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| 1 | 谷氨酰胺、癌症及其治疗显示文摘目的回顾谷氨酰胺、癌症及其治疗方面的一些进展,主要是关于谷氨酰胺与肿瘤生长方面的体内与体外、动物和人体的研究结果。对荷瘤宿主在接受放疗和化疗时补充谷氨酰胺的某些益处进行总结。背景谷氨酰胺是体内最丰富的游离氨基酸。而肿瘤组织就象一个“谷氨酰胺网”消耗大量的谷氨酰胺,从而促使机体恶病质的发生。体外研究中,肿瘤细胞的生长依赖于谷氨酰胺的结果使得人们未在临床上给癌症病人补充谷氨酰胺。方法对谷氨酰胺与接受放、化疗荷瘤宿主的关系的研究结果进行归纳和总结。结果大量体内研究表明,补充谷氨酰胺不但不会使肿瘤生长,而且还会通过刺激机体的免疫系统来抑制肿瘤的生长。在机体接受放疗和化疗时,谷氨酰胺可以保护机体并增加化疗对肿瘤的选择性。结论还需要进行前瞻、随机的研究来证明在接受放疗和化疗的病人补充谷氨酰胺的安全性和有效性。 | V.Suzanne Klimberg John L.McClellan Little Rock Arkansas | 1999 | 中国临床营养杂志1999，7，2： | 24 |
| 2 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 3 | Surgical use of breast ultrasound显示文摘 | Rubio IT Henry-Tillman R Klimberg VS | 2003 | Surg Clin North Am2003，83，： | 1 |
| 4 | Glutamine suppresses PGE2 synthesis and breast cancer growth显示文摘 | klimberg V komhluth J Cao Y | 1996 | J Surg Res1996，63，1： | 1 |
| 5 | Clip migration in stereotactic biopsy显示文摘 | Kass R Kumar G Klimberg V S | 2002 | Am J Surg2002，184，4： | 1 |
| 6 | Glutamine suppresses PGE2 synthesis and breast cancer growth 显示文摘 | Klimberg VS Kornbluth J Cao Y | 1996 | J Surg Res1996，63，1： | 1 |
| 7 | A multiple objective approach to data envelopment analysis显示文摘 | KLIMBERG R PUDDECOMBE M | 1999 | Advances in Mathematical Programming and Financial Planning1999，5，： | 1 |
| 8 | Subareolar versus peritumoral injection for location of the sentinel lymph node显示文摘 | Klimberg VS Rubio IT Henry R | | 0，，： | 1 |
| 9 | Subareolar versus peritumoral injection for location of the sentinel lymph node显示文摘 | KLIMBERG VS RUBIO IT HENRY R | 1999 | Ann Surg1999，229，： | 1 |
| 10 | Glutamine suppresses PGE2 synthesis and breast cancer growth显示文摘 | | 1996 | J Surg Res1996，63，： | 1 |
| 11 | Glutamine protects against doxorubicin-induced cardiotoxicity显示文摘 | Cao Y Kenned R Klimberg VS | 1999 | J Surg Res1999，85，2： | 1 |
| 12 | Gluta mine-enrich total parenteral nutrition supports gut metabolism显示文摘 | Klimberg | 1989 | Surg Porum1989，40，： | 1 |
| 13 | Doxazosin for I-enign pro- static hyperplasia long term efficacy and safety in hypertensive and normotensive patients显示文摘 | Lepor H Kaplan SA Klimberg I | 1997 | J Urol1997，157，： | 1 |
| 14 | Glutamine,cancer,and itstherapy显示文摘 | Vsuzanne Klimberg | 1996 | Am Jsurg1996，172，： | 1 |
| 15 | Single-dose oral ciprofloxacin versus placebo for prophylaxis during transrectal prostate biopsy显示文摘 | Kapoor DA Klimberg LW Malek GH | 1998 | Urology1998，52，： | 1 |
| 16 | Glutamine-enriehed diets support muscle glulamine metabolism without stimulating tumor growth 显示文摘 | Klimberg VS Souba WW Salloum RM | 1991 | J Surg Res1991，48，4： | 1 |
| 17 | The receptor expression pattern in ductal carcinoma in situ predicts recurrence 显示文摘 | Kepple J Henry-Tillman RS Klimberg VS | 2006 | Am J Surg2006，192，1： | 1 |
| 18 | Benign Breast Disease:Diagnosis and Assessment显示文摘 | Margaret Thompson V Suzanne Klimberg | | 0，，： | 1 |
| 19 | Long-term results of phase II ablation after breast lumpectomy added to extend intraoperative margins(ABLATE l)trial显示文摘 | Klimberg VS Ochoa D Henry-Tillman R | 2014 | J Am Coll Surg2014，218，4： | 1 |
| 20 | Prophylactic glutamine protects the intestinal mucosa from radiation injury显示文摘 | | 1990 | Cancer1990，1，： | 1 |
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