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| 1 | Biomimetic nanoparticles for inflammation targeting显示文摘There have been many recent exciting developments in biomimetic nanoparticles for biomedical applications. Inflammation, a protective response involving immune cells, blood vessels,and molecular mediators directed against harmful stimuli, is closely associated with many human diseases.As a result, biomimetic nanoparticles mimicking immune cells can help achieve molecular imaging and precise drug delivery to these inflammatory sites. This review is focused on inflammation-targeting biomimetic nanoparticles and will provide an in-depth look at the design of these nanoparticles to maximize their benefits for disease diagnosis and treatment. | Kai Jin Zimiao Luo Bo Zhang Zhiqing Pang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 27 |
| 2 | Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis显示文摘The effective drug treatment of rheumatoid arthritis (RA) is hindered by poordelivery efficiency to the diseased site and the serious side effects caused bywide-spread drug distribution. Traditional drug-targeting strategies, such asligand modification, are complex, laborious, and inefficient. Inspired by theintrinsic relationship between platelets and RA, platelet-mimetic nanoparticles(PNPs) were developed for targeted drug delivery in RA. Through plateletreceptor-mediated adhesion, an intact platelet membrane was coated onto poly(lactic-co-glycolic add) nanopartides, endowing the resulting PNPs with variousfunctional receptors. By coating with platelet membranes, the nanoparticleswere stabilized and had a better circulation profile, providing a benefit forpassive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivoaccumulation in joints of a collagen-induced arthritis (CIA) mouse model of RAwere significantly improved via P-selectin and GVPI recognition, indicating thatthe PNPs could effectively target to RA tissues through multiple mechanisms,similar to natural platelets. Moreover, FK506, a model drug, was loaded into thePNPs and used to treat RA. Pharmacodynamic studies demonstrated that theFK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides anew biomimetic targeting strategy with great potential for the treatment of RA. | Yuwei He Ruixiang Li Jianming Liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang | 2018 | Nano Research2018，11，11： | 9 |
| 3 | 2001-2005年中国4省份精神疾病的患病率、治疗情况和相关残疾:一项流行病学调查显示文摘背景在中国和其他中等收入国家,神经精神状况是影响男性和女性健康的最重要的原因,但由于缺乏有关各种精神疾病患病率、治疗情况和相关残疾的高质量的和具有国家特异性的资料,这些国家提高精神卫生服务的工作受到了限制。因此,我们在中国4个省份开展了一系列流行病学研究,以此来估算相关数据。方法采用多阶段分层随机抽样的方法在中国的4个省抽取了96个城市和267个农村作为初级抽样点;1.13亿个年龄≥18岁的成年人的抽样框架涵盖了中国12%的成年人。在抽样点使用简单随机抽样法选取63004例受试者,采用一般健康问卷(GHQ)的扩展版对这些个体进行筛查,并由精神科医生使用中文版的诊断与统计手册(DSM).Iv轴I障碍定式临床检查(SCID)问卷对其中的16577例受试者进行调查。结果所有精神疾病近1个月的校正患病率为17.5%(95%CI16.6%~18.5%)。其中,心境障碍患病率为6.1%(95%CI5.7%~6.6%),焦虑障碍为5.6%(95%cI5.0%~6.3%),物质滥用障碍为5.9%(95%CI5-3%~6.5%),精神病性障碍为1.0%(95%C10.8%~1.1%)。女性的心境障碍和焦虑障碍的患病率比男性高,年龄〉140岁个体的患病率高于年龄〈40岁的个体。男性酒精使用障碍的患病率是女性的48倍。农村居民比城市居民更可能患有抑郁障碍和酒精依赖。在被诊断患有某种精神疾病的人群中,24%存在由所患精神疾病引起的中度或重度残疾,8%曾向专业人员寻求过帮助,5%曾就诊于精神科。结论本研究结果与全球疾病负担分析中使用的中国精神疾病的患病率、残疾和治疗率估计值有相当大的差距,这需要引起中、低收入国家注意,在提高精神卫生服务前需针对国家具体情况进行详细的现状分析。 | Jingxuan Zhang Qichang Shi Zhiqiang Song Zhijie Ding Shutao Pang Xianyun Li Yali Zhang Zhiqing Wang 张亚利(译) 安静(审校) 费立鹏(审校) | 2009 | 世界临床医学2009，，11： | 5 |
| 4 | Recent insights for the emerging COVID-19:Drug discovery,therapeutic options and vaccine development显示文摘SARS-CoV-2 has been marked as a highly pathogenic coronavirus of COVID-19 disease into the human population,causing over 5.5 million confirmed cases worldwide.As COVID-19 has posed a global threat with significant human casualties and severe economic losses,there is a pressing demand to further understand the current situation and develop rational strategies to contain the drastic spread of the virus.Although there are no specific antiviral therapies that have proven effective in randomized clinical trials,currently,the rapid detection technology along with several promising therapeutics for COVID-19 have mitigated its drastic transmission.Besides,global institutions and corporations have commenced to parse out effective vaccines for the prevention of COVID-19.Herein,the present review will give exhaustive details of extensive researches concerning the drug discovery and therapeutic options for COVID-19 as well as some insightful discussions of the status of COVID-19. | Yuefei Zhu Jia Li Zhiqing Pang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，1： | 4 |
| 5 | Aptamer-functionalized PEG–PLGA nanoparticles for enhanced anti-glioma drug delivery显示文摘 | Jianwei Guo Xiaoling Gao Lina Su Huimin Xia Guangzhi Gu Zhiqing Pang Xinguo Jiang Lei Yao Jun Chen Hongzhuan Chen | 2011 | Biomaterials2011，，31： | 2 |
| 6 | Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment显示文摘Decades have passed since the first nanoparticles-base medicine was approved for human cancer treatment, and the research and development of nanoparticles for drug delivery are always undergoing.Nowadays, the significant advances complicate nanoparticles’ branches, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines and nano-antibodies, etc. These nanoparticles show numerous capabilities in treatment and diagnosis of stubborn diseases like cancer and neurodegenerative diseases, emerging as novel drug carriers or therapeutic agents in future. In this review, the complicated branches of nanoparticles are classified and summarized, with their property and functions concluded. Besides, there are also some delivery strategies that make nanoparticles smarter and more efficient in drug delivery, and frontiers in these strategies are also summarized in this review. Except these excellent works in newly-produced drug delivery nanoparticles, some points of view and future expectations are made in the end. | Rui Liu Cong Luo Zhiqing Pang Jinming Zhang Shaobo Ruan Meiying Wu Lei Wang Tao Sun Nan Li Liang Han Jinjin Shi Yuanyu Huang Weisheng Guo Shaojun Peng Wenhu Zhou Huile Gao | 2023 | Chinese Chemical Letters2023，34，2： | 2 |
| 7 | Preparation and brain de- livery property of biodegradable polymersomes conjugated with OX26 显示文摘 | Zhiqing Pang Wei Lu Huile Gao | 2008 | J Controlled Release2008，128，： | 1 |
| 8 | Identification of peptide sequences that target to the brain using in vivo phage display 显示文摘 | Li Jingwei Zhang Qizhi Pang Zhiqing et aL | 2012 | Amino Acids2012，42，6： | 1 |
| 9 | Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis显示文摘Hemophagocytic lymphohistiocytosis(HLH)is a highly fatal condition with the positive feedback loop between continued immune cell activation and cytokine storm as the core mechanism to mediate multiple organ dysfunction.Inspired by macrophage membranes harbor the receptors with special high affinity for proin-flammation cytokines,lipopolysaccharide(LPS)-stimulated macrophage membrane-coated nanoparticles(LMNP)were developed to show strong sponge ability to both IFN-γand IL-6 and suppressed overactivation of macrophages by inhibiting JAK/STAT signaling pathway both in vitro and in vivo.Besides,LMNP also efficiently alleviated HLH-related symptoms including cytopenia,hepatosplenomegaly and hepatorenal dysfunction and save the life of mouse models.Furthermore,its sponge effect also worked well for five human HLH samples in vitro.Altogether,it’s firstly demonstrated that biocompatible LMNP could dampen HLH with high potential for clinical transformation,which also provided alternative insights for the treatment of other cytokine storm-mediated pathologic conditions such as COVID-19 infection and cytokine releasing syndrome during CAR-T therapy. | Honglan Wang Huiwen Liu Jia Li Chunying Liu Hui Chen Junying Li Chunyan Sun Tao Guo Zhiqing Pang Bo Zhang Yu Hu | 2023 | Bioactive Materials2023，，3： | 1 |
| 10 | F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery显示文摘 | Quanyin Hu Guangzhi Gu Zhongyang Liu Mengyin Jiang Ting Kang Deyu Miao Yifan Tu Zhiqing Pang Qingxiang Song Lei Yao Huimin Xia Hongzhan Chen Xinguo Jiang Xiaoling Gao Jun Chen | 2013 | Biomaterials2013，，4： | 1 |
| 11 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 12 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 13 | Aptamer-functionalized PEG–PLGA nanoparticles for enhanced anti-glioma drug delivery显示文摘 | Jianwei Guo Xiaoling Gao Lina Su Huimin Xia Guangzhi Gu Zhiqing Pang Xinguo Jiang Lei Yao Jun Chen Hongzhuan Chen | 2011 | Biomaterials2011，，31： | 1 |
| 14 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 15 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 16 | A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein显示文摘 | Gao Huile Pan Shuaiqi Yang Zhi Cao Shijie Chen Chen Jiang Xinguo Shen Shun Pang Zhiqing Hu Yu | 2011 | Biomaterials2011，，33： | 1 |
| 17 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 18 | A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein显示文摘 | Gao Huile Pan Shuaiqi Yang Zhi Cao Shijie Chen Chen Jiang Xinguo Shen Shun Pang Zhiqing Hu Yu | 2011 | Biomaterials2011，，33： | 1 |
| 19 | Broad-spectrum and powerful neutralization of bacterial toxins by erythroliposomes with the help of macrophage uptake and degradation显示文摘Anti virulence strategy has been considered as one of the most promising approaches to combat drug-rcesistant bacterial infections.Porc-forming toxins(PFTs)are the largest class of bacterial toxins,inficting their virulence ffect through creating pores on the cell membrane.However,curent solutions for eliminating PFTs are mostly designed based on their molecular structure,requiring customized design for different interactions.In the present study,we employed erythroliposome(denoted as RM-PL),a biomimetic platform constructed by artificial lipid membranes and natural erythrocyle membranes,to necutralize different hemolytic PFTs regardless of their molecular structure.When tested with model PFTs,including a-hemolysin,listeriolysin O,and streptolysin O,RM-PL could completely inhibit toxin-induced hemolysis in a concentration-dependent manner.In vivo studies further confirmed that RM-PL.could eficiently neuralize various toxins and save animals'lives without causing damage to 0rgans or tissues.In addition,we explored the underlying mechanisms of this efficient detoxification ability and found that it was mainly macrophages in the spleen and the liver that took up RM-PL-absorbed toxins through a variety of endocytosis pathways and digested them in lysosomes.In summary,the biomimetic RM-PL presented a promising system for broad-spectrum and powerful toxin neutralization with a mech-anism of lysosome-mediaed loxin degradation. | Chunying Liu Shuangrong Ruan Ying He Xuejing Li Yuefei Zhu Honglan Wang Hanwei Huang Zhiqing Pang | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 1 |
| 20 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
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