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| 1 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 2 | Necessity and indications of invasive treatment for Budd-Chiari syndrome显示文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure should be performed if the patient's situation worsens in the course of regular follow-up. | Department of General Surgery (Fu Y,Sun YL,Ma XX,Xu PQ,Feng LS,Tang Z and Luo CH),Institute of Hepatic Vascular Disease (Sun YL),Department of Radiological Intervention (Guan S and Wang ZW),First Affiliated Hospital,Zhengzhou University School of Medicine,Zhengzhou 450052,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 10 |
| 3 | Magnetic resonance evaluation of transplanted mesenchymal stem cells after myocardial infarction in swine显示文摘Objectives To trace and evaluate intracoronary transplanted mesenchymal stem cells(MSCs) labeled with superparamagnetic iron oxide(SPIO) by using magnetic resonance imaging(MRI) in a swine model of myocardial infarction (MI).Methods MSCs were transfected with a lentiviral vector carrying the gene encoding green fluorescent protein (GFP) and labeled in vitro with SPIO.Two weeks after MI, swine were randomized to intracoronary transplantation of dual -labeled MSCs(n = 10),MSCs-GFP(n = 10) and saline(n = 5).MRI examination was performed with a 1.5T clinical scanner at 24 hours,3 weeks and 8 weeks after cells transplantation. Signal intensity(SI) changes,cardiac function and MI size were measured using MRI.Correlation between MR findings and histomorphologic findings was also investigated. Results The labeling efficiency at a combination of 25μg Fe/ml SPIO and 0.8 pi/ml Lipofectamine 2000 reached 100%.SPIO labeling did not affect GFP fluorescence and dual-labeling did not affect cell proliferation(P>0.05). Multipotentiality was not affected especially for cardiomyocyte-like cells differentiation.Cardiac cell marker of a-MHC and actinin were positively expressed by immunofluorescence staining after induction.SI on T2 * WI decreased substantial- ly in the interventricular septum 24 hours after injection of MSCs.The intensity of hypo-intense signals appeared to increase throughout the later time points.Changes in SI at 24 hours,3 weeks and 8 weeks were 52.98%±10.74%,21.53%±5.40%and 6.23%±2.01%,respectively(P<0.01).DE-MRI demonstrated both dual-labeled MSCSs and MSCs-GFP could dramatically reduce the size of MI and improve cardiac function. Histological data revealed that prussian blue stain-positive cells were found mainly in the border zone which also showed green fluorescence but negative for macrophage marker(CD68).Gross pathologic examination revealed that engrafted MSCs dramatically reduce the extent of necrotic myocardium and promote the regeneration of new,contractile myocardium along the subendocardial surface of the MI. Conclusions MSCs could be efficiently and safely labeled with SPIO and GFP,and could be detected reproducibly and noninvasively in vivo using cardiac MRI.Intracoronary transplantation of dual-labeled MSCs could increase cardiac function and reduce the size of MI. | KE Yang~1,PENG Chao-quan~1,XIANG Peng~1,ZHANG Cheng-xi~1, ZOU Li-yuan~1,WU Xiao~1,YA Gao~1,KANG Z huang~2,HE Ke-ke~2,LIU Jin-lai~1 (1.Department of Cardiology,The Third Affiliated Hospital, Sun Yat-sen University,Guangzhou 2.Department of Radiology, the Third Affiliated Hospital,Sun Yat-sen University, Guangzhou 5100630 3.Center for Stem Cell Biology and Tissue Engineering,Sun Yat-sen University,Guangzhou 5100120) | 2011 | 岭南心血管病杂志2011，17，S1： | 7 |
| 4 | Novel Manufacturing Technology of Hyperbolic Plates for Shipbuilding显示文摘On the basis of the principle of dieless hydrobulging technology, a novel hydrobulging technology for manufacturinghyperbolic plates is proposed. First, a toroidal pipe elbow or a partial toroidal pipe elbow is formed, then the single hydrobulgedstructure can be cut up into some desired plates. It is proved by experiments and finite element simulation that manufacturingtechnology of hyperbolic plates adopting integrated hydrobulging forming technology is feasible. | ZHANG Xu , ZHANG Jia-tai , LIU Gang, YUAN S J, WANG Z R College of Mechanical and Electrical Engineering, Harbin Engineering University, Harbin, 150001, China College of Material Science and Engineering, Harbin Institute of Technology, Harbin , 150001 , China | 2002 | Journal of Marine Science and Application2002，1，1： | 6 |
| 5 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 6 | Thermal and Transmission Properties of UV Nonlinear Optical Material——ZnCd(SCN)_4 Crystal显示文摘Zinc cadmium thiocyanate(ZCTC), ZnCd(SCN) 4, has been discovered as a UV second order nonlinear optical coordination crystal. Its thermal and transmission properties are reported. The thermal decomposition is characterized by using the X ray powder diffraction (XRPD) and infrared (IR) spectroscopy at room temperature. The absorptions of intrinsic ions and ZCTC in a solution state are discussed as well as transmission properties of the ZCTC crystal. An effective method of reducing the surface reflection loss of ZCTC crystal is introduced. | NING H X, XU D, WANG X Q, CHENG X F, YANG Z H (Institute of Cryst. Mater. and State Key Lab. of Cryst. Mater., Shandong University, Jinan 250100, CHN) | 2002 | Semiconductor Photonics and Technology2002，8，1： | 4 |
| 7 | DEBRIS FLOW CONTROL BY USING SLIT DAMS显示文摘Slit dams have been shown to be effective in trapping coarse sediment and retarding the debris flow. It is necessary to establish the controlling efficiency and the systematic procedures for designing slit dams, as well as reasonable sites for their location. Using the principle of mass conservation and laboratory experiments, this paper develops the sediment flow-out ratio and sediment concentration ratio to evaluate the effectiveness of the slit dam, and confirms that sediment concentration ratio increases with an increase in relative spacing and slit density. The sediment flow-out ratio depends on the sediment concentration ratio and sediment concentration before passing through a slit dam. For sediment concentration before passing through a slit dam, based upon Bagnold’s concept of the dispersive stress generated by grain collisions in flow and bed shear stress, a semi-empirical relationship is obtained. Compared with other researchers’ studies, this study is found to be in excellent conformity with theirs, when taking 0.1 as the empirical coefficient. Besides, height, spacing and location factors affecting a slit dam design for debris flow mitigation are established herein. Furthermore, the design procedures of a slit dam are provided as a useful tool for controlling the debris flow hazards and are illustrated by a numerical example. | Hui-Pang LIEN and Fang-Wu TSAI (1 Associate Professor, Department of Hydraulic Engineering, Feng Chia University, Taichung, Taiwan 407, China z Associate Professor, Department of Mechanic Engineering, Chung Chou College of Technology and Commerce, Changhu | 2000 | International Journal of Sediment Research2000，15，4： | 3 |
| 8 | 云南富合山地区滇金丝猴游走模式的季节性差异(英文)显示文摘从 2 0 0 0年 11月至 2 0 0 2年 1月 ,我们在云南富合山 (99°2 0′E ,2 6°2 5′N)记录了滇金丝猴 (Rhinopithe cusbieti)的游走以及其他行为 ,以描述猴群行为模式的季节性变化及其对温带环境的适应。由于季节间行为方式的相似 ,我们将冬季和春季、夏季和秋季的数据合并表述。猴群终年以取食树叶为主 ,多在过夜地附近活动。在冬 -春季 ,猴群一般在低海拔的南部地区活动 ,同时缩短日行走距离 ,花费较多的时间取食树叶、竹叶和竹笋 ;而在夏 -秋季猴群的活动模式与冬 -春季相反 ,并取食大量果实。我们将富合地区猴群的季节性游走模式以及食性看作是食物供给和温度变化之间折中的结果 ,这些行为特征和其它温带灵长类的相似。此外 。 | 刘泽华 丁伟 Cyril C.GRTER.Anthropological Institute and Museum University of Zürich-Irchel Switzerland | 2004 | 动物学报2004，50，5： | 2 |
| 9 | Processing of Low-carbon Steel by Equal-Channel Angular Pressing显示文摘 | Fukuda Y Oh-ishi K Horita Z and Langdon T G | 2002 | Acta Materialia2002，50，： | 2 |
| 10 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 11 | sinensis: regeneration and characterization of hybrid shoots显示文摘 | XU X Y HU Z Y LI J F et aL Asymmetric somatic hybridization between UV-irradiated Citrus unshiu and C | 2007 | Plant Cell Reports2007，26，： | 1 |
| 12 | A Extended Class of Time-Continuous Branching Processes显示文摘 | Zhang H J and Hou Z T | 1999 | Submitted,19991999，1999，： | 1 |
| 13 | Interesting physical properties of the new spinel phase of Si《,3》N《,4》 and C《,3》N《,4》显示文摘 | Ouyang L Z and Ching W Y | 1999 | Physical Review Letters1999，83，： | 1 |
| 14 | Oscillation of second order neutral differential equations显示文摘 | Xia Y and Xu Z | 2006 | Southeast Asia Ball Math2006，，30： | 1 |
| 15 | Optimal discriminant plane for a small number of samples and design method of classifier on the plane 显示文摘 | Hong Z Q and Yaag J Y | 1991 | Pattern Recognition1991，24，4： | 1 |
| 16 | Testing structural change in time-series nonparametric regression models 显示文摘 | Su L J and Xiao Z J | 2008 | Statistics and Its Interface2008，，1： | 1 |
| 17 | A class of pseudonoise sequence overGF(p)with low correlation zone显示文摘 | Tang X H and Fan P Z | 2001 | IEEE Transactions onInformation Theory2001，47，4： | 1 |
| 18 | Designing polymorphic circuits with polymorphic gates: a general design approach显示文摘 | Luo W Zhang Z and Wang X | 2007 | lET Circuits Devices & Systems2007，1，6： | 1 |
| 19 | The Influence of retained austenite in high chromium cast iron on impact-abrasive wear显示文摘 | TONG J M ZHOU Y Z SHEN T Y and DENG H J | 1990 | Wear1990，135，2： | 1 |
| 20 | Molecular cloning, overexpression, purification, and characterization of an aerobic FMN - dependent azoreductase from Enterococcus faecalis 显示文摘 | Chen H Z Wang R F and Cemiglia C E | 2004 | Protein Expression and Purification2004，34，： | 1 |
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