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| 1 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 2 | Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274显示文摘 | Bingfa Sun Shunling Guo Qingyu Tang Chen Li Rong Zeng Zhiqi Xiong Chen Zhong Jianping Ding | 2011 | Cell Research2011，21，8： | 1 |
| 3 | Synergistic oxidation-reforming of biomass for high quality syngas production based on a bifunctional catalyst显示文摘Conventional O_(2)gasification for low-rank biomass/sludge conversion is prone to high CO_(2)concentrations in the syngas because of its high O content and low calorific value.This study establishes a synergistic oxidationreforming reaction route for the conversion of low-rank carbon-containing resources into high-quality syngas.The efficient oxidation-reforming reaction is based on the bifunctional catalyst NiO-Fe2O3/Al2O3,which includes Fe2O3 oxidation sites and NiO reforming sites.Hydrogen temperature-programmed reduction,together with X-ray diffraction and X-ray photoelectron spectroscopy experiments,demonstrated that the two functional active sites have strong interactions with the support,leading to efficient cooperation between the oxidation reaction and reforming reaction with regards to both the reaction sequence and C/H/O element balance.Syngas produced from biomass/sludge based on oxidation-reforming reactions has an extremely low CO_(2)concentration of approximately 3%,and the valid gas(CO,H_(2))concentration exceeds 95%.The valid gas yield of walnut shell reached 1452.9 mL/g,the total gas yield was 1507.2 mL/g,and the H_(2)/CO ratio was 1.02,which are all very close to the theoretical maximum values of 1553.1 mL/g and 1.01,respectively,demonstrating that the inherent CO_(2)/H_(2)O along with CH4/tar species were efficiently converted to H_(2)and CO through oxidation-reforming reactions.During a 60-cycle test,NiO-Fe2O3/Al2O3 exhibited good redox stability. | Tao He Dan Zhang Wenqing Chen Zeng Liu Ruidong Zhao Jianqing Li Jingli Wu Zhiqi Wang Jinhu Wu | 2024 | Green Carbon2024，2，1： | 0 |
| 4 | Antigenic Drift of the Hemagglutinin from an Influenza A(H1N1) pdm09 Clinical Isolate Increases its Pathogenicity In Vitro显示文摘The influenza A(H1 N1)pdm09 virus emerged in 2009 and has been continuously circulating in humans for over ten years.Here,we analyzed a clinical influenza A(H1 N1)pdm09-infected patient case hospitalized for two months in Guangdong(from December 14,2019 to February 15,2020).This isolate,named A/Guangdong/LCF/2019(LCF/19),was genetically sequenced,rescued by reverse genetics,and phylogenetically analyzed in the context of other relevant pdm09 isolates.Compared with earlier isolates,this pdm09 virus’s genetic sequence contains four substitutions,S186 P,T188 I,D190 A,and Q192 E,of the hemagglutinin(HA)segment at position 186–192(H3 numbering)in the epitope Sb,and two of which are located at the 190-helix.Phylogenetic analysis indicated that the epitope Sb started undergoing a rapid antigenic change in2018.To characterize the pathogenicity of this novel substitution motif,a panel of reassortant viruses containing the LCF/2019 HA segment or the chimeric HA segment with the four substitutions were rescued.Kinetic growth data revealed that the reassortant viruses,including the LCF/2019 with the PTIAAQE substitution,propagated faster than those rescued ones having the STTADQQ motif in the epitope Sb in Madin-Darby Canine Kidney(MDCK)cells.The HI test showed that the binding activity of escape mutant to 2018 pdm09 sera was weaker than GLW/2018,suggesting that old vaccines might not effectively protect people from infection.Due to the difference in the selection of vaccine strains,people vaccinated in the southern hemisphere could still suffer a severe infection if infected with this antigenic drift pdm09 virus. | Lei Xing Yunbo Chen Boqian Chen Ling Bu Ying Liu Zhiqi Zeng Wenda Guan Qigao Chen Yongping Lin Kun Qin Honglin Chen Xilong Deng Xinhua Wang Wenjun Song | 2021 | Virologica Sinica2021，36，5： | 0 |
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