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| 1 | Tea polyphenol-gut microbiota interactions:hints on improving the metabolic syndrome in a multi-element and multi-target manner显示文摘The metabolic syndrome(MS)has become one of the main problems in public health.Tea polyphenols(TPs),the main bioactive components of tea,has been claimed to have the potential to regulate metabolism and effectively prevent or mitigate the MS.However,many studies into the effects of TPs on MS have provided conflicting findings and the underlying mechanism has been elusive.The predominant TPs in unfermentedand and fermented tea are catechins and oxidized polyphenols(theaflavins and thearubigins),both of which have low bioavailability and reach the colon where most gut microbes inhabit.Gut microbiota has been demonstrated to be tightly associated with host metabolism.The interactions between TPs and gut microbiota will lead to the alterations of gut microbiota composition and the production of metabolites including short chain fatty acids,bile acids,amino acids and TPs derived metabolites,accordingly exerting their biological effects both locally and systemically.This review highlighted the contribution of metabolites and specific gut bacteria in the process of TPs intervention on the MS and further discuss how TPs impact the MS via gut microbiota from the viewpoint of gut organ/tissue axis. | Hui Ma Yaozhong Hu Bowei Zhang Zeping Shao Eugeni Roura Shuo Wang | 2022 | Food Science and Human Wellness2022，11，1： | 5 |
| 2 | APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease显示文摘Current evidence shows that apolipoprotein E(APOE), apolipoprotein CI(APOC1) and low density lipoprotein receptor-related protein(LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE ε4 carriers compared with non-carriers. In addition, the APOE ε4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease. | Qin Zhou Dantao Peng Xinrui Yuan Zeping Lv Shenghang Pang Wenyu Jiang Chuyu Yang Xiaohong Shi Guofang Pang Yige Yang Haiqun Xie Wandong Zhang Caiyou Hu Ze Yang | 2014 | Neural Regeneration Research2014，9，6： | 4 |
| 3 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://links.lww.com7CM9/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 4 | Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters显示文摘Dear Editor,Different from normal differentiated cells,metabolic reprogramming was spotted in cancer cells,due to increased demand for energy and macromolecule synthesis during their rapid proliferation(Hanahan and Weinberg,2011;Pavlova and Thompson,2016).Most cancer cells prefer anaerobic glycolysis even with oxygen in the environment due to its higher speed to produce macromolecular materials required for biosynthesis(Vander Heiden et al.,2009;DeBerardinis and Chandel,2016).But to compensate for the lower efficiency of anaerobic glycolysis in producing ATP,these cancer cells demand much higher glucose supply(Warburg,1956;Vander Heiden et al.,2009).These metabolic characteristics point to the huge demand of cancer cells for carbohydrate substrates,which creates the possibility of treating tumors by exploiting this feature(Patra et al.,2013;DeBerardinis and Chandel,2016). | Meng Gao Jian Huang Xin Jiang Yafei Yuan Huanhuan Pang Shuchen Luo Nan Wang Chengbo Yao Zuwan Lin Debing Pu Shuo Zhang Pengcheng Sun Zhuoyi Liu Yu Xiao Qian Wang Zeping Hu Hang Yin | 2020 | Protein & Cell2020，11，6： | 2 |
| 5 | Experimental investigation of Z-pinch radiation source for indirect drive inertial confinement fusion显示文摘Z-pinch dynamic hohlraums(ZPDHs)could potentially be used to drive inertial confinement fusion targets.Double-or multishell capsules using the technique of volume ignition could exploit the advantages of ZPDHs while tolerating their radiation asymmetry,which would be unacceptable for a central ignition target.In this paper,we review research on Z-pinch implosions and ZPDHs for indirect drive targets at the Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics.The characteristics of double-shell targets and the associated technical requirements are analyzed through a one-dimensional computer code developed from MULTI-IFE.Some key issues regarding the establishment of suitable sources for dynamic hohlraums are introduced,such as soft X-ray power optimization,novel methods for plasma profile modulation,and the use of thin-shell liner implosions to inhibit the generation of prior-stagnated plasma.Finally,shock propagation and radiation characteristics in a ZPDH are presented and discussed,together with some plans for future work. | Zhenghong Li Zhen Wang Rongkun Xu Jianlun Yang Fan Ye Yanyun Chu Zeping Xu Faxin Chen Shijian Meng Jianmin Qi Qinyuan Hu Yi Qin Jiaming Ning Zhanchang Huang Linbo Li Shuqing Jiang | 2019 | Matter and Radiation at Extremes2019，4，4： | 1 |
| 6 | Simultaneous determination of the lactone and carboxylate forms of irinotecan (CPT-11) and its active metabolite SN-38 by high-performance liquid chromatography: Application to plasma pharmacokinetic studies in the rat显示文摘 | Xiaoxia Yang Zeping Hu Sui Yung Chan Boon Cher Goh Wei Duan Eli Chan Shufeng Zhou | 2005 | Journal of Chromatography B2005，，2： | 1 |
| 7 | 1178 J,527 nm near diffraction limited laser based on a complete closed-loop adaptive optics controlled off-axis multi-pass amplification laser system显示文摘A 1178 J near diffraction limited 527 nm laser is realized in a complete closed-loop adaptive optics(AO)controlled off-axis multi-pass amplification laser system.Generated from a fiber laser and amplified by the pre-amplifier and the main amplifier,a 1053 nm laser beam with the energy of 1900 J is obtained and converted into a 527 nm laser beam by a KDP crystal with 62%conversion efficiency,1178 J and beam quality of 7.93 times the diffraction limit(DL).By using a complete closed-loop AO configuration,the static and dynamic wavefront distortions of the laser system are measured and compensated.After correction,the diameter of the circle enclosing 80%energy is improved remarkably from 7.93DL to 1.29DL.The focal spot is highly concentrated and the 1178 J,527 nm near diffraction limited laser is achieved. | Deen Wang Xin Zhang Wanjun Dai Ying Yang Xuewei Deng Lin Chen Xudong Xie Dongxia Hu Feng Jing Zeping Yang Qiang Yuan Xiaofeng Wei Qihua Zhu Wanguo Zheng Xiaomin Zhang Lei Huang | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 8 | Herb-drug interaction显示文摘 | Zeping Hu 1 Xiaoxia Yang 1 Paul Chi Lui Ho | 2005 | Drugs2005，65，9： | 1 |
| 9 | Herb- Drug Interactions : A Literature Review 显示文摘 | Hu Zeping Yang Xiaoxia Ho Paul Chi Lui | 2005 | Drugs2005，65，9： | 1 |
| 10 | Small-molecule agents for cancer immunotherapy显示文摘Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer therapy.They induce long-term tumor regression and overall survival benefit in many types of cancer.With the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for immunotherapy.Small molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively investigated.Monotherapy of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor resistance.Here,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations. | Fang Wang Kai Fu Yujue Wang Can Pan Xueping Wang Zeyu Liu Chuan Yang Ying Zheng Xiaopeng Li Yu Lu Kenneth Kin Wah To Chenglai Xia Jianye Zhang Zhi Shi Zeping Hu Min Huang Liwu Fu | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 11 | Cupressaceae Plants in China显示文摘This paper examed the Cupressaceae taxa in China. It is identifled that 30 species and 16 varieties in 7 genera in thefamily are indigenous, and estimated that about 25 species and 4 varieties have been introduced into this country since the beginning of this century. It is urgent that more furthur studies need to be carried out in the country on the taxonomy especially of junipers and cypresses, on the re-classification ofexisting cultivars, and on the development of new cultivars for future needs. | JIANG Zeping MA Zongyan1. Chinese Academy of Forestry. Beijing 100091. China2. Department of Forestry. Central South Forestry Collese, Zhuzhou. Hu’nan, China | 2002 | Chinese Forestry Science and Technology2002，1，3： | 0 |
| 12 | Metabolomics in drug research and development: The recent advances in technologies and applications显示文摘Emerging evidence has demonstrated the vital role of metabolism in various diseases or disorders.Metabolomics provides a comprehensive understanding of metabolism in biological systems.With advanced analytical techniques,metabolomics exhibits unprecedented significant value in basic drug research,including understanding disease mechanisms,identifying drug targets,and elucidating the mode of action of drugs.More importantly,metabolomics greatly accelerates the drug development process by predicting pharmacokinetics,pharmacodynamics,and drug response.In addition,metabolomics facilitates the exploration of drug repurposing and drug-drug interactions,as well as the development of personalized treatment strategies.Here,we briefly review the recent advances in technologies in metabolomics and update our knowledge of the applications of metabolomics in drug research and development. | Huanhuan Pang Zeping Hu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
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