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| 1 | Bone marrow stromal cells as a therapeutic treatment for ischemic stroke显示文摘Cerebral ischemia remains the most frequent cause of death and quality-of-life impairments due to neurological deficits, and accounts for the majority of total healthcare costs. However, treatments for cerebral ischemia are limited. Over the last decade, bone marrow stromal cell(BMSC) therapy has emerged as a particularly appealing option, as it is possible to help patients even when initiated days or even weeks after the ischemic insult. BMSCs are a class of multipotent, self-renewing cells that give rise to differentiated progeny when implanted into appropriate tissues. Therapeutic effects of BMSC treatment for ischemic stroke, including sensory and motor recovery, have been reported in pre-clinical studies and clinical trials. In this article, we review the recent progress in BMSC-based therapy for ischemic stroke, focusing on the route of delivery and pre-processing of BMSCs. Selecting an optimal delivery route is of particular importance. The ideal approach, as well as the least risky, for translational applications still requires further identification. Appropriate preprocessing of BMSCs or combination therapy has the benefit of achieving the maximum possible restoration. Further pre-clinical studies are required to determine the time-window for transplantation and the appropriate dosage of cells. | Zizhen Yang Lei Zhu Fangqin Li Jing Wang Huan Wan Yujun Pan | 2014 | Neuroscience Bulletin2014，30，3： | 16 |
| 2 | Recent Advances on the Electrochemical Difunctionalization of Alkenes/Alkynes显示文摘Electroorganic synthesis is an emerging area of high impact research in organic chemistry, which is considered as one of the green and efficient methods and attracts growing research attention. In this review, we summarized comprehensively the recent literature reports on the electrochemical oxidative difunctionalization of unsaturated C—C bonds. The reaction types described in this review included electrochemical intermolecular cyclization, electrochemical intramolecular cyclization, and electrochemical difunctionalization of alkenes/alkynes. This review focuses on the discussion of its synthetic generality for the preparation of functionalized compounds and the related electrochemical oxidative reaction mechanism. | Haibo Mei Zizhen Yin Jiang Liu Hailong Sun Jianlin Han | 2019 | Chinese Journal of Chemistry2019，37，3： | 8 |
| 3 | IL-17 signaling in host defense and inflammatory diseases显示文摘Interleukin(IL)-17,the signature cytokine secreted by T helper(Th)17 cells,plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune inflammatory diseases.Here we review the recent advances in IL-17-mediated functions with emphasis on the studies of IL-17-mediated signal transduction,providing perspective on potential drug targets for the treatment of autoimmune inflammatory diseases. | Youcun Qian Zizhen Kang Caini Liu Xiaoxia Li | 2010 | Cellular & Molecular Immunology2010，7，5： | 7 |
| 4 | Sediment pollution characteristics and in situ control in a deep drinking water reservoir显示文摘Sediment pollution characteristics, in situ sediment release potential, and in situ inhibition of sediment release were investigated in a drinking water reservoir. Results showed that organic carbon(OC), total nitrogen(TN), and total phosphorus(TP) in sediments increased from the reservoir mouth to the main reservoir. Fraction analysis indicated that nitrogen in ion exchangeable form and Na OH-extractable P(Fe/Al-P) accounted for 43% and 26% of TN and TP in sediments of the main reservoir. The Risk Assessment Code for metal elements showed that Fe and Mn posed high to very high risk. The results of the in situ reactor experiment in the main reservoir showed the same trends as those observed in the natural state of the reservoir in 2011 and 2012; the maximum concentrations of total OC, TN, TP, Fe,and Mn reached 4.42 mg/L, 3.33 mg/L, 0.22 mg/L, 2.56 mg/L, and 0.61 mg/L, respectively. An in situ sediment release inhibition technology, the water-lifting aerator, was utilized in the reservoir. The results of operating the water-lifting aerator indicated that sediment release was successfully inhibited and that OC, TN, TP, Fe, and Mn in surface sediment could be reduced by 13.25%, 15.23%, 14.10%, 5.32%, and 3.94%, respectively. | Zizhen Zhou Tinglin Huang Yang Li Weixing Ma Shilei Zhou Shenghai Long | 2017 | Journal of Environmental Sciences2017，29，2： | 6 |
| 5 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
| 6 | Mitochondrial metabolism in regulating macrophage polarization:an emerging regulator of metabolic inflammatory diseases显示文摘As a major type of immune cells with heterogeneity and plasticity,macrophages are classically divided into inflammatory(M1)and alternative/anti-inflammatory(M2)types and play a crucial role in the progress of the inflammatory diseases.Recent studies have shown that metabolism is an importa nt determ inant of macrophage phe no type.Mitoch on dria,one of the most importa nt compartments involving cell metabolism,are closely associated with the regulation of cell functions.In most types of cell,mitochondrial oxidative phosphorylation(OXPHOS)is the primary mode of cellular energy production.However,mitochondrial OXPHOS is inhibited in activated M1 macrophages,ren deri ng them un able to be converted into M2 phe no type.Thus,mitochondrial metabolism is a crucial regulator in macrophage functions.This review summarizes the roles of mitochondria in macrophage polarization and analyzes the molecular mechanisms underlying mitochondrial metabolism and function,which may provide new approaches for the treatment of metabolic inflammatory diseases. | Jina Qing Zizhen Zhang Petr Novak Guojun Zhao Kai Yin | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 5 |
| 7 | A large Middle Pleistocene freshwater to oligohaline lake in the contemporary hyperarid Qaidam Basin (China)显示文摘 | Steffen Mischke Ulrike Herzschuh Naida Sun Zizhen Qiao Zhencheng Sun | 2006 | Episodes2006，29，1： | 4 |
| 8 | α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis显示文摘Doxorubicin (纪录影片) ,广泛地使用的反肿瘤药,能由氧化应力和房间 apoptosis 产生严重 cardiotoxicity,它限制它的临床的申请。亚麻酸的酸(翼) 被显示了用作一个有势力 cardioprotective 代理人。这研究的目的是在老鼠为这 cardioprotection 在导致纪录影片的 cardiotoxicity 和内在的分子的机制上探索翼的保护的效果。老鼠随机被划分成四个组并且与正常管理了盐,翼(500 梭织,任何一个 CheRs 都不能维持上述的互补功能,考虑到类似于 E 的接受甲基的趋化性蛋白质,建议他们的关键角色。coli。由 microarray 试金示威了,在 L 的 cheR1 的表示。在 28 点有教养的 | Xiaohua Yu Libao Cui Zizhen Zhang Qihui Zhao Shuangjie Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 4 |
| 9 | Factors influencing pore-pressure prediction in complex carbonates based on effective medium theory显示文摘A calculation model based on effective medium theory has been developed for predicting elastic properties of dry carbonates with complex pore structures by integrating the Kuster-Toksǒz model with a differential method.All types of pores are simultaneously introduced to the composite during the differential iteration process according to the ratio of their volume fractions.Based on this model,the effects of pore structures on predicted pore-pressure in carbonates were analyzed.Calculation results indicate that cracks with low pore aspect ratios lead to pore-pressure overestimation which results in lost circulation and reservoir damage.However,moldic pores and vugs with high pore aspect ratios lead to pore-pressure underestimation which results in well kick and even blowout.The pore-pressure deviation due to cracks and moldic pores increases with an increase in porosity.For carbonates with complex pore structures,adopting conventional pore-pressure prediction methods and casing program designs will expose the well drilling engineering to high uncertainties.Velocity prediction models considering the influence of pore structure need to be built to improve the reliability and accuracy of pore-pressure prediction in carbonates. | Wang Ruihe Wang Zizhen Shan Xun Qiu Hao Li Tianyang | 2013 | Petroleum Science2013，10，4： | 3 |
| 10 | Destratification and oxygenation efficiency of a water-lifting aerator system in a deep reservoir:Implications for optimal operation显示文摘Thermal stratification is a common phenomenon in lakes and reservoirs and has a significant influence on water quality dynamics.Heihe Reservoir is a canyon-shaped reservoir in Shaanxi Province with strong thermal stratification.Therefore,eight water-lifting aerators(WLAs) were installed in this reservoir,which could overcome thermal stratification and increase oxygenation with gas flows between 20 and 50 m3/hr,and oxygenate the hypolimnion with gas flows less than 20 m3/hr.To examine the destratification efficiency of the WLA system,we used a threedimensional hydrodynamic module based on MIKE 3 to simulate the thermal structure of Heihe Reservoir and compared the simulations with measured data.Results showed that operation of the WLA system promoted water mixing and effectively oxygenated the hypolimnion.Through the established energy utilization assessment method,the energy utilization efficiency of the WLA system was between 5.36% and 7.30%,indicating the capability of the technique for destratification in such a large reservoir.When the surface water temperature dropped to the theoretical mixed water temperature calculated by the energy utilization assessment method,reducing gas flow could save energy.This would prevent anaerobic conditions from occurring in the bottom water and maintain good water quality in Heihe Reservoir. | Yang Li Tinglin Huang Xinlin Tan Zizhen Zhou Weixing Ma | 2018 | Journal of Environmental Sciences2018，30，11： | 3 |
| 11 | Solving Multitrip Pickup and Delivery Problem With Time Windows and Manpower Planning Using Multiobjective Algorithms显示文摘The multitrip pickup and delivery problem with time windows and manpower planning(MTPDPTW-MP)determines a set of ambulance routes and finds staff assignment for a hospital. It involves different stakeholders with diverse interests and objectives. This study firstly introduces a multiobjective MTPDPTW-MP(MO-MTPDPTWMP) with three objectives to better describe the real-world scenario. A multiobjective iterated local search algorithm with adaptive neighborhood selection(MOILS-ANS) is proposed to solve the problem. MOILS-ANS can generate a diverse set of alternative solutions for decision makers to meet their requirements. To better explore the search space, problem-specific neighborhood structures and an adaptive neighborhood selection strategy are carefully designed in MOILS-ANS. Experimental results show that the proposed MOILS-ANS significantly outperforms the other two multiobjective algorithms. Besides, the nature of objective functions and the properties of the problem are analyzed. Finally, the proposed MOILS-ANS is compared with the previous single-objective algorithm and the benefits of multiobjective optimization are discussed. | Jiahai Wang Yuyan Sun Zizhen Zhang Shangce Gao | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，4： | 2 |
| 12 | A modified method of ecological footprint calculation and its application显示文摘 | SHENG ZHAO ZIZHEN LIB WENLONG LIA | 2005 | Ecological Modeling2005，185，： | 1 |
| 13 | Couple analysis on strength reduction theory and rheological mechanism for slope stability 显示文摘 | Liu Zizhen Yan Zhixin Duan Jian | 2008 | Journal of Central South University of Technology2008，15，2： | 1 |
| 14 | The method and expert system for riskassessment of drilling in high-sulfur gas field显示文摘 | Zang Yanbin Wang Ruihe Zhang Rui Wang Zizhen Li Xinzhi | 2010 | Societyof Petroleum Engineers-SPE Asia Pacific Oil and GasConference and Exhibition2010，，： | 1 |
| 15 | Microbial biomass and activity in alkalized magnesic soils under arid conditions显示文摘 | Yuan Bingcheng Xu Xuegong Li Zizhen et at | 2007 | Soil Biology & Biochemistry2007，393，： | 1 |
| 16 | Ecological value at risk:The temporal analysis of the emergy ecological footprint and biological capacity in Gansu,China 1980-2020显示文摘 | Xiaohong Wei Zizhen Li | | 0，，： | 1 |
| 17 | Hopf bifurcation in a predator-prey system with Holling type III functional response and time delays显示文摘 | Zizhen Zhang Huizhong Yang Ming Fu | 2014 | Journal of Applied Mathematics and Computing2014，44，12： | 1 |
| 18 | Spatiotemporal analysis of ecological footprint and biological capacity of Gansu, China 1991-2015: Down from the environmental clif显示文摘 | Dongxia Yue Xiaofeng Xu Zizhen Li | 2006 | Ecological economics2006，58，2： | 1 |
| 19 | Global stability of a delayed SIR epidemic model with density dependent birth and death rates显示文摘 | Fengpan Zhang Zizhen Li Feng Zhang | 2008 | Appl Math Comput2008，199，1： | 1 |
| 20 | The niche-fitness model of crop population and its application显示文摘 | Li Zizhen Lin Hong | 1997 | Ecological Modeling1997，104，23： | 1 |
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