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| 1 | 动力性心理治疗联合帕罗西汀对抑郁症的临床效果及心理状态分析显示文摘目的观察抑郁症应用帕罗西汀、动力性心理疗法联合治疗的效果。方法选取2017年7月-2018年7月在新乡医学院第二附属医院就诊的90例抑郁症患者临床资料,按不同治疗方案分两组,每组45例。对照组行帕罗西汀治疗,观察组在其基础上联合动力性心理治疗,比较两组疗效。结果观察组治疗总有效率高于对照组(P<0.05),观察组治疗后HADM评分比对照组低(P<0.05);观察组治疗后心理、生理、社会、环境评分均比对照组高(P<0.05)。结论抑郁症通过帕罗西汀、动力性心理疗法联合治疗后,抑郁心态明显改善,且生活质量提升,疗效显著。 | 张红胜 孙丽新 LI Huilin CHEN Zuoming | 2019 | 临床研究2019，27，11： | 8 |
| 2 | ^(18)F-FDG PET/CT for malignant small intestinal neoplasms显示文摘In this paper, 18F-FDG PET/CT data of 19 malignant SINs (small intestinal neoplasms) were consecutively reviewed. Nnine patients accepted PET/CT scan for preoperative diagnosis and staging, while ten patients presented follow-up after treatment and restaging. The results were correlated with abdomen enhanced CT and surgical pathological findings. Abdominal pain and weight loss were the most common findings. About 16% SINs located in the duodenum, 52% in the jejunum and 32% in the ileum. Lymphoma was the most frequent neoplasms. PET/CT revealed residual or recurrent malignant SINs in 5 patients who had negative or non-definite findings by abdomen CT and demonstrated extra-abdomen metastasis in 3 patients. Clinical decisions of treatment were changed for 6 patients after PET/CT examinations. The 18F-FDG PET/CT were better than CT in accuracy, negative predictive value and positive predictive value (89.5% vs 68.4%, 100% vs 66.7%, and 81.8% vs 69.2%, respectively). Whole body 18F-FDG PET/CT may be an effective molecular imaging method for staging and restaging of malignant SINs. | SUN Long ZHAO Long LUO Zuoming WEI Jihong SUN Yonghong YANG Rongshui WU Hua | 2010 | Nuclear Science and Techniques2010，21，2： | 4 |
| 3 | The noncellulosomal family 48 cellobiohydrolase from Clostridium phytofermentans ISDg: heterologous expression, characterization, and processivity显示文摘 | Xiao-Zhou Zhang Zuoming Zhang Zhiguang Zhu Noppadon Sathitsuksanoh Yunfeng Yang Y.-H. Percival Zhang | 2010 | Applied Microbiology and Biotechnology2010，，2： | 1 |
| 4 | Catalytic ozonation of Acid Red B in aqueous solution over a Fe-Cu-O catalyst显示文摘 | Liu Xiaoyu Zhou Zuoming Jing Guohua | 2013 | Separation and Purification Technology2013，115，： | 1 |
| 5 | Clinical value of ^(18)F-FDG PET/CT in evaluation of hepatic vein,inferior vena cava and right atrium tumor thrombi in hepatocellular carcinoma:Initial results显示文摘In this paper,eleven consecutive hepatocellular carcinoma(HCC) patients with an embolus in the hepatic vein(HV),inferior vena cava(IVC)and right atrium(RA) were studied with 18F-FDG PET/CT and contrast enhanced CT.When correlated with final diagnosis,18F-FDG PET/CT and contrast enhanced CT was positive in 11 patients(100%),7 patients(63.6%),respectively.The accuracy of PET/CT and contrast-enhanced CT were 100%,63.6%.Three cases with secondary blood thrombi in the distant IVC,which were confirmed by PET/CT,cannot be identified by contrast enhanced CT.The average survival was 3 months(range,1-12mo).The 12 months survival rate was 9.1%.Our results suggest that highly metabolic tumor thrombus in the HV,IVC and RA may be depicted on 18F-FDG PET/CT in HCC patients.It may discriminate between malignant and secondary benign blood thrombi. | SUN Long ZHAO Long LUO Zuoming JIANG Maoqing WU Hua | 2012 | Nuclear Science and Techniques2012，23，3： | 1 |
| 6 | Optimalreplacement policy for a deteriorating production system with preventive maintenance显示文摘 | Zhang Y L Yam R CM ZuoM J | 2001 | International Journal of System Science2001，32，10： | 1 |
| 7 | Catalytic ozonation of Acid Red B in aqueous solution over a Fe-Cu-O catalyst显示文摘 | Xiaoyu Liu Zuoming Zhou Guohua Jing | 2013 | Separation and Purification Technolog2013，115，： | 1 |
| 8 | Solvent effects on the enantioselectivity of the thermophilic lipase QLM in the resolution of ( R , S )-2-octanol and ( R , S )-2-pentanol显示文摘 | Yuanhong Wang Quanshun Li Zuoming Zhang Jiutong Ma Yan Feng | 2008 | Journal of Molecular Catalysis B Enzymatic2008，，2： | 1 |
| 9 | A Study on the Training Mode of Discipline-oriented Innovative and Entrepreneurial Talents——Taking Agricultural,Forestry and Normal Universities as an Example显示文摘With the gradual expansion of the scale and enrollment of colleges and universities in China,the university education has changed from the elite education to the mass education. The decline of students' quality and the backwardness of the mode of cultivating talents in colleges and universities have resulted in the general low employability of college students and the prominent phenomenon of structural unemployment. Against a background of mass innovation and mass entrepreneurship,colleges and universities should make timely adjustments to the major structure according to social development,cultivate innovative and entrepreneurial talents,and make the objectives and quality of talent training meet the needs of social development. Based on the analysis of the status quo of innovation and entrepreneurship in colleges and universities,especially in agricultural and forestry,normal universities,this paper explores the training model of innovative and entrepreneurial talents in colleges and universities to provide a reference for the training of specialized talents in different disciplines. | Wei WU Zuoming ZHONG Min CHEN | 2018 | Asian Agricultural Research2018，10，12： | 1 |
| 10 | Changes in the Prevalence of Visual Impairment Due to Blinding Trachoma in Sichuan Province, China: A Comparative Study Between 1987 and 2006显示文摘 | Hui Chen Xiaoyun Wu Min Wei June E. Eichner Yingchuan Fan Zuoming Zhang Chuntao Lei Donald U. Stone Jingyun Yang | 2012 | Ophthalmic Epidemiology2012，，1： | 1 |
| 11 | The effect of temperature, substrate, light, oxygen availability and burial depth on Ottelia alismoides seed germination显示文摘 | YIN Liyan ZHANG Ruifen XIE Zuoming | 2013 | Aquatic Botany2013，111，5： | 1 |
| 12 | Kinetics of carbon diox- ide absorption into aqueous 显示文摘 | Guo Hongxiu Zhou Zuoming Jing Guohua | 2013 | Interna- tional Journal of Greenhouse Gas Control2013，16，8： | 1 |
| 13 | D-spaces,aD-spaces and finite unions显示文摘 | Yu Zuoming Yun Ziqiu | 2009 | Topology and its Applications2009，156，： | 1 |
| 14 | Adaptive response surface method : A global optimization scheme for approximation-based design problems 显示文摘 | Wang G G Dong Zuoming Aitchison P | 2001 | Engineering Optimization2001，33，6： | 1 |
| 15 | Quantitative structure–activity relationship (QSAR) study of toxicity of quaternary ammonium compounds on Chlorella pyrenoidosa and Scenedesmus quadricauda显示文摘 | Guohua Jing Zuoming Zhou Jing Zhuo | 2011 | Chemosphere2011，，1： | 1 |
| 16 | Treatment of hypertensive cerebral hemorrhage, 68 cases of clinical experience 显示文摘 | Zhang Longping ZuoMing wu | 2006 | Journal of grassroots medical BBS2006，10，6： | 1 |
| 17 | D- spaces, aD - spaces and finite unions 显示文摘 | Yu Zuoming Yun Ziqiu | 2009 | Topology and its Application2009，156，： | 1 |
| 18 | Relationships between the biomass of algal crusts in fields and their compressive strength显示文摘 | Xie Zuoming Liu Yongding Hu Chunxiang | 2007 | Soil Biology and Biochemistry2007，39，2： | 1 |
| 19 | A TRAIL-BLAZER'S FOOTPRINTS ——A biographic sketch of CAS member Li Yiyi显示文摘People will never forget a scene at the First National Conference of Model Workers held in 1959,when the No.1 blast furnace of the No.1 Steelworks under the Benxi Iron & Steel Corporation was named a national standard bearer of the Red Flag,with its productivity ratio having won the national championship.The story was reported by the People’s Daily,Soviet Women’s Journal and Benxi Daily.As the young leader of the cited team of furnacemen, Li Yiyi became known to all. Time flies by and 34 years have elapsed since then. | Wang Zuoming & Fan Guilan(Shenyang Institute of Metal Research, CAS) | 1996 | Bulletin of the Chinese Academy of Sciences1996，10，3： | 0 |
| 20 | Switch of substrate specificity of hyperthermophilic acylaminoacyl peptidase by combination of protein and solvent engineering显示文摘The inherent evolvability of promiscuous enzymes endows them with great potential to be artificially evolved for novel functions.Previously,we succeeded in transforming a promiscuous acylaminoacyl peptidase(apAAP)from the hyperthermophilic archaeon Aeropyrum pernix K1 into a specific carboxylesterase by making a single mutation.In order to fulfill the urgent requirement of thermostable lipolytic enzymes,in this paper we describe how the substrate preference of apAAP can be further changed from p-nitrophenyl caprylate(pNP-C8)to p-nitrophenyl laurate(pNP-C12)by protein and solvent engineering.After one round of directed evolution and subsequent saturation mutagenesis at selected residues in the active site,three variants with enhanced activity towards pNP-C12 were identified.Additionally,a combined mutant W474V/F488G/R526V/T560W was generated,which had the highest catalytic efficiency(kcat/Km)for pNP-C12,about 71-fold higher than the wild type.Its activity was further increased by solvent engineering,resulting in an activity enhancement of 280-fold compared with the wild type in the presence of 30%DMSO.The structural basis for the improved activity was studied by substrate docking and molecular dynamics simulation.It was revealed that W474V and F488G mutations caused a significant change in the geometry of the active center,which may facilitate binding and subsequent hydrolysis of bulky substrates.In conclusion,the combination of protein and solvent engineering may be an effective approach to improve the activities of promiscuous enzymes and could be used to create naturally rare hyperthermophilic enzymes. | Chang Liu Guangyu Yang Lie Wu Guohe Tian Zuoming Zhang Yan Feng | 2011 | Protein & Cell2011，2，6： | 0 |
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