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| 1 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling. | Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi | 2014 | Genes & Diseases2014，1，1： | 47 |
| 2 | UKF-based multi-sensor passive tracking with active assistance显示文摘A new synergy tracking method of infrared and ra dar is presented. To improve tracking accuracy, the unscented Kalman filter (UKF ), which has better nonlinear approximation ability, is adopted. In addition, to reduce the possibility of radar being locked-on by adverse electronic support measure (ESM), radar is under the intermittent-working state. After radar is tu rned off, the possible target position is estimated by a set of time polynomials , which is constructed based on the sufficient observations done before radar is turned off, the estimated values from time polynomials are compared with the cu rrent observation values from infrared to determine the time when radar is turne d on. Simulation results show the method has a good tracking accuracy and effect ively reduces the possibility of radar being locked-on by adverse ESM. | Li Anping Jing Zhongliang Hu Shiqiang | 2006 | Journal of Systems Engineering and Electronics2006，17，2： | 20 |
| 3 | TGF-β promotes invasion and metastasis of gastric cancer cells by increasing fascinl expression via ERK and JNK signal pathways显示文摘 | Hua Fu Zhongliang Hu Jifang Wen Kuansong Wang Ying Liu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 19 |
| 4 | Near-perfect fidelity polarization-encoded multilayer optical data storage based on aligned gold nanorods显示文摘Encoding information in light polarization is of great importance in facilitating optical data storage(ODS)for information security and data storage capacity escalation.However,despite recent advances in nanophotonic techniques vastly en-hancing the feasibility of applying polarization channels,the data fidelity in reconstructed bits has been constrained by severe crosstalks occurring between varied polarization angles during data recording and reading process,which gravely hindered the utilization of this technique in practice.In this paper,we demonstrate an ultra-low crosstalk polarization-en-coding multilayer ODS technique for high-fidelity data recording and retrieving by utilizing a nanofibre-based nanocom-posite film involving highly aligned gold nanorods(GNRs).With parallelizing the gold nanorods in the recording medium,the information carrier configuration minimizes miswriting and misreading possibilities for information input and output,respectively,compared with its randomly self-assembled counterparts.The enhanced data accuracy has significantly im-proved the bit recall fidelity that is quantified by a correlation coefficient higher than 0.99.It is anticipated that the demon-strated technique can facilitate the development of multiplexing ODS for a greener future. | Linwei Zhu Yaoyu Cao Qiuqun Chen Xu Ouyang Yi Xu Zhongliang Hu Jianrong Qiu Xiangping Li | 2021 | Opto-Electronic Advances2021，4，11： | 9 |
| 5 | TGF-β1 alters microRNA profile in human gastric cancer cells显示文摘Objective: MicroRNAs (miRNAs) are important regulators that play a key role in tumorigenesis and tumor progression. Transforming growth factor-β1 (TGF-β1) is involved in invasion and metastasis in many tumors. In this study, we investigated the microRNAs (miRNA) profiles altered by TGF-β1 in gastric cancer (GC) cells. Methods: We detected the expression profiles of miRNA by miRNA microarray and quantitative real-time polymerase chain reaction. Migration and invasion, wound-healing assay, prediction of miRNA targets, Western blot and qRT-PCR analysis were carried out to determine the role of one selected miRNA, namely miR-193b, in affecting the biological behaviors of GC BGC823 cells. Results: Among 847 human miRNAs in the microarray, three miRNAs (miR-27a, miR-29b-1 and miR-194) were up-regulated and three (miR-574-3p, miR-193b and miR-130b) were down-regulated in BGC823 cells treated with TGF-β1 compared with control. miR-193b suppressed the invasion and metastasis of GC cells in vivo and in vitro, and down-regulated urokinase-type plasminogen activator (uPA) protein in GC cells. Conclusions: TGF-β1 altered miRNA expression profile in BGC823 cells. Among the altered miRNAs, TGF-β1 induced the down-regulation of miR-193b, which inhibited cell invasion and metastasis in vivo and in vitro, and down-regulated uPA protein in GC cells. | Haiyan Zhou Kuansong Wang Zhongliang Hu Jifang Wen | 2013 | Chinese Journal of Cancer Research2013，25，1： | 5 |
| 6 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 7 | On the sensor order in sequential integrated probability data association filter显示文摘The processing order of sensors with different detection probabilities and in different clutter densities in a multi-sensor system is investigated in this paper. A sequential implementation of the integrated probability data association (IPDA) algorithm under random set framework is derived. Under the assumptions of different detection probabilities and different clutter densities of individual sensor in a multi-sensor system, we reach the conclusion that the sequential IPDA filter depends on the order analyzing the target existence probability of varying sensor orders. Moreover, we obtain the optimal order of sensors for the sequential IPDA filter in terms of maximizing the target existence probability. The conclusions are demonstrated by simulation results. | WANG Yang JING ZhongLiang HU ShiQiang ZHANG HongJian WU JingJing | 2012 | Science China(Information Sciences)2012，55，3： | 2 |
| 8 | New trajectory linearization control for nonlinear systems undergoing harmonic disturbance显示文摘This paper presents a new trajectory linearization control scheme for a class of nonlinear systems subject to harmonic disturbance.It is supposed that the frequency of the disturbance is known,but the amplitude and the phase are unknown.A disturbance observer dynamics is constructed to estimate the harmonic disturbance, and then the estimation is used to implement a compensation control law to cancel the disturbance.By Lyapunov's direct method,a rigorous poof shows that the composite error of the closed-loop system can approach zero exponentially. Finally,the proposed method is illustrated by the application to control of an inverted pendulum.Compared with two existing methods,the proposed method demonstrates better performance in tracking error and response time. | Zhu Liang Chen Li Jing Zhongliang Hu Shiqiang | 2009 | Journal of Systems Engineering and Electronics2009，20，3： | 1 |
| 9 | Modified maximum likelihood registration based on information fusion显示文摘 | Qi Yongqing Jing Zhongliang Hu Shiqiang | 2007 | Chinese Optics Letters2007，11，： | 1 |
| 10 | Geochem- istry and episodic accumulation of natural gases from the Ire dong Gasfield in the Yinggehai Basin, offshore South China Sea显示文摘 | Baojia Huang Xianming Xiao Zhongliang Hu | 2005 | Organic Geochemistry2005，36，12： | 1 |
| 11 | Geochemistry and episodic accumulation of natural gases from the Ledong gas field in the Yinggehai Basin, offshore South China Sea 显示文摘 | Huang Baojia Xiao Xianming Hu Zhongliang | 2005 | Organic Geochemistry2005，36，12： | 1 |
| 12 | Gaussian mixture CPHD filter with gating technique 显示文摘 | Zhang Hongjian Jing Zhongliang Hu Shiqiang | 2009 | Signal Processing (S0165-1684)2009，，89： | 1 |
| 13 | Geochemistry and episodic accumulation of natural gases from the Ledong gas field in the YinggehaiBasin,off shore SouthChina Sea显示文摘 | Huang Baojia Xiao Xianming Hu Zhongliang | | 0，，12： | 1 |
| 14 | Dammarane-type glycosides from Gynostemma pentaphyllum显示文摘 | Hu Lihong Chen Zhongliang Xie Yuyuan | 1997 | Phytochemistry1997，44，4： | 1 |
| 15 | New method for dynamic bias estimation: gaussian mean shift registration显示文摘 | QI YONGQING JING ZHONGLIANG HU SHIQIANG | 2008 | Optical Engineering2008，47，2： | 1 |
| 16 | New Method for Dynamic Bias Estimation:Gaussian Mean Shift Registration 显示文摘 | Yong qing Qi Zhongliang Jing Shiqiang Hu Haitao Zhao | 2008 | Optical Engineering2008，47，2： | 1 |
| 17 | New methods for dynamic bias estimation Gaussian mean shift registrar on 显示文摘 | Qi Yongqing Jing Zhongliang Hu Shiqiang | 2008 | Optical Engineering2008，47，2： | 1 |
| 18 | Dammarane-type glycosides from gynostemma pentaphyllum显示文摘 | Lihong Hu Zhongliang Chen Yuyuan Xie | 1997 | Phytoehemistry1997，44，4： | 1 |
| 19 | Dammarane-type glycosides from Gynostemma pentaphyllum显示文摘 | Lihong Hu Zhongliang Chen Yuyuan Xie | 1997 | Phytochemistry1997，44，4： | 1 |
| 20 | Geo- chemistry and episodic accumulation of natural gases from the Ledong gas field in the Yinggehai Basin, offshore South Chi na Sea显示文摘 | Baojia Huang Xianming Xiao Zhongliang Hu | 2005 | Organic Geochemistry2005，36，： | 1 |
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