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| 1 | AMPK activation by peri-sciatic nerve administration of ozone attenuates CCl-induced neuropathic pain in rats显示文摘 | Lijuan Lu Cailong Pan Lu Chen Liang Hu Chaoyu Wang Yuan Han Yanjing Yang Zhixiang Cheng Wen-Tao Liu | 2017 | Journal of Molecular Cell Biology2017，9，2： | 14 |
| 2 | HMGB1-mediated autophagy promotes gefitinib resistance in human non-small cell lung cancer显示文摘Non-small cell lung cancer(NSCLC)ranks the first in incidence and mortality among malignant tumors in China.Molecular targeted therapies such as gefitinib,an oral inhibitor of the epidermal growth factor receptor tyrosine kinase,have shown significant benefits in patients with advanced NSCLC.However,most patients have unsatisfactory outcomes due to the development of drug resistance,and there is an urgent need to better understand the pathways involved in the resistance mechanisms.In this study,we found that HMGB1 is highly expressed in drug-resistant cells and confers to gefitinib resistance in NSCLC cells via activating autophagy process.Gefitinib upregulates HMGB1 expression in time-dependent and dose-dependent manners in human NSCLC cells.RNA interference-mediated knockdown of HMGB1 reduces PC9GR cell viability,induces apoptosis,and partially restores gefitinib sensitivity.Mechanistic analyses indicate that elevated HMGB1 expression contributes to gefitinib resistance by inducing autophagy.Thus,our results suggest that HMGB1 is an autophagy regulator and plays a key role in gefitinib resistance of NSCLC. | Tianyao Lei Jiali Huang Fei Xie Jingyao Gu Zhixiang Cheng Zhaoxia Wang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，4： | 2 |
| 3 | Connecting Calcium-Based Nanomaterials and Cancer:From Diagnosis to Therapy显示文摘As the indispensable second cellular messenger,calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins.The importance of calcium ions(Ca^(2+))makes its“Janus nature”strictly regulated by its concentration.Abnormal regulation of calcium signals may cause some diseases;however,artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role.“Calcium overload,”for example,is characterized by excessive enrichment of intracellular Ca^(2+),which irreversibly switches calcium signaling from“positive regulation”to“reverse destruction,”leading to cell death.However,this undesirable death could be defined as“calcicoptosis”to offer a novel approach for cancer treatment.Indeed,Ca^(2+)is involved in various cancer diagnostic and therapeutic events,including calcium overload-induced calcium homeostasis disorder,calcium channels dysregulation,mitochondrial dysfunction,calcium-associated immunoregulation,cell/vascular/tumor calcification,and calcification-mediated CT imaging.In paral-lel,the development of multifunctional calcium-based nanomaterials(e.g.,calcium phosphate,calcium carbonate,calcium peroxide,and hydroxyapatite)is becoming abundantly available.This review will highlight the latest insights of the calcium-based nanomaterials,explain their application,and provide novel perspective.Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics. | Shuang Bai Yulu Lan Shiying Fu Hongwei Cheng Zhixiang Lu Gang Liu | 2022 | Nano-Micro Letters2022，14，9： | 2 |
| 4 | A Late Pleistocene-Holocene lacustrine record from Lake Manas, Zunggar (northern Xinjiang, western China)显示文摘 | Thomas E. Rhodes Fran?oise Gasse Ruifen Lin Jean-Charles Fontes Keqin Wei Philippe Bertrand Elisabeth Gibert Frédéric Mélières Piotr Tucholka Zhixiang Wang Zhi-Yuan Cheng | 1996 | Palaeogeography Palaeoclimatology Palaeoecology1996，，1： | 1 |
| 5 | A Two Dimensional Partial Flooding Model for PEMFC显示文摘 | Liu Zhixiang Mao Zongqiang Wang Cheng | 2006 | Journal of Power Sources2006，，158： | 1 |
| 6 | Arabidopsis Sigma Factor Binding Proteins Are Activators of the WRKY33 Transcription Factor in Plant Defense(W)显示文摘 | Lai Zhibing Li Ying Wang Fei Cheng Yuan Fan Baofang Yu Jing-Quan Chen Zhixiang | 2011 | EN2011，，10： | 1 |
| 7 | Structural and Functional Analysis of VQ Motif-Containing Proteins in Arabidopsis as Interacting Proteins ofWRKY Transcription Factors1[W][OA]显示文摘 | Cheng Yuan Zhou Yuan Yang Yan Chi Ying-Jun Zhou Jie Chen Jian-Ye Wang Fei Fan Baofang Shi Kai Zhou Yan-Hong Yu Jing-Quan Chen Zhixiang | 2012 | Plant Physiology2012，，2： | 1 |
| 8 | A 10kW-scale Distributed Power Plant of Natural Gas-Proton Exchange Membrane Fuel Cell显示文摘A 10 kW-scale natural gas fueled proton exchange membrane fuel cell(PEMFC) distributed power plant is presented in this paper,which is designed for cogeneration of power and heat. With homemade catalysts for CO removal in a two-stage methanation process and integrated reactor in the fuel processing system,the reformed fuel with CO molar fraction less than 10-5 is obtained for the fuel cell stack. Based on Matlab/Simulink/Stateflow and xPC Target platform,a rapid control prototype(RCP) is developed for real-time condition management,signal tracking and parameter tuning,data storing,and man-machine interaction. In a typical running with 4.3 kW stack power,the hydrogen production efficiency,gross power generation efficiency and heat recovery efficiency approach to 76%,41% and 50%,respectively. The peak stack power reaches 7.3 kW. Though there is still considerable dis-tance to long-term operation at 10 kW-scale net power generation,it is a milestone for the PEMFC-based stationary application in China. | BAO Cheng SU Qingquan MI Wanliang LI Zhiyuan HI Quan JI Zhonghua LIU Zhixiang MAO Zongqiang | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 1 |
| 9 | Preparation and optical absorption of InAs nanocrystal-embedded thin films显示文摘InAs-SiO2 nanocrystal-embedded films were prepared by using radio-frequency cosputtering. The growth behavior of InAs in the composite film has been studied by a transmission electron microscope. It has been found that with the increasing substrate temperature, InAs in the matrix undergoes transitions from an initial dispersed phase to a fractal structure of the InAs phase, then to nucleation, and finally to grain growth. Large blueshift of the optical absorption edges of the films was observed from the optical absorption spectra. The relationship between the blueshift of optical absorption edge and the average size of the nanocrystals has been explained by the effective-mass approximation. | Jianzhong Shi Kaigui Zhu Weiguo Yao Juhui Jia Zhixiang Cheng Lide Zhang | 1999 | Chinese Science Bulletin1999，44，3： | 0 |
| 10 | Investigation on interfacial and electrical properties of Ge MOS capacitor with different NH_3-plasma treatment procedure显示文摘The effects of different NH_3-plasma treatment procedures on interfacial and electrical properties of Ge MOS capacitors with stacked gate dielectric of HfTiON/TaON were investigated.The NH3-plasma treatment was performed at different steps during fabrication of the stacked gate dielectric,i.e.before or after interlayer(TaON)deposition,or after deposition of high-k dielectric(HfTiON).It was found that the excellent interface quality with an interface-state density of 4.79×10^(11) eV^(-1) cm^(-2) and low gate leakage current(3.43 × 10^(-5) A/cm^2 at V_g = 1 V)could be achieved for the sample with NH_3-plasma treatment directly on the Ge surface before TaON deposition.The involved mechanisms are attributed to the fact that the NH_3-plasma can directly react with the Ge surface to form more Ge-N bonds,i.e.more GeO_xN_y,which effectively blocks the inter-diffusion of elements and suppresses the formation of unstable GeO_x interfacial layer,and also passivates oxygen vacancies and dangling bonds near/at the interface due to more N incorporation and decomposed H atoms from the NH_3-plasma. | Xiaoyu Liu Jingping Xu Lu Liu Zhixiang Cheng Yong Huang Jingkang Gong | 2017 | Journal of Semiconductors2017，38，8： | 0 |
| 11 | Research Article In situ reconstruction induced oxygen-deficient multiphase Cu based species hybridized with Ni single atoms as tandem platform for CO_(2) electroreduction显示文摘Tandem catalysis,capable of decoupling individual steps,provides a feasible way to build a high-efficiency CO_(2) electro-conversion system for multicarbons(C_(2+)).The construction of electrocatalytic materials is one of focusing issues.Herein,we fabricated a single atom involved multivalent oxide-derived Cu composite material and found it inclined to reconstruct into oxygen-deficient multiphase Cu based species hybridized with monatomic Ni on N doped C matrix.In this prototype,rapid CO generation and C-C coupling are successively achieved on NiN4 sites and surface amorphized Cu species with defects,resembling a micro-production line.In this way,the in situ formed tandem catalyst exhibited a high Faradaic efficiency(FE)of~78%for C_(2+)products along with satisfactory durability over 50 h.Particularly,the reconstruction-induced amorphous layer with abundant asymmetric sites should be favorable to improve the ethanol selectivity(FE:63%),which is about 10 times higher than that of the non-tandem Cu-based contrast material.This work offers a new approach for manipulating tandem catalyst systems towards enhancing C_(2+)products. | Juzhe Liu Yuheng Wang Pengpeng Mo Feng Yang Kaiqi Jiang Zhixiang Cheng Yuxuan Liu Zhiyi Sun Zheng Liu Yimei Zhang Wenxing Chen | 2024 | Nano Research2024，17，5： | 0 |
| 12 | Specialized endoplasmic reticulum-derived vesicles in plants:Functional diversity,evolution,and biotechnological exploitation显示文摘A central role of the endoplasmic reticulum(ER)is the synthesis,folding and quality control of secretory proteins.Secretory proteins usually exit the ER to enter the Golgi apparatus in coat protein complex II(COPII)-coated vesicles before transport to different subcellular destinations.However,in plants there are specialized ER-derived vesicles(ERDVs)that carry specific proteins but,unlike COPII vesicles,can exist as independent organelles or travel to the vacuole in a Golgi-independent manner.These specialized ERDVs include protein bodies and precursor-accumulating vesicles that accumulate storage proteins in the endosperm during seed development.Specialized ERDVs also include precursor protease vesicles that accumulate amino acid sequence KDEL-tailed cysteine proteases and ER bodies in Brassicales plants that accumulate myrosinases that hydrolyzes glucosinolates.These functionally specialized ERDVs act not only as storage organelles but also as platforms for signal-triggered processing,activation and deployment of specific proteins with important roles in plant growth,development and adaptive responses.Some specialized ERDVs have also been exploited to increase production of recombinant proteins and metabolites.Here we discuss our current understanding of the functional diversity,evolutionary mechanisms and biotechnological application of specialized ERDVs,which are associated with some of the highly remarkable characteristics important to plants. | Xie Li Xifeng Li Baofang Fan Cheng Zhu Zhixiang Chen | 2022 | Journal of Integrative Plant Biology2022，64，4： | 0 |
| 13 | The metabolite, alpha-ketoglutarate inhibits non-alcoholic fatty liver disease progression by targeting lipid metabolism显示文摘Background:Non-alcoholic liver disease is of increased concern and contributing to economic burdens not only in developing countries but in developed countries as well.Identifying the biomarker of early diagnosis and early intervention approaches for non-alcoholic liver disease is unmet and required further investigation.Although the alpha-ketoglutarate(a-KG)is recently proposed to be a potential biomarker in differentiating patients with obesity from those with non-alcoholic liver disease,how a-ketoglutatate is involved in the fatty liver progression is not clear.Methods:A high-fat diet(HFD)feeding animal model,liver functional assays,and molecular approaches were adopted to clarify the impact of a-KG in fatty liver progression.Results:In the current study,it was found that dietary a-KG would inhibit weight gain in male and female mice fed with a normal chew or HFD.HFD feeding caused fatty liver in male mice,but a-KG treatment could substantially inhibit hepatic steatosis progression.Biochemical studies revealed the possible linkage of a-KG protective functions to lipid metabolism.Further analysis identified the important role of peroxisome proliferator-activated receptors in beneficial a-KG-mediated effects on fatty liver progression.Conclusions:The current study demonstrates the therapeutic potential of a-KG and how it may be used,via dietary supplementation,as a preventive intervention for non-alcoholic liver disease in obese patients. | Katsuya Nagaoka Joud Mulla Kevin Cao Zhixiang Cheng Dan Liu William Mueller Amalia Bay Grace Hildebrand Shaolei Lu Chiung-Kuei Huang | 2020 | Liver Research2020，4，2： | 0 |
| 14 | Investigation of charge transfer between donor and acceptor for small-molecule organic solar cells by scanning tunneling microscopy and ultrafast transient absorption spectroscopy显示文摘Small-molecule organic solar cell is a category of clean energy potential device since charge transfers between donor and acceptor.The morphologies,co-assembly behavior,interaction sites,and charge transfer of BTID-nF(n=1,2)/PC71BM donor-acceptor system in the active layer of organic solar cell have been studied employing scanning tunneling microscopy(STM),scanning tunneling spectroscopy(STS),density functional theory(DFT)calculations,and transient absorption(TA)spectroscopy.The results show that BTID-1F and BTID-2F form bright strip structures,whereas BTID-nF(n=1,2)/PC71BM form ridge-like structures with each complex composed of one BTID-nF(n=1,2)molecule and four PC71BM molecules which adsorbed around the BTID-nF(n=1,2)molecule by S···πinteraction.With the assistance of S···πinteraction between BTID-nF(n=1,2)and PC71BM,BTID-nF(n=1,2)/PC71BM co-assembled ridge-like structures are more stable than the BTID-nF(n=1,2)ridge structures.To investigate the charge transfer of BTID-nF(n=1,2)/PC71BM system,STS measurements,DFT calculation,and TA spectroscopy are further performed.The results show that charge transfer occurs in BTID-nF(n=1,2)/PC71BM system with the electron transferring from BTID-nF(n=1,2)molecules to PC71BM. | Yuchuan Xiao Linxiu Cheng Xinyu Sui Qi Wang Jie Chen Dan Deng Jianqi Zhang Xuan Peng Xiaokang Li Xunwen Xiao Ke Deng Xinfeng Liu Zhixiang Wei Qingdao Zeng | 2022 | Nano Research2022，15，9： | 0 |
| 15 | Prevalence and Clinical Implication of t(11;14)in Light-Chain Amyloidosis with or without Coexistent Multiple Myeloma in the Era of Proteasome Inhibitors显示文摘Background Light-chain amyloidosis(AL)and multiple myeloma(MM)may coexist in some patients and,although they share some cytogenetic abnormalities,they usually present with different clinical phenotypes.Translocation(11;14)is the most common cytogenetic abnormality in AL,but the prevalence and clinical implication of t(11;14)in patients with AL,with or without coexistent MM,remains unclear.Methods A total of 119 consecutive newly diagnosed AL patients with available fluorescence in situ hybridization(FISH)data were retrospectively included and classified as primary AL alone(pAL-alone)or AL with coexistent MM(AL-MM).Clinical characteristics,FISH profiles,and hematologic and survival outcomes were analyzed.Results There were 53 patients in the pAL-alone group and 66 in the AL-MM group.The prevalence of t(11;14)was significantly higher in the pAL-alone group than the AL-MM group(49.1%vs.26.2%,P=0.012).A significantly higher proportion of the pAL-alone group achieved hematologic response compared with the AL-MM group(60.4%vs.39.4%,P=0.023).Patients with AL-MM experienced significantly shorter hematologic event-free survival(hemEFS)than those with pAL-alone(median,4.8 months vs.44.3 months,P<0.001),as well as significantly shorter overall survival(OS;median,15.2 months vs.not reached,P<0.001).When stratified by the presence or absence of coexistent MM and t(11;14),AL-MM patients with t(11;14)had the worst hemEFS(median,3.8 months,P<0.001)and OS(median,5.4 months,P=0.001).Conclusions Patients with pAL-alone had a higher prevalence of t(11;14)than those with AL-MM.The AL-MM group had poorer outcomes,despite the availability of proteasome inhibitor treatment,with AL-MM patients with t(11;14)showing the worst outcomes.Better diagnostic and treatment approaches are warranted for this population. | Tianhong XU Zheng WEI Jing LI Jiadai XU Yang YANG Wenjing WANG Jingli ZHUANG Zhimei WANG Lili JI Luya CHENG Weiguang WANG Zhixiang CHENG Yang KE Ling YUAN Peng LIU | 2022 | Clinical Cancer Bulletin2022，1，1： | 0 |
| 16 | Enhanced efficiency of the Sb_(2)Se_(3)thin-film solar cell by the anode passivation using an organic small molecular of TCTA显示文摘Antimony selenide(Sb_(2)Se_(3))is an emerging solar cell material.Here,we demonstrate that an organic small molecule of 4,4',4''-tris(carbazol-9-yl)-triphenylamine(TCTA)can efficiently passivate the anode interface of the Sb_(2)Se_(3)solar cell.We fabricated the device by the vacuum thermal evaporation,and took ITO/TCTA(3.0 nm)/Sb_(2)Se_(3)(50 nm)/C60(5.0 nm)/Alq3(3.0 nm)/Al as the device architecture,where Alq3 is the tris(8-hydroxyquinolinato)aluminum.By introducing a TCTA layer,the open-circuit voltage is raised from 0.36 to 0.42 V,and the power conversion efficiency is significantly improved from 3.2%to 4.3%.The TCTA layer not only inhibits the chemical reaction between the ITO and Sb_(2)Se_(3)during the annealing process but it also blocks the electron diffusion from Sb_(2)Se_(3)to ITO anode.The enhanced performance is mainly attributed to the suppression of the charge recombination at the anode interface. | Yujie Hu Zhixiang Chen Yi Xiang Chuanhui Cheng Weifeng Liu Weishen Zhan | 2023 | Journal of Semiconductors2023，44，8： | 0 |
| 17 | Probing molecular orientation at bulk heterojunctions by polarization-selective transient absorption spectroscopy显示文摘A bulk heterojunction in organic solar cells is where charge separation and recombination occur.Molecular orientation at the interface is one of the key factors that dictate solar cell efficiency.Although X-ray scattering-based methods can determine donor/acceptor domain orientations between an anisotropic phase and an isotropic fullerene-based phase,the rise of nonfullerene solar cells presents a new challenge in delineating local molecular directions at the interface between two anisotropic donor/acceptor domains.Here,we determine interfacial molecular orientations of three high-efficiency small molecule solar cells(ZR1:Y6,B1:BO-4 Cl,and BTR:BO-4 Cl)using polarization-selective transient absorption spectroscopy.The polarization anisotropy of charge separation dynamics indicates an angle of~90°between ZR1 and Y6 molecules at the interface,an angle close to 0°between B1 and BO-4 Cl,and random orientations between BTR and BO-4 Cl.These observations provide complementary information to X-ray scattering measurements and highlight polarization-selective transient absorption spectroscopy as a tool to probe interfacial structure and dynamics of key photophysical steps in energy conversion. | Cankun Zhang Yuzhe Zhang Zhiye Wang Yuming Su Zhixiang Wei Jianhui Hou Shan He Kaifeng Wu Chang He Jianqi Zhang Cheng Wang | 2021 | Science China Chemistry2021，64，9： | 0 |
| 18 | Screening of rootstocks with resistance to chilling and continuous cropping but without compromising fruit quality for protected watermelon production显示文摘Chilling stress and continuous cropping obstacles limit sustainable production of watermelons under controlled environments.Grafting of watermelon scions onto resistant rootstocks is an effective strategy currently used to overcome these environment limitations.However,currently used commercial rootstocks adversely affect watermelon fruit quality.The chilling tolerance and Fusarium oxysporum f.sp.niveum race 1(FON1)resistance of seven Cucurbit germplasms,including four watermelon germplasms(M08,TC,YL,and MY),two muskmelon cultivars(JT1 and JSM),and one commercial Cucurbita rootstock(QZ1)of watermelon,were explored in the current study.The effects of the rootstocks of these germplasms on watermelon resistance to chilling stress and continuous cropping obstacles were evaluated.TC rootstock showed the highest chilling tolerance and increased chilling tolerance of watermelon scion.All Cucurbit germplasms showed higher resistance to FON1 than watermelon cultivar N5(control).Watermelons grafted onto QZ1 showed the lowest wilt incidence and highest fruit yield but had the worst fruit quality after planting on soils continuously cropped for 11 years.Watermelons grafted onto TC showed higher resistance and yield and the best fruit quality.These findings indicate that TC has a large potential for use in grafting watermelon planted in continuously cropped soils(<10 years).TC can also be used as breeding rootstocks to improve watermelon resistance against continuous cropping obstacles without compromising fruit quality. | Kai Xu Zhixiang Lan Qing Liu Yuxing Xue Jingyi Yan Zhuangzhuang Su Mengjie Cheng Feishi Luan Xian Zhang Hao Li | 2022 | Vegetable Research2022，2，1： | 0 |
| 19 | Enhancing Hydrocarbon-Rich Bio-Oil Production via Catalytic Pyrolysis Fortified with Microorganism Pretreatment显示文摘A new method of pretreatment of corn straw with Phanerochaete chrysosporium combined with pyrolysis was proposed to improve the quality of bio-oil.The characterization results demonstrated that microbial pretreatment was an effective method to decrease the lignin,which can achieve a maximum removal rate of 44.19%.Due to the destruction of biomass structure,the content of alkali metal and alkaline earth metal is reduced.Meanwhile,the depolymerized biomass structure created better pyrolysis conditions to promote the pyrolysis efficiency,increase the average decomposition rate of pyrolysis and reduce the residue.In fast pyrolysis,because of the enrichment of cellulose and the removal of lignin,the contents of acids,linear carbonyls,furans,and sugars increased while the contents of phenols decreased.As for the catalytic pyrolysis,due to the hydrocarbon pool reaction and shape selection deoxidation of ZSM-5 catalyst,the total hydrocarbon and aromatics contents can significantly increase up to 34.37%and 30.59%,respectively,with 3 weeks of pretreatment.And the the low molecular content of bio-oil increased after pretreatment,which can significantly benefit the entry of primary pyrolysis steam into the catalyst pores to improve the catalytic efficiency and hydrocarbon contents.This method provides a new treatment idea for high-quality utilization of biomass. | Jiapeng Wang Bo Zhang Haoqiang Cheng Zhixiang Xu | 2023 | Journal of Renewable Materials2023，11，10： | 0 |
| 20 | Aromatic compounds-mediated synthesis of anatase-free hierarchical TS-1 zeolite:Exploring design strategies via machine learning and enhanced catalytic performance显示文摘Simultaneous achievement of constructing mesopores and eliminating anatase is a long-term pursuit for enhancing the catalytic performance of TS-1.Here,we developed an aromatic compounds-mediated synthesis method to prepare anatase-free and hierarchical TS-1 for olefin epoxidation.A series of hierarchical TS-1 zeolites were prepared by introducing aromatic compounds containing different functional groups via the crystallization process.The formation of intercrystalline mesopores and insertion of titanium into framework were facilitated at different extent.The synergistic coordination of carboxyl and hydroxyl in aromatic compounds with Ti(OH)4 realizes the uniform distribution of titanium species and eliminates the generation of anatase.Noteworthily,eight machine learning models were trained to reveal the mechanism of additive functional groups and preparation conditions on anatase formation and microstructure optimization.The prediction accuracy of most models can reach more than 80%.Benefiting from the larger mesopore volumes(0.37 cm3⋅g−1)and higher content of framework Ti species,TS-DHBDC-48h samples exhibit a higher catalytic performance than other zeolites,giving 1-hexene conversion of 49.3%and 1,2-epoxyhenane selectivity of 99.9%.The paper provides a facile aromatic compounds-mediated synthesis strategy and promotes the application of machine learning toward the design and optimization of new zeolites. | Chang’an Wang Guoqing An Jing Lin Xiaowei Zhang Zhiyuan Liu Yibin Luo Siqi Liu Zhixiang Cheng Tingting Guo Hongyi Gao Ge Wang Xingtian Shu | 2023 | Aggregate2023，4，4： | 0 |
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