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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | A telomere-to-telomere gap-free reference genome of watermelon and its mutation library provide important resources for gene discovery and breeding显示文摘Watermelon,Citrullus lanatus,is the world's third largest fruit crop.Reference genomes with gaps and a narrow genetic base hinder functional genomics and genetic improvement of watermelon.Here,we report the assembly of a telomere-to-telomere gap-free genome of the elite watermelon inbred line G42 by incorporating high-coverage and accurate long-read sequencing data with multiple assembly strategies.All 11 chromosomes have been assembled into single-contig pseudomolecules without gaps,representing the highest completeness and assembly quality to date.The G42 reference genome is 369321829 bp in length and contains 24205 predicted protein-coding genes,with all 22 telomeres and 11 centromeres characterized.Furthermore,we established a pollen-EMS mutagenesis protocol and obtained over 200000M1 seeds from G42.In a sampling pool,48 monogenic phenotypic mutations,selected from 223M1and 78 M2 mutants with morphological changes,were confirmed.The average mutation density was 1 SNP/1.69Mband1 indel/4.55 Mb per M1 plant and 1SNP/1.08Mb and 1 indel/6.25 Mb per M2 plant.Taking advantage of the gap-free G42 genome,8039 mutations from 32 plants sampled from M1 and M2 families were identified with 100%accuracy,whereas only 25% of the randomly selected mutations identified using the 97103v2 reference genome could be confirmed.Using this library and the gap-free genome,two genes responsible for elongated fruit shape and male sterility(CiMs1)were identified,both caused by a single basechange from G to A.The validated gap-free genome and its EMS mutation library provide invaluable resources for functional genomics and genetic improvement of watermelon. | Yun Deng Shoucheng Liu Yilin Zhang Jingsheng Tan Xiaopeng Li Xiao Chu Binghua Xu Yao Tian Yudong Sun Bosheng Li YunbiXu Xing Wang Deng Hang He Xingping Zhang | 2022 | Molecular Plant2022，15，8： | 9 |
| 3 | A Case of New Variant COVID-19 First Emerging in South Africa Detected in Airplane Pilot—Guangdong Province,China,January 6,2021显示文摘On January 6,2021,Guangdong CDC successfully isolated the 501Y.V2 variant of coronavirus disease 2019(COVID-19)virus from a throat swab of a patient.The 501Y.V2 variant was first detected in South Africa,and the patient is a 55-year-old male airline pilot of South African nationality.He entered Guangzhou City,the capital of Guangdong Province,from Singapore on the evening of December 8,2020 and was subject to a COVID-19 test. | Fengjuan Chen Bosheng Li Peter Hao Yang Song Wenbo Xu Nankun Liu Chunliang Lei Changwen Ke | 2021 | China CDC weekly2021，3，2： | 5 |
| 4 | Accelerating DNN-based 3D point cloud processing for mobile computing显示文摘3D point cloud data,which are produced by various 3D sensors such as LIDAR and stereo cameras,have been widely deployed by industry leaders such as Google,Uber,Tesla,and Mobileye,for mobile robotic applications such as autonomous driving and humanoid robots.Point cloud data,which are composed of reliable depth information,can provide accurate location and shape characteristics for scene understanding,such as object recognition and semantic segmentation.However,deep neural networks(DNNs),which directly consume point cloud data,are particularly computation-intensive because they have to not only perform multiplication-and-accumulation(MAC)operations but also search neighbors from the irregular 3D point cloud data.Such a task goes beyond the capabilities of general-purpose processors in realtime to figure out the solution as the scales of both point cloud data and DNNs increase from application to application.We present the first accelerator architecture that dynamically configures the hardware onthe-fly to match the computation of both neighbor point search and MAC computation for point-based DNNs.To facilitate the process of neighbor point search and reduce the computation costs,a grid-based algorithm is introduced to search neighbor points from a local region of grids.Evaluation results based on the scene recognition and segmentation tasks show that the proposed design harvests 16.4x higher performance and saves 99.95%of energy than an NVIDIA Tesla K40 GPU baseline in point cloud scene understanding applications. | Bosheng LIU Xiaoming CHEN Yinhe HAN Jiajun LI Haobo XU Xiaowei LI | 2019 | Science China(Information Sciences)2019，62，11： | 4 |
| 5 | PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness显示文摘PHYTOCHROME-INTERACTING FACTORS(PIFs)are a group of basic helix-loop-helix transcription factors that can physically interact with photoreceptors,including phytochromes and cryptochromes.It was previously demonstrated that PIFs accumulated in darkness and repressed seedling photomorphogenesis,and that PIFs linked different photosensory and hormonal pathways to control plant growth and development.In this study,we show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically in darkness.We found that PIFs positively regulate ABI5 transcript and protein levels in darkness in response to exogenous ABA treatment by binding directly to the G-box motifs in the ABI5 promoter.Consistently,PIFs and the G-box motifs in the ABI5 promoter determine ABI5 expression in darkness,and overexpression of ABI5 could rescue the ABA-insensitive phenotypes of pifq mutants in the dark.Moreover,we discovered that PIFs can physically interact with the ABA receptors PYL8 and PYL9,and that this interaction is not regulated by ABA.Further analyses showed that PYL8 and PYL9 promote PIF4 protein accumulation in the dark and enhance PIF4 binding to the ABI5 promoter,but negatively regulate PIF4-mediated ABI5 activation.Taken together,our data demonstrate that PIFs interact with ABA receptors to orchestrate ABA signaling in darkness by controlling ABI5 expression,providing new insights into the pivotal roles of PIFs as signal integrators in regulating plant growth and development. | Lijuan Qi Shan Liu Cong Li Jingying Fu Yanjun Jing Jinkui Cheng Hong Li Dun Zhang Xiaoji Wang Xiaojing Dong Run Han Bosheng Li Yu Zhang Zhen Li William Terzaghi Chun-Peng Song Rongcheng Lin Zhizhong Gong Jigang Li | 2020 | Molecular Plant2020，13，3： | 3 |
| 6 | Comparison of Omicron and Delta Variant Infection COVID-19 Cases—Guangdong Province,China,2022显示文摘What is already known about this topic?The Omicron variant has been listed as a variant of concern,but the characteristics still remain unclear.What is added by this report?The vaccinated proportion of 65 imported coronavirus disease 2019 cases that were infected with Omicron variant in this study was 89.23%,which was higher than Delta cases.Most imported cases infected with Omicron were tested positive using polymerase chain reaction after entering Guangdong within 3 days,a shorter period than Delta. | Ting Hu Meng Zhang Aiping Deng Yingtao Zhang Bosheng Li Yan Li Min Kang | 2022 | China CDC weekly2022，4，18： | 3 |
| 7 | An Outbreak of the SARS-CoV-2 Omicron Variant BA.1—Zhuhai City,Guangdong Province,China,January 13,2022显示文摘On January 13,2022,Zhuhai CDC received a notification that a coronavirus disease 2019(COVID-19)case was found in the fever clinic in nearby Zhongshan City.Zhuhai CDC promptly carried out large-scale population screening in three nearby counties.A total of 4 COVID-19 cases were found in Nanping County.34 cases were screened from close contacts,and 2 cases were reported from close contacts in other cities of Guangdong Province.The 20 cases were sequenced by Guangdong CDC and identified as the variant of concern(VOC)/Omicron variant BA.1.Since January 14,Zhuhai has carried out 8 rounds of nucleic acid screening for COVID-19 in the county where the cases occurred.Four large-scale nucleic acid screening tests for COVID-19 were conducted across the city,and no new community cases were reported after January 15. | Feng Ruan Xuebao Zhang Songjian Xiao Xihe Ni Xiling Yin Zhongwen Ye Guorong Chen Tingting Zhu Zeling Chen Gang Yao Long Chen Sichen Huang Huitao Huang Yi Zhou Heyan Wu Hui Huang Kejing Zhu Shanzi Huang Xiaoou Tang Min Kang Bosheng Li Wenhua Mei | 2022 | China CDC weekly2022，4，30： | 2 |
| 8 | A Comprehensive Online Database for Exploring ∼20,000 Public Arabidopsis RNA-Seq Libraries显示文摘In the last decade,RNA-sequencing(RNA-seq)has surpassed microarray to become the gold standard for gene expression profiling due to the continuous drop in sequencing cost and the latest development of easy-to-use library construction kits.To date,the Arabidopsis community has collectively released more than 20000 RNA-seq libraries,with over 1300 libraries deposited just in the first quarter of 2019(Figure 1A).This vast resource is tremendously useful for all Arabidopsis researchers to study transcriptional regulation,tissue specificity,stress responses,and developmental dynamics of genes in which they are interested. | Hong Zhang Fei Zhang Yiming Yu Li Feng Jinbu Jia Bo Liu Bosheng Li Hongwei Guo Jixian Zhai | 2020 | Molecular Plant2020，13，9： | 2 |
| 9 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 10 | A Distributed Design for Minimum 2-Connected m-Dominating Set in Bidirectional Wireless Ad-Hoc Networks显示文摘Wireless ad-hoc network is widely used in many fields for its convenience and outstanding suitability. Because of the inherent lack of infrastructure and the nature of wireless channels, people select the k-Connected m-Dominating Set ((k; m)-CDS) in a network as a fault-tolerant virtual backbone to help the routing process, which will save the energy of non-dominators and improve the network performance significantly. Considering the economic cost and efficiency, we choose (2,m)-CDS as the object of this paper, which is helpful enough in practical applications and has a smaller size. We firstly study the existing algorithms for (k,m)- CDS and figure out the problems of these designs. Then we propose a new distributed algorithm named Dominating Set Based Algorithm (DSBA) with three sub-routines: Dominating Set Algorithm (DSA), Connection Algorithm (CA), and Connectivity Expansion Algorithm (CEA). Instead of commonly used Maximal Independent Set (MIS), we pick dominating set directly from the given graph, and then connect them by a two-step ring based connecting strategy to satisfy the 2-connectivity. We also provide the correctness and complexity analysis of DSBA. At last, we compare DSBA with the last construction Distributed Deterministic Algorithm (DDA) by several numerical experiments. The simulation results show that DSBA improves over 30 percent of the performance of DDA, proving that DSBA is more practical for real-world applications. | Xiaofeng Gao Bosheng Xu Jun Li | 2012 | Tsinghua Science and Technology2012，17，5： | 2 |
| 11 | A New Species of Spirulina(Arthrospira) from the Mu Us Sandy Land of In- ner Mongolia Autonomous Region in China显示文摘 | Li Bosheng Qiao Chen Tseng Chao Tsi | 2001 | Fores Stud China2001，3，2： | 1 |
| 12 | Up-regulated microRNA-146a negatively modulate Helicobacter pylori -induced inflammatory response in human gastric epithelial cells显示文摘 | Zhen Liu Bin Xiao Bin Tang Bosheng Li Na Li Endong Zhu Gang Guo Jiang Gu Yuan Zhuang Xiaofei Liu Honglei Ding Xiaoyan Zhao Hong Guo Xuhu Mao Quanming Zou | 2010 | Microbes and Infection2010，，11： | 1 |
| 13 | A novel protein domain is important for photosystem Ⅱ complex assembly and photoautotrophic growth in angiosperms显示文摘Photosystem Ⅱ(PSⅡ)is a multi-subunit protein complex of the photosynthetic electron transport chain that is vital to photosynthesis.Although the structure,composition,and function of PSⅡ have been extensively studied,its biogenesis mechanism remains less understood.Thylakoid rhodanese-like(TROL)provides an anchor for leaf-type ferredoxin:NADP^(+)oxidoreductase.Here,we report the chacterizaton of a second type of TROL protein,TROL2,encoded by seed plant genomes whose function has not previously been reported.We show that TROL2 is a PSⅡ assembly cofactor with essential roles in the establishment of photoautotrophy.TROL2 contains a 45-amino-acid domain,termed the chlorotic lethal seedling(CLS)domain,that is both necessary and sufficient for TROL2 function in PSⅡ assembly and photoautotrophic growth.Phylogenetic analyses suggest that TROL2 may have arisen from ancestral TROL1 via gene duplication before the emergence of seed plants and acquired the CLS domain via evolution of the sequence encoding its N-terminal portion.We further reveal that TROL2(or CLS)forms an assembly cofactor complex with the intrinsic thylakoid membrane protein LOW PSⅡ ACCUMULATION2 and interacts with small PSⅡ subunits to facilitate PSⅡ complex assembly.Collectively,our study not only shows that TROL2(CLS)is essential for photoautotrophy in angiosperms but also reveals its mechanistic role in PSⅡ complex assembly,shedding light on the molecular and evolutionary mechanisms of photosynthetic complex assemblyin angiosperms. | Wei Li Jiangfan Guo Xue Han Xiaowen Da Kai Wang Hongfei Zhao Shi-Tang Huange Bosheng Li Hang He Ruirui Jiang Shichen Zhou Peng Yan Tao Chen Yi He Jiming Xu Yu Liu Yunrong Wu Huixia Shou Zhongchang Wu Chuanzao Mao Xiaorong Mo | 2023 | Molecular Plant2023，16，2： | 0 |
| 14 | Pictorial Album on Tibetan Vegetation显示文摘At the First Conference of East Asia State Parks and Protection held in Bejing from September 13-18,1993,I met Prof,Xu Fengxiang.As the secretary-general of the confer-ence,I obtained lttle hime to engage in deep discussion with her.She presented the symposium witha pic-torial album entitled Mountaim and Rioer Vegctahion in China's Tibet. | Li Bosheng | 1994 | China's Tibet1994，5，5： | 0 |
| 15 | Superplasticity of a Ti-24Al-14Nb-3V-0.5Mo Intermetallic Alloy显示文摘Superplastic properties and microstructural evolution of a Ti-24Al-14Nb-3V-0.5Mo (at. pct) intermetallic alloy were studied. Optimum superplastic properties were obtained for temperatures in the interval 960℃≤5 T≤5980℃. The apparent activation energy in the superplastic regime was determined and the deformation mechanism was also discussed. Based on the studies, a curve panel with three sheets sandwich structure was fabricated successfully. The microstructures corresponding to different strain in the part were also studied. | Hanliang ZHU Zhiqiang LI Bosheng SHANG Wenfeng MAO and Chunxiao WANG Beijing Aeronautical Manufacturing Technology Research institute, Beijing 100024, China Shiqiong LI and Jianwei ZHANG Central iron and Steel Research institute, Beijing 100081, China | 2001 | Journal of Materials Science & Technology2001，17，1： | 0 |
| 16 | Monodirectional evolutional symport tissue P systems with channel states and cell division显示文摘Bioinspired computing is a research framework that solves computer science problems based on the principles of biology and the natural world,including DNA and membrane computing.Membrane computing(MC),an active subfield of bioinspired computing based on the biological cell structure,emerged as an unconventional computational paradigm and has generated an extensive fundamental research scope in theoretical computer science[1].The models discussed in the MC paradigm are termed as P systems.In summary,P systems have three basic models:neural-like P systems[2],tissue-like P systems[3](models are associated with a structure of directed graph),and cell-like P systems(models are associated with a structure of rooted tree)[4].For a comprehensive guide to membrane computing,the Handbook of Membrane Computing is suggested[5]. | Bosheng SONG Kenli LI Xiangxiang ZENG Mario J.PEREZ-JIMENEZ Claudio ZANDRON | 2023 | Science China(Information Sciences)2023，66，3： | 0 |
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