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| 1 | Fields of applications,diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients显示文摘AIM:To retrospectively analyze the fields of application,diagnostic yields and findings of OMOM capsule endoscopy in Chinese patients.METHODS:A database including 2400 Chinese patients who received OMOM capsule endoscopy in 27 endoscopy centers in China was retrieved from the Jianshan Science and Technology Ltd.OMOM capsule endoscopy database.The patient's age,gender,fields of application,the potentially relevant findings,pyloric transit time(PTT),small bowel transit time(SBTT),and complete small-bowel examination rate(CSER) were recorded and analyzed.RESULTS:Two thousand four hundred patients aged 9-91 years(mean,49 years),of whom 1510 were males(62.9%),underwent 2400 OMOM capsule endoscopy procedures.One thousand two hundred and thirty two(51.3%) were referred with obscure gastrointestinal bleeding(OGIB),642(26.8%) with abdominal pain,and 223(9.3%) with chronic diarrhea.The overall diagnostic yield was 47.7%(1144/2400).The diagnostic yield of OMOM capsule endoscopy in OGIB subgroup was much higher than in the non-OGIB subgroup(62.4% vs 32.1%,P<0.001).The most common findings of the small bowel in Chinese patients with OGIB were arteriovenous malformation(28.1%) and tumors(18.9%).There was no significant difference in the diagnostic yield between the male and female patients with OGIB.However,the diagnostic yield in patients aged more than 60 was higher than in patients aged less than 60(69.8% vs 58.9%,P<0.001).The median PTT was 41 min(range:1-544 min) and the mean SBTT was 247.2 ± 88.9 min.The overall CSER was 86.8%.CONCLUSION:The OMOM capsule endoscopy is a valuable tool for small bowel evaluation with good overall diagnostic yield and CSER. | Liao, Zhuan Gao, Rui Li, Feng Xu, Can Zhou, Yi Wang, Jin-Shan Li, Zhao-Shen | 2010 | World Journal of Gastroenterology2010，16，21： | 35 |
| 2 | Large-field high-resolution two-photon digital scanned light-sheet microscopy显示文摘 | Weijian Zong Jia Zhao Xuanyang Chen Yuan Lin Huixia Ren Yunfeng Zhang Ming Fan Zhuan Zhou Heping Cheng Yujie Sun Liangyi Chen | 2015 | Cell Research2015，25，2： | 12 |
| 3 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 4 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 5 | Development and Evaluation of a MAb-Based ELISA for Detection of Chlamy- dophila pneumoniae Infection with Variable Domain 2 and 3 of the Major Outer Membrane protein显示文摘Objective This paper aims to develop a monoclonal antibodies (MAbs)- based ELISA for detecting Chlamydophila pneumoniae (C. pneumoniae) antigens in humans with the variable domains (VD) 2 and 3 of the major outer membrane protein (MOMP VD2-VD3 ) and to assess its sensitivity and specificity by comparing with a widely used MAb that is able to recognize the elementary bodies of C. pneumoniae. Methods MOMP VD2-VD3 were overexpressed in Escherichia coli and purified by affinity chromatography. Mice were immunized with the recombinant antigen, and hybridomas secreting MAbs were screened. Three stable hybridomas clones were selected and named 5D6, 7G3, and 8C9. The MAbs-based ELISA was scrutinized for species-specific recognition with a number of human throat swab samples from Group I (156 patients with typical respiratory illness clinically confirmed before) and Group II (57 healthy donors). Results In Group I, 55 positive cases were detected by anti-EB MAb-based ELISA, 51 cases were positive by MAbs 5D6-based ELISA, and 33 and 38 cases were positive by MAb 8C9 and 7G3-based ELISA respectively. Of the 57 samples from Group II 'healthy donors', 5 were positive and 52 were negative with both anti-EB and 5D6-based tests, while 2 and 3 positive cases were identified by the other two MAb-based ELISAs respectively. Conclusion The novel MOMP VD2-VD3 MAb-based assay may have higher specificity than the anti-EB MAb, which may possibly be used as an alternative tool for the diagnosis of C. pneumoniae infection. | ZHOU Zhou WU Yi Mou CHEN Li Li LIU Guang Chao LIU Liang Zhuan ZHOU An Wen ZHANG Jun Hua | 2012 | Biomedical and Environmental Sciences2012，25，6： | 2 |
| 6 | P-Cadherin Promotes Liver Metastasis and Is Associated with Poor Prognosis in Colon Cancer显示文摘 | Lichao Sun Hai Hu Liang Peng Zhuan Zhou Xuan Zhao Jian Pan Lixin Sun Zhihua Yang Yuliang Ran | 2011 | The American Journal of Pathology2011，，： | 1 |
| 7 | An Epidemiologic Study of Posttraumatic Stress Disorder in Flood Victims in Hunan China显示文摘 | Aizhong Liu Hong zhuan Tan Jia Zhou | 2006 | Canadian Journal of Psychiatry2006，51，6： | 1 |
| 8 | Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrestin human gastric cancer cells显示文摘 | Jian Pan Hai Hu Zhuan Zhou Lichao Sun Liang Peng Long Yu Lixin Sun Jun Liu Zhihua Yang Yuliang Ran | 2010 | Oncology Reports2010，，1： | 1 |
| 9 | Preparation of bioconjugates of CdTe nanocrystals for cancer marker detection显示文摘 | HU Fengqin RAN Yuliang ZHOU Zhuan | 2006 | Nanotechnol2006，17，： | 1 |
| 10 | Is China ready to go mainstream in molecular medicine?显示文摘 | Ruiping Xiao Heping Cheng Zhuan Zhou | 2003 | Nature2003，432，： | 1 |
| 11 | TM4SF3 promotes esophageal carcinoma metastasis via upregulating ADAM12m expression显示文摘 | Zhuan Zhou Yu-Liang Ran Hai Hu Jian Pan Zhi-Feng Li Li-Zhao Chen Li-Chao Sun Liang Peng Xi-Lu Zhao Long Yu Li-Xin Sun Zhi-Hua Yang | 2008 | Clinical & Experimental Metastasis2008，，5： | 1 |
| 12 | Activation of Delta Opioid Receptors Induces Receptor Insertion and Neuropeptide Secretion显示文摘 | Lan Bao Shan-Xue Jin Chen Zhang Li-Hua Wang Zhen-Zhong Xu Fang-Xiong Zhang Lie-Chen Wang Feng-Shou Ning Hai-Jiang Cai Ji-Song Guan Hua-Sheng Xiao Zhi-Qing D. Xu Cheng He Tomas H?kfelt Zhuan Zhou Xu Zhang | 2003 | Neuron2003，，1： | 1 |
| 13 | Enhanced oxidation and detection of toxic ractopamine using carbon nanotube film- modified electrode显示文摘 | Liu Zhuan Zhou Yikai Wang Yanying | 2012 | Eleetrochimica Acta2012，74，： | 1 |
| 14 | Generation of Hematopoietic Stem Cells from Purified Embryonic Endothelial Cells by a Simple and Efficient Strategy显示文摘Recent progress by versatile approaches supports the new hypothesis that multi-potent hematopoietic stem cells(HSCs) are directly formed from a rare population of endothelial cells in mid-gestation mouse embryos.This process is therefore known as the endothelial-tohematopoietic transition(EHT).Nevertheless,there is no functional evidence that documents the HSC transition from purified endothelial cells.In this study,we developed an OP9-DL1-based co-culture system that was able to facilitate the HSC specification and/or expansion in vitro of mouse embryonic day 10.5(E10.5) Tie2^+ cells remarkably.Then,the immunophenotypically defined endothelial cells were harvested by a combination of surface markers(Flk1^+CD31^+CD41^-CD45^-Ter119^-) from the caudal half of E10.0-E11.0 mouse cmbryos.The transplantation of the endothelia/OP9-DL1 co-cultures led to long-term,high-level,multi-lineage,and multi-organ hematopoietic reconstitution in the irradiated adult recipients.The induced HSC activity was initially observed at E10.5,and a significant increase was detected at E11.0,which suggests a temporally specific regulation.Taken together,for the first time,we provide functional evidence showing the HSC potential of purified embryonic endothelial cells,which is indispensable for the emerging EHT concept. Moreover,the newly defined co-culture system will aid the exploration of the key molecules governing the HSC transition from embryonic and even postnatal endothelial cells,which has enormous significance in basic and translational research. | Zhuan Li Fan Zhou Dongbo Chen Wenyan He Yanli Ni Lingfei Luo Bing Liu | 2013 | Journal of Genetics and Genomics2013，40，11： | 1 |
| 15 | Novel nanofiltration membranes with tunable permselectivity by polymer mediated phase separation in polyamide selective layer显示文摘Microstructure in selective layer has played a decisive role in permselectivity of nanofiltration(NF) membranes,and nanomaterials were well-known additives that had been applied to mediate the microstructure and permeability of polyamide NF membranes. However, nanoadditives generally displayed a poor dispersion in membranes or in fabrication process. To solve this problem, we showed an interesting concept that novel NF membranes with hybrid selective layer consisting of flexible polyisobutylene(PIB) and rigid polyamide could be fabricated from well-defined interfacial polymerization. The hydrophobic polymer mediated phase separation and microdomains formation in polyamide layer were found. The immiscibility between the rigid polyamide and flexible PIB as well as the resultant interface effect was interpreted as the reason for the polymer enhanced permselectivity, which was similar with the well-known thin film nanocomposite(TFN) membranes that nanoparticles incorporated contributed significantly to membrane permeability and rejection performance.Our results have demonstrated that novel NF membranes with enhanced performance can be prepared from immiscible polymers, which is a new area that has not been extensively studied before. | Zhuan Yi Fa-dong Wu Yong Zhou Cong-jie Gao | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 1 |
| 16 | Activation of Delta Opioid Receptors Induces Receptor Insertion and Neuropeptide Secretion显示文摘 | Lan Bao Shan-Xue Jin Chen Zhang Li-Hua Wang Zhen-Zhong Xu Fang-Xiong Zhang Lie-Chen Wang Feng-Shou Ning Hai-Jiang Cai Ji-Song Guan Hua-Sheng Xiao Zhi-Qing D. Xu Cheng He Tomas H?kfelt Zhuan Zhou Xu Zhang | 2003 | Neuron2003，，1： | 1 |
| 17 | Deciphering the Origin and Formation of Aminopyrrole Moiety in Kosinostatin Biosynthesis显示文摘Kosinostatin(KST)contains an uncommon aminopyrrole moiety,whose biosynthesis has remained elusive.Herein,aminopyrrolinic acid,which was generated by an L-ectoine synthase-like enzyme KstB3 via cyclization of L-glutamine,was identified to be the real substrate of adenylation enzyme KstB1.Subsequently,a FAD-dependent dehydrogenase KstB4 along with a transglutaminase-like enzyme KstB6 were also involved in formation of aminopyrrole.These results provided an unusual pathway for 2-aminopyrrole formation in KST biosynthesis. | Yu Hu Qiang Zhou Zhuan Zhang Hai-Xue Pan Yulia Ilina Mikko Metsa-Ketela Yasuhiro Igarashi Gong-Li Tang | 2021 | Chinese Journal of Chemistry2021，39，12： | 1 |
| 18 | Maximum road analysis of traffic network显示文摘 | Yao Zengshan Liu Wenbin Zhou Zhuan | 2004 | Advances in Systems Science and Applications2004，4，4： | 1 |
| 19 | Exogenous nucleic acids aggregate in non-P-body cytoplasmic granules when transfected into cultured cells显示文摘To modulate gene expression in research studies or in potential clinical therapies,transfection of exogenous nucleic acids including plasmid DNA and small interference RNA(siRNA)are generally performed.However,the cellular processing and the fate of these nucleic acids remain elusive.By investigating the cellular behavior of transfected nucleic acids using confocal imaging,here we show that when siRNA was cotransfected into cultured cells with other nucleic acids,including single-stranded RNA oligonucleotides,single and double-stranded DNA oligonucleotides,as well as long double-stranded plasmid DNA,they all aggregate in the same cytoplasmic granules.Interestingly,the amount of siRNA aggregating in granules was found not to correlate with the gene silencing activity,suggesting that assembly of cytoplasmic granules triggered by siRNA transfection may be separable from the siRNA silencing event.Our results argue against the claim that the siRNAaggregating granules are the functional site of RNA interference(RNAi).Taken together,our studies suggest that,independent of their types or forms,extraneously transfected nucleic acids are processed through a common cytoplasmic pathway and trigger the formation of a new type of cytoplasmic granules“transfection granules”. | Huang HUANG Na WEI Yingfei XIONG Feng YANG Huaqiang FANG Wenjun XIE Zhuan ZHOU Heping CHENG Zicai LIANG Quan DU | 2010 | Frontiers in Biology2010，5，3： | 0 |
| 20 | Physiological relevance of soma secretion in dorsal root ganglion neurons显示文摘Dorsal root ganglion (DRG) cells are primary sensory neurons and are important in pain. Recently, a distinct type of exocytosis, Ca2+ independent but voltage-dependent, is found | Zheng Liang Hong, Wang Chang He, Sun Lei, Wang Ye Shi, Liu Tao, Zheng Hui, Zhang Claire Xi, Zhou Zhuan Institute of Molecular Medicine, Peking University, Beijing 100871, China | 2009 | 生物物理学报2009，25，S1： | 0 |
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