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| 1 | Vertically standing PtSe_2 film: a saturable absorber for a passively mode-locked Nd:LuVO_4 laser显示文摘The novel vertically standing Pt Se2 film on transparent quartz was prepared by selenization of platinum film deposited by the magnetron sputtering method, and an Nd:Lu VO4 passively mode-locked solid-state laser was realized by using the fabricated Pt Se2 film as a saturable absorber. The X-ray diffraction pattern and Raman spectrum of the film indicate its good crystallinity with a layered structure. The thickness of Pt Se2 film is measured to be 24 nm according to the cross-section height profile of the atomic force microscope image. Highresolution transmission electron microscopy images clearly demonstrate its vertically standing structure with an interlayer distance of 0.54 nm along the c-axis direction. The modulation depth(ΔT) and saturation fluence(Φs)of Pt Se2 film are measured to be 12.6% and 17.1 μJ∕cm2, respectively. The obtained mode-locked laser spectrum has a central wavelength of 1066.573 nm, with a 3 d B bandwidth of 0.106 nm. The transform limited pulse width of the mode-locked laser was calculated to be 15.8 ps. A maximum average output power of 180 m W with a working repetition rate of 61.3 MHz is obtained. To the best of our knowledge, this is the first report of the generation of ultrafast mode-locked laser pulses by using layered Pt Se2 as a saturable absorber. | LILI TAO XIAOWEN HUANG JUNSHAN HE YAJUN LOU LONGHUI ZENG YONGHUI LI HUI LONG JINGBO LI LING ZHANG YUEN HONG TSANG | 2018 | Photonics Research2018，6，7： | 8 |
| 2 | V4C3Tx MXene:A promising active substrate for reactive surface modification and the enhanced electrocatalytic oxygen evolution activity显示文摘Presented are the synthesis,characterizations,and reactive surface modification(RSM)of a novel nine atomic layered V4C3Tx MXene.With the advantages of the multilayered V4C3Tx MXene that can simultaneously support the RSM reaction and keep the inner skeleton stable,a series of amorphous Ni/Fe/Vternary oxide hydroxides thin layer can be successfully modified on the surface of the V4C3Tx MXene(denoted as MOOH@V4C3Tx,M=Ni,Fe,and V)without disrupting its original structure.Attributed to the in situ reconstruction of highly active oxide hydroxide layer,the nanohybrids exhibited an enhanced oxygen evolution reaction(OER)activity and excellent long-time stability over 70 hours.In particular,a current density of 10 mA cm−2 can be reached by the nanohybrid with the optimized Ni/Fe ratio at an overpotential(η)as low as 275.2 mV,which is comparable to most of the state-of-the-art OER catalysts and better than other MXene-based derivatives.Demonstrated by the tunable physicochemical properties and excellent structural stability of these nanohybrids,we may envision the promising role of the M4X3-based MXenes as substrates for a wide range of energy conversion and storage materials. | Cheng-Feng Du Xiaoli Sun Hong Yu Wei Fang Yao Jing Yonghui Wang Shuiqing Li Xianhu Liu Qingyu Yan | 2020 | InfoMat2020，2，5： | 8 |
| 3 | Study on variational aerosol fields over Beijing and its adjoining areas derived from Terra-MODIS and ground sunphotometer observation显示文摘This paper presents a comprehensive observa-tion technique on derived aerosols data from mobile sun-photometer graph and Terra-Moderate Resolution Imaging Spectroradiometer (MODIS) observation. Research results suggest that after being treated by the variational technique with respect to sunphotometer observations, the Terra- MODIS remote sensing aerosol data are remarkably im-proved, thus for the first time revealing features of the influ-ence of aerosols and pollution emissions of Beijing and its adjoining areas (Hebei, Shandong, etc. provinces). The re-gional impact features of aerosols are related with the pe-ripheral U-shape topography of Beijing. Analyses with Hy-brid Single Particle Lagrangian Integrated Trajectory model (HYSPLIT-4) and meteorological data in the case studied confirm the pollutants diffusion process along the trajectory from the sources in the south-west region, and the regional aerosol impact features. | XU Xiangde ZHOU Xiuji WENG Yonghui TIAN Guoliang LIU Yujie YAN Peng DING Guoan ZHANG Yuxiang MAO Jietai QIU Hong | 2003 | Chinese Science Bulletin2003，48，18： | 7 |
| 4 | Allergic diseases, immunoglobulin E, and autoimmune pancreatitis: a retrospective study of 22 patients显示文摘 | Guo Limei Huang Yonghui Wang Tianli Shi Xueying Chang Hong Yao Wei Huang Xuebiao | 2014 | Chinese Medical Journal2014，，23： | 5 |
| 5 | All-Solid-State Thin-Film Lithium-Sulfur Batteries显示文摘Lithium-sulfur(Li-S)system coupled with thin-film solid electrolyte as a novel high-energy micro-battery has enormous potential for complementing embedded energy harvesters to enable the autonomy of the Internet of Things microdevice.However,the volatility in high vacuum and intrinsic sluggish kinetics of S hinder researchers from empirically integrating it into allsolid-state thin-film batteries,leading to inexperience in fabricating all-solid-state thin-film Li-S batteries(TFLSBs).Herein,for the first time,TFLSBs have been successfully constructed by stacking vertical graphene nanosheets-Li2S(VGsLi2S)composite thin-film cathode,lithium-phosphorous-oxynitride(LiPON)thin-film solid electrolyte,and Li metal anode.Fundamentally eliminating Lipolysulfide shuttle effect and maintaining a stable VGs-Li2S/LiPON interface upon prolonged cycles have been well identified by employing the solid-state Li-S system with an“unlimited Li”reservoir,which exhibits excellent longterm cycling stability with a capacity retention of 81%for 3,000 cycles,and an exceptional high temperature tolerance up to 60℃.More impressively,VGs-Li2S-based TFLSBs with evaporated-Li thin-film anode also demonstrate outstanding cycling performance over 500 cycles with a high Coulombic efficiency of 99.71%.Collectively,this study presents a new development strategy for secure and high-performance rechargeable all-solid-state thin-film batteries. | Renming Deng Bingyuan Ke Yonghui Xie Shoulin Cheng Congcong Zhang Hong Zhang Bingan Lu Xinghui Wang | 2023 | Nano-Micro Letters2023，15，5： | 1 |
| 6 | elegans and human 显示文摘 | LIEW A W C WU YONGHUI YAN HONG Effective sta-tistical features for coding and non-coding DNA sequence classifica- tion for yeast C | 2005 | International Journal of Bioinfolmatics Research and Applications2005，1，2： | 1 |
| 7 | Long noncoding RNA(lncRNA)H19:An essential developmental regulator with expanding roles in cancer,stem cell differentiation,and metabolic diseases显示文摘Recent advances in deep sequencing technologies have revealed that,while less than 2%of the human genome is transcribed into mRNA for protein synthesis,over 80%of the genome is transcribed,leading to the production of large amounts of noncoding RNAs(ncRNAs).It has been shown that ncRNAs,especially long non-coding RNAs(lncRNAs),may play crucial regulatory roles in gene expression.As one of the first isolated and reported lncRNAs,H19 has gained much attention due to its essential roles in regulating many physiological and/or pathological processes including embryogenesis,development,tumorigenesis,osteogen-esis,and metabolism.Mechanistically,H19 mediates diverse regulatory functions by serving as competing endogenous RNAs(CeRNAs),Igf2/H19 imprinted tandem gene,modular scaffold,cooperating with H19 antisense,and acting directly with other mRNAs or lncRNAs.Here,we summarized the current understanding of H19 in embryogenesis and development,cancer development and progression,mesenchymal stem cell lineage-specific differentiation,and metabolic diseases.We discussed the potential regulatory mechanisms underlying H19’s func-tions in those processes although more in-depth studies are warranted to delineate the exact molecular,cellular,epigenetic,and genomic regulatory mechanisms underlying the physiolog-ical and pathological roles of H19.Ultimately,these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting H19 functions. | Junyi Liao Bowen Chen Zhenglin Zhu Chengcheng Du Shengqiang Gao Guozhi Zhao Piao Zhao Yonghui Wang Annie Wang Zander Schwartz Lily Song Jeffrey Hong William Wagstaff Rex CHaydon Hue HLuu Jiaming Fan Russell RReid Tong-Chuan He Lewis Shi Ning Hu Wei Huang | 2023 | Genes & Diseases2023，10，4： | 1 |
| 8 | Electronic structures and NIR-II optical properties of black phosphorus using first principles显示文摘Near infrared-II(NIR-II, 1 000-1 700 nm) imaging with high penetration tissue depth and signal-noise ratio has attracted wide interest in biomedicine. As a two-dimensional(2D) material with narrow band gap, the band structure of layered black phosphorus, as an important characteristic of electronic structure, determines the electronic transport and infrared optical properties, which show great potential in NIIR-II imaging. Here, the electronic structure and NIR-II optical properties of black phosphorus have been investigated in detail by employing the generalized gradient approximation + U(GGA+U) correction based on density functional theory(DFT). First, we performed the band structure and density of states for different layers of black phosphorus. From the electronic structures, the location of valence band maximum didn’t shift obviously, and the position of conduction band minimum shifted downward gradually, inducing the band gaps decreased gradually with the increasing layer number. While the layer number increased to 5, the behaviour of electronic structure was very similar to that of the bulk black phosphorus. Then, we calculated the NIR-II optical properties, and found the optical band gap of black phosphorus also showed layer dependent properties. From a single layer to 5 layers, the optical band gap changed from 1.71 e V to 0.92 e V. It is noting that black phosphorus also showed the significant optical absorption in NIR-IIa(1 300-1 400 nm) and NIR-IIb(1 500-1 700 nm) windows. Especially, the NIR-II optical absorption can be enhanced with increasing the layer number to 5, indicating promising photoresponse materials in NIR-II imaging. | HONG Xiaofeng GUO Meili LIU Ling LI Yonghui ZHANG Xiaodong | 2022 | Optoelectronics Letters2022，18，10： | 0 |
| 9 | A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F显示文摘Respiratory syncytial virus(RSV) continues to pose serious threats to pediatric populations due to the lack of a vaccine and effective antiviral drugs. RSV fusion(F) glycoprotein mediates viral-host membrane fusion and is a key target for neutralizing antibodies. We generated 23 full-human monoclonal antibodies(hm Abs) against prefusion F protein(pre-F) from a healthy adult with natural RSV infection by single B cell cloning technique. A highly potent RSV-neutralizing hm Ab, named as 25-20, is selected, which targets a new site Φ-specific epitope. Site-directed mutagenesis and structural modelling analysis demonstrated that 25-20 mainly targets a highly conserved hydrophobic region located at the a4 helix and a1 helix of pre-F, indicating a site of vulnerability for drug and vaccine design. It is worth noting that 25-20 uses an unreported inferred germline(i GL) that binds very poorly to pre-F, thus high levels of somatic mutations are needed to gain high binding affinity with pre-F. Our observation helps to understand the evolution of RSV antibody during natural infection. Furthermore, by in silico prediction and experimental verification, we optimized 25-20 with KD values as low as picomolar range. Therefore, the optimized 25-20 represents an excellent candidate for passive protection against RSV infection. | Chunyan Yi Caixia Su Xiaoyu Sun Xiao Lu Chuanya Si Caixuan Liu Zhuo Yang Hong Yuan Yuying Huang Jing Wen Yonghui He Yaguang Zhang Liyan Ma Yao Cong Gan Zhao Zhiyang Ling Bin Wang Bing Sun | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 10 | Optimization of PCR system in EST-SSR analysis of Pinus massoniana Lamb显示文摘All factors affecting the PCR system in Pinus massoniana Lamb were investigated one by one.The results show that the optimum PCR system of EST-SSR were:2μL 10×Buffer(Mg2+ Free), 30 ng template DNA,0.187 5 mmol/L dNTPs, 3.75 mmol/L Mg2+,8 pmol primer pair,1.0 U Taq DNA poly-merase in total 20μL reaction system. Finally,a total of 11 isolates of P.massoniana was used for testing the stability of the PCR amplification.The results prove that the optimum PCR system was stable,reliable,highly repetitive. | Shao Junpei Li Zhihui Yang Mohua Huang Liqun Hong Yonghui Huang Yifa | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 11 | Alum colloid encapsulated insideβ-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine显示文摘We have developed a MUC1 antigen-based antitumor vaccine loaded on alum colloid encapsulated insideβ-glucan particles(GP-Al).The constructed vaccine induced strong MUC1 antigen specific Ig G antibody titers and enhanced CD^(8+)T cells cytotoxic effect to kill tumor cells.These results indicated that GP-Al can be served as an efficient delivery system and adjuvant for the development of cancer vaccines especially small molecule antigens based cancer vaccines. | Yonghui Liu Mingjing Li Haomiao Zhu Zhe Jing Xiaona Yin Kun Wang Zhangyong Hong Wei Zhao | 2021 | Chinese Chemical Letters2021，32，6： | 0 |
| 12 | Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk显示文摘Wnt signaling plays a major role in regulating cell proliferation and differentiation.The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical pathway.Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling pathways.This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes.Dys-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic lethality.The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments.However,both stimulatory and inhibitory treatments come with potential risks that need to be addressed.This review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt signaling.It thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+pathway.Further description involved each of its components and their involvement in other cellular processes.Finally,this review explained the various other pathways and processes that crosstalk with Wnt signaling. | Kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong Lily Song William Wagstaff Rex C.Haydon Hue H.Luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi | 2024 | Genes & Diseases2024，11，1： | 0 |
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