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| 1 | The origin and evolution of the diosgenin biosynthetic pathway in yam显示文摘Diosgenin,mainly produced by Dioscorea species,is a traditional precursor of most hormonal drugs in the pharmaceutical industry.The mechanisms that underlie the origin and evolution of diosgenin biosynthesis in plants remain unclear.After sequencing the whole genome of Dioscorea zingiberensis,we revealed the evolutionary trajectory of the diosgenin biosynthetic pathway in Dioscorea and demonstrated the de novo biosynthesis of diosgenin in a yeast cell factory.First,we found that P450 gene duplication and neofunctionalization,driven by positive selection,played important roles in the origin of the diosgenin biosynthetic pathway.Subsequently,we found that the enrichment of diosgenin in the yam lineage was regulated by CpG islands,which evolved to regulate gene expression in the diosgenin pathway and balance the carbon flux between the biosynthesis of diosgenin and starch.Finally,by integrating genes fromplants,animals,and yeast,weheterologously synthesized diosgenin to 10mg/l in genetically-engineered yeast.Our study not only reveals the origin and evolutionary mechanisms of the diosgenin biosynthetic pathway in Dioscorea,but also introduces an alternative approach for the production of diosgenin through synthetic biology. | Jian Cheng Jing Chen Xiaonan Liu Xiangchen Li Weixiong Zhang Zhubo Dai Lina Lu Xiang Zhou Jing Cai Xueli Zhang Huifeng Jiang Yanhe Ma | 2021 | Plant Communications2021，2，1： | 2 |
| 2 | Mycobacterium tuberculosis favors its survival by utilizing host ubiquitin to impair innate immunity显示文摘The host innate immune system can eliminate invading pathogens by activating innate signaling pathways upon recognition of pathogenic components;meanwhile,the pathogens have developed strategies to evade innate response and be able to survive in host cells.Feedback inhibition of the host innate immune system is one of well-known | Zhubo Chen | 2015 | National Science Review2015，2，3： | 2 |
| 3 | 显示文摘 | JingMin(井敏) WangChengguo(王成国) ZhuBo(朱波) | | 航空材料学报0，，： | 1 |
| 4 | Simultaneous Analysis of Hexaconazole, Myclobutanil, and Tebuconazole Residues in Apples and Soil by SPE Clean-Up and GC with Nitrogen–Phosphorus Detection显示文摘 | Zhubo Deng Jiye Hu Dongmei Qin Hui Li | 2010 | Chromatographia (-)2010，，7： | 1 |
| 5 | Assessment of potential productivity of debrisflow waste-shoal land-a study on Jiangjia ravine, Xiaojiang valley显示文摘 | WANGDaojie(王道杰) CUIPeng(崔鹏) ZHUBo(朱波) | 2004 | Chinese Journal of Soil Science2004，35，： | 1 |
| 6 | Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation显示文摘 | Zhubo Dai Guanghong Cui Shu-Feng Zhou Xianan Zhang Luqi Huang | 2010 | Journal of Plant Physiology2010，，2： | 1 |
| 7 | Determination of diacylhydrazines: type insect growth regulator JS-118 residues in cabbage and soil by high performance liquid chromatography with DAD detection显示文摘 | HU Jiye DENG Zhubo QIN Dongmei | 2009 | Bulletin Environmental Contamination Toxicology2009，83，6： | 1 |
| 8 | Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation显示文摘 | Zhubo D Guanghong C Shu F Z | 2011 | Journal of Plant Physiology2011，168，2： | 1 |
| 9 | FDTD modeling of scatterers in stratified media显示文摘 | Demarest K Plumb R Zhubo H | 1995 | IEEE transactions on antennas and propagation1995，43，10： | 1 |
| 10 | 促进晚期癌症恶性进展的新型红细胞样亚群Ter细胞的发现显示文摘文章简介医学界对于癌症患者出现全身性异常变化越来越重视,但对于远端器官异常在晚期癌症转移以及恶性进展中的作用尚不十分清楚。通过动态分析早晚期癌症宿主主要器官中的细胞异常变化,在晚期癌症宿主肿大的脾脏中发现了一种称之为Ter细胞的新型红细胞样亚群. | 韩岩梅 刘秋燕 侯晋 Yan Gu Yi Zhang Zhubo Chen Jia Fan Weiping Zhou Shuangjian Qiu Yonghong Zhang Tao Dong Ning Li Zhengping Jiang Ha Zhu Qian Zhang Yuanwu Ma Lianfeng Zhang Qingqing Wang Yizhi Yu Nan Li 曹雪涛 | 2019 | 科学新闻2019，0，2： | 0 |
| 11 | 鹤山十里方圆显示文摘自古以来,人们选宅建房都认为“选宅应择山而居.得水为上”,有”智者乐水、仁者乐山”之说,并视此为居家的最高境界。近年来.为满足城市扩张的发展需求.郊区化居住品质不断提升,亲近自然的生活、节约资源、回归天人合一的人文居住文化等需求使大型山地混合社区的居住模式应运而生。 | Shenzhen Zhubo Architechture & Engineering Design Co.,Ltd(Dept.3) | 2009 | 城市建筑2009，，1： | 0 |
| 12 | 从化温泉高尔夫花园显示文摘当我国的土地资源越来越紧缺,山居时代来临之际.我们是否已经做好准备迎接挑战.当老套的低设计含量、高建造成本、大生态破坏的“推平式”建设模式.还在蚕食我国脆弱生态环境的时候,我们是否已经意识到自己责任的重大。从化温泉高尔夫花园项目是一个山地型社区,我们以此为例对该类型项目的开发进行探索.其中包括开发利用与环境保护、建造成本与居住舒适度、自然景观与人文景观等方面。 | Shenzhen Zhubo Architechture & Engineering Design Co.,Ltd(Dept.5) | 2009 | 城市建筑2009，，1： | 0 |
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