dan Liu | 2020 | Precision Clinical Medicine2020，3，4： | 0 |
| 17 | Enhancement of CH_(3)CO^(*) adsorption by editing d-orbital states of Pd to boost C–C bond cleavage of ethanol eletrooxidation显示文摘Improving the complete ethanol electrooxidation on Pd-based catalysts in alkaline media has drawn widely attention due to the high mass energy density.However,the weak adsorption energy of CH_(3)CO^(*) on Pd restricts the C–C bond cleavage.Inspired by the molecular orbital theory,we proposed the d-state-editing strategy to construct more unoccupied d-states of Pd for the enhanced interaction with CH_(3)CO^(*) to break C–C bonds.As expected,the reduced number of e_g electrons and more unoccupied d-states of Pd successfully formed on as-prepared porous Rh Au–Pd Cu nanosheets(PNSs).Theoretical calculations show that the optimized d-states of Rh Au–Pd Cu PNS can effectively improve the adsorption of CH_(3)CO^(*) and drastically reduce the energy barrier of C–C bond cleavage,thus boosting the complete oxidation of ethanol.The charge ratio of C_1 pathway on Rh Au–Pd Cu PNSs is 51.5%,more than 2 times higher than that of Pd NSs.Our finding provides an innovative perspective for the design of highly-efficient noble-based electrocatalysts. | Yuchen Qin Fengqi Wang Pei Liu Jinyu Ye Qian Wang Yao Wang Guangce Jiang Lijie Liu Pengfang Zhang Xiaobiao Liu Xin Zheng Yunlai Ren Junjun Li Zhicheng Zhang | 2024 | Science China Chemistry2024，67，2： | 0 |
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