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| 1 | Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters显示文摘Dear Editor,Different from normal differentiated cells,metabolic reprogramming was spotted in cancer cells,due to increased demand for energy and macromolecule synthesis during their rapid proliferation(Hanahan and Weinberg,2011;Pavlova and Thompson,2016).Most cancer cells prefer anaerobic glycolysis even with oxygen in the environment due to its higher speed to produce macromolecular materials required for biosynthesis(Vander Heiden et al.,2009;DeBerardinis and Chandel,2016).But to compensate for the lower efficiency of anaerobic glycolysis in producing ATP,these cancer cells demand much higher glucose supply(Warburg,1956;Vander Heiden et al.,2009).These metabolic characteristics point to the huge demand of cancer cells for carbohydrate substrates,which creates the possibility of treating tumors by exploiting this feature(Patra et al.,2013;DeBerardinis and Chandel,2016). | Meng Gao Jian Huang Xin Jiang Yafei Yuan Huanhuan Pang Shuchen Luo Nan Wang Chengbo Yao Zuwan Lin Debing Pu Shuo Zhang Pengcheng Sun Zhuoyi Liu Yu Xiao Qian Wang Zeping Hu Hang Yin | 2020 | Protein & Cell2020，11，6： | 2 |
| 2 | Aerodynamic and Acoustic Optimization for Multi-element Airfoils显示文摘The paper is to integrate aerodynamic and aero-acoustic optimizatiom design of high lift devices,especially for two-element airfoils with slat.Aerodynamic analysis on flow field utilizes a high-order,high-resolution spatial differential method for large eddy simulation(LES),which can guarantee accuracy and efficiency.The aeroacoustic analysis for noise level is calculated with Ffowcs Williams-Hawkings(FW-H)integration formula.Fidelity of calculation is verified by standard models.Method of streamline-based Euler simulation(MSES)is used to obtain the aerodynamic characters.Based on the confirmation of numerical methods,detailed research has been conducted for the leading edge slat on multi-element airfoils.Various slot parameter influences on noise are analyzed.The results of the slot optimization parameters can be used in multi-element airfoil design. | Deng Yiju Duan Zhuoyi Liu Xueqiang | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，4： | 1 |
| 3 | Seasonal metal fluxes derived by the interaction of surface water and groundwater in an aquaculture estuary显示文摘Submarine groundwater discharge(SGD)plays a major role as a conveyor of metals to coastal waters.However,the seasonal change of metal fluxes derived through SGD is unclear.Here,we evaluated the behaviours and fluxes of trace metals(Mn,Fe,Ba,Pb,U,Cr,Zn,Cu)in an estuary under different seasonal conditions.The behaviours of trace metals revealed that SGD was the source of Mn(3.51 mmol/(m^(2)·d)),Fe(0.174 mmol/(m^(2)·d))and Ba(0.024 mmol/(m^(2)·d)),but the Cu sink(−0.55μmol/(m^(2)·d))and other metals exhibited a seasonal source‒sink conversion.The seasonal variation of dissolved organic matter and the fresh groundwater proportion in subterranean estuaries may have an important effect on metals fluxes especially for the Fe,Mn and Ba.Our result shows that the single seasonal metal fluxes estimation applied to the annual scale will cause a large deviation,up to 3.6 times for Fe,5.5 times for Mn,and 15 times for Ba.Therefore,the influence of seasonal fluctuations on SGDderived metal fluxes cannot be ignored,and our findings will be important for comprehending the metal budget and cycle in nearshore environment. | Xiaoxiong Wang Jordi Garcia-Orellana Xiaogang Chen Jianan Liu Fenfen Zhang Jianguo Qu Zhuoyi Zhu Jinzhou Du | 2023 | Acta Oceanologica Sinica2023，42，8： | 0 |
| 4 | Experimental and Numerical Analysis of Particle Migration and Patterning Behavior in a Gravel Pack显示文摘Due to its long lifespan and high sand-removal efficiency,gravel packing is one of the most applied sand control methods during the recovery of reservoirs with sanding problems.The blockage and retention of injected sand in a gravel pack is a complex process affected by multiple mechanisms.The majority of existing studies based on the phenomenological deep bed filtration(DBF)theory focused on the gravel pack’s overall permeability damage and failed to obtain the inner-pore particle distribution pattern.In this work,experiments and simulations were carried out to reveal the particle distribution in a gravel pack during flooding.In particular,through real-time monitoring of particle migration,the penetration depth and distribution pattern of invaded particles with different gravel-sand particle ratios,fluid viscosities and injection rates could be determined.By simplifying each unit bed element(UBE)into a pore-throat structure with four tunnels(two horizontals for discharge and two verticals for sedimentation),a new network simulation method,which combines deep bed filtration with a particle trajectory model,was implemented.Cross comparison of experimental and numerical results demonstrates the validity and accuracy of the model. | Bobo Luo Yunbin Xiong Zhuoyi Li Zhanqing Qu Fenggang Liu Tiankui Guo Zugui Yang Yina Shi | 2023 | Fluid Dynamics & Materials Processing2023，19，4： | 0 |
| 5 | STUDIES ON STATISTICAL CHARACTERISTICS OF THE PRESSURE FLUCTUATION AMPLITUDE IN OUTLET WORKS显示文摘The pressure fluctuation amplitude is very important for the load design of structures and to research flow cavitation, using 182 sample records of fluctuation pressure obtained from model tests and prototype observations for many kinds of outlet works,this paper studies statistical characteristics of fluctuating pressure amplitude in outlet works. The results indicate that the probability of fluctuating pressure amplitude in outlet works obeys Gaussian normal distribution,and the verification of prototype observation data from Gezhouba project further proves that the conclusion is true. | Ding, Zhuoyi Liu, Caiyun | 1997 | Journal of Hydrodynamics1997，9，2： | 0 |
| 6 | Using triple oxygen isotopes and oxygen-argon ratio to quantify ecosystem production in the mixed layer of northern South China Sea slope region显示文摘Quantifying the gross and net production is an essential component of carbon cycling and marine ecosystem studies.Triple oxygen isotope measurements and the O_(2)/Ar ratio are powerful indices in quantifying the gross primary production and net community production of the mixed layer zone,respectively.Although there is a substantial advantage in refining the gas exchange term and water column vertical mixing calibration,application of mixed layer depth history to the gas exchange term and its contribution to reducing indices error are unclear.Therefore,two cruises were conducted in the slope regions of the northern South China Sea in October 2014(autumn)and June 2015(spring).Discrete water samples at Station L07 in the upper 150 m depth were collected for the determination ofδ^(17)0,δ^(18)O,and the O_(2)/Ar ratio of dissolved gases.Gross oxygen production(GOP)was estimated using the triple oxygen isotopes of the dissolved O_(2),and net oxygen production(NOP)was calculated using O_(2)/Ar ratio and O_(2)concentration.The vertical mixing effect in NOP was calibrated via a N_(2)O based approach.GOP for autumn and spring was(169±23)mmol/(m^(2)·d)(by O_(2))and(189±26)mmol/(m^(2)·d)(by O_(2)),respectively.While NOP was 1.5 mmol/(m^(2)·d)(by O_(2))in autumn and 8.2 mmol/(m^(2)·d)(by O_(2))in spring.Application of mixed layer depth history in the gas flux parametrization reduced up to 9.5%error in the GOP and NOP estimations.A comparison with an independent O_(2)budget calculation in the diel observation indicated a26%overestimation in the current GOP,likely due to the vertical mixing effect.Both GOP and NOP in June were higher than those in October.Potential explanations for this include the occurrence of an eddy process in June,which may have exerted a submesoscale upwelling at the sampling station,and also the markedly higher terrestrial impact in June. | Zhuoyi Zhu Jun Wang Guiling Zhang Sumei Liu Shan Zheng Xiaoxia Sun Dongfeng Xu Meng Zhou | 2021 | Acta Oceanologica Sinica2021，40，6： | 0 |
| 7 | From the water sources of the Tibetan Plateau to the ocean:State of nutrients in the Changjiang linked to land use changes and climate variability显示文摘Anthropogenic activity is an important driver of changes in the chemistry of nutrients(N,P,and Si)over watersheds at the sub-continental scale(e.g.,106km~2)and can markedly modify their seaward fluxes to the global ocean.In the present study,we reviewed the current status of nutrient chemistry in Changjiang(Yangtze River)based on data collected through 11 expeditions along a river course spanning 4,500 km and 15–20 major tributaries during 1997–2016 as well as monthly monitoring at the river mouth since 1980.The data were analyzed together with published results in the literature to synthesize the recent developments and current state of nutrients in the Changjiang.Previously published results from the Qinghai-Tibetan Plateau head waters were included to realize the systematics of nutrients for the whole drainage basin.Here,we showed that tributaries of the upper reaches of watersheds collectively determine the regime with high concentration and skewed species ratio of nutrients in the Changjiang mainstream,producing profound effects over a water course of 2,000–2,500 km further downstream and until the river mouth.Moreover,using data across the Three Gorges Reservoir(TGR)during 2003–2016,we evaluated the trapping and/or amplifying effects of the Three Gorges Dam(TGD)on nutrient chemistry.Tide-influenced river delta contributed an additional 20%dissolved inorganic phosphorus and 5–10%dissolved inorganic nitrogen and dissolved silicates to the seaward flux,dramatically affecting the stoichiometry of nutrients at the river mouth.Next,based on compiled data on supply and export,legacy nutrients were evaluated.Both nitrogen and phosphorus are in the accumulation phase over the watersheds,and the legacy nutrient fluxes are much higher than the annual riverine seaward fluxes.Finally,we demonstrated that the seaward fluxes of anthropogenic nutrients from the Changjiang exceed those from other top 10 largest rivers on this planet,which can be attributed to land use changes in the China over the last three to four decades. | Jing ZHANG Guosen ZHANG Yanan DU Anyu ZHANG Yan CHANG Yingchun ZHOU Zhuoyi ZHU Ying WU Zaifeng ZHANG Sumei LIU | 2022 | Science China Earth Sciences2022，65，11： | 0 |
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