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| 1 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 2 | A simple way to make pre-stressed ceramics with high strength显示文摘A pre-stressing design and a simple fabrication technology to substantially improve the strength of ceramic components are presented.Residual surface compressive stress is generated in ceramic components by pressureless sintering of a green bulk coated with a thin layer of low coefficient of thermal expansion(CTE).The stress level can be controlled by changing the cross-section area ratio,Young's modulus ratio and CTE ratio of the coating.Pre-stressed ZrO_(2) ceramics coated with Al_(2)O_(3) can achieve a flexural strength of 1330±52MPa,45% higher than their uncoated counterpart.Similarly,the flexural strength of building porcelain tiles is increased by 70%,from 67±3 MPa to 114±5MPa.The damage tolerance of pre-stressed ZrO_(2) ceramics is excellent with a high residual strength of ~1200 MPa in a thermal shock test at 325℃.This simple technique can improve the mechanical performance of ceramic components with no limitation of size and shape. | Yiwang Bao Fenghua Kuang Yi Sun Yueming Li Detian Wan Zongyang Shen Delong Ma Lingfeng He | 2019 | Journal of Materiomics2019，5，4： | 7 |
| 3 | Adaptive Attitude Control for a Coaxial Tilt-Rotor UAV via Immersion and Invariance Methodology显示文摘Dear Editor,This letter is concerned with the attitude control for a novel tiltrotor unmanned aerial vehicle with two pairs of tiltable coaxial rotors and one rear rotor.An immersion and invariance-based adaptive attitude controller for the tilt-rotor unmanned aerial vehicle is proposed.In the proposed control strategy,an adaptive update law is specially designed to compensate for the uncertainties of damping coefficients.The stability of the resulting closed-loop coaxial tiltrotor unmanned aerial vehicle(CTRUAV)system is proved by the Lyapunov methodology and LaSalle’s invariance theory.Finally。 | Longlong Chen Zongyang Lv Xiangyu Shen Yuhu Wu Xi-Ming Sun | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 2 |
| 4 | The effect of periosteal injury and masticatory micromovement on the healing of a mandibular distraction osteogenesis site显示文摘 | Zongyang Sun Susan W Herring | 2009 | Arch Oral Biol2009，54，3： | 1 |
| 5 | Effect of bone thickness on alveolar bone-height measurements from cone-beam computed tomography images显示文摘 | Zongyang Sun Tharon Smith Sahira Kortam Do-Gyoon Kim Boon Ching Tee Henry Fields | 2011 | American Journal of Orthodontics & Dentofacial Orthopedics2011，，2： | 1 |
| 6 | Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies显示文摘Genomic imprinting can lead to allele-specific expression(ASE),where one allele is preferentially expressed more than the other.Perturbations in genomic imprinting or ASE genes have been widely observed across various neurological disorders,notably autism spectrum disorder(ASD).In this study,we crossed rhesus cynomolgus monkeys to produce hybrid monkeys and established a framework to evaluate their allele-specific gene expression patterns using the parental genomes as a reference.Our proof-of-concept analysis of the hybrid monkeys identified 353 genes with allele-biased expression in the brain,enabling us to determine the chromosomal locations of ASE clusters.Importantly,we confirmed a significant enrichment of ASE genes associated with neuropsychiatric disorders,including ASD,highlighting the potential of hybrid monkey models in advancing our understanding of genomic imprinting. | Zongyang Lu Jie Li Yong Lu Ling Li Wei Wang Chenchen Zhang Libing Xu Yanhong Nie Changshan Gao Xinyan Bian Zhen Liu Guang-Zhong Wang Qiang Sun | 2023 | The Innovation2023，4，3： | 0 |
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