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| 1 | Conversion characteristics and mechanism analysis of gaseous dichloromethane degraded by a VUV light in different reaction media显示文摘The photodegradation of gaseous dichloromethane(DCM) by a vacuum ultraviolet(VUV) light in a spiral reactor was investigated with different reaction media and initial concentrations.Through the combination of direct photolysis,O 3 oxidation and HO· oxidation,DCM was ultimately mineralized into inorganic compounds(such as HCl,CO 2,H 2 O,etc.) in the air with relative humidity(RH) of 75%-85%.During the photodegradation process,some small organic acids(including formic acid,acetic acid) were also detected and the intermediates were more soluble than DCM,providing a possibility for its combination with subsequent biodegradation.Based on the detected intermediates and the confirmed radicals,a photodegradation pathway of DCM by VUV was proposed.With RH 75%-80% air as the reaction medium,the DCM removal followed the second-order kinetic model at inlet concentration of 100-1000 mg/m 3.Kinetic analysis showed that the reaction media affected the kinetic constants of DCM conversion by a large extent,and RH 80% air could cause a much lower half-life for its conversion.Such results supported the possibility that VUV photodegradation could be used not only for the mineralization of DCM but also as a pretreatment before biodegradation. | Jianming Yu Wenji Cai Jianmeng Chen Li Feng Yifeng Jiang Zhuowei Cheng | 2012 | Journal of Environmental Sciences2012，24，10： | 4 |
| 2 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 3 | Establishment of an indicator framework for the transmission risk of the mountain-type zoonotic visceral leishmaniasis based on the Delphi-entropy weight method显示文摘Background: Visceral leishmaniasis (VL) is one of the most important neglected tropical diseases. Although VL was controlled in several regions of China during the last century, the mountain-type zoonotic visceral leishmaniasis (MT-ZVL) has reemerged in the hilly areas of China in recent decades. The purpose of this study was to construct an indicator framework for assessing the risk of the MT-ZVL in China, and to provide guidance for preventing disease.Methods: Based on a literature review and expert interview, a 3-level indicator framework was initially established in November 2021, and 28 experts were selected to perform two rounds of consultation using the Delphi method. The comprehensive weight of the tertiary indicators was determined by the Delphi and the entropy weight methods.Results: Two rounds of Delphi consultation were conducted. Four primary indicators, 11 secondary indicators, and 35 tertiary indicators were identified. The Delphi-entropy weight method was performed to calculate the comprehensive weight of the tertiary indicators. The normalized weights of the primary indicators were 0.268, 0.261, 0.242, and 0.229, respectively, for biological factors, interventions, environmental factors, and social factors. The normalized weights of the top four secondary indicators were 0.122, 0.120, 0.098, and 0.096, respectively, for climatic features, geographical features, sandflies, and dogs. Among the tertiary indicators, the top four normalized comprehensive weights were the population density of sandflies (0.076), topography (0.057), the population density of dogs, including tethering (0.056), and use of bed nets or other protective measures (0.056).Conclusions: An indicator framework of transmission risk assessment for MT-ZVL was established using the Delphientropy weight method. The framework provides a practical tool to evaluate transmission risk in endemic areas. | Zhuowei Luo Zhengbin Zhou Yuwan Hao Jiaxin Feng Yanfeng Gong Yuanyuan Li Yun Huang Yi Zhang Shizhu Li | 2022 | Infectious Diseases of Poverty2022，11，6： | 0 |
| 4 | Cohort profile: design and methods of the Chinese colorectal, breast, lung, liver, and stomach cancer screening trial(C-BLAST)显示文摘Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health problem1.Extensive evidence has indicated that screening can decrease cancer mortality,particularly among high-risk groups,and several representative national and regional cancer screening programs have been launched in China to cope with the increasing burden of cancer. | Yubei Huang Zhangyan Lyu Yu Zhang Xiaomin Liu Yacong Zhang Ya Liu Chao Sheng Hongyuan Duan Zeyu Fani Chenyang Li Xiao Lin Zhuowei Feng Lu Zheng Zhaoxiang Ye Hong Lu Ying Zhu Dejun Zhou Xi Wei Li Ren Bin Meng Fangfang Song Fengju Song Kexin Chen | 2023 | Cancer Biology & Medicine2023，20，10： | 0 |
| 5 | Spatiotemporal heterogeneity of schistosomiasis in China's Mainland:Evidence from a multi-stage continuous downscaling sentinel monitoring显示文摘Objective:To determine the spatiotemporal distribution of Schistosoma(S.)japonicum infections in humans,livestock,and Oncomelania(O.)hupensis across the endemic foci of China.Methods:Based on multi-stage continuous downscaling of sentinel monitoring,county-based schistosomiasis surveillance data were captured from the national schistosomiasis surveillance sites of China from 2005 to 2019.The data included S.japonicum infections in humans,livestock,and O.hupensis.The spatiotemporal trends for schistosomiasis were detected using a Joinpoint regression model,with a standard deviational ellipse(SDE)tool,which determined the central tendency and dispersion in the spatial distribution of schistosomiasis.Further,more spatiotemporal clusters of S.japonicum infections in humans,livestock,and O.hupensis were evaluated by the Poisson model.Results:The prevalence of S.japonicum human infections decreased from 2.06%to zero based on data of the national schistosomiasis surveillance sites of China from 2005 to 2019,with a reduction from 9.42%to zero for the prevalence of S.japonicum infections in livestock,and from 0.26%to zero for the prevalence of S.japonicum infections in O.hupensis.Analysis using an SDE tool showed that schistosomiasis-affected regions were reduced yearly from 2005 to 2014 in the endemic provinces of Hunan,Hubei,Jiangxi,and Anhui,as well as in the Poyang and Dongting Lake regions.Poisson model revealed 11 clusters of S.japonicum human infections,six clusters of S.japonicum infections in livestock,and nine clusters of S.japonicum infections in O.hupensis.The clusters of human infection were highly consistent with clusters of S.japonicum infections in livestock and O.hupensis.They were in the 5 provinces of Hunan,Hubei,Jiangxi,Anhui,and Jiangsu,as well as along the middle and lower reaches of the Yangtze River.Humans,livestock,and O.hupensis infections with S.japonicum were mainly concentrated in the north of the Hunan Province,south of the Hubei Province,north of the Jiangxi Province,and southwestern portion of Anhui Province.In the 2 mountainous provinces of Sichuan and Yunnan,human,livestock,and O.hupensis infections with S.japonicum were mainly concentrated in the northwestern portion of the Yunnan Province,the Daliangshan area in the south of Sichuan Province,and the hilly regions in the middle of Sichuan Province.Conclusions:A remarkable decline in the disease prevalence of S.japonicum infection was observed in endemic schistosomiasis in China between 2005 and 2019.However,there remains a long-term risk of transmission in local areas,with the highest-risk areas primarily in Poyang Lake and Dongting Lake regions,requiring to focus on vigilance against the rebound of the epidemic.Development of high-sensitivity detection methods and integrating the transmission links such as human and livestock infection,wild animal infection,and O.hupensis into the surveillance-response system will ensure the elimination of schistosomiasis in China by 2030. | Yanfeng Gong Jiaxin Feng Zhuowei Luo Jingbo Xue Zhaoyu Guo Lijuan Zhang Shang Xia Shan Lv Jing Xu Shizhu Li | 2022 | Asian Pacific Journal of Tropical Medicine2022，15，1： | 0 |
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