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| 1 | Chimeric flagellin expressed by Salmonella typhimurium induces an ESAT-6-specific Th1-type immune response and CTL effects following intranasal immunization显示文摘The flagellin component FliC of Salmonella typhimurium is capable of activating the innate immune system via specific interactions with TLR5 and can also act as a carrier of foreign antigen to elicit antigen-specific immune responses.Thus,we constructed an attenuated Salmonella strain SL5928(fliC/esat)expressing chimeric flagellin that contained the ESAT-6 antigen coding sequence of Mycobacterium tuberculosis inserted into the highly variable region of the Salmonella flagellin coding gene fliCi.The chimeric flagellin functioned normally,as demonstrated using a flagella swarming assay and electron microscopy.To analyze the effects of chimeric flagellin,the cell-mediated immune response and cytotoxic T lymphocyte(CTL)effects specific for ESAT-6 antigen were tested after intranasal immunization of mice with flagellated Salmonella SL5928(fliC/esat).The results showed that SL5928(fliC/esat)intranasal immunization can strongly elicit an ESAT-6-specific T helper(Th)1-type immune response in mucosal lymphoid tissues,such as nasopharynx-associated lymph nodes,lung and Peyer’s patches,and a Th1/Th2 response was elicited in spleen and mesenteric lymph nodes.Furthermore,intranasal immunization of SL5928(fliC/esat)produced efficient CTL effects,as demonstrated using a 5-and 6-carboxyfluorescein diacetate succinimidyl ester(CFSE)assay.Thus,our study revealed that Salmonella flagellin acts as a carrier for foreign antigen and triggers strong Th1 and CTL responses during intranasal immunization.Chimeric flagellin is potentially an effective strategy for the development of novel vaccines against tuberculosis in humans and animals. | Hui Zhang Liu Liu Ke Wen Jinlin Huang Shizhong Geng Junsong Shen Zhiming Pan Xinan Jiao | 2011 | Cellular & Molecular Immunology2011，8，6： | 6 |
| 2 | Amino acids 89-96 of Salmonella typhimunum Tlagell=n represent the major domain responsible for TLR5-independent adjuvanticity in the humoral immune response显示文摘 | Lei Zhang Zhiming Pan Xilong Kang Yun Yang Heekap Kang Na Zhang James M Rosati Xinan Jiao | 2015 | Cellular & Molecular Immunology2015，12，5： | 6 |
| 3 | The First Quantitative Slip-Rate Estimated Along the Ashikule Fault at the Western Segment of the Altyn Tagh Fault System显示文摘As one of the longest strike-slip fault in Asia,the Altyn Tagh Fault(ATF)defines the northern boundary of the Tibetan Plateau and plays a significant role inaccommodating the deformation resulting from the IndiaAsia convergence.Slip-rate and seismic behavior of the fault are critical to understand the present-day | PAN Jiawei LI Haibing VAN DER WOERD Jerome SUN Zhiming SI Jialiang PEI Junling WU Fuyao CHEVALIER Marie-Luce | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 5 |
| 4 | Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2α显示文摘离氨酸(K) 特定的 demethylase 6B (KDM6B ) 是 histone H3K27 demethylase,它明确地催化 H3 lysine-27 tri/dimethylation (H3K27me3/2 ) 的 demethylation。KDM6B 能由支持与 RNA 聚合酶 II 和相关延伸因素被联系的 transcriptional 延伸激活基因抄写。KDM6B 因此为基因表示的规定是重要的。以前的研究显示了象 KDM3A, KDM4B,和 KDM4C 那样的几 histone demethylases 被组织缺氧可诱导的因素(HIF ) 调整。但是, KDM6B 上的组织缺氧的效果充分没被理解。在这研究,我们发现 KDM6B mRNA 和蛋白质的表示层次在组织缺氧下面是平常地起来调整的(1% O 2) 或模仿组织缺氧(desferrioxamine mesylate 或 CoCl 2 处理)(P < 0.05 ) 。RNAi 的结果证明 KDM6B 的起来规定依赖于 HIF-2,然而并非在 HIF-1 上。染色质 immunoprecipitation 试金的结果显示在 KDM6B 倡导者(4041 ~ 4037 ) 有一个组织缺氧反应元素。Co-IP 试金的结果显示 KDM6B 能与 HIF-2 或 HIF-1 形成建筑群。击倒的实验暗示 KDM6B 是为 HIF-2 目标基因的一个潜在的管理者。这些数据证明 KDM6B 是 HIF-2 调整的新组织缺氧反应基因。我们的结果也证明 KDM6B 是 HIF- 的潜在的激活剂,它为组织缺氧反应基因的激活是重要的。 | Xiaoqiang Guo Zha ntao Tian Xuliang Wang Shuhong Pan Weiren Huang Yongqing Shen Yaoting Gui Xianglin Duan Zhiming Cai | 2015 | Acta Biochimica et Biophysica Sinica2015，47，2： | 5 |
| 5 | Review of Mg alloy corrosion rates显示文摘A review of the literature confirmed that the intrinsic corrosion rate of high-purity Mg as measured by weight-loss is 0.3mm/y in a concentrated chloride solution.Atmospheric corrosion of Mg alloys has produced corrosion rates of Mg-Al alloys an order of magnitude lower than the intrinsic corrosion rate of Mg in a concentrated chloride solution of 0.3 mm/y.The only successful strategy to produce a Mg alloy with a corrosion rate in a concentrated chloride solution substantially less than the intrinsic corrosion rate as measured by weight loss of Mg of 0.3 mm/y has been to improve the protectiveness of the corrosion product film. | Andrej Atrens Zhiming Shi Syeda UMehreen Sean Johnston Guang-Ling Song Xianhua Chen Fusheng Pan | 2020 | Journal of Magnesium and Alloys2020，8，4： | 5 |
| 6 | A flexible multi-16QAM transmitter based on cascaded dual-parallel Mach-Zehnder modulator and phase modulator显示文摘In this paper,we propose a novel and flexible 16-quadrature amplitude modulation(16QAM) transmitter based on cascaded dual-parallel Mach-Zehnder modulator(DPMZM) and phase modulator(PM).The proposed transmitter is able to generate three types of 16QAM signals:square 16QAM,star 16QAM and four-amplitude-four-phase-16-QAM(FAFP-16QAM).The feasibility of the transmitter is verified through experiment,20-Gb/s eye diagrams of the 16QAM signals are obtained.In order to evaluate the performances of the 16QAM signals,simulations are also conducted using VPI Transmission Maker,clear constellations of 40-Gb/s 16QAM signals are achieved by coherent detection. | ZHANG Liang HU XiaoFeng CAO Pan ZHUANG ZhiMing JIANG XinHong SU YiKai | 2013 | Chinese Science Bulletin2013，58，7： | 3 |
| 7 | Amino acids 89–96 of Salmonella flagellin: a key site for its adjuvant effect independent of the TLR5 signaling pathway显示文摘Flagellin,the main component of bacterial flagella,is a well-known pathogen-associated molecular pattern(PAMP)that can be recognized by the cell surface-localized Toll-like receptor 5(TLR5)and the cytosolic NOD-like receptor protein 4(NLRC4)inflammasome receptor NAIP5/6.1 Hosts can detect flagellated bacteria using the dual sensors,TLR5 and NAIP5/6,to recognize flagellin,and these sensors then initiate innate immune responses to protect the host from bacterial infection.Recognition by extracellular TLR5 can trigger the MyD88-dependent signaling pathway and activate nuclear factorκB,leading to the upregulation of several proinflammatory cytokines. | Xilong Kang Zhiming Pan Xinan Jiao | 2017 | Cellular & Molecular Immunology2017，14，12： | 3 |
| 8 | Obesity pandemic in China:epidemiology,burden,challenges,and opportunities显示文摘China faces a substantial burdensome pandemic of obesity.Recent data from the Chinese Centre for Disease Control and Prevention suggested that over an estimated 8.1%of Chinese adults(85 million Chinese adults)had obesity in 2018,which was three times the level in 2004.[1]To understand the trends of overweight and obesity in China,we accessed the country/territory-level year-specific data of age-standardized summary exposure value(SEV,standing for the pooled proportion among the population),deaths,and disability-adjusted life of years(DALYs)for high body mass index(BMI,high BMI was defined as the BMI level higher than theoretical minimum risk exposure level[25 kg/m2])and its associated diseases for 204 countries/territories between 1990 and 2019 using data from the Global Burden of Disease Collaborative Network.[2]Previous literature described detailed methods for the data synthesis.[3,4]Using the country/territory-level data by year,we calculated the estimated annual percentage changes(EAPCs)with 95%uncertainty intervals(UI)to estimate the annual changing patterns of age-standardized SEV,death,and DALY rates among 204 countries/territories.To compare statistics from China and other regions,we calculated the corresponding estimates from regions including global,North Africa and Middle East,Sub-Saharan Africa,Western Pacific Region,European Union,Latin America and Caribbean,and South Asia. | Jing Li Qingyang Shi Qingyang Gao Xiong-Fei Pan Li Zhao Yazhou He Haoming Tian Zhiming Zhu Sheyu Li | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 9 | Identification of New Resistance Loci Against Sheath Blight Disease in Rice Through Genome-Wide Association Study显示文摘Sheath blight(SB) caused by the soil borne pathogen Rhizoctonia solani is one of the most serious global rice diseases. Breeding resistant cultivar is the most economical and effective strategy to control the disease. However, no rice varieties are completely resistant to SB, and only a few reliable quantitative trait loci(QTLs) linked with SB resistance have been identified to date. In this study, we conducted a genome-wide association study(GWAS) of SB resistance using 299 varieties from the rice diversity panel 1(RDP1) that were genotyped using 44 000 high-density single nucleotide polymorphism(SNP) markers. Through artificial inoculation, we found that only 36.5% of the tested varieties displayed resistance or moderate resistance to SB. In particular, the aromatic and aus sub-populations displayed higher SB resistance than the tropical japonica(TRJ), indica and temperate japonica sub-populations. Seven varieties showed similar resistance levels to the resistant control YSBR1. GWAS identified at least 11 SNP loci significantly associated with SB resistance in the three independent trials, leading to the identification of two reliable QTLs, qSB-3 and qSB-6, on chromosomes 3 and 6. Using favorable alleles or haplotypes of significantly associated SNP loci, we estimated that both QTLs had obvious effects on reducing SB disease severity and can be used for enhancing SB resistance, especially in improving SB resistance of TRJ sub-population rice varieties. These results provided important information and genetic materials for developing SB resistant varieties through breeding. | CHEN Zongxiang FENG Zhiming KANG Houxiang ZHAO Jianhua CHEN Tianxiao LI Qianqian GONG Hongbing ZHANG Yafang CHEN Xijun PAN Xuebiao LIU Wende WANG Guoliang ZUO Shimin | 2019 | Rice science2019，26，1： | 3 |
| 10 | Self-supported hierarchical porous Li_(4)Ti_(5)O_(12)/carbon arrays for boosted lithium ion storage显示文摘The development of fast rechargeable lithium ion batteries(LIBs)is highly dependent on the innovation of advanced high-power electrode materials.In this work,for the first time,we report a sacrificial NiO arrays template method for controllable synthesis of self-supported hierarchical porous Li_(4)Ti_(5)O_(12)/C(LTO/C)nanoflakes arrays,for use as fast rechargeable anodes for LIBs.The ultrathin(2-3 nm)carbon layer was uniformly coated on the LTO forming arrays architecture.The hierarchical porous LTO/C nanoflakes consisted of primary cross-linked nanoparticles of 50-100 nm and showed large porosity.Because of the enhanced electrical conductivity and accelerated ion transfer channels,the well-designed binderfree porous LTO/C nanoflakes arrays exhibited notable high-rate lithium ion storage performance with smaller polarization,better electrochemical reactivity,higher specific capacity(157 mAh g^(-1) at the current density of 20C)and improved long-term cycling life(96.2% after 6000 cycles at 20C),superior to the unmodified porous LTO arrays counterpart(126 mAh g^(-1) at 20C and 88.0%after 6000 cycles at 20C).Our work provides a new template for the construction of high-performance high-rate electrodes for electrochemical energy storage. | Jun Liu Aixiang Wei Guoxiang Pan Shenghui Shen Zhiming Xiao Yu Zhao Xinhui Xia | 2021 | Journal of Energy Chemistry2021，30，3： | 2 |
| 11 | Cloning and characterization of miRNAs from maize seedling roots under low phosphorus stress显示文摘 | Zhiming Zhang Haijian Lin Yaou Shen Jian Gao Kui Xiang Li Liu Haiping Ding Guangsheng Yuan Hai Lan Shufeng Zhou Maojun Zhao Shibin Gao Tingzhao Rong Guangtang Pan | 2012 | Molecular Biology Reports2012，，8： | 1 |
| 12 | Pulsed inert gas metal arc welding with feed back control显示文摘 | Pan Jiluan Ou Zhiming Wu Zhiqiang | 1985 | Schweissen und Schneiden1985，37，4： | 1 |
| 13 | Fabrication and characterization of chitosan microcarrier for hepatocyte culture显示文摘 | Chen Wu Jilun Pan Zhiming Bao Yaoting Yu | 2007 | Journal of Materials Science: Materials in Medicine2007，，11： | 1 |
| 14 | Virulence determinants of Salmonella Gallinarum biovar Pullorum identified by PCR signature-tagged mutagenesis and the spiC mutant as a candidate live attenuated vaccine显示文摘 | Shizhong Geng Xinan Jiao Paul Barrow Zhiming Pan Xiang Chen | 2013 | Veterinary Microbiology2013，，： | 1 |
| 15 | A ZVS/ZCS solution to crossover distortion in BOOST PFC rectififer显示文摘 | Mansoor K M Wu Zhiming Pan J'tmrnin | 2005 | Journal of Circuits Systems & Computers2005，14，6： | 1 |
| 16 | Pulsed inert gas metal arc welding with feed back control显示文摘 | Jiluan Pan Zhiming Ou Zhiqiang Wu | 1985 | Schweissen and Schneiden1985，37，4： | 1 |
| 17 | Detection of cotton waterlogging stress based on hyperspectral images and convolutional neural network显示文摘Waterlogging in the early stage of cotton will reduce the number of bolls and do harm to yield.Early detection of waterlogging will help farmers to adjust cotton management and save the loss.To evaluate the application of deep learning for the detection of early waterlogging,this study applied a convolutional neural network(CNN)to classify different durations of waterlogging stress(0,2,4,6,8,10 d)based on hyperspectral images(HSIs)of cotton leaves.An experiment was designed to simulate the situation of cotton under waterlogging stress and collect HSIs of visible and near-infrared(VNIR 450-950 nm)spectra with 126 bands 66 d after cotton sowing(66 DAS).It was found the spectral curve reflectance of waterlogging cotton was higher than that of non-waterlogging cotton.Especially near 550 nm and 750 nm,and the spectral curve increased with durations of waterlogging stress and there were‘blue shift’phenomena for the position of the red edge of the spectra.The first principal components of HSIs after band randomly discarding and principal component analysis(PCA)were used to build a dataset.GoogLeNet Inception-v3(GLNI-v3)and VGG-16 models were selected to detect cotton waterlogging stress with the dataset.The results showed that the average time for a round training for GLNI-v3 was 13.337 s,with a classification accuracy of 96.95%and a loss value of 0.09431.The average time for a round training for VGG-16 was 21.470 s,with a classification accuracy of 97.00%and a loss value of 0.17912.Though these two models had similar classification accuracy and loss value,GLNI-v3 achieved a high accuracy with fewer training iterations.The durations of waterlogging stress of cotton in a short-term can be detected by HSIs of cotton leaves and CNN models are suitable for the classification of HSIs,and this method can provide support for cotton yield estimation and loss assessment after waterlogging. | Jing Zhao Fangjiang Pan Zhiming Li Yubin Lan Liqun Lu Dongjian Yang Yuting Wen | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 1 |
| 18 | Pulsed Inert Gas Metal Arc Welding With Feed Back Control显示文摘 | Jiluan Pan Zhiming Ou Zhiqiang Wu | 1985 | Schweissen and Schneiden1985，，4： | 1 |
| 19 | Fabrication and characterization of chitosan microcarrier for hepatocyte culture显示文摘 | Chen Wu Pan Jilun Bao Zhiming | 2007 | J Mater Sci:Mater Med2007，18，： | 1 |
| 20 | Fabrication andcharacterization of chitosan microcarrier for hepatocyteculture显示文摘 | Wu Chen Pan Jilun Bao Zhiming | 2007 | J Materials Sci Mater Med2007，18，11： | 1 |
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