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| 1 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 2 | Hepatitis C virus infection in patients infected with human immunodeficiency virus 显示文摘 | Quan CM Krajden M GA | 1993 | Clin Infect Dis1993，17，： | 1 |
| 3 | Examination of human stomach biopsies, saliva, and dental plaque for Campylobaeter pylori显示文摘 | Krajden S Fuksa M Anderson J | 1989 | J Clin Microbiol1989，27，： | 1 |
| 4 | Polymerase chain reaction based assessment of leukoreduction efficacy using a cytomegalovirus DNA transfected human T-cell line显示文摘 | Lau W Onizuka R Krajden M | 1998 | J Clin Virol1998，11，2： | 1 |
| 5 | Evidence for the occurrence of the same strain of Campylobaeter pylori in the stomach and dental plaque 显示文摘 | Shames B Krajden S Fuksa M | 1989 | J Clin Microbiol1989，27，： | 1 |
| 6 | Cytomegalovirus viremia in lung transplant receiving ganciclovir and immune globulin显示文摘 | Gutierrez CA Chaparro C Krajden M | 1998 | Chest1998，113，4： | 1 |
| 7 | A randomized controlled trial of human papillomavirus(HPV) testing for cervical cancerscreening:trial design and preliminary results(HPV FOCAL Trial)显示文摘 | Ogilvie GS van Niekerk DJ Krajden M | 2010 | BMC Cancer2010，10，2： | 1 |
| 8 | Evaluation of the core antigen assay as a second-line supplemental test for diagnosis of active hepatitis C virus infection 显示文摘 | Krajden M Shivji R Gunadasa K et ol | 2004 | J Clin Microbiol2004，42，9： | 1 |
| 9 | Cytomegalovirus viremia in lung transplant recipients receiving ganciclovir and immune globulin显示文摘 | Gutierrez CA Chaparro C Krajden M | | 0，，04： | 1 |
| 10 | Toll‐like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre‐eclampsia显示文摘 | F Xie Y Hu SE Turvey LA Magee RM Brunham K‐C Choi M Krajden PCK Leung DM Money DM Patrick E Thomas P von Dadelszen | 2009 | BJOG: An International Journal of Obstetrics & Gy2009，，： | 1 |
| 11 | Evidence for the occurrence of the same stain of Helieobacter Pylori in the stomach and dental plaque显示文摘 | Shames B Krajden S Fuksa M | 1989 | J Clin Microbiol1989，27，： | 1 |
| 12 | Examination of human stomach biopsies,saliva,and dental plaque for Campylobacter pylori显示文摘 | Krajden S Fuksa M Anderson J | 1989 | J Clin Microbiol1989，27，6： | 1 |
| 13 | Detection of antibiotic resistance genes associated with methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative staphylococci in hospital air filter dust by PCR显示文摘 | Drudge C N Krajden S Summerbell R C | 2012 | Aerobiologia2012，28，2： | 1 |
| 14 | Pooled nucleic acid testing increases the diagnostic yield of acute HIV infections in a high - risk population compared to 3rd and 4th generation HIV enzyme immunoassays 显示文摘 | Krajden M Cook D Mak A | 2014 | J Clin Virol2014，61，1： | 1 |
| 15 | A randomized controlled trial of Human Papillomavirus (HPV) testing for cervical cancer screening:trial design and preliminary results显示文摘 | Gina S Ogilvie Dirk J van Niekerk Mel krajden | | 0，，02： | 1 |
| 16 | Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management 显示文摘 | Lira S Katz K Krajden S | 2004 | Can MedAssocJ2004，171，5： | 1 |
| 17 | Assessment of HPV 16 and HPV 18 antibody responses by pseudovirus neutralization, Merck eLlA and Merck total IgG L1A immunoas- says in a reduced dosage quadrivalent HPV vaccine trial 显示文摘 | Krajden M Cook D Yu A | 2013 | Vaccine2013，29，13： | 1 |
| 18 | Pooled nucleic acid testing increases the diagnostic yield of acute HIV infections in a high-risk population compared to 3rd and 4th generation HIV enzyme immunoassays显示文摘 | Krajden M Cook D Mak A | 2014 | J Clinical Virology2014，61，1： | 1 |
| 19 | Polymerase chain reaction based assessment of leukoreduction efficacy using a cytomegalovirus DNA transfected human T-cell line显示文摘 | Lau W Onizuka R Krajden M | 1998 | J Clin Virol1998，2011，2： | 1 |
| 20 | Examination of hu- man stomach biopsies, saliva, and dental plaque for Campy- lobacter pylori 显示文摘 | Krajden S Fuksa M Anderson J | 1989 | J Clin Microbiol1989，27，6： | 1 |
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